3,045 research outputs found
Complex noise in diffusion-limited reactions of replicating and competing species
We derive exact Langevin-type equations governing quasispecies dynamics. The
inherent multiplicative noise has both real and imaginary parts. The numerical
simulation of the underlying complex stochastic partial differential equations
is carried out employing the Cholesky decomposition for the noise covariance
matrix. This noise produces unavoidable spatio-temporal density fluctuations
about the mean field value. In two dimensions, the fluctuations are suppressed
only when the diffusion time scale is much smaller than the amplification time
scale for the master species.Comment: 10 pages, 2 composite figure
Statistical interpretations and new findings on Variation in Cancer Risk Among Tissues
Tomasetti and Vogelstein (2015a) find that the incidence of a set of cancer types is correlated with the total number of normal stem cell divisions. Here, we separate the effects of standing stem cell number (i.e., organ or tissue size) and per stem cell lifetime replication rate. We show that each has a statistically significant and independent effect on explaining variation in cancer incidence over the 31 cases considered by Tomasetti and Vogelstein. When considering the total number of stem cell divisions and when removing cases associated with disease or carcinogens, we find that cancer incidence attains a plateau of approximately 0.6% incidence for the cases considered by these authors. We further demonstrate that grouping by anatomical site explains most of the remaining variation in risk between cancer types. This new analysis suggests that cancer risk depends not only on the number of stem cell divisions but varies enormously (10,000 times) depending on the stem cell's environment. Future research should investigate how tissue characteristics (anatomical site, type, size, stem cell divisions) explain cancer incidence over a wider range of cancers, to what extent different tissues express specific protective mechanisms, and whether any differential protection can be attributed to natural selection
Wormhole Cosmology and the Horizon Problem
We construct an explicit class of dynamic lorentzian wormholes connecting
Friedmann-Robertson-Walker (FRW) spacetimes. These wormholes can allow two-way
transmission of signals between spatially separated regions of spacetime and
could permit such regions to come into thermal contact. The cosmology of a
network of early Universe wormholes is discussed.Comment: 13 pages, in RevTe
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A Hypothesis to Explain Cancers in Confined Colonies of Naked Mole Rats
Abstract: Naked mole rats (NMRs) are subterranean eusocial mammals, known for their virtual absence of aging in their first 20 to 30 years of life, and their apparent resistance to cancer development. As such, this species has become an important biological model for investigating the physiological and molecular mechanisms behind cancer resistance. Two recent studies have discovered middle and late-aged worker (that is, non-breeding) NMRs in captive populations exhibiting neoplasms, consistent with cancer development, challenging the claim that NMRs are cancer resistant. These cases are possibly artefacts of inbreeding or certain rearing conditions in captivity, but they are also consistent with evolutionary theory.We present field data showing that worker NMRs live on average for 1 to 2 years. This, together with considerable knowledge about the biology of this species, provides the basis for an evolutionary explanation for why debilitating cancers in NMRs should be rare in captive populations and absent in the wild. Whereas workers are important for maintaining tunnels, colony defence, brood care, and foraging, they are highly vulnerable to predation. However, surviving workers either replace dead breeders, or assume other less active functions whilst preparing for possible dispersal. These countervailing forces (selection resulting in aging due to early-life investments in worker function, and selection for breeder longevity) along with the fact that all breeders derive from the worker morph, can explain the low levels of cancer observed by these recent studies in captive colonies. Because workers in the field typically never reach ages where cancer becomes a risk to performance or mortality, those rare observations of neoplastic growth should be confined to the artificial environments where workers survive to ages rarely if ever occurring in the wild. Thus, we predict that the worker phenotype fortuitously benefits from anti-aging and cancer protection in captive populations
Electromagnetic waves in a wormhole geometry
We investigate the propagation of electromagnetic waves through a static
wormhole. It is shown that the problem can be reduced to a one-dimensional
Schr\"odinger-like equation with a barrier-type potential. Using numerical
methods, we calculate the transmission coefficient as a function of the energy.
We also discuss the polarization of the outgoing radiation due to this
gravitational scattering.Comment: LaTex file, 5 pages, 2 figures, one reference added, accepted for
publication in PR
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Overestimating the Role of Environment in Cancers
In a recent article, Wu and colleagues (Nature 2016;529:43-47) review previous studies and present new estimates for the contribution of extrinsic factors to cancer development. The new estimates are generally close to 100%, even for bone and brain cancers that have no known associations with lifestyle and are typically not considered to be preventable. We find that the results of Wu and colleagues are incompatible with previous estimates derived from epidemiological and genetic data. We further argue that their methods are fundamentally flawed because they overlook important effects of tissue type on cancer risk. We therefore conclude that their results give a misleading view of cancer etiology and preventability. Cancer Prev Res; 9(10); 773-6. ©2016 AACR
Energy Density of Non-Minimally Coupled Scalar Field Cosmologies
Scalar fields coupled to gravity via in arbitrary
Friedmann-Robertson-Walker backgrounds can be represented by an effective flat
space field theory. We derive an expression for the scalar energy density where
the effective scalar mass becomes an explicit function of and the scale
factor. The scalar quartic self-coupling gets shifted and can vanish for a
particular choice of . Gravitationally induced symmetry breaking and
de-stabilization are possible in this theory.Comment: 18 pages in standard Late
Vacuum polarization in the spacetime of charged nonlinear black hole
Building on general formulas obtained from the approximate renormalized
effective action, the approximate stress-energy tensor of the quantized massive
scalar field with arbitrary curvature coupling in the spacetime of charged
black hole being a solution of coupled equations of nonlinear electrodynamics
and general relativity is constructed and analysed. It is shown that in a few
limiting cases, the analytical expressions relating obtained tensor to the
general renormalized stress-energy tensor evaluated in the geometry of the
Reissner-Nordstr\"{o}m black hole could be derived. A detailed numerical
analysis with special emphasis put on the minimal coupling is presented and the
results are compared with those obtained earlier for the conformally coupled
field. Some novel features of the renormalized stress-energy tensor are
discussed
Cylindrical thin-shell wormholes
A general formalism for the dynamics of non rotating cylindrical thin-shell
wormholes is developed. The time evolution of the throat is explicitly obtained
for thin-shell wormholes whose metric has the form associated to local cosmic
strings. It is found that the throat collapses to zero radius, remains static
or expands forever, depending only on the sign of its initial velocity.Comment: 10 page
Thin-shell wormholes in Einstein-Maxwell theory with a Gauss-Bonnet term
We study five dimensional thin-shell wormholes in Einstein-Maxwell theory
with a Gauss-Bonnet term. The linearized stability under radial perturbations
and the amount of exotic matter are analyzed as a function of the parameters of
the model. We find that the inclusion of the quadratic correction substantially
widens the range of possible stable configurations, and besides it allows for a
reduction of the exotic matter required to construct the wormholes.Comment: 13 pages, 6 figures; v2: minor changes and new references added.
Accepted for publication in General Relativity and Gravitatio
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