1,859 research outputs found
Reheating temperature from the CMB
In the recent paper by Mielczarek \emph{et al.} (JCAP {\bf 1007} (2010) 004)
an idea of the method which can be used to put some constraint for the
reheating phase was proposed. Another method of constraining the reheating
temperature has been recently studied by Martin and Ringeval (Phys.\ Rev.\ D
{\bf 82} (2010) 023511). Both methods are based on observations of the cosmic
microwave background (CMB) radiation. In this paper, we develop the idea
introduced in this first article to put constraint on the reheating after the
slow-roll inflation. We restrict our considerations to the case of a massive
inflaton field. The method can be, however, easily extended to the different
inflationary scenarios. As a main result, we derive an expression on the
reheating temperature . Surprisingly, the obtained equation is
independent on the unknown number of relativistic degrees of freedom
produced during the reheating. Based on this equation and the WMAP 7
observations, we find GeV, which is consistent
with the current constraints. The relative uncertainty of the result is,
however, very high and equal to . As we show, this uncertainty will be significantly reduced with future CMB
experiments.Comment: 6 pages, 3 figures. Matches version published in Phys. Rev.
Development of Novel Nucleophile-Intercepted Beckmann Fragmentations and Progress Toward the Total Synthesis of 2(S)-Cathafoline
This thesis is comprised of two chapters, the first being the discovery of a novel nucleophile-intercepted Beckmann fragmentation of [2.2.1] indoline systems that resulted in highly stereo- and regioselective reactions. Chapter one details the exploration of this reaction as well as its relevant background information detailing its significance. Chapter two describes the application of the novel nucleophile-intercepted Beckmann fragmentation in the context of a total synthesis of akuammilline alkaloid 2(S)-cathafoline. While the target natural product was never synthesized, unpredicted reactivity resulted in interesting discoveries worthy of discussion
The initial conditions of the universe: how much isocurvature is allowed?
We investigate the constraints imposed by the current data on correlated
mixtures of adiabatic and non-adiabatic primordial perturbations. We discover
subtle flat directions in parameter space that tolerate large (~60%)
contributions of non-adiabatic fluctuations. In particular, larger values of
the baryon density and a spectral tilt are allowed. The cancellations in the
degenerate directions are explored and the role of priors elucidated.Comment: 4 pages, 4 figures. Submitted to PR
Assumptions of the primordial spectrum and cosmological parameter estimation
The observables of the perturbed universe, CMB anisotropy and large
structures, depend on a set of cosmological parameters, as well as, the assumed
nature of primordial perturbations. In particular, the shape of the primordial
power spectrum (PPS) is, at best, a well motivated assumption. It is known that
the assumed functional form of the PPS in cosmological parameter estimation can
affect the best fit parameters and their relative confidence limits. In this
paper, we demonstrate that a specific assumed form actually drives the best fit
parameters into distinct basins of likelihood in the space of cosmological
parameters where the likelihood resists improvement via modifications to the
PPS. The regions where considerably better likelihoods are obtained allowing
free form PPS lie outside these basins. In the absence of a preferred model of
inflation, this raises a concern that current cosmological parameters estimates
are strongly prejudiced by the assumed form of PPS. Our results strongly
motivate approaches toward simultaneous estimation of the cosmological
parameters and the shape of the primordial spectrum from upcoming cosmological
data. It is equally important for theorists to keep an open mind towards early
universe scenarios that produce features in the PPS.Comment: 11 pages, 2 figures, discussions extended, main results unchanged,
matches published versio
Constraints on isocurvature models from the WMAP first-year data
We investigate the constraints imposed by the first-year WMAP CMB data
extended to higher multipole by data from ACBAR, BOOMERANG, CBI and the VSA and
by the LSS data from the 2dF galaxy redshift survey on the possible amplitude
of primordial isocurvature modes. A flat universe with CDM and Lambda is
assumed, and the baryon, CDM (CI), and neutrino density (NID) and velocity
(NIV) isocurvature modes are considered. Constraints on the allowed
isocurvature contributions are established from the data for various
combinations of the adiabatic mode and one, two, and three isocurvature modes,
with intermode cross-correlations allowed. Since baryon and CDM isocurvature
are observationally virtually indistinguishable, these modes are not considered
separately. We find that when just a single isocurvature mode is added, the
present data allows an isocurvature fraction as large as 13+-6, 7+-4, and 13+-7
percent for adiabatic plus the CI, NID, and NIV modes, respectively. When two
isocurvature modes plus the adiabatic mode and cross-correlations are allowed,
these percentages rise to 47+-16, 34+-12, and 44+-12 for the combinations
CI+NID, CI+NIV, and NID+NIV, respectively. Finally, when all three isocurvature
modes and cross-correlations are allowed, the admissible isocurvature fraction
rises to 57+-9 per cent. The sensitivity of the results to the choice of prior
probability distribution is examined.Comment: 20 pages, 24 figures. Submitted to PR
A Histological Assessment of the Mechanism of Early-Stage Healing of a Biphasic Calcium Phosphate in an \u3cem\u3eIn vivo\u3c/em\u3e Rabbit Model
The healing mechanism of osteoconductive biphasic calcium phosphate granules was investigated by a histological assessment of early-stage bone deposition and remodeling. The deposition of de novo bone on the scaffold granules was observed to initiate at the defect periphery by week one and in the bulk of the defect incorporating the granules by week four. New bone tissue was deposited in the space provided by the macroporosity and was observed in direct apposition to the implanted material confirming the bioactivity of the biphasic calcium phosphate. The granules were removed through a cell-mediated resorption process that was observed to begin as early as week two following surgery. Mature lamellar bone, fatty bone marrow, and vascularization was observed throughout the bulk of the defect with the cortical shell healed by week twelve. This healing mechanism was found to balance bone formation and implant resorption resulting in complete healing of the corticocancellous defect in the rabbit femoral condyle
The African Hospitalist Fellowship
The African Paediatric Fellowship Programme is rolling out a training course for newly qualified paediatricians to equip them with the leadership skills to function in complex general paediatric settings. The care of children in Africa carries its own unique demands, from the layering effects of multiple conditions through to establishing and sustaining services under severe resource constraints. This novel training concept aims to strengthen confidence and knowledge in areas that are not priorities during standard general paediatric training. The skills gained are considered of great relevance in assisting general paediatricians to achieve their full potential in their careers
Perceptions of Healthcare professionals and people with Type 2 diabetes on emotional support: a qualitative study
Background Type 2 diabetes mellitus (T2DM) is a demanding condition that impacts the person living with the condition physically and psychologically. Promoting emotional support is a key strategy to improve diabetes care.Aim To explore the views and experiences of people with T2DM and healthcare professionals (HCPs) on emotional support in diabetes care, and identify barriers and facilitators to the provision of emotional support in clinical practice.Design & setting A qualitative study in England with data collected from four focus groups.Method Focus group discussions were conducted with people with T2DM (n = 10) and HCPs (n = 10). The analysis was informed by the framework method and principles of the constant comparative approach.Results Emotional support was lacking in diabetes primary care, and there was a need to normalise the emotional impact of T2DM. Barriers to emotional support included: lack of HCP confidence to discuss emotional issues; lack of counselling training; and time constraints in consultations. Inappropriate use of the word ‘depression’ creates a sense of taboo for those experiencing emotions other than depression.Conclusion Consensus between the two target groups indicated a strong need to integrate emotional support in diabetes care, and the need to support and train HCPs in addressing psychosocial aspects of T2DM. Shared language is recommended across diabetes services to appropriately refer to wellbeing. Addressing barriers and considering ways to incorporate emotional management in diabetes consultations is recommended, includings introducing HCP training to increase confidence and enhance counselling skills.</div
Changes in zircon chemistry during archean UHT metamorphism in the Napier complex, Antarctica
Zircons from two paragneisses (from Mount Sones and Dallwitz Nunatak) and one orthogneiss (from Gage Ridge) in the Tula Mountains, Napier Complex (East Antarctica) were analyzed for U-Pb age, oxygen isotopes, REEs and by scanning ion imaging. A large number of zircons from all samples are reversely discordant. Mount Sones zircons show an age range from 3.0 Ga to 2.5 Ga and underwent high-grade metamorphism at both ~2.8 Ga and 2.5 Ga. Zircons from Dallwitz Nunatak record detrital ages between 3.5 Ga and 2.5 Ga. Zircons from Gage Ridge record multiple age groups, with concordant data between 3.6 Ga and 3.3 Ga and reversely discordant data that form a discrete ~3.8 Ga population. All of the grains show evidence of Pb mobility during metamorphism. Ion imaging of zircons reveals Y and U zonation, characteristic of magmatic zircon, together with a micro-scale patchy distribution of 206Pb and 207Pb that does not correspond to either growth zonation or crystal imperfections. Some of these patches yield 207Pb/206Pb ages >4 Ga, whereas others yield ages younger than the magmatic crystallization age. Reversely discordant data are the result of ancient Pb mobilization, which is independent of the degree of metamictisation, oxygen isotope and REE content of the zircons. This mobilization can result in spurious ages and was most likely caused by polymetamorphism under anhydrous conditions; that is two high-grade events; one poorly defined at ~2.8 Ga and the other ultra-high temperature (UHT) metamorphism at 2.5 Ga
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