Redistribution of ions within the active layer and upper permafrost, Yamal, Russia

A landslide-affected slope was chosen to study the ionic migration in the active layer and upper portion of permafrost. The research was conducted in two stages, in 1994 and 2001. Several boreholes, in dry and wet environments of the shearing surface of a 1989-landslide, were drilled. A background borehole on an undisturbed site was sampled as well. Each sample, collected from the core, underwent a conventional chemical cation-anion analysis. The results showed desalinization of the active layer and upper permafrost, which occurred in 7 years. Different migration rates noted for various salts determine change of ionic composition from marine pattern to continental, because mobile ions are washed away by surface and subsurface runoff, while the less mobile ones are accumulating in the upper portion of the active layer due to capillary rise and at the active layer base on a geochemical barrier

Uniformity in the Wiener-Wintner theorem for nilsequences

We prove a uniform extension of the Wiener-Wintner theorem for nilsequences due to Host and Kra and a nilsequence extension of the topological Wiener-Wintner theorem due to Assani. Our argument is based on (vertical) Fourier analysis and a Sobolev embedding theorem.Comment: v3: 18 p., proof that the cube construction produces compact homogeneous spaces added, measurability issues in the proof of Theorem 1.5 addressed. We thank the anonymous referees for pointing out these gaps in v

Long-Term Follow-Up of Patients Immunized with AN1792: Reduced Functional Decline in Antibody Responders

BACKGROUND: Immunization of patients with Alzheimer's disease (AD) with synthetic amyloid-beta peptide (Abeta(42)) (AN1792) was previously studied in a randomized, double-blind, placebo-controlled phase 2a clinical trial, Study AN1792(QS-21)-201. Treatment was discontinued following reports of encephalitis. One year follow-up revealed that AN1792 antibody responders showed improvements in cognitive measures as assessed by the neuropsychological test battery (NTB) and a decrease in brain volume compared with placebo. METHODS: A follow-up study, Study AN1792(QS-21)-251, was conducted to assess the long-term functional, psychometric, neuroimaging, and safety outcomes of patients from the phase 2a study 4.6 years after immunization with AN1792. The results were analyzed by comparing patients originally identified as antibody responders in the AN1792 phase 2a study with placebo-treated patients. RESULTS: One hundred and fifty-nine patients/caregivers (30 placebo; 129 AN1792) participated in this follow-up study. Of the 129 AN1792-treated patients, 25 were classified in the phase 2a study as antibody responders (anti-AN1792 titers > or = 1:2,200 at any time after the first injection). Low but detectable, sustained anti-AN1792 titers were found in 17 of 19 samples obtained from patients classified as antibody responders in the phase 2a study. No detectable anti-AN1792 antibodies were found in patients not classified as antibody responders in the phase 2a study. Significantly less decline was observed on the Disability Assessment for Dementia scale among antibody responders than placebo-treated patients (p=0.015) after 4.6 years. Significant differences in favor of responders were also observed on the Dependence Scale (p=0.033). Of the small number of patients who underwent a follow-up MRI, antibody responders showed similar brain volume loss during the follow-up period subsequent to the AN1792 phase 2a study compared with placebo-treated patients. CONCLUSIONS: Approximately 4.6 years after immunization with AN1792, patients defined as responders in the phase 2a study maintained low but detectable, sustained anti-AN1792 antibody titers and demonstrated significantly reduced functional decline compared with placebo-treated patients. Brain volume loss in antibody responders was not significantly different from placebo-treated patients approximately 3.6 years from the end of the original study. No further cases of encephalitis were noted. These data support the hypothesis that Abeta immunotherapy may have long-term functional benefits

Eurasian Arctic greening reveals teleconnections and the potential for novel ecosystems

Arctic warming has been linked to observed increases in tundra shrub cover and growth in recent decades on the basis of significant relationships between deciduous shrub growth/biomass and temperature. These vegetation trends have been linked to Arctic sea ice decline and thus to the sea ice/albedo feedback known as Arctic amplification. However, the interactions between climate, sea ice and tundra vegetation remain poorly understood. Here we reveal a 50- year growth response over a >100,000 km2 area to a rise in summer temperature for alder (Alnus) and willow (Salix), the most abundant shrub genera respectively at and north of the continental treeline. We demonstrate that whereas plant productivity is related to sea ice in late spring, the growing season peak responds to persistent synoptic-scale air masses over West Siberia associated with Fennoscandian weather systems through the Rossby wave train. Substrate is important for biomass accumulation, yet a strong correlation between growth and temperature encompasses all observed soil types. Vegetation is especially responsive to temperature in early summer. These results have significant implications for modelling present and future Low Arctic vegetation responses to climate change, and emphasize the potential for structurally novel ecosystems to emerge fromwithin the tundra zone.Vertaisarviointia edeltävä käsikirjoitu

Geodatabase and WebGIS project for long-term permafrost monitoring at the Vaskiny Dachi Research Station, Yamal, Russia

The research station Vaskiny Dachi (VD) in central Yamal, Western Siberia was established in 1988. Continuous monitoring of the permafrost state is conducted since 25 years, which allows collecting a large amount of data related to permafrost state and environment of this region. To store and visualise the geospatial data, containing our knowledge of the research area and research topic, we created a geodatabase (GDB) to operatively process different types of geospatial data. The produced GDB contains so far 11 vector feature datasets and raster data in the same coordinate system. The vector data represent: 1) bathymetry; 2) social-economic objects; 3) field data; 4) geomorphology; 5) hydrography; 6) landscapes; 7) permafrost; 8) snow; 9) topography; 10) vegetation; 11) long-term measurement grids and transects (Circumpolar Active Layer Monitoring (CALM) transect, CALM measurement grid). All these feature datasets contain 60 feature classes of spatial data in total. Some of the geodata layers are directly linked to data bases of field data. The raster data contain 37 layers, including a digital ele vation model with derivatives, a map of snow distribution for the key site, ba thymetric maps and other maps of different scale. Moreover, the key area is a site for international research projects and the ongoing exchange of the data is supported by the VD GDB. Geographical Information System (GIS) allows collecting, storing and processing geospatial data from different sources in a wide range of types and formats. WebGIS platforms allow displaying the geospatial data for different users, giving the impression of the general pro cesses on the certain geographic area. Also, we use the WebGIS service to publish the data and to make it available for the larger community. This paper is an overview on the permafrost studies at the VD research station, the GDB for permafrost monitoring as well as the established Yamal WebGIS project

Классификация криогенно-оползневых форм рельефа для целей картографирования и прогноза

A classification of cryogenic-landslide landforms is developed for mapping their distribution and dynamics. It is based on the previously suggested classification subdividing cryogenic landsliding into two main types: cryogenic translational landslides (or active-layer detachment slides), and cryogenic earth flows (or retrogressive thaw slumps). The increased proportion of retrogressive thaw slumps compared to active layer detachments in the North of West Siberia in the last decade creates the need for an expanded classification of cryogenic earth flows. One of the important issues is separating the process of landsliding and resulting landforms, which in English are covered by one term ‘retrogressive thaw slump’. In dealing with the landforms, we distinguish (1) open and (2) closed ones. Open cryogenic-landslide landforms are those formed by the retreating of the coast bluff due to the thaw of ice or ice-rich deposits with an additional impact from wave or stream action. Closed cryogenic-landslide landforms are those initiated on a slope landward, and thawed material is delivered to the coast or stream through an erosional channel. Morphologically we distinguish thermocirques and thermoterraces depending on the shape of the retreating headwall, crescent or linear, respectively. An important issue is the type of ground ice subjected to thaw: tabular, ice-wedge or constitutional ground ice are distinguished. Landforms can be active, stabilized or ancient. One can find both single landforms and their combination. The classification is based on a significant amount of field studies and interpretation of remote sensing data. Mapping of the cryogenic-landslide landforms is suggested using the proposed classification and indication features. The classification is based on the experience obtained mainly in the north of West Siberia. Applying it to other regions may require additional studies.Разработана классификация криогенно-оползневых форм рельефа, сформированных криогенными оползнями течения (КОТФР), для картографирования их распространения и динамики. В основе лежит значительный объем полевых исследований и интерпретации данных дистанционного зондирования Земли. Классификация включает генетические, морфологические и криолитологические особенности пород, определяющие морфологию и динамику КОТФР, их положение в рельефе, степень их активности, сочетание и комплексирование единичных КОТФР. Предложенная классификация и индикационные признаки используются для картографирования КОТФР на севере Западной Сибири

Inter- and intraobserver reliability of the MTM-classification for proximal humeral fractures: A prospective study

<p>Abstract</p> <p>Background</p> <p>A precise modular topographic-morphological (MTM) classification for proximal humeral fractures may address current classification problems. The classification was developed to evaluate whether a very detailed classification exceeding the analysis of fractured parts may be a valuable tool.</p> <p>Methods</p> <p>Three observers classified plain radiographs of 22 fractures using both a simple version (fracture displacement, number of parts) and an extensive version (individual topographic fracture type and morphology) of the MTM classification. Kappa-statistics were used to determine reliability.</p> <p>Results</p> <p>An acceptable reliability was found for the simple version classifying fracture displacement and fractured main parts. Fair interobserver agreement was found for the extensive version with individual topographic fracture type and morphology.</p> <p>Conclusion</p> <p>Although the MTM-classification covers a wide spectrum of fracture types, our results indicate that the precise topographic and morphological description is not delivering reproducible results. Therefore, simplicity in fracture classification may be more useful than extensive approaches, which are not adequately reliable to address current classification problems.</p

The rice NLR pair Pikp-1/Pikp-2 initiates cell death through receptor cooperation rather than negative regulation

Plant NLR immune receptors are multidomain proteins that can function as specialized sensor/helper pairs. Paired NLR immune receptors are generally thought to function via negative regulation, where one NLR represses the activity of the second and detection of pathogen effectors relieves this repression to initiate immunity. However, whether this mechanism is common to all NLR pairs is not known. Here, we show that the rice NLR pair Pikp-1/Pikp-2, which confers resistance to strains of the blast pathogen Magnaporthe oryzae (syn. Pyricularia oryzae) expressing the AVR-PikD effector, functions via receptor cooperation, with effector-triggered activation requiring both NLRs to trigger the immune response. To investigate the mechanism of Pikp-1/Pikp-2 activation, we expressed truncated variants of these proteins, and made mutations in previously identified NLR sequence motifs. We found that any domain truncation, in either Pikp-1 or Pikp-2, prevented cell death in the presence of AVR-PikD, revealing that all domains are required for activity. Further, expression of individual Pikp-1 or Pikp-2 domains did not result in cell death. Mutations in the conserved P-loop and MHD sequence motifs in both Pikp-1 and Pikp-2 prevented cell death activation, demonstrating that these motifs are required for the function of the two partner NLRs. Finally, we showed that Pikp-1 and Pikp-2 associate to form homo- and hetero-complexes in planta in the absence of AVR-PikD; on co-expression the effector binds to Pikp-1 generating a tri-partite complex. Taken together, we provide evidence that Pikp-1 and Pikp-2 form a fine-tuned system that is activated by AVR-PikD via receptor cooperation rather than negative regulation