18,369 research outputs found

    Universal Conductance Distribution in the Quantum Size Regime

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    We study the conductance (g) distribution function of an ensemble of isolated conducting rings, with an Aharonov--Bohm flux. This is done in the discrete spectrum limit, i.e., when the inelastic rate, frequency and temperature are all smaller than the mean level spacing. Over a wide range of g the distribution function exhibits universal behavior P(g)\sim g^{-(4+\beta)/3}, where \beta=1 (2) for systems with (without) a time reversal symmetry. The nonuniversal large g tail of this distribution determines the values of high moments.Comment: 13 pages+1 figure, RevTEX

    Test Characteristics of Urinary Lipoarabinomannan and Predictors of Mortality among Hospitalized HIV-Infected Tuberculosis Suspects in Tanzania.

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    Tuberculosis is the most common cause of death among patients with HIV infection living in tuberculosis endemic countries, but many cases are not diagnosed pre-mortem. We assessed the test characteristics of urinary lipoarabinomannan (LAM) and predictors of mortality among HIV-associated tuberculosis suspects in Tanzania. We prospectively enrolled hospitalized HIV-infected patients in Dar es Salaam, with ≥2 weeks of cough or fever, or weight loss. Subjects gave 2 mLs of urine to test for LAM using a commercially available ELISA, ≥2 sputum specimens for concentrated AFB smear and solid media culture, and 40 mLs of blood for culture. Among 212 evaluable subjects, 143 (68%) were female; mean age was 36 years; and the median CD4 count 86 cells/mm(3). 69 subjects (33%) had culture confirmation of tuberculosis and 65 (31%) were LAM positive. For 69 cases of sputum or blood culture-confirmed tuberculosis, LAM sensitivity was 65% and specificity 86% compared to 36% and 98% for sputum smear. LAM test characteristics were not different in patients with bacteremia but showed higher sensitivity and lower specificity with decreasing CD4 cell count. Two month mortality was 64 (53%) of 121 with outcomes available. In multivariate analysis there was significant association of mortality with absence of anti-retroviral therapy (p = 0.004) and a trend toward association with a positive urine LAM (p = 0.16). Among culture-negative patients mortality was 9 (75%) of 12 in LAM positive patients and 27 (38%) of 71 in LAM negative patients (p = 0.02). Urine LAM is more sensitive than sputum smear and has utility for the rapid diagnosis of culture-confirmed tuberculosis in this high-risk population. Mortality data raise the possibility that urine LAM may also be a marker for culture-negative tuberculosis

    Heat Treated NiP–SiC Composite Coatings: Elaboration and Tribocorrosion Behaviour in NaCl Solution

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    Tribocorrosion behaviour of heat-treated NiP and NiP–SiC composite coatings was investigated in a 0.6 M NaCl solution. The tribocorrosion tests were performed in a linear sliding tribometer with an electrochemical cell interface. It was analyzed the influence of SiC particles dispersion in the NiP matrix on current density developed, on coefficient of friction and on wear volume loss. The results showed that NiP–SiC composite coatings had a lower wear volume loss compared to NiP coatings. However, the incorporation of SiC particles into the metallic matrix affects the current density developed by the system during the tribocorrosion test. It was verified that not only the volume of co-deposited particles (SiC vol.%) but also the number of SiC particles per coating area unit (and consequently the SiC particles size) have made influence on the tribocorrosion behaviour of NiP–SiC composite coatings

    Nonconservative Lagrangian mechanics II: purely causal equations of motion

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    This work builds on the Volterra series formalism presented in [D. W. Dreisigmeyer and P. M. Young, J. Phys. A \textbf{36}, 8297, (2003)] to model nonconservative systems. Here we treat Lagrangians and actions as `time dependent' Volterra series. We present a new family of kernels to be used in these Volterra series that allow us to derive a single retarded equation of motion using a variational principle

    Evolutionary Algorithms with Linkage Information for Feature Selection in Brain Computer Interfaces

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    Abstract Brain Computer Interfaces are an essential technology for the advancement of prosthetic limbs, but current signal acquisition methods are hindered by a number of factors, not least, noise. In this context, Feature Selection is required to choose the important signal features and improve classifier accuracy. Evolutionary algorithms have proven to outperform filtering methods (in terms of accuracy) for Feature Selection. This paper applies a single-point heuristic search method, Iterated Local Search (ILS), and compares it to a genetic algorithm (GA) and a memetic algorithm (MA). It then further attempts to utilise Linkage between features to guide search operators in the algorithms stated. The GA was found to outperform ILS. Counter-intuitively, linkage-guided algorithms resulted in higher classification error rates than their unguided alternatives. Explanations for this are explored

    A Facile and Green Microwave-Assisted Strategy to Induce Surface Properties on Complex-Shape Polymeric 3D Printed Structures

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    Light- induced polymeric 3D printing is becoming a well-established fabrication method, showing manifold advantages such as control of the local chemistry of the manufactured devices. It can be considered a green technology, since the parts are produced when needed and with minimum amount of materials. In this work 3D printing is combined with another green technology, microwave-assisted reaction, to fabricate objects of complex geometry with controllable surface properties, exploiting the presence of remaining functional groups on the surface of 3D printed specimens. In this context, surface functionalization with different amines is studied, optimizing formulations, reaction times, and avoiding surface deterioration. Then, two different applications are investigated. MW-functionalized filter-type structures have been tested against Staphylococcus aureus bacteria, showing high bactericidal activity on the surface along all areas of the complex-shaped structure. Second, a fluidic chip composed of three separated channels is 3D printed, filled with different amine-reactive dyes (dansyl and eosine derivatives), and made to react simultaneously. Complete and independent functionalization of the surface of the three channels is achieved only after 2 min of irradiation. This study demonstrates that light induced 3D printing and microwave-induced chemistry can be used together effectively, and used to produce functional devices

    Molecular analysis of hepatitis C virus infection in Bulgarian injecting drug users

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    Intravenous drug users constitute a group at risk for hepatitis C virus (HCV) infection. Today, no data are available on the molecular epidemiology of HCV in Bulgaria despite the fact that in recent years the incidence of acute hepatitis C infection among Bulgarian intravenous drug users increased sixfold and about 2/3 of them developed a chronic infection. The aim of this study was to determine the circulation of hepatitis C genotypes among drug users and to study the evolution and transmission history of the virus by molecular clock and Bayesian methods, respectively. Sequencing of NS5B gene showed that the genotype 3a was the most prevalent type among intravenous drug users. In the Bayesian tree, the 3a subtypes grouped in one main clade with one small cluster well statistically supported. The root of the tree was dated back to the year 1836, and the main clade from Bulgaria was dated 1960. The effective number of infections remained constant until about years 1950s, growing exponentially from the 1960s to the 1990s, reaching a plateau in the years 2000. The not significant intermixing with isolates from other countries may suggest a segregated circulation of the epidemic between 1940s and 1980s. The plateau reached by the epidemic in the early 2000s may indicate the partial success of the new preventive policies adopted in Bulgaria. J. Med. Virol. 83:1565-1570, 2011. © 2011 Wiley-Liss, Inc

    Passive water control at the surface of a superhydrophobic lichen

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    Some lichens have a super-hydrophobic upper surface, which repels water drops, keeping the surface dry but probably preventing water uptake. Spore ejection requires water and is most efficient just after rainfall. This study was carried out to investigate how super-hydrophobic lichens manage water uptake and repellence at their fruiting bodies, or podetia. Drops of water were placed onto separate podetia of Cladonia chlorophaea and observed using optical microscopy and cryo-scanning-electron microscopy (cryo-SEM) techniques to determine the structure of podetia and to visualise their interaction with water droplets. SEM and optical microscopy studies revealed that the surface of the podetia was constructed in a three-level structural hierarchy. By cryo-SEM of water-glycerol droplets placed on the upper part of the podetium, pinning of the droplet to specific, hydrophilic spots (pycnidia/apothecia) was observed. The results suggest a mechanism for water uptake, which is highly sophisticated, using surface wettability to generate a passive response to different types of precipitation in a manner similar to the Namib Desert beetle. This mechanism is likely to be found in other organisms as it offers passive but selective water control

    A Definitive Signal of Multiple Supersymmetry Breaking

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    If the lightest observable-sector supersymmetric particle (LOSP) is charged and long-lived, then it may be possible to indirectly measure the Planck mass at the LHC and provide a spectacular confirmation of supergravity as a symmetry of nature. Unfortunately, this proposal is only feasible if the gravitino is heavy enough to be measured at colliders, and this condition is in direct conflict with constraints from big bang nucleosynthesis (BBN). In this work, we show that the BBN bound can be naturally evaded in the presence of multiple sectors which independently break supersymmetry, since there is a new decay channel of the LOSP to a goldstino. Certain regions of parameter space allow for a direct measurement of LOSP decays into both the goldstino and the gravitino at the LHC. If the goldstino/gravitino mass ratio is measured to be 2, as suggested by theory, then this would provide dramatic verification of the existence of multiple supersymmetry breaking and sequestering. A variety of consistent cosmological scenarios are obtained within this framework. In particular, if an R symmetry is imposed, then the gauge-gaugino-goldstino interaction vertices can be forbidden. In this case, there is no bound on the reheating temperature from goldstino overproduction, and thermal leptogenesis can be accommodated consistently with gravitino dark matter.Comment: 10 pages, 5 figures, title changed to match the version published in JHE
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