20 research outputs found

    Corema album archaeobotanical remains in western Mediterranean basin. Assessing fruit consumption during Upper Palaeolithic in Cova de les Cendres (Alicante, Spain)

    Full text link
    [EN] Information about plant gathering by Palaeolithic hunter-gatherers in Europe is scarce because of the problems of preservation of plant remains in archaeological sites and due to the lack of application of archaebotanical analysis in many of them. Botanical macroremains wood charcoal, seeds, fruits, leaves, etc. - provide information not only about palaeoeconomy of hunter-gatherers, but also about climate, landscape and vegetation dynamics. In Gravettian and Solutrean levels of Cova de les Cendres (Alicante, Spain), Corema album pyrenes (Empetraceae or crowberries family) have been identified. On the contrary, wood charcoal of this species has not been documented among the remains of firewood. This differential presence of plant organs, together with the nutritional value of its fruits, which is presented here, make us hypothesize the systematic gathering of C. album fruits for human consumption. They have a high content in vitamin C, as well as potassium, magnesium and copper. Corema album (camariria) is a unique species, nowadays in danger of extinction. Its main population is located on the Atlantic coast of Iberian Peninsula, but in 1996 a small population was discovered on the Mediterranean Iberian coast (Benidorm, Spain). Archaeobotanical data from Cova de les Cendres (Teulada-Moraira, Spain) presented here point to a larger population of camariria during Upper Palaeolithic on the coast of Alicante. The harsh climatic conditions of the Last Glacial Maximum during Solutrean period, with colder temperatures and aridity increase, could explain the reduction of the presence of C album remains until its absence in Magdalenian. The climatic amelioration during Upper Magdalenian did not mean the recovery of camariria population in the Moraira headland area. Probably, the rising of the sea level would affect them destroying its dune habitat. (C) 2019 Elsevier Ltd. All rights reserved.Archaeological research at Cova de les Cendres was funded by Spanish Ministerio de Ciencia e Innovacion (HAR2011-24878; CGL2012-34717; HAR2014-5267 degrees 1-P; HAR2017-85153/P) and by Generalitat Valenciana (Grant PROMETEOII/2013/016; PROMETEO/2017/060). Seed analyses were carried out as doctoral research at the Departament de Prehistoria, Arqueologia i Historia Antiga (Universitat de Valencia) with the financial support of an "Atraccio de Talent" of VLC-Campus predoctoral grant to C.M. Martinez-Varea. Thanks to the Donana Biological Reserve for having allowed us to use the Singular Technical Scientific Installation for the Corema sampling. Authors want to thank M. Macias from Universitat Politecnica de Valencia for software development to draw the charcoal diagram and Eva Arnau from Universitat de Valencia for 3D modeling.Martínez-Varea, CM.; Ferrer-Gallego, P.; Raigón Jiménez, MD.; Badal, E.; Ferrando-Pardo, I.; Laguna-Lumbreras, E.; Real, C.... (2019). Corema album archaeobotanical remains in western Mediterranean basin. Assessing fruit consumption during Upper Palaeolithic in Cova de les Cendres (Alicante, Spain). Quaternary Science Reviews. 207:1-12. https://doi.org/10.1016/j.quascirev.2019.01.004S112207Allué, E., Martínez-Moreno, J., Alonso, N., & Mora, R. (2012). Changes in the vegetation and human management of forest resources in mountain ecosystems at the beginning of MIS 1 (14.7–8 ka cal BP) in Balma Guilanyà (Southeastern Pre-Pyrenees, Spain). Comptes Rendus Palevol, 11(7), 507-518. doi:10.1016/j.crpv.2012.04.004Anderberg, A. A. (1994). Phylogeny of the Empetraceae, with Special Emphasis on Character Evolution in the Genus Empetrum. Systematic Botany, 19(1), 35. doi:10.2307/2419710Andrade, S. C., Guiné, R. P. F., & Gonçalves, F. J. A. (2017). Evaluation of phenolic compounds, antioxidant activity and bioaccessibility in white crowberry (Corema album). Journal of Food Measurement and Characterization, 11(4), 1936-1946. doi:10.1007/s11694-017-9576-4Asouti, E., Ntinou, M., & Kabukcu, C. (2018). The impact of environmental change on Palaeolithic and Mesolithic plant use and the transition to agriculture at Franchthi Cave, Greece. PLOS ONE, 13(11), e0207805. doi:10.1371/journal.pone.0207805Aura, J. E., Carrión, Y., Estrelles, E., & Jordà, G. P. (2005). Plant economy of hunter-gatherer groups at the end of the last Ice Age: plant macroremains from the cave of Santa Maira (Alacant, Spain) ca. 12000–9000 b.p. Vegetation History and Archaeobotany, 14(4), 542-550. doi:10.1007/s00334-005-0002-1Badal García, E., & Martínez Varea, C. M. (2018). Different parts of the same plants. Charcoals and seeds from Cova de les Cendres (Alicante, Spain). Quaternary International, 463, 391-400. doi:10.1016/j.quaint.2016.12.020Baines, J. A., Riehl, S., Conard, N., & Zeidi-Kulehparcheh, M. (2014). Upper Palaeolithic archaeobotany of Ghar-e Boof cave, Iran: a case study in site disturbance and methodology. Archaeological and Anthropological Sciences, 7(2), 245-256. doi:10.1007/s12520-014-0191-6BEDCA. Base de datos Española de Composición de Alimentos. http://www.bedca.net/bdpub/index.php (accessed 14 May 2018).Boivin, N. L., Zeder, M. A., Fuller, D. Q., Crowther, A., Larson, G., Erlandson, J. M., … Petraglia, M. D. (2016). Ecological consequences of human niche construction: Examining long-term anthropogenic shaping of global species distributions. Proceedings of the National Academy of Sciences, 113(23), 6388-6396. doi:10.1073/pnas.1525200113Briggs, J. M., Spielmann, K. A., Schaafsma, H., Kintigh, K. W., Kruse, M., Morehouse, K., & Schollmeyer, K. (2006). Why ecology needs archaeologists and archaeology needs ecologists. Frontiers in Ecology and the Environment, 4(4), 180-188. doi:10.1890/1540-9295(2006)004[0180:wenaaa]2.0.co;2Calviño-Cancela, M. (2004). Ingestion and dispersal: direct and indirect effects of frugivores on seed viability and germination of Corema album (Empetraceae). Acta Oecologica, 26(1), 55-64. doi:10.1016/j.actao.2004.03.006Erlandson, J. M., & Braje, T. J. (2013). Archeology and the Anthropocene. Anthropocene, 4, 1-7. doi:10.1016/j.ancene.2014.05.003Gil-López, M. J. (2011). Etnobotánica de la camarina (Corema album, Empetraceae) en Cádiz. Ethnobotany of Corema album (Empetraceae) in Cadiz. Acta Botanica Malacitana, 36, 137-144. doi:10.24310/abm.v36i1.2784Hardy, B. L. (2010). Climatic variability and plant food distribution in Pleistocene Europe: Implications for Neanderthal diet and subsistence. Quaternary Science Reviews, 29(5-6), 662-679. doi:10.1016/j.quascirev.2009.11.016Hardy, K. (2018). Plant use in the Lower and Middle Palaeolithic: Food, medicine and raw materials. Quaternary Science Reviews, 191, 393-405. doi:10.1016/j.quascirev.2018.04.028Henry, A. G., Brooks, A. S., & Piperno, D. R. (2014). Plant foods and the dietary ecology of Neanderthals and early modern humans. Journal of Human Evolution, 69, 44-54. doi:10.1016/j.jhevol.2013.12.014Hernández-Molina, F. ., Somoza, L., Rey, J., & Pomar, L. (1994). Late Pleistocene-Holocene sediments on the Spanish continental shelves: Model for very high resolution sequence stratigraphy. Marine Geology, 120(3-4), 129-174. doi:10.1016/0025-3227(94)90057-4Hockett, B. (2012). The consequences of Middle Paleolithic diets on pregnant Neanderthal women. Quaternary International, 264, 78-82. doi:10.1016/j.quaint.2011.07.002Holst, D. (2010). Hazelnut economy of early Holocene hunter–gatherers: a case study from Mesolithic Duvensee, northern Germany. Journal of Archaeological Science, 37(11), 2871-2880. doi:10.1016/j.jas.2010.06.028Humphrey, L. T., De Groote, I., Morales, J., Barton, N., Collcutt, S., Bronk Ramsey, C., & Bouzouggar, A. (2014). Earliest evidence for caries and exploitation of starchy plant foods in Pleistocene hunter-gatherers from Morocco. Proceedings of the National Academy of Sciences, 111(3), 954-959. doi:10.1073/pnas.1318176111Kron, K. A., & Chase, M. W. (1993). Systematics of the Ericaceae, Empetraceae, Epacridaceae and Related Taxa Based Upon rbcL Sequence Data. Annals of the Missouri Botanical Garden, 80(3), 735. doi:10.2307/2399857Kubiak-Martens, L. (1999). The plant food component of the diet at the late Mesolithic (Ertebolle) settlement at Tybrind Vig, Denmark. Vegetation History and Archaeobotany, 8(1-2), 117-127. doi:10.1007/bf02042850Laguna, E., Deltoro, V. ., Pèrez-Botella, J., Pèrez-Rovira, P., Serra, L., Olivares, A., & Fabregat, C. (2004). The role of small reserves in plant conservation in a region of high diversity in eastern Spain. Biological Conservation, 119(3), 421-426. doi:10.1016/j.biocon.2004.01.001León-González, A. J., Mateos, R., Ramos, S., Martín, M. Á., Sarriá, B., Martín-Cordero, C., … Goya, L. (2012). Chemo-protective activity and characterization of phenolic extracts from Corema album. Food Research International, 49(2), 728-738. doi:10.1016/j.foodres.2012.09.016León-González, A. J., Truchado, P., Tomás-Barberán, F. A., López-Lázaro, M., Barradas, M. C. D., & Martín-Cordero, C. (2013). Phenolic acids, flavonols and anthocyanins in Corema album (L.) D. Don berries. Journal of Food Composition and Analysis, 29(1), 58-63. doi:10.1016/j.jfca.2012.10.003Lev, E., Kislev, M. E., & Bar-Yosef, O. (2005). Mousterian vegetal food in Kebara Cave, Mt. Carmel. Journal of Archaeological Science, 32(3), 475-484. doi:10.1016/j.jas.2004.11.006LI, J. (2002). Phylogenetic relationships of Empetraceae inferred from sequences of chloroplast gene matK and nuclear ribosomal DNA ITS region. Molecular Phylogenetics and Evolution, 25(2), 306-315. doi:10.1016/s1055-7903(02)00241-5Lopez-Doriga, I. (2018). The Archaeobotany and Ethnobotany of Portuguese or White Crowberry (Corema album). Ethnobiology Letters, 9(2), 19-32. doi:10.14237/ebl.9.2.2018.1069Macedo, D., Tavares, L., McDougall, G. J., Vicente Miranda, H., Stewart, D., Ferreira, R. B., … Santos, C. N. (2014). (Poly)phenols protect from α-synuclein toxicity by reducing oxidative stress and promoting autophagy. Human Molecular Genetics, 24(6), 1717-1732. doi:10.1093/hmg/ddu585Martínez Varea, C. M., & Badal García, E. (2017). Plant use at the end of the Upper Palaeolithic: archaeobotanical remains from Cova de les Cendres (Teulada-Moraira, Alicante, Spain). Vegetation History and Archaeobotany, 27(1), 3-14. doi:10.1007/s00334-017-0616-0Martinoli, D., & Jacomet, S. (2004). Identifying endocarp remains and exploring their use at Epipalaeolithic �k�zini in southwest Anatolia, Turkey. Vegetation History and Archaeobotany, 13(1), 45-54. doi:10.1007/s00334-003-0029-0McEwen, M. C. (1894). The Comparative Anatomy of Corema alba and Corema Conradii. Bulletin of the Torrey Botanical Club, 21(7), 277. doi:10.2307/2477916Milton, K. (1999). Nutritional characteristics of wild primate foods: do the diets of our closest living relatives have lessons for us? Nutrition, 15(6), 488-498. doi:10.1016/s0899-9007(99)00078-7Morales, J., Mulazzani, S., Belhouchet, L., Zazzo, A., Berrio, L., Eddargach, W., … Peña-Chocarro, L. (2015). First preliminary evidence for basketry and nut consumption in the Capsian culture (ca. 10,000–7500BP): Archaeobotanical data from new excavations at El Mekta, Tunisia. Journal of Anthropological Archaeology, 37, 128-139. doi:10.1016/j.jaa.2014.12.005Noli, D., & Avery, G. (1988). Protein poisoning and coastal subsistence. Journal of Archaeological Science, 15(4), 395-401. doi:10.1016/0305-4403(88)90037-4De Oliveira, P. B., & Dale, A. (2012). Corema album (L.) D. Don, the white crowberry – a new crop. Journal of Berry Research, 2(3), 123-133. doi:10.3233/jbr-2012-033Pimpão, R. C., Dew, T., Oliveira, P. B., Williamson, G., Ferreira, R. B., & Santos, C. N. (2013). Analysis of Phenolic Compounds in Portuguese Wild and Commercial Berries after Multienzyme Hydrolysis. Journal of Agricultural and Food Chemistry, 61(17), 4053-4062. doi:10.1021/jf305498jPower, R. C., & Williams, F. L. (2018). Evidence of Increasing Intensity of Food Processing During the Upper Paleolithic of Western Eurasia. Journal of Paleolithic Archaeology, 1(4), 281-301. doi:10.1007/s41982-018-0014-xPryor, A. J. E., Steele, M., Jones, M. K., Svoboda, J., & Beresford-Jones, D. G. (2013). Plant foods in the Upper Palaeolithic at Dolní Vӗstonice? Parenchyma redux. Antiquity, 87(338), 971-984. doi:10.1017/s0003598x00049802Redfield, J. H. (1884). Corema Conradii and Its Localities. Bulletin of the Torrey Botanical Club, 11(9), 97. doi:10.2307/2477643Reveal, J. L., & Chase, M. W. (2011). APG III: Bibliographical Information and Synonymy of Magnoliidae. Phytotaxa, 19(1), 71. doi:10.11646/phytotaxa.19.1.4Revedin, A., Longo, L., Mariotti Lippi, M., Marconi, E., Ronchitelli, A., Svoboda, J., … Aranguren, B. (2015). New technologies for plant food processing in the Gravettian. Quaternary International, 359-360, 77-88. doi:10.1016/j.quaint.2014.09.066Richards, M. P., & Trinkaus, E. (2009). Isotopic evidence for the diets of European Neanderthals and early modern humans. Proceedings of the National Academy of Sciences, 106(38), 16034-16039. doi:10.1073/pnas.0903821106Ruddiman, W. F., Ellis, E. C., Kaplan, J. O., & Fuller, D. Q. (2015). Defining the epoch we live in. Science, 348(6230), 38-39. doi:10.1126/science.aaa7297Santos, M. S., de Oliveira, C. M., Valdiviesso, T., & de Oliveira, P. B. (2014). Effects of pretreatments on Corema album (L.) D. Don (subsp. album) seeds’ germination. Journal of Berry Research, 4(4), 183-192. doi:10.3233/jbr-140079Slavin, J. L., & Lloyd, B. (2012). Health Benefits of Fruits and Vegetables. Advances in Nutrition, 3(4), 506-516. doi:10.3945/an.112.002154Snir, A., Nadel, D., Groman-Yaroslavski, I., Melamed, Y., Sternberg, M., Bar-Yosef, O., & Weiss, E. (2015). The Origin of Cultivation and Proto-Weeds, Long Before Neolithic Farming. PLOS ONE, 10(7), e0131422. doi:10.1371/journal.pone.0131422Speth, J. D., & Spielmann, K. A. (1983). Energy source, protein metabolism, and hunter-gatherer subsistence strategies. Journal of Anthropological Archaeology, 2(1), 1-31. doi:10.1016/0278-4165(83)90006-5Villaverde, V., Real, C., Roman, D., Albert, R. M., Badal, E., Bel, M. Á., … Pérez-Ripoll, M. (2019). The early Upper Palaeolithic of Cova de les Cendres (Alicante, Spain). Quaternary International, 515, 92-124. doi:10.1016/j.quaint.2017.11.051Villaverde Bonilla, V., Román, D., Ripoll, M. P., Bergadà, M. M., & Real, C. (2012). The end of the Upper Palaeolithic in the Mediterranean Basin of the Iberian Peninsula. Quaternary International, 272-273, 17-32. doi:10.1016/j.quaint.2012.04.025Weiss, E., Kislev, M. E., Simchoni, O., & Nadel, D. (2004). Small-Grained Wild Grasses as Staple Food at the 23 000-Year-Old Site of Ohalo II, Israel. Economic Botany, 58(sp1), S125-S134. doi:10.1663/0013-0001(2004)58[s125:swgasf]2.0.co;2Weiss, E., Wetterstrom, W., Nadel, D., & Bar-Yosef, O. (2004). The broad spectrum revisited: Evidence from plant remains. Proceedings of the National Academy of Sciences, 101(26), 9551-9555. doi:10.1073/pnas.0402362101Zunzunegui, M., Díaz Barradas, M. C., Clavijo, A., Alvarez Cansino, L., Ain Lhout, F., & García Novo, F. (2005). Ecophysiology, growth timing and reproductive effort of three sexual foms of Corema album (Empetraceae). Plant Ecology, 183(1), 35-46. doi:10.1007/s11258-005-9004-

    Sustained low disease activity measured by ASDAS slow radiographic spinal progression in axial spondyloarthritis patients treated with TNF-inhibitors: data from REGISPONSERBIO

    Get PDF
    Background To evaluate the influence of the disease activity on radiographic progression in axial spondyloarthritis (axSpA) patients treated with TNF inhibitors (TNFi). Methods The study included 101 axSpA patients from the Spanish Register of Biological Therapy in Spondyloarthritides (REGISPONSERBIO), which had clinical data and radiographic assessment available. Patients were classified into 2 groups based on the duration of TNFi treatment at baseline: (i) long-term treatment (>= 4 years) and (ii) no long-term treatment (= 2 mSASSS units. At inclusion, approximately half of the patients (45.5%) were receiving long-term treatment with TNFi (>= 4 years). In this group of subjects, a significant difference in averaged Ankylosing Spondylitis disease Activity Score (ASDAS) across follow-up was found between progressors and non-progressors (2.33 vs 1.76, p=0.027, respectively). In patients not under long-term TNFi treatment (54.5%) though, no significant ASDAS differences were observed between progressors and non-progressors until the third year of follow-up. Furthermore, no significant differences were found in progression status, when disease activity was measured by Bath Ankylosing spondylitis Disease Activity Index (BASDAI) and C reactive protein (CRP). Conclusions Patients on long-term TNFi treatment with a mean sustained low disease activity measures by ASDAS presented lower radiographic progression than those with active disease

    The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

    Get PDF
    Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation

    Exploring the link between innate immune activation and thymic function by measuring sCD14 and TRECs in HIV patients living in Belgium

    Full text link
    Microbial translocation is now viewed as a central event in the pathogenesis of chronic inflammation during HIV infection. Thymic function failure is another crucial factor involved in HIV disease progression. The goal of this study was to explore the hypothesis of potential links between microbial translocation and thymic function in HIV-1 patients living in Belgium. The extent of microbial translocation was assessed through the measurement of soluble CD14 (sCD14). T-cell receptor excision circles (sjTRECs and dβTRECs) were used as a measure of thymic function. Data were collected from 75 HIV-infected patients. Simple and complex linear regressions were done to analyze the link between these two processes. We found a statistically relevant negative correlation between thymopoiesis (sjTREC) and sCD14 level (p = 0.004). These results suggest a link between thymic function failure, microbial translocation and innate immune activation
    corecore