ARM-Cortex M3-Based Two-Wheel Robot for Assessing Grid Cell Model of Medial Entorhinal Cortex: Progress towards Building Robots with Biologically Inspired Navigation-Cognitive Maps

This article presents the implementation and use of a two-wheel autonomous robot and its effectiveness as a tool for studying the recently discovered use of grid cells as part of mammalian’s brains space-mapping circuitry (specifically the medial entorhinal cortex). A proposed discrete-time algorithm that emulates the medial entorhinal cortex is programed into the robot. The robot freely explores a limited laboratory area in the manner of a rat or mouse and reports information to a PC, thus enabling research without the use of live individuals. Position coordinate neural maps are achieved as mathematically predicted although for a reduced number of implemented neurons (i.e., 200 neurons). However, this type of computational embedded system (robot’s microcontroller) is found to be insufficient for simulating huge numbers of neurons in real time (as in the medial entorhinal cortex). It is considered that the results of this work provide an insight into achieving an enhanced embedded systems design for emulating and understanding mathematical neural network models to be used as biologically inspired navigation system for robots

Radio frequency plasma processing effects on the emission characteristics of a MeV electron beam cathode

Experiments have proven that surface contaminants on the cathode of an electron beam diode influence electron emission current and impedance collapse. This letter reports on an investigation to reduce parasitic cathode current loss and to increase high voltage hold off capabilities by reactive sputter cleaning of contaminants. Experiments have characterized effective radio frequency (rf) plasma processing protocols for high voltage anode–cathode (A–K) gaps using a two-stage argon/oxygen and argon rf plasma discharge. Time-resolved optical emission spectroscopy measures contaminant (hydrogen) and bulk cathode (aluminum) plasma emission versus transported axial electron beam current turn on. Experiments were performed at accelerator parameters: V = −0.7V=−0.7 to −1.1 MV,−1.1MV, I(diode)=3–30 kA,I(diode)=3–30kA, and pulse length=0.4–1.0 μs.length=0.4–1.0μs. Experiments using a two-stage low power (100 W) argon/oxygen rf discharge followed by a higher power (200 W) pure argon rf discharge yielded an increase in cathode turn-on voltage required for axial current emission from 662±174 kV662±174kV to 981±97 kV.981±97kV. The turn-on time of axial current was increased from 100±22100±22 to 175±42 ns.175±42ns. © 1999 American Institute of Physics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/69353/2/APPLAB-75-1-31-1.pd

Individual quality assessment of autografting by probability estimation for clinical endpoints: a prospective validation study from the European group for blood and marrow transplantation.

The aim of supportive autografting is to reduce the side effects from stem cell transplantation and avoid procedure-related health disadvantages for patients at the lowest possible cost and resource expenditure. Economic evaluation of health care is becoming increasingly important. We report clinical and laboratory data collected from 397 consecutive adult patients (173 non-Hodgkin lymphoma, 30 Hodgkin lymphoma, 160 multiple myeloma, 7 autoimmune diseases, and 28 acute leukemia) who underwent their first autologous peripheral blood stem cell transplantation (PBSCT). We considered primary endpoints evaluating health economic efficacy (eg, antibiotic administration, transfusion of blood components, and time in hospital), secondary endpoints evaluating toxicity (in accordance with Common Toxicity Criteria), and tertiary endpoints evaluating safety (ie, the risk of regimen-related death or disease progression within the first year after PBSCT). A time-dependent grading of efficacy is proposed with day 21 for multiple myeloma and day 25 for the other disease categories (depending on the length of the conditioning regimen) as the acceptable maximum time in hospital, which together with antibiotics, antifungal, or transfusion therapy delineates four groups: favorable (≤7 days on antibiotics and no transfusions; ≤21 [25] days in hospital), intermediate (from 7 to 10 days on antibiotics and 7 days on antibiotics, >3 but 30/34 days in hospital after transplantation), and very unfavorable (>10 days on antibiotics, >6 transfusions; >30 to 34 days in hospital). The multivariate analysis showed that (1) PBSC harvests of ≥4 × 106/kg CD34 + cells in 1 apheresis procedure were associated with a favorable outcome in all patient categories except acute myelogenous leukemia and acute lymphoblastic leukemia (P = .001), (2) ≥5 × 106/kg CD34 + cells infused predicted better transplantation outcome in all patient categories (P 500 mL) (P = .002), and (5) patients with a central venous catheter during both collection and infusion of PBSC had a more favorable outcome post-PBSCT than peripheral access (P = .007). The type of mobilization regimen did not affect the outcome of auto-PBSCT. The present study identified predictive variables, which may be useful in future individual pretransplantation probability evaluations with the goal to improve supportive care

White matter connectome edge density in children with Autism Spectrum Disorders: potential imaging biomarkers using machine learning models

Prior neuroimaging studies have reported white matter network underconnectivity as a potential mechanism for Autism Spectrum Disorder (ASD). In this study, we examined the structural connectome of children with ASD using Edge Density Imaging (EDI); and then applied machine leaning algorithms to identify children with ASD based on tract-based connectivity metrics. Boys aged 8 to 12 years were included: 14 with ASD and 33 typically developing children (TDC). The Edge Density (ED) maps were computed from probabilistic streamline tractography applied to high angular resolution diffusion imaging (HARDI). Tract-Based Spatial Statistics (TBSS) was used for voxel-wise comparison and coregistration of ED maps in addition to conventional DTI metrics of Fractional Anisotropy (FA), Mean Diffusivity (MD), and Radial Diffusivity (RD). Tract-based average DTI/connectome metrics were calculated and used as input for different machine learning models: naïve Bayes, random forest, support vector machines (SVM), neural networks. For these models, cross-validation was performed with stratified random sampling (×1000 permutations). The average accuracy among validation samples was calculated. In voxel-wise analysis, the body and splenium of corpus callosum, bilateral superior and posterior corona radiata, and left superior longitudinal fasciculus showed significantly lower ED in children with ASD; whereas, we could not find significant difference in FA, MD, and RD maps between the two study groups. Overall, machine-learning models using tract-based ED metrics had better performance in identification of children with ASD compared to those using FA, MD, and RD. The EDI-based random forest models had greater average accuracy (75.3%), specificity (97.0%), and positive predictive value (81.5%), whereas EDI-based polynomial SVM had greater sensitivity (51.4%), and negative predictive values (77.7%). In conclusion, we found reduced density of connectome edges in the posterior white matter tracts of children with ASD; and demonstrated the feasibility of connectome-based machine-learning algorithms in identification of children with ASD

Radiation Science Using Z-Pinch X-Rays

Present-day Z-pinch experiments generate 200 TW peak power, 5–10 ns duration x-ray bursts that provide new possibilities to advance radiation science. The experiments support both the underlying atomic and plasma physics, as well as inertial confinement fusion and astrophysics applications. A typical configuration consists of a sample located 1–10 cm away from the pinch, where it is heated to 10–100 eV temperatures by the pinch radiation. The spectrally-resolved sample-plasma absorption is measured by aiming x-ray spectrographs through the sample at the pinch. The pinch plasma thus both heats the sample and serves as a backlighter. Opacitymeasurements with this source are promising because of the large sample size, the relatively long radiation duration, and the possibility to measureopacities at temperatures above 100 eV. Initial opacity experiments are under way with CH-tamped NaBr foil samples. The Na serves as a thermometer and absorption spectra are recorded to determine the opacity of Br with a partially-filled M-shell. The large sample size and brightness of the Z pinch as a backlighter are also exploited in a novel method measuring re-emission from radiation-heated gold plasmas. The method uses a CH-tamped layered foil with Al+MgF2 facing the radiationsource. A gold backing layer that covers a portion of the foil absorbs radiation from the source and provides re-emission that further heats the Al+MgF2. The Al and Mg heating is measured using space-resolved Kα absorption spectroscopy and the difference between the two regions enables a determination of the gold re-emission. Measurements are also performed at lower densities where photoionization is expected to dominate over collisions. Absorption spectra have been obtained for both Ne-like Fe and He-like Ne, confirming production of the relevant charge states needed to benchmark atomic kinetics models. Refinement of the methods described here is in progress to address multiple issues for radiation science

A cross validation of Consumer-Based Brand Equity (CBBE) with Private Labels in Spain

Molinillo,S., Ekinci, Y., Japutra, A. (2014)'A cross validation of Consumer-Based Brand Equity (CBBE) with Private Labels in Spain'. in Martínez-López, Gázquez-Abad, J.C. and Sethuraman, R. J.A. (eds.) Advances in National Brand and Private Label Marketing. Second International Conference, 2015. Springer Proceedings in Business and Economics, pp. 113-125In recent years a number of Consumer-Based Brand Equity (CBBE) models and measurement scales have been introduced in the branding literature. However, examinations of brand equity in Private Labels (PL) are rather limited. This study aims to compare the validity of the two prominent CBBE models those introduced by Yoo and Donthu (2001) and Nam et al. (2011). In order to test the models and make this comparison, the study collected data from 236 respondents who rated private labels in Spain. A list of 30 different fashion and sportswear PL was introduced to respondents. These brands do not make any reference to the retail store in which they are sold. Research findings suggest that the extended CBBE model introduced by Nam et al. (2011) and Ciftci et al. (2014) is more reliable and valid than Yoo and Donthu’s model for assessing PL. Theoretical contributions and managerial implications are discussed.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

The orbital period, black hole mass and distance to the X-ray transient GRS 1716-249 (=N Oph 93)

We present evidence for a 0.278(8) d (=6.7 h) orbital period in the X-ray transient GRS 1716-249 (=N Oph 93), based on a superhump modulation detected during the 1995 mini-outburst plus ellipsoidal variability in quiescence. With a quiescent magnitude of r=23.19+-0.15 N Oph 93 is too faint to warrant a full dynamical study through dedicated time-resolved spectroscopy. Instead, we apply the FWHM-K2 correlation to the disc Halpha emission line detected in Gran Telescopio Canarias spectra and obtain K2=521+-52 km/s. This leads to a mass function f(M)=4.1+-1.2 Msun, thus indicating the presence of a black hole in this historic X-ray transient. Furthermore, from the depth of the Halpha trough and the quiescent light curve we constrain the binary inclination to i=61+-15 deg, while the detection of superhumps sets an upper limit to the donor to compact star mass ratio q=M2/M1<=0.25. Our de-reddened (r-i) colour is consistent with a ~K6 main sequence star that fills its Roche lobe in a 0.278 d orbit. Using all this information we derive a compact object mass M1=6.4+3.2-2.0 Msun at 68 per cent confidence. We also constrain the distance to GRS 1716-249 to 6.9+-1.1 kpc, placing the binary ~0.8 kpc above the Galactic Plane, in support of a large natal kick.Comment: Accepted for publication in MNRAS, 12 pages, 9 figures, 2 Table