Lactogenic Activity of Rats Stimulated by Gunnera Perpensa L. (Gunneraceae) from South Africa

Gunnera perpensa L. (Gunneraceae) is a medicinal plant used by Zulu traditional healers to stimulate milk production. The effect of an aqueous extract of the rhizome of the plant on milk production in rats was investigated. Female lactating rats that received oral doses of the extract of G.perpensa significantly (p<0.05) produced more milk than controls. The plant extract did not however, significantly influence the levels of prolactin, growth hormone, progesterone, cortisol, ALT, AST and albumin in the blood. The mammary glands of rats treated with the extract showed lobuloalveolar development. The extract (0.8 μg/ml) was also found to stimulate the contraction of the uterus and inhibit (23%) acetylcholinesterase activity. The cytotoxicity of the extract (LC50) to two human cell lines (HEK293 and HepG2) was 279.43 μg/ml and 222.33μg/ml, respectively. It is inferred that the plant extract exerts its activity on milk production and secretion by stimulating lobuloalveolar cell development and the contraction of myoepithelial cells in the alveoli. It is concluded that Gunnera perpensa contains constituents with lactogenic activity that apparently contribute to its effectiveness in folk medicine

Physical, anthropometric and physiological profiles of experienced junior male and female South African Taekwondo athletes

The research was aimed at identifying the anthropometric, physical and physiological characteristics of junior Taekwondo athletes to achieve an international status. Data were collected from 25 males and 11 females aged 15.5 ±2.6 years. Measurements consisted of body composition (body fat percentage (%BF), sum of 6 skinfolds), flexibility (sit & reach, hip flexor (HF) and quadriceps flexibility (QF), lower extremity explosive power (vertical jump (Diff VJ) and vertical jump relative power (R Power), muscle endurance (sit-ups and push-ups), muscular strength (handgrip right and left), hexagonal agility (HEX) and agility T-test, aerobic power (20 m bleep test (20MST) converted to maximum oxygen uptake (VO2max.). Data were analyzed using t-test for independent samples and Z-score statistics. Significant higher %BF and sum of skinfolds were recorded in junior female players. No differences in body mass, stature and BMI were found. Male athletes had higher (p<0.001) VO2max (42.2±6.8 ml/kg/min) compared to females (31.7±6.5 ml/kg/min). Female athletes showed lower (p<0.001) results in push-ups (9.0±6.5 reps) compared to males (25.6±10.5 reps). Maximal grip strength (kg) of both hands was higher (p<0.05) in males. No differences in sit-ups, explosive leg power and agility were found between males and females. The analysis of individual Z-score for assessment of fitness variables has practical implications contributing to the trainability and performance of junior taekwondo athletes.http://www.ajol.info/journal_index.php?jid=153&ab=ajpherd2017-12-31am201

LACTOGENIC ACTIVITY OF RATS STIMULATED BY GUNNERA PERPENSA L. (GUNNERACEAE) FROM SOUTH AFRICA

Gunnera perpensa L. (Gunneraceae) is a medicinal plant used by Zulu traditional healers to stimulate milk production. The effect of an aqueous extract of the rhizome of the plant on milk production in rats was investigated. Female lactating rats that received oral doses of the extract of G.perpensa significantly (

Living with type 1 diabetes is challenging for Zambian adolescents: qualitative data on stress, coping with stress and quality of care and life

Abstract: Background: Psychosocial problems are common in patients with diabetes. However, data on psychosocial issues affecting patients with diabetes in Zambia are scarce. The present study explored sources of stress, stress coping strategies, stigma and perceived quality of life and care as experienced by adolescents living with Type 1 Diabetes in Zambia. Methods: Semi-structured interviews were carried out. Three groups of participants involving adolescents with Type 1 Diabetes (n = 10), caregivers (n = 8) and health practitioners (n = 4) were interviewed. Transcripts were analyzed using a thematic approach. Results: Stress was commonly reported by adolescents mainly stemming from social, psychological and physical sources. To deal with stress, adolescents often employed different coping strategies such as adapting, accepting and avoiding among others. Both internal factors (those relating to the patients themselves) and external factors (those related to the context of the patients’) influenced the patients’ quality of health care. In addition, low quality of life was an issue among adolescents and their families. Poor diet, low socioeconomic status and lack of medicine were factors affecting quality of health care. Conclusion: Stress was an issue affecting adolescents; the coping strategies employed were sometimes maladaptive such as avoiding injecting themselves to escape stress. Several aspects of quality of life were suboptimal in both adolescents and their families, such as stigmatization, short life expectancy, low socioeconomic status and poor social participation. Findings show that there is an urgent need for a strong response from all stakeholders (governments, patients, organizations and companies) to improve diabetes care and living conditions for young people with type 1 diabetes living in Zambia