Out of equilibrium quantum field dynamics of an initial thermal state after a change in the external field

The effects of the initial temperature in the out of equilibrium quantum field dynamics in the presence of an homogeneous external field are investigated. We consider an initial thermal state of temperature T for a constant external field J. A subsequent sign flip of the external field, J to -J, gives rise to an out of equilibrium nonperturbative quantum field dynamics. The dynamics is studied here for the symmetry broken lambda(Phi^2)^2 scalar N component field theory in the large N limit. We find a dynamical effective potential for the expectation value that helps to understand the dynamics. The dynamics presents two regimes defined by the presence or absence of a temporal trapping close to the metastable equilibrium position of the potential. The two regimes are separated by a critical value of the external field that depends on the initial temperature. The temporal trapping is shorter for larger initial temperatures or larger external fields. Parametric resonances and spinodal instabilities amplify the quantum fluctuations in the field components transverse to the external field. When there is a temporal trapping this is the main mechanism that allows the system to escape from the metastable state for large N. Subsequently backreaction stops the growth of the quantum fluctuations and the system enters a quasiperiodic regime.Comment: LaTeX, 19 pages, 12 .eps figures, improved version to appear in Phys Rev

Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development

<p>Background: Plasmodium falciparum contains three genes encoding potential glutamate dehydrogenases. The protein encoded by gdha has previously been biochemically and structurally characterized. It was suggested that it is important for the supply of reducing equivalents during intra-erythrocytic development of Plasmodium and, therefore, a suitable drug target.</p> <p>Methods: The gene encoding the NADP(H)-dependent GDHa has been disrupted by reverse genetics in P. falciparum and the effect on the antioxidant and metabolic capacities of the resulting mutant parasites was investigated.</p> <p>Results: No growth defect under low and elevated oxygen tension, no up-or down-regulation of a number of antioxidant and NADP(H)-generating proteins or mRNAs and no increased levels of GSH were detected in the D10(Delta gdha) parasite lines. Further, the fate of the carbon skeleton of [(13)C] labelled glutamine was assessed by metabolomic studies, revealing no differences in the labelling of a-ketoglutarate and other TCA pathway intermediates between wild type and mutant parasites.</p> <p>Conclusions: First, the data support the conclusion that D10(Delta gdha) parasites are not experiencing enhanced oxidative stress and that GDHa function may not be the provision of NADP(H) for reductive reactions. Second, the results imply that the cytosolic, NADP(H)-dependent GDHa protein is not involved in the oxidative deamination of glutamate but that the protein may play a role in ammonia assimilation as has been described for other NADP(H)dependent GDH from plants and fungi. The lack of an obvious phenotype in the absence of GDHa may point to a regulatory role of the protein providing glutamate (as nitrogen storage molecule) in situations where the parasites experience a limiting supply of carbon sources and, therefore, under in vitro conditions the enzyme is unlikely to be of significant importance. The data imply that the protein is not a suitable target for future drug development against intra-erythrocytic parasite development.</p&gt

Electro-osmosis on anisotropic super-hydrophobic surfaces

We give a general theoretical description of electro-osmotic flow at striped super-hydrophobic surfaces in a thin double layer limit, and derive a relation between the electro-osmotic mobility and hydrodynamic slip-length tensors. Our analysis demonstrates that electro-osmotic flow shows a very rich behavior controlled by slip length and charge at the gas sectors. In case of uncharged liquid-gas interface, the flow is the same or inhibited relative to flow in homogeneous channel with zero interfacial slip. By contrast, it can be amplified by several orders of magnitude provided slip regions are uniformly charged. When gas and solid regions are oppositely charged, we predict a flow reversal, which suggests a possibility of huge electro-osmotic slip even for electro-neutral surfaces. On the basis of these observations we suggest strategies for practical microfluidic mixing devices. These results provide a framework for the rational design of super-hydrophobic surfaces.Comment: 4 pages, 4 figures; submitted to PRL Revised version: several references added, typos corrected. Supplementary file was restructured, the second part of the original EPAPS was removed and is supposed to be published as a separate pape

Connective neck evolution and conductance steps in hot point contacts

Dynamic evolution of the connective neck in Al and Pb mechanically controllable break junctions was studied during continuous approach of electrodes at bias voltages V_b up to a few hundred mV. A high level of power dissipation (10^-4 - 10^-3 W) and high current density (j > 10^10 A/cm^2) in the constriction lead to overheating of the contact area, electromigration and current-enhanced diffusion of atoms out of the "hot spot". At a low electrode approach rate (10 - 50 pm/s) the transverse dimension of the neck and the conductance of the junction depend on V_b and remain nearly constant over the approach distance of 10 - 30 nm. For V_b > 300 mV the connective neck consists of a few atoms only and the quantum nature of conductance manifests itself in abrupt steps and reversible jumps between two or more levels. These features are related to an ever changing number of individual conductance channels due to the continuous rearrangement in atomic configuration of the neck, the recurring motion of atoms between metastable states, the formation and breaking of isolated one-atom contacts and the switching between energetically preferable neck geometries.Comment: 21 pages 10 figure

Phase diversity restoration of sunspot images I. Relations between penumbral and photospheric features

We investigate the dynamics of and the relations between small-scale penumbral and photospheric features near the outer penumbral boundary: penumbral grains (PGs), dark penumbral fibrils, granules, and photospheric G-band bright points. The analysis is based on a 2 h time sequence of a sunspot close to disc center, taken simultaneously in the G-band and in the blue continuum at 450.7 nm. Observations were performed at the Swedish Vacuum Solar Telescope (La Palma) in July 1999. A total of 2564 images (46 arcsec x 75 arcsec) were corrected for telescope aberrations and turbulence perturbations by applying the inversion method of phase diversity. Our findings can by summarized as follows: (a) One third of the outward-moving PGs pass through the outer penumbral boundary and then either continue moving as small bright features or expand and develop into granules. (b) Former PGs and G-band bright points next to the spot reveal a different nature. The latter have not been identified as a continuation of PGs escaping from the penumbra. The G-band bright points are mostly born close to dark penumbral fibrils where the magnetic field is strong, whereas PGs stem from the less-magnetized penumbral component and evolve presumably to non-magnetic granules or small bright features.Comment: Accepted by A&A, 9 pages and 5 figure

Crossover from Electronic to Atomic Shell Structure in Alkali Metal Nanowires

After making a cold weld by pressing two clean metal surfaces together, upon gradually separating the two pieces a metallic nanowire is formed, which progressively thins down to a single atom before contact is lost. In previous experiments [1,2] we have observed that the stability of such nanowires is influenced by electronic shell filling effects, in analogy to shell effects in metal clusters [3]. For sodium and potassium at larger diameters there is a crossover to crystalline wires with shell-closings corresponding to the completion of additional atomic layers. This observation completes the analogy between shell effects observed for clusters and nanowires.Comment: 4 page

Probing the jet base of the blazar PKS1830-211 from the chromatic variability of its lensed images. Serendipitous ALMA observations of a strong gamma-ray flare

The launching mechanism of the jets of active galactic nuclei is observationally poorly constrained, due to the large distances to these objects and the very small scales (sub-parsec) involved. In order to better constrain theoretical models, it is especially important to get information from the region close to the physical base of the jet, where the plasma acceleration takes place. In this paper, we report multi-epoch and multi-frequency continuum observations of the z=2.5 blazar PKS1830-211 with ALMA, serendipitously coincident with a strong $\gamma$-ray flare reported by Fermi-LAT. The blazar is lensed by a foreground z=0.89 galaxy, with two bright images of the compact core separated by 1". Our ALMA observations individually resolve these two images (although not any of their substructures), and we study the change of their relative flux ratio with time (four epochs spread over nearly three times the time delay between the two lensed images) and frequency (between 350 and 1050 GHz, rest-frame of the blazar), during the $\gamma$-ray flare. In particular, we detect a remarkable frequency-dependent behaviour of the flux ratio, which implies the presence of a chromatic structure in the blazar (i.e., a core-shift effect). We rule out the possiblity of micro- and milli-lensing effects and propose instead a simple model of plasmon ejection in the blazar's jet to explain the time and frequency variability of the flux ratio. We suggest that PKS1830-211 is likely one of the best sources to probe the activity at the base of a blazar's jet at submillimeter wavelengths, thanks to the peculiar geometry of the system. The implications of the core-shift in absorption studies of the foreground z=0.89 galaxy (e.g., constraints on the cosmological variations of fundamental constants) are discussed.Comment: Accepted for publication in A&

Levels of genetic polymorphism: marker loci versus quantitative traits

Species are the units used to measure ecological diversity and alleles are the units of genetic diversity. Genetic variation within and among species has been documented most extensively using allozyme electrophoresis. This reveals wide differences in genetic variability within, and genetic distances among, species, demonstrating that species are not equivalent units of diversity. The extent to which the pattern observed for allozymes can be used to infer patterns of genetic variation in quantitative traits depends on the forces generating and maintaining variability. Allozyme variation is probably not strictly neutral but, nevertheless, heterozygosity is expected to be influenced by population size and genetic distance will be affected by time since divergence. The same is true for quantitative traits influenced by many genes and under weak stabilizing selection. However, the limited data available suggest that allozyme variability is a poor predictor of genetic variation in quantitative traits within populations. It is a better predictor of general phenotypic divergence and of postzygotic isolation between populations or species, but is only weakly correlated with prezygotic isolation. Studies of grasshopper and planthopper mating signal variation and assortative mating illustrate how these characters evolve independently of general genetic and morphological variation. The role of such traits in prezygotic isolation, and hence speciation, means that they will contribute significantly to the diversity of levels of genetic variation within and among species

Spatial population expansion promotes the evolution of cooperation in an experimental Prisoner's Dilemma

Cooperation is ubiquitous in nature, but explaining its existence remains a central interdisciplinary challenge. Cooperation is most difficult to explain in the Prisoner's Dilemma game, where cooperators always lose in direct competition with defectors despite increasing mean fitness. Here we demonstrate how spatial population expansion, a widespread natural phenomenon, promotes the evolution of cooperation. We engineer an experimental Prisoner's Dilemma game in the budding yeast Saccharomyces cerevisiae to show that, despite losing to defectors in nonexpanding conditions, cooperators increase in frequency in spatially expanding populations. Fluorescently labeled colonies show genetic demixing of cooperators and defectors, followed by increase in cooperator frequency as cooperator sectors overtake neighboring defector sectors. Together with lattice-based spatial simulations, our results suggest that spatial population expansion drives the evolution of cooperation by (1) increasing positive genetic assortment at population frontiers and (2) selecting for phenotypes maximizing local deme productivity. Spatial expansion thus creates a selective force whereby cooperator-enriched demes overtake neighboring defector-enriched demes in a "survival of the fastest". We conclude that colony growth alone can promote cooperation and prevent defection in microbes. Our results extend to other species with spatially restricted dispersal undergoing range expansion, including pathogens, invasive species, and humans

Observation of Supershell Structure in Alkali Metal Nanowires

Nanowires are formed by indenting and subsequently retracting two pieces of sodium metal. Their cross-section gradually reduces upon retraction and the diameters can be obtained from the conductance. In previous work we have demonstrated that when one constructs a histogram of diameters from large numbers of indentation-retraction cycles, such histograms show a periodic pattern of stable nanowire diameters due to shell structure in the conductance modes. Here, we report the observation of a modulation of this periodic pattern, in agreement with predictions of a supershell structure.Comment: Phys. Rev. Lett., in prin