Inflamm-aging of the stem cell niche: Breast cancer as a paradigmatic example: Breakdown of the multi-shell cytokine network fuels cancer in aged people.

Inflamm-aging is a relatively new terminology used to describe the age-related increase in the systemic pro-inflammatory status of humans. Here, we represent inflamm-aging as a breakdown in the multi-shell cytokine network, in which stem cells and stromal fibroblasts (referred to as the stem cell niche) become pro-inflammatory cytokine over-expressing cells due to the accumulation of DNA damage. Inflamm-aging self-propagates owing to the capability of pro-inflammatory cytokines to ignite the DNA-damage response in other cells surrounding DNA-damaged cells. Macrophages, the major cellular player in inflamm-aging, amplify the phenomenon, by broadcasting pro-inflammatory signals at both local and systemic levels. On the basis of this, we propose that inflamm-aging is a major contributor to the increase in cancer incidence and progression in aged people. Breast cancer will be presented as a paradigmatic example for this relationship

Networks from gene expression time series: characterization of correlation patterns

This paper describes characteristic features of networks reconstructed from gene expression time series data. Several null models are considered in order to discriminate between informations embedded in the network that are related to real data, and features that are due to the method used for network reconstruction (time correlation).Comment: 10 pages, 3 BMP figures, 1 Table. To appear in Int. J. Bif. Chaos, July 2007, Volume 17, Issue

The Kondo Effect in the Unitary Limit

We observe a strong Kondo effect in a semiconductor quantum dot when a small magnetic field is applied. The Coulomb blockade for electron tunneling is overcome completely by the Kondo effect and the conductance reaches the unitary-limit value. We compare the experimental Kondo temperature with the theoretical predictions for the spin-1/2 Anderson impurity model. Excellent agreement is found throughout the Kondo regime. Phase coherence is preserved when a Kondo quantum dot is included in one of the arms of an Aharonov-Bohm ring structure and the phase behavior differs from previous results on a non-Kondo dot.Comment: 10 page

Development and Validation of a New Questionnaire for the Evaluation of Upper Gastrointestinal Symptoms in the Elderly Population: A Multicenter Study

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Down syndrome, accelerated aging and immunosenescence

Down syndrome is the most common chromosomal disorder, associated with moderate to severe intellectual disability. While life expectancy of Down syndrome population has greatly increased over the last decades, mortality rates are still high and subjects are facing prematurely a phenomenon of atypical and accelerated aging. The presence of an immune impairment in Down syndrome subjects is suggested for a long time by the existence of an increased incidence of infections, the incomplete efficacy of vaccinations, and a high prevalence of autoimmunity. Immunologic abnormalities have been described since many years in this population, both from a numerical and a functional points of view, and these abnormalities can mirror the ones observed during normal aging. In this review, we summarize our knowledge on immunologic disturbances commonly observed in subjects with Down syndrome, and in innate and adaptive immunity, as well as regarding chronic inflammation. We then discuss the role of accelerated aging in these observed abnormalities and finally review the potential age-associated molecular and cellular mechanisms involved

Riometry at the Italian Antarctic station of Terra Nova Bay

A solid-state riometer has been installed at Terra Nova Bay (74-420S and 164-060E) during the IX Italian Antarctic expedition (1993/1994) to provide, in the frame of the geophysical observatories, studies on the ionospheric absorption in the lower part of the ionosphere. This kind of measurements will integrate the already existing active vertical ionospheric sounding and the magnetic absolute vector observations, with the objective of investigating the state of the ionosphere-magnetosphere coupling. In order to evaluate the base disturbance to the riometer, a remote campaign has been performed at McCarthy Ridge, rather far from the base station, where no anthropic noise is expected. Preliminary data analysis confirms the good quality of the Antarctic riometer observations

Magnetically induced chessboard pattern in the conductance of a Kondo quantum dot

We quantitatively describe the main features of the magnetically induced conductance modulation of a Kondo quantum dot -- or chessboard pattern -- in terms of a constant-interaction double quantum dot model. We show that the analogy with a double dot holds down to remarkably low magnetic fields. The analysis is extended by full 3D spin density functional calculations. Introducing an effective Kondo coupling parameter, the chessboard pattern is self-consistently computed as a function of magnetic field and electron number, which enables us to quantitatively explain our experimental data.Comment: 4 pages, 3 color figure

Development of a measurement platformon a light airplane and analysis of airborne measurementsin the atmospheric boundary layer

In the present paper we provide an overview of a long term research project aimed at setting up a suitable platform for measurements in the atmospheric boundary layer on a light airplane along with some preliminary results obtained from fi eld campaigns at selected sites. Measurements of air pressure, temperature and relative humidity have been performed in various Alpine valleys up to a height of about 2500 m a.m.s.l. By means of GPS resources and specifi c post-processing procedures careful positioning of measurement points within the explored domain has been achieved. The analysis of collected data allowed detailed investigation of atmospheric vertical structures and dynamics typical of valley environment, such as morning transition from ground based inversion to fully developed well mixed convective boundary layer. Based on data collected along fl ights, 3D fi elds of the explored variables have been detected and identifi ed through application of geostatistical techniques (Kriging). The adopted procedures allowed evaluation of the intrinsic statistical structure of the spatial distribution of measured quantities and the estimate of the values of the same variable at unexplored locations by suitable weighted average of data recorded at close locations. Results thus obtained are presented and discussed