Sigma Exchange in the Nonmesonic Decays of Light Hypernuclei and Violation of the Delta I=1/2 Rule

Nonmesonic weak decays of s-shell hypernuclei are analyzed in microscopic models for the Lambda N to NN weak interaction. A scalar-isoscalar meson, sigma, is introduced and its importance in accounting the decay rates, n/p ratios and proton asymmetry is demonstrated. Possible violation of the Delta I=1/2 rule in the nonmesonic weak decay of Lambda is discussed in a phenomenological analysis and several useful constraints are presented. The microscopic calculation shows that the current experimental data indicate a large violation of the Delta I=1/2 rule, although no definite conclusion can be derived due to large ambiguity of the decay rate of {^4_Lambda H}.Comment: 13 pages, 5 figure

A field-induced reentrant insulator state of a gap-closed topological insulator (Bi_{1-x}Sb_x) in quantum-limit states

In the extreme quantum limit states under high magnetic fields, enhanced electronic correlation effects can stabilize anomalous quantum states. Using band-tuning with a magnetic field, we realized a spin-polarized quantum limit state in the field-induced semimetallic phase of a topological insulator Bi_{1-x}Sb_x. Further increase in the field injects more electrons and holes to this state and results in an unexpected reentrant insulator state in this topological semimetallic state. A single-particle picture cannot explain this reentrant insulator state, reminiscent of phase transitions due to many-body effects. Estimates of the binding energy and spacing of electron-hole pairs and the thermal de Broglie wavelength indicate that Bi_{1-x}Sb_x may host the excitonic insulator phase in this extreme environment.Comment: 26pages, 6figure

Josephson effect in a CeCoIn5CeCoIn_5 microbridge

We report DC Josephson effects observed in a microbridge prepared from an individual crystalline growth domain of $CeCoIn_5$ thin film. Josephson effects were observed by periodic voltage modulations under external magnetic field $\Delta V(B)$ with the expected periodicity and by the temperature dependence of the Josephson critical current $I_c(T)$. The shape of $\Delta V(B)$ was found to be asymmetric, as it is expected for microbridges. The dependence $I_c(T)$ follows the Ambegaokar-Baratoff relation, which is unexpected for microbridges. Features in the dynamical resistance curves were attributed to the periodic motion of Abricosov vortices within the microbridge.Comment: 12 pages, 5 figures, submitted to Physica

Aqueous Solution Preparation, Structure, and Magnetic Properties of Nano-Granular ZnxFe3−xO4 Ferrite Films

This paper reports a simple and novel process for preparing nano-granular ZnxFe3−xO4 ferrite films (0 ≤ x ≤ 0.99) on Ag-coated glass substrates in DMAB-Fe(NO3)3-Zn(NO3)2 solutions. The deposition process may be applied in preparing other cations-doped spinel ferrite films. The Zn content x in the ZnxFe3−xO4 films depends linearly on the Zn2+ ion concentration ranging from 0.0 to 1.0 mM in the aqueous solutions. With x increasing from 0 to 0.99, the lattice constant increases from 0.8399 to 0.8464 nm; and the microstructure of the films changes from the non-uniform nano-granules to the fine and uniform nano-granules of 50–60 nm in size. The saturation magnetization of the films first increases from 75 emu/g to the maximum 108 emu/g with x increasing from 0 to 0.33 and then decreases monotonously to 5 emu/g with x increasing from 0.33 to 0.99. Meanwhile, the coercive force decreases monotonously from 116 to 13 Oe

Control parameters on the fabrication of ZnO hollow nanocolumns

[EN] The present work reports on the fabrication of hollow ZnO nanocolumns by a sequential combination of electrochemical deposition, chemical attack and regeneration. Initially, ZnO nanocolumns were deposited in two different substrates, namely Fluor Tin Oxide and Indium Tin Oxide. In a further step, a statistical analysis on the most influencing control parameters in the dissolution stage to produce the hollow ZnO nanowires on the FTO substrates was carried out. The control variables considered were electrolyte concentration, dissolution time and temperature, whereas the output variable was the percentage of the hollow nanocolumns obtained. The statistical analysis consisted of a two-level factorial design of experiments on three variables, therefore involving a series of 8 experiments. An analysis of variance (ANOVA) on the results was also carried out. The results showed that all the control variables were significant, the most important being the dissolution time.This work was supported by the Spanish Government through MCINN Grant MAT2009-14625-C03-03, Generalitat Valenciana programme PROMETEO/2009/063 and European Commission through NanoCIS project FP7-PEOPLE-2010-IRSES (ref. 269279). Technical support given to the authors by the Servei de Microscopia at the Universitat Politecnica de Valencia (Spain) is greatly acknowledged.Cembrero Cil, J.; Busquets Mataix, DJ.; Rayón Encinas, E.; Pascual Guillamón, M.; Pérez Puig, MA.; Marí Soucase, B. (2013). Control parameters on the fabrication of ZnO hollow nanocolumns. Materials Science in Semiconductor Processing. 16:211-216. https://doi.org/10.1016/j.mssp.2012.04.014S2112161

ParaHaplo: A program package for haplotype-based whole-genome association study using parallel computing

<p>Abstract</p> <p>Background</p> <p>Since more than a million single-nucleotide polymorphisms (SNPs) are analyzed in any given genome-wide association study (GWAS), performing multiple comparisons can be problematic. To cope with multiple-comparison problems in GWAS, haplotype-based algorithms were developed to correct for multiple comparisons at multiple SNP loci in linkage disequilibrium. A permutation test can also control problems inherent in multiple testing; however, both the calculation of exact probability and the execution of permutation tests are time-consuming. Faster methods for calculating exact probabilities and executing permutation tests are required.</p> <p>Methods</p> <p>We developed a set of computer programs for the parallel computation of accurate P-values in haplotype-based GWAS. Our program, ParaHaplo, is intended for workstation clusters using the Intel Message Passing Interface (MPI). We compared the performance of our algorithm to that of the regular permutation test on JPT and CHB of HapMap.</p> <p>Results</p> <p>ParaHaplo can detect smaller differences between 2 populations than SNP-based GWAS. We also found that parallel-computing techniques made ParaHaplo 100-fold faster than a non-parallel version of the program.</p> <p>Conclusion</p> <p>ParaHaplo is a useful tool in conducting haplotype-based GWAS. Since the data sizes of such projects continue to increase, the use of fast computations with parallel computing--such as that used in ParaHaplo--will become increasingly important. The executable binaries and program sources of ParaHaplo are available at the following address: <url>http://sourceforge.jp/projects/parallelgwas/?_sl=1</url></p

Quantitative Analysis of Immune Infiltrates in Primary Melanoma.

Novel methods to analyze the tumor microenvironment (TME) are urgently needed to stratify melanoma patients for adjuvant immunotherapy. Tumor-infiltrating lymphocyte (TIL) analysis, by conventional pathologic methods, is predictive but is insufficiently precise for clinical application. Quantitative multiplex immunofluorescence (qmIF) allows for evaluation of the TME using multiparameter phenotyping, tissue segmentation, and quantitative spatial analysis (qSA). Given that CD3+CD8+ cytotoxic lymphocytes (CTLs) promote antitumor immunity, whereas CD68+ macrophages impair immunity, we hypothesized that quantification and spatial analysis of macrophages and CTLs would correlate with clinical outcome. We applied qmIF to 104 primary stage II to III melanoma tumors and found that CTLs were closer in proximity to activated (CD68+HLA-DR+) macrophages than nonactivated (CD68+HLA-DR-) macrophages (P < 0.0001). CTLs were further in proximity from proliferating SOX10+ melanoma cells than nonproliferating ones (P < 0.0001). In 64 patients with known cause of death, we found that high CTL and low macrophage density in the stroma (P = 0.0038 and P = 0.0006, respectively) correlated with disease-specific survival (DSS), but the correlation was less significant for CTL and macrophage density in the tumor (P = 0.0147 and P = 0.0426, respectively). DSS correlation was strongest for stromal HLA-DR+ CTLs (P = 0.0005). CTL distance to HLA-DR- macrophages associated with poor DSS (P = 0.0016), whereas distance to Ki67- tumor cells associated inversely with DSS (P = 0.0006). A low CTL/macrophage ratio in the stroma conferred a hazard ratio (HR) of 3.719 for death from melanoma and correlated with shortened overall survival (OS) in the complete 104 patient cohort by Cox analysis (P = 0.009) and merits further development as a biomarker for clinical application

Platelet activating factor stimulates arachidonic acid release in differentiated keratinocytes via arachidonyl non-selective phospholipase A2

Platelet activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is known to be present in excess in psoriatic skin, but its exact role is uncertain. In the present study we demonstrate for the first time the role of group VI PLA2 in PAF-induced arachidonic acid release in highly differentiated human keratinocytes. The group IVα PLA2 also participates in the release, while secretory PLA2s play a minor role. Two anti-inflammatory synthetic fatty acids, tetradecylthioacetic acid and tetradecylselenoacetic acid, are shown to interfere with signalling events upstream of group IVα PLA2 activation. In summary, our major novel finding is the involvement of the arachidonyl non-selective group VI PLA2 in PAF-induced inflammatory responses

Cell Wall Antibiotics Provoke Accumulation of Anchored mCherry in the Cross Wall of Staphylococcus aureus

A fluorescence microscopy method to directly follow the localization of defined proteins in Staphylococcus was hampered by the unstable fluorescence of fluorescent proteins. Here, we constructed plasmid (pCX) encoded red fluorescence (RF) mCherry (mCh) hybrids, namely mCh-cyto (no signal peptide and no sorting sequence), mCh-sec (with signal peptide), and mCh-cw (with signal peptide and cell wall sorting sequence). The S. aureus clones targeted mCh-fusion proteins into the cytosol, the supernatant and the cell envelope respectively; in all cases mCherry exhibited bright fluorescence. In staphylococci two types of signal peptides (SP) can be distinguished: the +YSIRK motif SPlip and the −YSIRK motif SPsasF. mCh-hybrids supplied with the +YSIRK motif SPlip were always expressed higher than those with −YSIRK motif SPsasF. To study the location of the anchoring process and also the influence of SP type, mCh-cw was supplied on the one hand with +YSIRK motif (mCh-cw1) and the other hand with -YSIRK motif (mCh-cw2). MCh-cw1 preferentially localized at the cross wall, while mCh-cw2 preferentially localized at the peripheral wall. Interestingly, when treated with sub-lethal concentrations of penicillin or moenomycin, both mCh-cw1 and mCh-cw2 were concentrated at the cross wall. The shift from the peripheral wall to the cross wall required Sortase A (SrtA), as in the srtA mutant this effect was blunted. The effect is most likely due to antibiotic mediated increase of free anchoring sites (Lipid II) at the cross wall, the substrate of SrtA, leading to a preferential incorporation of anchored proteins at the cross wall

Engineering Schottky contacts in open-air fabricated heterojunction solar cells to enable high performance and ohmic charge transport.

The efficiencies of open-air processed Cu2O/Zn(1-x)Mg(x)O heterojunction solar cells are doubled by reducing the effect of the Schottky barrier between Zn(1-x)Mg(x)O and the indium tin oxide (ITO) top contact. By depositing Zn(1-x)Mg(x)O with a long band-tail, charge flows through the Zn(1-x)Mg(x)O/ITO Schottky barrier without rectification by hopping between the sub-bandgap states. High current densities are obtained by controlling the Zn(1-x)Mg(x)O thickness to ensure that the Schottky barrier is spatially removed from the p-n junction, allowing the full built-in potential to form, in addition to taking advantage of the increased electrical conductivity of the Zn(1-x)Mg(x)O films with increasing thickness. This work therefore shows that the Zn(1-x)Mg(x)O window layer sub-bandgap state density and thickness are critical parameters that can be engineered to minimize the effect of Schottky barriers on device performance. More generally, these findings show how to improve the performance of other photovoltaic system reliant on transparent top contacts, e.g., CZTS and CIGS.This work was supported by EPSRC of the UK (award number RG3717)This is the accepted manuscript. The final version is available from ACS at http://pubs.acs.org/doi/abs/10.1021/am5058663