MRI/TRUS data fusion for brachytherapy

BACKGROUND: Prostate brachytherapy consists in placing radioactive seeds for tumour destruction under transrectal ultrasound imaging (TRUS) control. It requires prostate delineation from the images for dose planning. Because ultrasound imaging is patient- and operator-dependent, we have proposed to fuse MRI data to TRUS data to make image processing more reliable. The technical accuracy of this approach has already been evaluated. METHODS: We present work in progress concerning the evaluation of the approach from the dosimetry viewpoint. The objective is to determine what impact this system may have on the treatment of the patient. Dose planning is performed from initial TRUS prostate contours and evaluated on contours modified by data fusion. RESULTS: For the eight patients included, we demonstrate that TRUS prostate volume is most often underestimated and that dose is overestimated in a correlated way. However, dose constraints are still verified for those eight patients. CONCLUSIONS: This confirms our initial hypothesis

Integrated Geomechanical and Digital Photogrammetric Survey in the Study of Slope Instability Processes of a Flysch Sea Cliff (Debeli Rtič Promontory, Slovenia)

This work presents an integrated study approach that combines the results of a geomechanical survey with data obtained using digital photogrammetry (DP), to assess slope instability processes affecting a sea cliff at the Debeli Rtič promontory (Slovenia). The investigated cliff is 4–18 m-high and is made up of an alternation of sandstones and marlstones belonging to the Flysch Formation of Trieste, which is Eocene in age. The studied cliff was subjected to localized slope failures that occurred in the past and is currently subject to frequent rock collapses, thus resulting in its partial and episodic retreat. Field evidence acquired through a traditional survey was integrated with outputs of the DP technique based on 1399 images that were collected using both a commercial unmanned aerial vehicle (UAV) and a mobile phone (MP). UAV-derived images were useful for performing rock mass structure analysis in the upper part of the investigated cliff, where the traditional survey was not possible due to hazardous operating conditions. In addition, the use of a MP was observed to be a useful tool for the rapid collection of images at the toe of unsafe marine cliff environments. This study highlights that UAV-DP and MP-DP techniques can only be effective if the outcomes obtained from the 3D model reconstruction are validated by direct measurements acquired by means of the traditional field survey, thus avoiding improper or even erroneous results while enlarging the amount of data and the area of investigation. The study approach presented herein allowed for the assessment of slope instabilities affecting the Flysch Sea cliff, whose retreat is caused by the combined action of marine erosion and slope gravitational processes

Integrated Geomechanical and Digital Photogrammetric Survey in the Study of Slope Instability Processes of a Flysch Sea Cliff (Debeli Rtic Promontory, Slovenia)

This work presents an integrated study approach that combines the results of a geomechanical survey with data obtained using digital photogrammetry (DP), to assess slope instability processes affecting a sea cliff at the Debeli Rtic promontory (Slovenia). The investigated cliff is 4-18 m-high and is made up of an alternation of sandstones and marlstones belonging to the Flysch Formation of Trieste, which is Eocene in age. The studied cliff was subjected to localized slope failures that occurred in the past and is currently subject to frequent rock collapses, thus resulting in its partial and episodic retreat. Field evidence acquired through a traditional survey was integrated with outputs of the DP technique based on 1399 images that were collected using both a commercial unmanned aerial vehicle (UAV) and a mobile phone (MP). UAV-derived images were useful for performing rock mass structure analysis in the upper part of the investigated cliff, where the traditional survey was not possible due to hazardous operating conditions. In addition, the use of a MP was observed to be a useful tool for the rapid collection of images at the toe of unsafe marine cliff environments. This study highlights that UAV-DP and MP-DP techniques can only be effective if the outcomes obtained from the 3D model reconstruction are validated by direct measurements acquired by means of the traditional field survey, thus avoiding improper or even erroneous results while enlarging the amount of data and the area of investigation. The study approach presented herein allowed for the assessment of slope instabilities affecting the Flysch Sea cliff, whose retreat is caused by the combined action of marine erosion and slope gravitational processes

Analisa Dampak Penerapan Sistem Lalu Lintas Satu Arah Pada Simpang 3 Strat-a Terhadap Arus Lalu Lintas Serta Kinerja Lahan Parkir Di Pasar Tradisional Oeba Kota Kupang

This study aims to determine the impact of the implementation of one-way traffic system simulated at the three-legged signalized intersection on Straat A towards the traffic flow, and the performance of parking area at Oeba, a traditional market in Kupang City. The analysis involves comparing the volume of vehicles and the performance of the parking area before and during the implementation of one-way traffic system simulation with the parking space requirements as well as the design models of parking spaces. The analysis shows that the implementation of one-way traffic system simulation affects the increase of traffic volume in one access that is at Cabang Air-Oeba, but overall it does not affect the increase of traffic volume in general. The result of the performance analysis on the market\u27s parking area reveals to be in trouble, with the parking index value that is greater than 1 (one). Based on that index value, the addition of a parking area is needed as follows: 357 m2 for motorcycles, 637.50 m2 for light vehicles and 680 m2 for heavy vehicles. In order to overcome this problem the government has prepared a new parking area with the width 1011 m2, but this additional parking area is not yet sufficient, so that the government still needs to provide 663.50 m2 as the new additional parking area

ORAL HEALTH PROMOTION THROUGH PEER-SUPPORT: 2ND EDITION OF THE ACTION UNDERTAKEN BY DENTAL STUDENTS IN THE UNIVERSITY OF NICE SOPHIA ANTIPOLIS

Oral Communication presented at the ";Forum des Jeunes Chercheurs";, Brest (France) 2011

DENTAL HEALTH IN TOULON VAR UNIVERSITY STUDENTS: RESULTS OF THE ACTION UNDERTAKEN BY NICE DENTAL STUDENTS

Oral Communication presented at the ";Forum des Jeunes Chercheurs";, Brest (France) 2011

Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors

Detergents enable the purification of membrane proteins and are indispensable reagents instructural biology. Even though a large variety of detergents have been developed in the lastcentury, the challenge remains to identify guidelines that allowfine-tuning of detergents forindividual applications in membrane protein research. Addressing this challenge, here weintroduce the family of oligoglycerol detergents (OGDs). Native mass spectrometry (MS)reveals that the modular OGD architecture offers the ability to control protein purificationand to preserve interactions with native membrane lipids during purification. In addition to abroad range of bacterial membrane proteins, OGDs also enable the purification and analysisof a functional G-protein coupled receptor (GPCR). Moreover, given the modular design ofthese detergents, we anticipatefine-tuning of their properties for specific applications instructural biology. Seen from a broader perspective, this represents a significant advance forthe investigation of membrane proteins and their interactions with lipids

Testbeam and Laboratory Characterization of CMS 3D Pixel Sensors

The pixel detector is the innermost tracking device in CMS, reconstructing interaction vertices and charged particle trajectories. The sensors located in the innermost layers of the pixel detector must be upgraded for the ten-fold increase in luminosity expected with the High- Luminosity LHC (HL-LHC) phase. As a possible replacement for planar sensors, 3D silicon technology is under consideration due to its good performance after high radiation fluence. In this paper, we report on pre- and post- irradiation measurements for CMS 3D pixel sensors with different electrode configurations. The effects of irradiation on electrical properties, charge collection efficiency, and position resolution of 3D sensors are discussed. Measurements of various test structures for monitoring the fabrication process and studying the bulk and surface properties, such as MOS capacitors, planar and gate-controlled diodes are also presented.Comment: 14 page

evaluation of ovine milk clotting aptitude

A comparative study of the lactodynamographic parameters was carried out on ovine milk. Besides evaluating the repeatability and reproducibility of the analytical method, the influence of some variables such as the genetic type (three breeds), the kind of milk (whole or skimmed), and its concentration after reconstitution (12g or 20g /100 ml) was evaluated. The working plan involved 6 laboratories for the final statistic analyses, by the use of freeze-dried milk samples (adequately reconstituted on the basis of established methods) from Sardinia, Comisana, and Massese ewes. All the considered variability factors showed a highly significant effect (P<0.001) on the lactodynamographic parameters considered. In particular, Massese ewe milk showed the shortest curd speed (k20) and the best coagulum strength (a30 and a45), although clotting time (CT) was the highest one. The same trend was registered for skimmed milk and for the most concentrated one (20g). Repeatability values within laboratories were 96% and 97% for CT and k20, lowering for a30 e a45, (respectively 87% and 85%). Much lower coefficients were found for the among laboratories reproducibility, ranging from a maximum of 58% for CT to a minimum of 18% for k20. The wide variability observed indicates that lactodynamographic parameters are comparable only within the same lab. Further investigation is needed to compare different labs in order to obtain more homogeneous results

Mutu Pelayanan Kesehatan Pasien Rawat Inap oleh Tenaga Kesehatan di Pusksesmas Sonimanu Kabupaten Rote Ndao

Service Quality can be obtained if what is expected by the patient to the service provider is in accordance with the patient's requirements. This study aims to determine the quality of patient health services by health workers at the Sonimanu health center in 2019. The sample in this study was all In patients with a total sample of 73 people the sampling technique in this study was totally sampling. Data collection was carried out with 20 items of hope and reality questionnaire, which is a quantitative description of this type of study. The analysis conducted is univariate using Importance Performance Analysis. The results of this study indicate that the value of conformity between expectations and quality of inpatient services of health workers to the tangible dimension is 97.28% (Very Satisfied), reliably 95.27% (Very Satisfied), responsiveness 86.38% (Satisfied), assurance 98.14% (Very Satisfied), empathy 97.21% (Very Satisfied). There is one attribute of inadequate quality of service that is a good nutrition officer providing and helping patients with dietary needs (58.42%), it is expected that the health staff at the Sonimanu health center need to prioritize and be more responsive in paying attention to the rights or needs of Inpatients. It is recommended that the quality of inpatient health services by health workers need to be further improved, especially in the dimension of responsiveness