799 research outputs found
The entropy of randomized network ensembles
Randomized network ensembles are the null models of real networks and are
extensivelly used to compare a real system to a null hypothesis. In this paper
we study network ensembles with the same degree distribution, the same
degree-correlations or the same community structure of any given real network.
We characterize these randomized network ensembles by their entropy, i.e. the
normalized logarithm of the total number of networks which are part of these
ensembles.
We estimate the entropy of randomized ensembles starting from a large set of
real directed and undirected networks. We propose entropy as an indicator to
assess the role of each structural feature in a given real network.We observe
that the ensembles with fixed scale-free degree distribution have smaller
entropy than the ensembles with homogeneous degree distribution indicating a
higher level of order in scale-free networks.Comment: (6 pages,1 figure,2 tables
Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5
Rab11 GTPases are involved in various cellular processes but their activation by guanine nucleotide exchange factors (GEFs) is not fully understood. Here, the authors present a structural and biochemical analysis of Rab11 bound to the GEF SH3BP5, providing insights how Rab-GEF specificity is achieved
Exploring the Hard X-/soft gamma-ray Continuum Spectra with Laue Lenses
The history of X-ray astronomy has shown that any advancement in our
knowledge of the X-ray sky is strictly related to an increase in instrument
sensitivity. At energies above 60 keV, there are interesting prospects for
greatly improving the limiting sensitivity of the current generation of direct
viewing telescopes (with or without coded masks), offered by the use of Laue
lenses. We will discuss below the development status of a Hard X-Ray focusing
Telescope (HAXTEL) based on Laue lenses with a broad bandpass (from 60 to 600
keV) for the study of the X-ray continuum of celestial sources. We show two
examplesof multi-lens configurations with expected sensitivity orders of
magnitude better ( photons cm s keV
at 200 keV) than that achieved so far. With this unprecedented sensitivity,
very exciting astrophysical prospects are opened.Comment: 4 pages, 10 figures, to be published in the Proc. of the 39th ESLAB
Symosium, 19-21 April 200
Reactive oxygen species and cellular interactions between Mycosphaerella fijiensis and banana.
Globally, the banana plant (Musa spp) is the fourth most important crop after rice, wheat and corn (based on production in tons). It is cultivated in more than 100 tropical and subtropical countries, mainly by small producers and is a fundamental food source for millions of people. Black leaf streak disease (BLSD), caused by Mycosphaerella fijiensis Morelet (sexual phase) or Paracercospora fijiensis (Morelet) Deighton (asexual phase), is the main disease affecting the world's banana culture. This disease has a wide geographical distribution accounting for losses exceeding 50% of global banana production. We conducted a comparative histocytological study on the kinetics of the infection process using three banana genotypes with phenotypes that differ in resistance to BLSD: Grand Naine (Susceptible), Pisang Madu (Partially Resistant) and Calcutta 4 (Resistant). Experiments were conducted under controlled conditions with the objective of characterizing the cellular interaction processes between M. fijiensis and Musa acuminata. Conidia germination occurred 24 hours after inoculation. Germination rates were high (97%) and there were no significant differences between the three genotypes (P>0.147). The Peroxidase enzyme and H2O2 were associated with a hypersensitivity-like reaction in the resistant genotype Calcutta 4, indicating a possible role of the enzyme or its product as defense mechanisms against M. fijiensis in banana plants
Rhythmogenic neuronal networks, pacemakers, and k-cores
Neuronal networks are controlled by a combination of the dynamics of
individual neurons and the connectivity of the network that links them
together. We study a minimal model of the preBotzinger complex, a small
neuronal network that controls the breathing rhythm of mammals through periodic
firing bursts. We show that the properties of a such a randomly connected
network of identical excitatory neurons are fundamentally different from those
of uniformly connected neuronal networks as described by mean-field theory. We
show that (i) the connectivity properties of the networks determines the
location of emergent pacemakers that trigger the firing bursts and (ii) that
the collective desensitization that terminates the firing bursts is determined
again by the network connectivity, through k-core clusters of neurons.Comment: 4+ pages, 4 figures, submitted to Phys. Rev. Let
The Huygens Atmospheric Structure Instrument (HASI): Expected Results at Titan and Performance Verification in Terrestrial Atmosphere
The Huygens ASI is a multi-sensor package resulting from an international cooperation, it has been designed to measure the physical quantities characterizing Titan's atmosphere during the Huygens probe mission. On 14th January, 2005, HASI will measure acceleration, pressure, temperature and electrical properties all along the Huygens probe descent on Titan in order to study Titan s atmospheric structure, dynamics and electric properties. Monitoring axial and normal accelerations and providing direct pressure and temperature measurements during the descent, HASI will mainly contribute to the Huygens probe entry and trajectory reconstruction. In order to simulate the Huygens probe descent and verify HASI sensors performance in terrestrial environment, stratospheric balloon flight experiment campaigns have been performed, in collaboration with the Italian Space Agency (ASI). The results of flight experiments have allowed to determine the atmospheric vertical profiles and to obtain a set of data for the analysis of probe trajectory and attitude reconstruction
Critical phenomena in complex networks
The combination of the compactness of networks, featuring small diameters,
and their complex architectures results in a variety of critical effects
dramatically different from those in cooperative systems on lattices. In the
last few years, researchers have made important steps toward understanding the
qualitatively new critical phenomena in complex networks. We review the
results, concepts, and methods of this rapidly developing field. Here we mostly
consider two closely related classes of these critical phenomena, namely
structural phase transitions in the network architectures and transitions in
cooperative models on networks as substrates. We also discuss systems where a
network and interacting agents on it influence each other. We overview a wide
range of critical phenomena in equilibrium and growing networks including the
birth of the giant connected component, percolation, k-core percolation,
phenomena near epidemic thresholds, condensation transitions, critical
phenomena in spin models placed on networks, synchronization, and
self-organized criticality effects in interacting systems on networks. We also
discuss strong finite size effects in these systems and highlight open problems
and perspectives.Comment: Review article, 79 pages, 43 figures, 1 table, 508 references,
extende
Organization of modular networks
We examine the global organization of heterogeneous equilibrium networks
consisting of a number of well distinguished interconnected
parts--``communities'' or modules. We develop an analytical approach allowing
us to obtain the statistics of connected components and an intervertex distance
distribution in these modular networks, and to describe their global
organization and structure. In particular, we study the evolution of the
intervertex distance distribution with an increasing number of interlinks
connecting two infinitely large uncorrelated networks. We demonstrate that even
a relatively small number of shortcuts unite the networks into one. In more
precise terms, if the number of the interlinks is any finite fraction of the
total number of connections, then the intervertex distance distribution
approaches a delta-function peaked form, and so the network is united.Comment: 9 pages, 3 figure
Mitotic Recombination and Rapid Genome Evolution in the Invasive Forest Pathogen Phytophthora ramorum
Invasive alien species often have reduced genetic diversity and must adapt to new environments. Given the success of many invasions, this is sometimes called the genetic paradox of invasion. Phytophthora ramorum is invasive, limited to asexual reproduction within four lineages, and presumed clonal. It is responsible for sudden oak death in the United States, sudden larch death in Europe, and ramorum blight in North America and Europe. We sequenced the genomes of 107 isolates to determine how this pathogen can overcome the invasion paradox. Mitotic recombination (MR) associated with transposons and low gene density has generated runs of homozygosity (ROH) affecting 2,698 genes, resulting in novel genotypic diversity within the lineages. One ROH enriched in effectors was fixed in the NA1 lineage. An independent ROH affected the same scaffold in the EU1 lineage, suggesting an MR hot spot and a selection target. Differences in host infection between EU1 isolates with and without the ROH suggest that they may differ in aggressiveness. Non-core regions (not shared by all lineages) had signatures of accelerated evolution and were enriched in putative pathogenicity genes and transposons. There was a striking pattern of gene loss, including all effectors, in the non-core EU2 genome. Positive selection was observed in 8.0% of RxLR and 18.8% of Crinkler effector genes compared with 0.9% of the core eukaryotic gene set. We conclude that the P. ramorum lineages are diverging via a rapidly evolving non-core genome and that the invasive asexual lineages are not clonal, but display genotypic diversity caused by MR
Robust estimation of microbial diversity in theory and in practice
Quantifying diversity is of central importance for the study of structure,
function and evolution of microbial communities. The estimation of microbial
diversity has received renewed attention with the advent of large-scale
metagenomic studies. Here, we consider what the diversity observed in a sample
tells us about the diversity of the community being sampled. First, we argue
that one cannot reliably estimate the absolute and relative number of microbial
species present in a community without making unsupported assumptions about
species abundance distributions. The reason for this is that sample data do not
contain information about the number of rare species in the tail of species
abundance distributions. We illustrate the difficulty in comparing species
richness estimates by applying Chao's estimator of species richness to a set of
in silico communities: they are ranked incorrectly in the presence of large
numbers of rare species. Next, we extend our analysis to a general family of
diversity metrics ("Hill diversities"), and construct lower and upper estimates
of diversity values consistent with the sample data. The theory generalizes
Chao's estimator, which we retrieve as the lower estimate of species richness.
We show that Shannon and Simpson diversity can be robustly estimated for the in
silico communities. We analyze nine metagenomic data sets from a wide range of
environments, and show that our findings are relevant for empirically-sampled
communities. Hence, we recommend the use of Shannon and Simpson diversity
rather than species richness in efforts to quantify and compare microbial
diversity.Comment: To be published in The ISME Journal. Main text: 16 pages, 5 figures.
Supplement: 16 pages, 4 figure
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