Polymorphism of inflammatory system genes in the pathogenesis of rheumatic heart disease

Aim. To assess the contribution of polymorphic variants of inflammatory response genes to the predisposition to rheumatic heart disease.Material and methods. Using real-time polymerase chain reaction, we analyzed the prevalence of 18 polymorphic variants of 8 genes involved in the inflammatory process in 251 patients with rheumatic heart disease and 300 healthy donors.Results. We found that homozygous TT genotypes of rs1800871 (IL10) (p=0,02) and TT rs1800872 (IL10) polymorphisms (p=0,027), as well as TT genotypes of CRP gene (rs1205) (p=0,015) and GG genotypes of rs375947 (IL12RB) (p=0,037) are "risky" and associated with the development of rheumatic heart disease.Conclusion. Associations of polymorphic variants rs1800871 and rs1800872 of the IL10 gene, rs1205 of the CRP gene, and rs375947 of the IL12RB gene can be an important link in the pathogenesis of rheumatic heart disease and can later be used as biological markers for a personalized assessment of the disease risk

Особенности течения туберкулеза у лиц пожилого и старческого возраста

The objective: to identify specific features of the clinical course of tuberculosis in elderly and senile patients under the current epidemic situation.The specific clinical course of tuberculosis was analyzed in 54 patients at the age of 61 years and older and compared with the course of 234 patients at the age from 18 to 39 years selected by the continuous sampling of all 472 patients discharged from hospital in 2018. The following features were found to be typical of patients of 61 years and older: more frequent chronic forms of the disease (37.0%) and complications (35.2%), the major complication was chronic cor pulmonale (33.3%); more frequent concurrent chronic nonspecific lung diseases (13.0%) and coronary heart disease/arterial hypertension (14.8%); more frequent deaths (31.5%), mainly due to pulmonary heart disease; less frequent generalization of tuberculosis (5.5%) and concurrent HIV infection (7.4%).Цель исследования: выявить особенности клинического течения туберкулеза у лиц пожилого и старческого возраста в современных эпидемических условиях.Проанализированы особенности клинического течения туберкулеза ‒ у 54 больных в возрасте 61 года и старше в сравнении с 234 пациентами 18-39 лет, отобранных сплошной выборкой из всех 472 больных, выписанных в 2018 г. Выявлено, что у лиц в возрасте 61 года и старше: более частая хронизация процесса (37,0%) и осложненное (35,2%), в основном хроническим легочным сердцем (33,3%), течение; более частые сопутствующие хронические неспецифические заболевания легких (13,0%) и ишемическая болезнь сердца/артериальная гипертония (14,8%); более частые летальные исходы (31,5%), преимущественно за счет легочно-сердечной недостаточности; более редки генерализация туберкулеза (5,5%) и сопутствующая ВИЧ-инфекция (7,4%)

Measurement of CNGS muon neutrino speed with Borexino

We have measured the speed of muon neutrinos with the Borexino detector using short-bunch CNGS beams. The final result for the difference in time-of-flight between a =17 GeV muon neutrino and a particle moving at the speed of light in vacuum is {\delta}t = 0.8 \pm 0.7stat \pm 2.9sys ns, well consistent with zero.Comment: 6 pages, 5 figure

Thermal Decomposition of Co-Doped Calcium Tartrate and Use of the Products for Catalytic Chemical Vapor Deposition Synthesis of Carbon Nanotubes.

Thermal decomposition of Co-doped calcium tartrate in an inert atmosphere or air was studied using thermogravimetric analysis and X-ray absorption fine structure (XAFS) spectroscopy. It was shown that the powder substance containing 4 at.% of cobalt completely decomposes within 650-730 °C, depending on the environment, and the formation of Co clusters does not proceed before 470 °C. The products of decomposition were characterized by transmission electron microscopy, XAFS, and X-ray photoelectron spectroscopy. Surfaceoxidized Co metal nanoparticles as large as ∼5.6 ( 1.2 nm were found to form in an inert atmosphere, while the annealing in air led to a wide distribution of diameters of the nanoparticles, with the largest nanoparticles (30-50 nm) mainly present as a Co3O4 phase. It was found that the former nanoparticles catalyze the growth of CNTs from alcohol while a reducing atmosphere is required for activation of the latter nanoparticles. We propose the scheme of formation of CaO-supported catalyst from Co-doped tartrate, depending on the thermal decomposition conditions

Bromination of double-walled carbon nanotubes

Double-walled carbon nanotubes (DWCNTs) synthesized by catalytic chemical vapor deposition (CCVD) have been functionalized by bromine vapor at room temperature. At least two different bromine species were detected in the product using X-ray photoelectron spectroscopy (XPS) and thermal gravimetric analysis. The primary form is negatively charged Br2 molecules exhibiting an intense resonance at ∼238 cm−1 in the Raman spectrum. The electron transfer from the nanotubes to the adsorbed molecules is detected from C 1s XPS and near-edge X-ray absorption fine structure spectra. The optical absorption spectra reveal that although the metallic nanotubes are more reactive to Br2, the outer semiconducting nanotubes also readily interact with Br2 adsorbates. The secondary bromine form is attributed to covalent C-Br bonding, and its possible sources are discussed in the light of quantum-chemical calculations. Analysis of the XPS, Raman, and optical absorption spectra of the Br-DWCNTs annealed at 100-170 ° C indicates preservation of a part of bromine molecules in samples that affects the electronic and vibration properties of nanotubes

Specific course of tuberculosis in elderly and senile patients

The objective: to identify specific features of the clinical course of tuberculosis in elderly and senile patients under the current epidemic situation.The specific clinical course of tuberculosis was analyzed in 54 patients at the age of 61 years and older and compared with the course of 234 patients at the age from 18 to 39 years selected by the continuous sampling of all 472 patients discharged from hospital in 2018. The following features were found to be typical of patients of 61 years and older: more frequent chronic forms of the disease (37.0%) and complications (35.2%), the major complication was chronic cor pulmonale (33.3%); more frequent concurrent chronic nonspecific lung diseases (13.0%) and coronary heart disease/arterial hypertension (14.8%); more frequent deaths (31.5%), mainly due to pulmonary heart disease; less frequent generalization of tuberculosis (5.5%) and concurrent HIV infection (7.4%)