14 research outputs found
PrĂ©lĂšvements dâorganes sur donneurs dĂ©cĂ©dĂ©s aprĂšs arrĂȘt cardiaque
Points essentielsLes prĂ©lĂšvements sur personne dĂ©cĂ©dĂ©e aprĂšs arrĂȘt cardiaque sont autorisĂ©s en France depuis 2005 (dĂ©cret du 2 aoĂ»t 2005 : art R.1232-4-1,2 et 3 du code de la santĂ© publique). RĂ©cemment, Ă lâĂ©chelle internationale, 4 types de situations pouvant conduire Ă un prĂ©lĂšvement sur personne dĂ©cĂ©dĂ©e aprĂšs arrĂȘt cardiaque ont Ă©tĂ© identifiĂ©s dans une classification dite de « Maastricht » qui dĂ©crit les donneurs potentiels. En France, les prĂ©lĂšvements sur les donneurs de classe III (arrĂȘt des soins) sont exclus. LâĂ©mergence de cette nouvelle technique soulĂšve des rĂ©flexions notamment dâordre Ă©thique, concernant la dĂ©finition mĂȘme de la mort, la place de cette pratique par rapport Ă des techniques de rĂ©animation nouvelles, le vĂ©cu des familles et des Ă©quipes. Elle apporte tout de mĂȘme un Ă©lĂ©ment de solution Ă la pĂ©nurie dâorganes manifeste, avec des rĂ©sultats de suivis des greffĂ©s trĂšs encourageants selon les publications Ă©trangĂšres appliquant ces techniques. Lâensemble du dispositif est dâautre part rĂ©glementĂ© et sous la tutelle de lâAgence de la biomĂ©decine qui en assure le bon fonctionnement technique et le respect des rĂšgles Ă©thiques
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Radiation Effects on Video Imagers
Radiation sensitivity of several photoconductive, photoemissive, and solid state silicon-based video imagers was measured by analyzing stored photocharge induced by irradiation with continuous and pulsed sources of high energy photons and neutrons. Transient effects as functions of absorbed dose, dose rate, fluences, and ionizing particle energy are presented
Developing and Validating Fuzzy-Based Trust Measures for Online Medical Diagnosis and Symptoms Analysis
Validation of Injection Parameters for Catheter-Directed Intraarterial Gadolinium-Enhanced MR Angiography
Prediction of domain organisation and secondary structure of thyroid peroxidase, a human autoantigen involved in destructive thyroiditis
AbstractOrgan specific autoimmune diseases are relatively common immunological disorders in man which include thyroid autoimmune disease, insulin-dependent diabetes mellitus and myasthenia gravis. The target autoantigens in some of these diseases have recently been characterised. In thyroid autoimmune disease this includes the key enzyme, thyroid peroxidase (TPO), which is involved in the generation of thyroid hormone. Structural knowledge about autoantigens such as thyroid peroxidase will allow a greater understanding of the interaction between autoantigens and the aberrant immune response, and facilitate the development of strategies for antigen-specific therapeutic manipulation. We report here a prediction of the secondary structure of thyroid peroxidase, together with the results of circular dichroic spectroscopy of a homologous purified enzyme. A combination of 3 secondary structure prediction programs has been used, following multiple sequence alignment, and TPO has been found to consist mainly of α-helical conformation, with little ÎČ-sheet present. This structure prediction, together with knowledge of the exon-intron boundaries allows a model for the domain organisation of the TPO molecule to be proposed