415 research outputs found
Two-dimensional SIR epidemics with long range infection
We extend a recent study of susceptible-infected-removed epidemic processes
with long range infection (referred to as I in the following) from
1-dimensional lattices to lattices in two dimensions. As in I we use hashing to
simulate very large lattices for which finite size effects can be neglected, in
spite of the assumed power law for the
probability that a site can infect another site a distance vector
apart. As in I we present detailed results for the critical case, for the
supercritical case with , and for the supercritical case with . For the latter we verify the stretched exponential growth of the
infected cluster with time predicted by M. Biskup. For we find
generic power laws with dependent exponents in the supercritical
phase, but no Kosterlitz-Thouless (KT) like critical point as in 1-d. Instead
of diverging exponentially with the distance from the critical point, the
correlation length increases with an inverse power, as in an ordinary critical
point. Finally we study the dependence of the critical exponents on in
the regime , and compare with field theoretic predictions. In
particular we discuss in detail whether the critical behavior for
slightly less than 2 is in the short range universality class, as conjectured
recently by F. Linder {\it et al.}. As in I we also consider a modified version
of the model where only some of the contacts are long range, the others being
between nearest neighbors. If the number of the latter reaches the percolation
threshold, the critical behavior is changed but the supercritical behavior
stays qualitatively the same.Comment: 14 pages, including 29 figure
Positive words carry less information than negative words
We show that the frequency of word use is not only determined by the word
length \cite{Zipf1935} and the average information content
\cite{Piantadosi2011}, but also by its emotional content. We have analyzed
three established lexica of affective word usage in English, German, and
Spanish, to verify that these lexica have a neutral, unbiased, emotional
content. Taking into account the frequency of word usage, we find that words
with a positive emotional content are more frequently used. This lends support
to Pollyanna hypothesis \cite{Boucher1969} that there should be a positive bias
in human expression. We also find that negative words contain more information
than positive words, as the informativeness of a word increases uniformly with
its valence decrease. Our findings support earlier conjectures about (i) the
relation between word frequency and information content, and (ii) the impact of
positive emotions on communication and social links.Comment: 16 pages, 3 figures, 3 table
Fatal outcome of a hypersensitivity reaction to paclitaxel: a critical review of premedication regimens
Hypersensitivity reactions (HSRs) to paclitaxel are frequently encountered in patients receiving this antitumour drug. Administration of histamine H1- and H2-receptor antagonists and corticosteroids has been shown to reduce significantly the risk of developing an HSR in patients receiving taxanes. In this case report, we describe the fatal outcome of an HSR in a patient receiving paclitaxel despite short-course premedication. The level of evidence supporting the short-course i.v. premedication schedule is challenged, as it is not compatible with the pharmacokinetic properties of dexamethasone
A Random Matrix Approach to Language Acquisition
Since language is tied to cognition, we expect the linguistic structures to
reflect patterns we encounter in nature and analyzed by physics. Within this
realm we investigate the process of protolanguage acquisition, using analytical
and tractable methods developed within physics. A protolanguage is a mapping
between sounds and objects (or concepts) of the perceived world. This mapping
is represented by a matrix and the linguistic interaction among individuals is
described by a random matrix model. There are two essential parameters in our
approach. The strength of the linguistic interaction , which following
Chomsky's tradition, we consider as a genetically determined ability, and the
number of employed sounds (the lexicon size). Our model of linguistic
interaction is analytically studied using methods of statistical physics and
simulated by Monte Carlo techniques. The analysis reveals an intricate
relationship between the innate propensity for language acquisition and
the lexicon size , . Thus a small increase of the
genetically determined may lead to an incredible lexical explosion. Our
approximate scheme offers an explanation for the biological affinity of
different species and their simultaneous linguistic disparity.Comment: 16 pages, 4 figures. Submitted to JSTA
Recommended from our members
INSPIRE: A European training network to foster research and training in cardiovascular safety pharmacology
Safety pharmacology is an essential part of drug development aiming to identify, evaluate and investigate undesirable pharmacodynamic properties of a drug primarily prior to clinical trials. In particular, cardiovascular adverse drug reactions (ADR) have halted many drug development programs. Safety pharmacology has successfully implemented a screening strategy to detect cardiovascular liabilities, but there is room for further refinement. In this setting, we present the INSPIRE project, a European Training Network in safety pharmacology for Early Stage Researchers (ESRs), funded by the European Commission's H2020-MSCA-ITN programme. INSPIRE has recruited 15 ESR fellows that will conduct an individual PhD-research project for a period of 36 months. INSPIRE aims to be complementary to ongoing research initiatives. With this as a goal, an inventory of collaborative research initiatives in safety pharmacology was created and the ESR projects have been designed to be complementary to this roadmap. Overall, INSPIRE aims to improve cardiovascular safety evaluation, either by investigating technological innovations or by adding mechanistic insight in emerging safety concerns, as observed in the field of cardio-oncology. Finally, in addition to its hands-on research pillar, INSPIRE will organize a number of summer schools and workshops that will be open to the wider community as well. In summary, INSPIRE aims to foster both research and training in safety pharmacology and hopes to inspire the future generation of safety scientists
- …