CLINICAL STUDY ON CHURNA BASTI ADMINISTERED IN MODIFIED KALA BASTI SCHEDULE IN AMAVATA

Amavata is most common debilitating joint disorder which makes the life of patient almost crippled. Amavata in the modern parlance can be correlated with Rheumatoid Arthritis which is a highly prevalent disease in the present life scenario due to the changing dietetic habits, social structure, environmental and mental stress. Ayurveda has a lot to offer in this regard. The Chikitsa explained for Amavata includes Shodhana as well as Shamana which includes Langhana, Deepana, Swedana, Virechana, Snehapana, Basti and Upanaha. Therefore, the study was planned to evaluate the efficacy of Churnabasti in modified Kalabasti schedule in the management of Amavata. Churna Basti yoga explained by Acharya Chakrapani comprises of drugs possessing Ushna & Teekshnagunas, Deepana-Pachana, Vata Kaphahara and Shula-Shothahara properties which may help in attaining Agnideepti, Laghutva, Nirama Lakshana and Shoolahara effect. Combination of Vaishwanara choorna, Rasna Saptaka Kashaya and Dhanyamla administered in Amavata is yielding beneficial effects as the ingredients possess the properties opposite to that of Amavata and therefore acts positively on the disease. The present study was planned based on this concept and statistically highly significant effects (P>0.0001) were observed in the various assessment parameters of Amavata such as Sandhishoola, Sandhishotha, Sandhistabdhata Sandhisparsa Asahyata etc. In overall effect of therapy maximum number of patients (40.12%) got marked improvement. Therefore, Churna Basti comprising of drugs possessing properties opposite to Ama can be considered as a good remedy in the management of Amavata

Abhyanga : Different contemporary massage technique and its importance in Ayurveda

Ayurveda is a ‘science of life’ which provides not only curative but also preventive principles for healthy and long life. Ayurveda is a life style, a science and an art of appropriate living that ensures health and longevity of human being. Abhyanga (oil massage) which is one among the Dinacharya, is also a part of pre therapeutic procedures of Panchakarma. Abhyanga is to be considered in Snehana therapy. As it nourishes the senses of mind and gives the strength. but if done in any region like localised in head, neck, legs etc then it is termed as Shiroabhyanga, Padabhyanga etc. Full body massage gives strength to whole body but localised massage gives strength to that particular part of the body. Localised massage can be practised by oneself. Thus it is easy to practise. But for Abhyanga one need to be dependent on massage trainer. The instructions to be followed under localised massage also. It gives its benefits; when it is done in right manner only

A CLINICAL EFFECT OF TRIVRT-ASHTAKA CHURNA AS A VIRECHAKA YOGA IN THE MANAGEMENT OF TAMAKA SHWASA (BRONCHIAL ASTHMA)

Virechana Karma is one of the prime modality of the treatment in Panchakarma. Different types and forms of Virechana Yogas are mentioned with specific indications in classics. The trail drug Trivrt Ashtaka Churna is one of the such Virechana Yoga told in our classic. Clinical validation of this drug is further requires, scientific explanation and justification for its global acceptance as a Virechaka Yoga. Tamaka Shwasa occurs mainly due to vitiation Kapha Vata Doshas in Pitta Sthana. It shows close resemblance with Bronchial Asthma on the basis of clinical manifestations. Managing Bronchial asthma on Ayurvedic line of treatment is totally different from that of conventional management. Virechana Karma is the best modality in management of Tamaka Shwasa. Hence the present study has been taken up to see the efficacy of trail drug Trivrt Ashtaka Churna on 30 cases of Tamaka Shwasa (Bronchial Asthma). Results: The study observations showed that the100% good palatability for Virechana Yoga, 64.3% patients got their first Vega on an average time 30 minutes, in 57.1% patients 16 - 18 Vegas were noted, Samyak Shuddi Lakshana with Pittanta was observed in 57.1% of patients.There was a highly significant improvement in symptoms like Swasa krichrata, Kasa, Ghurghuraka, Kaphanishtivana and in signs like Ronchi, Wheeze and Respiration rate got highly significant results (at p<0.001). Conclusion: After going through the clinical changes observed during and after the treatment, it may be opined that, Trivrt Ashtaka Churna acts as a Virechaka Yoga significantly in the management of signs and symptoms of Tamaka Shwasa

Management of Khalitya through Pracchana followed by Vanadhanyakadi Lepa - A Case Report

Alopecia is caused by androgen and genetic factors. Androgens cause hair follicles to shrink and eventually disappear if they are not addressed. It is inherited as an autosomal dominant trait. A 26-year-old male presented to the Panchakarma OPD Sri Dharmasthala Manjunatheshwara College of Ayurveda and Hospital, Hassan, with complaints of gradual hair loss and scalp itching over a two-year period. It was diagnosed as a case of Khalitya and was treated with Udwartana to Shira Pradesha, Pracchana, and Lepa application. The Norman Hamilton scale, hair pull test and symptoms before and after treatment were used to evaluate the case. Following treatment, there was a significant reduction in symptoms and significant hair growth

Cortical suspensory endobutton versus aperture interference screw fixation for arthroscopic anterior cruciate ligament reconstruction using hamstring graft: a prospective study

Background: Anterior cruciate ligament injury is a common injury which occurs in sports with an annual incidence of 68.6% per 100,000 population. Anatomic arthroscopic reconstruction remains the main stay treatment of ACL injury. Fixation of graft is classified as direct and indirect. To compare the stability of knee joint, complications in arthroscopic anterior cruciate ligament reconstruction by aperture interference screw fixation versus suspensory device fixation in femur. Methods: The randomized control study was conducted in department of orthopedics, The Oxford Medical College Hospital and RC from 2020-2021. 30 knees were operated, Ethical clearance taken and patient is followed up for six months. Results: The preoperative Tegner Lysholm knee score was poor in both groups. Post-op in interference screw group, 12 patients 80% had excellent functional outcome, 3 patients 20% had good outcome. In the Endbutton group, 11 patients (73%) had excellent outcome while 4 patients (27%) had good outcome. Conclusions: Suspensory device fixation gives equivalent results when compared to aperture screw fixation. complications of screw fixation were graft rupture cyst formation; complications of suspensory devices were loosening of graft and bungee cord effect. Hence, Both the techniques showed no statistical difference in post operative outcome

Upanaha Sveda and its modification - A Critical Review

A fired building is best saved by pouring water , in the same way tropical problems are successfully managed by tropical treatment rather than systemic treatment. Upanaha is an ideal tropical treatment. Pradeha, Sankara/Panda Sveda, Bandhana are three varieties of Upanaha. It helps in reducing Vata Dosha, Sheeta (coldness), Shoola (pain), Sthambha (stiffness), Gouravatha (heaviness). It induces sweating and brings Doshavilayana. Sveda helps in Gatravinamana (increase the flexibility of body). Upanaha an Ayurvedic tropical treatment needs to evolve or adapt according to time so that it is easy to practice without changing its efficacy. Here an effort made to bring some modification in Upanaha

Role of Panchakarma in the management of Hypothyroidism

We are in technical era where there is more of sedentary life style and stress along with this urbanization is affecting our quality of food and health. This is leading to many lifestyle disorders and hormonal imbalances in our body. Hypothyroidism one among the endocrinal disorder. Thyroid is an endocrinal gland secrets T3 and T4 hormones regulated by TSH which is secreted by Pituitary gland. These hormones have two major effects on the body, 1) To increase the overall metabolic rate in the body 2) To stimulate growth in children. Hypothyroidism is common health issue in India. The highest prevalence of hypothyroidism (13.1%) is noted in people aged 46-54yrs old. With people aged 18-35 yrs being less affected (7.5%). To prevent these hazards Panchakarma is beneficiary to maintain metabolic rate. Here an attempt is made to diagnose hypothyroidism in the light of Ayurveda and management guidelines through Panchakarma

Compartmental Genomics in Living Cells Revealed by Single-Cell Nanobiopsy

The ability to study the molecular biology of living single cells in heterogeneous cell populations is essential for next generation analysis of cellular circuitry and function. Here, we developed a single-cell nanobiopsy platform based on scanning ion conductance microscopy (SICM) for continuous sampling of intracellular content from individual cells. The nanobiopsy platform uses electrowetting within a nanopipette to extract cellular material from living cells with minimal disruption of the cellular milieu. We demonstrate the subcellular resolution of the nanobiopsy platform by isolating small subpopulations of mitochondria from single living cells, and quantify mutant mitochondrial genomes in those single cells with high throughput sequencing technology. These findings may provide the foundation for dynamic subcellular genomic analysis

Risk classification at diagnosis predicts post-HCT outcomes in intermediate-, adverse-risk, and KMT2A-rearranged AML.

Little is known about whether risk classification at diagnosis predicts post-hematopoietic cell transplantation (HCT) outcomes for acute myeloid leukemia (AML) patients. We evaluated 8709 AML patients from the CIBMTR database and, after selection and manual curation of cytogenetics data, 3779 patients in CR1 were included in the final analysis: 2384 with intermediate-risk, 969 with adverse-risk, and 426 with KMT2A-rearranged disease. An adjusted multivariable analysis compared to intermediate-risk patients detected an increased risk of relapse for KMT2A-rearranged and adverse-risk patients (HR 1.27, p = 0.01 and HR 1.71, p < 0.001, respectively). Leukemia-free survival (LFS) was similar for KMT2A and adverse-risk patients (HR 1.26, p = 0.002 and HR 1.47, p < 0.001), as was overall survival (OS) (HR 1.32, p < 0.001 and HR 1.45, p < 0.001). No differences in outcome could be detected when patients were stratified by KMT2A fusion partner. This is the largest study conducted to date on post-HCT outcomes in AML using manually curated cytogenetics for risk stratification. Our work demonstrates that risk classification at diagnosis remains predictive of post-HCT outcomes in AML. It also highlights the critical need to develop novel treatment strategies for patients with KMT2A rearrangements and adverse-risk disease

Imaging tumour hypoxia with positron emission tomography.

Hypoxia, a hallmark of most solid tumours, is a negative prognostic factor due to its association with an aggressive tumour phenotype and therapeutic resistance. Given its prominent role in oncology, accurate detection of hypoxia is important, as it impacts on prognosis and could influence treatment planning. A variety of approaches have been explored over the years for detecting and monitoring changes in hypoxia in tumours, including biological markers and noninvasive imaging techniques. Positron emission tomography (PET) is the preferred method for imaging tumour hypoxia due to its high specificity and sensitivity to probe physiological processes in vivo, as well as the ability to provide information about intracellular oxygenation levels. This review provides an overview of imaging hypoxia with PET, with an emphasis on the advantages and limitations of the currently available hypoxia radiotracers.Cancer Research UK (CRUK) funded the National Cancer Research Institute (NCRI) PET Research Working party to organise a meeting to discuss imaging cancer with hypoxia tracers and Positron Emission Tomography. IF was funded by CRUK and is also supported by the Chief Scientific Office. ALH is supported by CRUK and the Breast Cancer Research Foundation. RM is funded by NIHR Cambridge Biomedical Research Centre.This is the accepted manuscript. The final version is available from Nature Publishing at http://www.nature.com/bjc/journal/vaop/ncurrent/full/bjc2014610a.html