Il vincolo di affinità profonda. Verso una filosofia ambientale panpsichista

The article provides some arguments in favour of a panpsychist turn in environmental philosophy. It first explains why dualism remains a favoured polemical target for many environmental activists and theorists, even though the scientific/metaphysical paradigm of reference is now generally physicalist. It then points to some of the tribulations of environmental philosophy in juggling dualism and physicalism. It goes on to describes some of the strategies adopted by environmental philosophers to establish an axiologically-relevant ontological affinity between humans and non-humans, and notes how these strategies punctually (and more or less explicitly and plausibly) return to the recognition (or attribution) of mind or mental characteristics to non-humans. Such recognition is easy in the case of non-human animals, revisionist in the case of plants and living non-sentient entities in general, and mostly left unattended in the case of non-human, non-living entities like rocks. This leaves us with a patchy result whereby humans have a deep ontological affinity with only small and selected portions of the non-human. The paper then articulates the contours of an alternative panpsychist cosmos, in which everything has mind or mental characteristics, and thus has a most profound bond with humans. Finally, it sketches some questions for a panpsychist research program in environmental philosophy

"Climate Change and Moral Corruption"

In “A Perfect Moral Storm”, S. Gardiner claims that "the peculiar features of the climate change problem pose substantial obstacles to our ability to make the hard choices necessary to address it. Climate change is a perfect moral storm. One consequence of this is that, even if difficult ethical questions could be answered, we might still find it difficult to act. For the storm makes us extremely vulnerable to moral corruption". Here I comment on the notion of moral corruption. In particular, I discuss the issues of who is susceptible to it and of what sort of problem moral corruption is

Mechanically-based approach to non-local elasticity: Variational principles

AbstractThe mechanically-based approach to non-local elastic continuum, will be captured through variational calculus, based on the assumptions that non-adjacent elements of the solid may exchange central body forces, monotonically decreasing with their interdistance, depending on the relative displacement, and on the volume products. Such a mechanical model is investigated introducing primarily the dual state variables by means of the virtual work principle. The constitutive relations between dual variables are introduced defining a proper, convex, potential energy. It is proved that the solution of the elastic problem corresponds to a global minimum of the potential energy functional. Moreover, the Euler–Lagrange equations together with the natural boundary conditions associated to the total potential energy functional are established with variational calculus and they coincide with analogous relations already obtained by means of mechanical considerations. Numerical analysis of a tensile specimen has been introduced to show the capabilities of the proposed approach

Primer relevamiento de marcadores de resistencia a antibióticos en Enterobacteriaceae en Cochabamba, Bolivia

Se llevó a cabo un relevamiento molecular de la resistencia a antibióticos de importancia clínica en aislamientos recuperados en Cochabamba, Bolivia. Se estudiaron los genes codificantes de β-lactamasas de espectro extendido y de resistencia a quinolonas de localización plasmídica (PMQR) en un total de 101 aislamientos de enterobacterias resistentes a oximinocefalosporinas recuperados en distintos centros de salud, durante 4 meses (2012-2013). En todos ellos se detectó la presencia de cefotaximasas, las CTX-M grupo 1 fueron las más prevalentes (88,1%). La presencia de blaOXA-1 se detectó en el 76,4% de estos aislamientos. Se observó una elevada proporción de aislamientos resistentes a quinolonas. El gen aac(6′)-Ib-cr fue el determinante PMQR más frecuentemente identificado (83%). Además, 6 aislamientos resultaron ser portadores de qnrB. Por otro lado, cabe remarcar que 7 Escherichia coli presentaron qepA1 (6) y oqxAB (1); se documenta así por primera vez la presencia de oqxAB en Bolivia. Este estudio constituye el primer relevamiento de marcadores de resistencia en aislamientos clínicos de enterobacterias en Cochabamba, Bolivia; de este modo se contribuye al conocimiento regional de la situación epidemiológica, la cual presenta un escenario similar al observado en el resto de Latinoamérica.A molecular survey was conducted in Cochabamba, Bolivia, to characterize the mechanism involved in the resistance to clinically relevant antibiotics. Extended Spectrum β-lactamase encoding genes and plasmid-mediated quinolone resistance (PMQR) markers were investigated in a total of 101 oxyimino-cephalosporin-resistant enterobacteria recovered from different health centers during four months (2012?2013). CTX-M enzymes were detected in all isolates, being the CTX-M-1 group the most prevalent (88.1%). The presence of blaOXA-1 was detected in 76.4% of these isolates. A high quinolone resistance rate was observed among the included isolates. The aac(6′)-Ib-cr gene was the most frequent PMQR identified (83.0%). Furthermore, 6 isolates harbored the qnrB gene. Interestingly, qepA1 (6) and oqxAB (1), were detected in 7 Escherichia coli, being the latter the first to be reported in Bolivia. This study constitutes the first molecular survey on resistance markers in clinical enterobacterial isolates in Cochabamba, Bolivia, contributing to the regional knowledge of the epidemiological situation. The molecular epidemiology observed herein resembles the scene reported in South America.Fil: Saba Villarroel, Paola M.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Di Conza, José Alejandro. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Radice, Marcela Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Integrated Biophysical Modeling of the SARS-CoV-2 Spike Protein Binding and Allosteric Interactions with Antibodies

Structural and biochemical studies of the severe acute respiratory syndrome (SARS)-CoV-2 spike glycoproteins and complexes with highly potent antibodies have revealed multiple conformation-dependent epitopes highlighting conformational plasticity of spike proteins and capacity for eliciting specific binding and broad neutralization responses. In this study, we used coevolutionary analysis, molecular simulations, and perturbation-based hierarchical network modeling of the SARS-CoV-2 spike protein complexes with a panel of antibodies targeting distinct epitopes to explore molecular mechanisms underlying binding-induced modulation of dynamics and allosteric signaling in the spike proteins. Through coevolutionary analysis of the SARS-CoV-2 spike proteins, we identified highly coevolving hotspots and functional clusters that enable a functional cross-talk between distant allosteric regions in the SARS-CoV-2 spike complexes with antibodies. Coarse-grained and all-atom molecular dynamics simulations combined with mutational sensitivity mapping and perturbation-based profiling of the SARS-CoV-2 receptor-binding domain (RBD) complexes with CR3022 and CB6 antibodies enabled a detailed validation of the proposed approach and an extensive quantitative comparison with the experimental structural and deep mutagenesis scanning data. By combining in silico mutational scanning, perturbation-based modeling, and network analysis of the SARS-CoV-2 spike trimer complexes with H014, S309, S2M11, and S2E12 antibodies, we demonstrated that antibodies can incur specific and functionally relevant changes by modulating allosteric propensities and collective dynamics of the SARS-CoV-2 spike proteins. The results provide a novel insight into regulatory mechanisms of SARS-CoV-2 S proteins showing that antibody-escaping mutations can preferentially target structurally adaptable energy hotspots and allosteric effector centers that control functional movements and allosteric communication in the complexes

Fractional differential equations of multiphase hereditary materials and exact mechanical models

Creep and relaxation tests, performed on various materials like polymers, rubbers and so on are well-tted by power-laws with exponent 2 [0; 1] (Nutting (1921), Di Paola et al. (2011)). The consequence of this observation is that the stress-strain relation of hereditary materials is ruled by fractional operators (Scott Blair (1947), Slonimsky (1961)). A large amount of researches have been performed in the second part of the last century with the aim to connect constitutive fractional relations with some mechanical models by means of fractance trees and ladders (see Podlubny (1999)). Recently, Di Paola and Zingales (2012) proposed a mechanical model that corresponds to fractional stress-strain relation with any real exponent and they have proposed a description of above model (Di Paola et al. (2012)). In this study the authors aim to extend the study to cases with more fractional phases and to fractional Kelvin-Voigt model of hereditariness