77 research outputs found
Hidradenitis supurativa con afectación glútea: análisis de 83 pacientes
Hidradenitis supurativa; Hidradenitis glĂştea; InflamaciĂłnHidradenitis supurativa; Hidradenitis glĂştea; InflamaciĂłHidradenitis suppurativa; Gluteal hidradenitis; InflammationBackground: In 2013, Canoui-Poitrine et al. identified three hidradenitis suppurativa (HS) phenotypes by a latent class (LC) analysis, based on anatomical sites of involvement.
Objective: To improve the classification of the gluteal phenotype (LC3) patients given their diverse lesion types and differences in clinical profile.
Material and methods: We designed a bicentric study gathering all LC3 patients (n=83) from two hospitals. We conducted a two-step cluster analysis among them and also compared their characteristics with the rest of the HS patients (n=661).
Results: Compared with global HS series, LC3 patients were more frequently non-obese men, with smoking habit, an associated arthropathy, and a more frequent history of pilonidal sinus. The analysis of LC3 patients yielded two clusters: cluster 1 (38.3%) included elderly female patients, with later diagnosis of the disease and more sinus tracts; cluster 2 (61.7%) encompassed more men with earlier disease onset and more nodules and folliculitis lesions.
Limitations: The study's limitations include its retrospective nature, bicentric design, and small sample size.
Conclusion: The heterogeneous clinical presentation of HS makes it essential to have a good classification of the patients. Gluteal phenotype could actually be classified into two "subphenotypes" with a different clinical profiles and management.Antecedentes: En 2013 Canoui-Poitrine et al. identificaron tres fenotipos de hidradenitis supurativa (HS) mediante un análisis de clases latentes (LC) basado en las regiones anatómicas
afectadas.
Objetivo: Mejorar la clasificaciĂłn de los pacientes con fenotipo glĂşteo (LC3) dados los diversos
tipos de lesiones y diferencias en el perfil clĂnico.
Material y métodos: Disenamos ˜ un estudio bicéntrico que incluyó a todos los pacientes con
LC3 (n = 83) de dos hospitales terciarios espanoles. ˜ Realizamos un análisis de conglomerados en
dos etapas dentro del grupo LC3 y tambiĂ©n comparamos sus caracterĂsticas con el resto de los
pacientes con HS (n = 661).
Resultados: En comparación con la serie global de HS, los pacientes con LC3 fueron más frecuentemente hombres no obesos, fumadores, con una artritis asociada y con mayor prevalencia
de sinus pilonidal. El análisis de los pacientes LC3 resultó en dos grupos: el grupo 1 (38,3%), que
incluĂa pacientes mayores, de sexo femenino, con diagnĂłstico más tardĂo de la enfermedad y
más trayectos sinusales; y el grupo 2 (61,7%), que englobaba a más hombres con inicio temprano
de la enfermedad y más nódulos y lesiones de foliculitis.
Limitaciones: Las limitaciones del estudio incluyen su naturaleza retrospectiva, el diseno˜ bicéntrico y el tamano˜ muestral reducido.
ConclusiĂłn: La presentaciĂłn clĂnica heterogĂ©nea de la HS hace que sea esencial disponer de una
buena clasificaciĂłn clĂnica de los pacientes. Como hemos visto, parece que el fenotipo glĂşteo
podrĂa clasificarse en dos «subfenotipos» con perfiles clĂnicos y, consecuentemente, enfoques
terapéuticos diferentes
Electronic Structure and Thermoelectric Prospects of Phosphide Skutterudites
The prospects for high thermoelectric performance in phosphide skutterudites
are investigated based on first principles calculations. We find that
stoichiometric CoP_3 differs from the corresponding arsenide and antimonide in
that it is metallic. As such the band structure must be modified if high
thermopowers are to be achieved. In analogy to the antimonides it is expected
that this may be done by filling with La. Calculations for LaFe_4P_12 show that
a gap can in fact be opened by La filling, but that the valence band is too
light to yield reasonable p-type thermopowers at appropriate carrier densities;
n-type La filled material may be more favorable.Comment: 3 pages, 3 figures, 1 tabl
Conformational analysis of enantiomerization coupled to internal rotation in triptycyl-n-helicenes
We present a computational study of a reduced potential energy surface (PES) to describe enantiomerization and internal rotation in three triptycyl-n-helicene molecules, centering the discussion on the issue of a proper reaction coordinate choice. To reflect the full symmetry of both strongly coupled enantiomerization and rotation processes, two non-fixed combinations of dihedral angles must be used, implying serious computational problems that required the development of a complex general algorithm. The characteristic points on each PES are analyzed, the intrinsic reaction coordinates are calculated, and finally they are projected on the reduced PES. Unlike what was previously found for triptycyl-3-helicene, the surfaces for triptycyl-4-helicene and triptycyl-5-helicene contain valley-ridge-inflection (VRI) points. The reaction paths on the reduced surfaces are analyzed to understand the dynamical behaviour of these molecules and to evaluate the possibility of a molecule of this family exhibiting a Brownian ratchet behaviour
Combining the Hybrid Functional Method with Dynamical Mean-Field Theory
We present a new method to compute the electronic structure of correlated
materials combining the hybrid functional method with the dynamical mean-field
theory. As a test example of the method we study cerium sesquioxide, a strongly
correlated Mott-band insulator. The hybrid functional part improves the
magnitude of the pd-band gap which is underestimated in the standard
approximations to density functional theory while the dynamical mean-field
theory part splits the 4f-electron spectra into a lower and an upper Hubbard
band.Comment: 5 pages, 2 figures, replaced with revised version, published in
Europhys. Let
New GOLD classification: longitudinal data on group assignment
Rationale: Little is known about the longitudinal changes associated with using the 2013 update of the
multidimensional GOLD strategy for chronic obstructive pulmonary disease (COPD).
Objective: To determine the COPD patient distribution of the new GOLD proposal and evaluate how this
classification changes over one year compared with the previous GOLD staging based on spirometry only.
Methods: We analyzed data from the CHAIN study, a multicenter observational Spanish cohort of COPD patients
who are monitored annually. Categories were defined according to the proposed GOLD: FEV1%, mMRC dyspnea,
COPD Assessment Test (CAT), Clinical COPD Questionnaire (CCQ), and exacerbations-hospitalizations. One-year
follow-up information was available for all variables except CCQ data.
Results: At baseline, 828 stable COPD patients were evaluated. On the basis of mMRC dyspnea versus CAT, the
patients were distributed as follows: 38.2% vs. 27.2% in group A, 17.6% vs. 28.3% in group B, 15.8% vs. 12.9% in
group C, and 28.4% vs. 31.6% in group D. Information was available for 526 patients at one year: 64.2% of patients
remained in the same group but groups C and D show different degrees of variability. The annual progression by
group was mainly associated with one-year changes in CAT scores (RR, 1.138; 95%CI: 1.074-1.206) and BODE index
values (RR, 2.012; 95%CI: 1.487-2.722).
Conclusions: In the new GOLD grading classification, the type of tool used to determine the level of symptoms
can substantially alter the group assignment. A change in category after one year was associated with longitudinal
changes in the CAT and BODE index
New GOLD classification: Longitudinal data on group assignment
Rationale:
Little is known about the longitudinal changes associated with using the 2013 update of the multidimensional GOLD strategy for chronic obstructive pulmonary disease (COPD).
Objective:
To determine the COPD patient distribution of the new GOLD proposal and evaluate how this classification changes over one year compared with the previous GOLD staging based on spirometry only.
Methods:
We analyzed data from the CHAIN study, a multicenter observational Spanish cohort of COPD patients who are monitored annually. Categories were defined according to the proposed GOLD: FEV1%, mMRC dyspnea, COPD Assessment Test (CAT), Clinical COPD Questionnaire (CCQ), and exacerbations-hospitalizations. One-year follow-up information was available for all variables except CCQ data.
Results:
At baseline, 828 stable COPD patients were evaluated. On the basis of mMRC dyspnea versus CAT, the patients were distributed as follows: 38.2% vs. 27.2% in group A, 17.6% vs. 28.3% in group B, 15.8% vs. 12.9% in group C, and 28.4% vs. 31.6% in group D. Information was available for 526 patients at one year: 64.2% of patients remained in the same group but groups C and D show different degrees of variability. The annual progression by group was mainly associated with one-year changes in CAT scores (RR, 1.138; 95%CI: 1.074-1.206) and BODE index values (RR, 2.012; 95%CI: 1.487-2.722).
Conclusions:
In the new GOLD grading classification, the type of tool used to determine the level of symptoms can substantially alter the group assignment. A change in category after one year was associated with longitudinal changes in the CAT and BODE index
New GOLD classification: longitudinal data on group assignment
In the new GOLD grading classification, the type of tool used to determine the level of symptoms can substantially alter the group assignment. A change in category after one year was associated with longitudinal changes in the CAT and BODE index
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