Section efficace de la réaction 16O(t, n) 18F application au dosage de l'oxygène

Des échantillons de tantale oxydés anodiquement ont été irradiés avec des tritons de 1,6 à 3,7 MeV. La section efficace a été déterminée par mesure de la radioactivité du 18F. La valeur trouvée à 2 MeV est de 220 mb. Nos résultats sont en désaccord avec les valeurs publiées par Jarmie jusqu'à 2,2 MeV et avec la forme de la courbe obtenue par Barrandon et Albert entre 2 et 3 MeV. La réaction 16O(t, n) 18F a été utilisée pour doser l'oxygène à la surface d'échantillons d'acier inoxydable. Une limite de détection de 0,004 μg.cm-2 a été obtenue à 2 MeV, après 10 min. d'irradiation avec un faisceau de 0,2 μA de tritons. Les possibilités d'application aux dosages dans la masse sont discutées

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to 300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m 2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to &lt;90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], &gt;300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of &lt;15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P&lt;0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P&lt;0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

COMPOSITIONAL DEPENDENCE OF Ms TEMPERATURES IN HIGH-PURITY IRON-CHROMIUM-NICKEL AUSTENITIC ALLOYS

The onset of martensitic transformation on cooling has been studied in high-purity Fe-14 to 20 wt % Cr -8 to 25 wt % Ni austenitic alloys. In samples with Fe 72 %, α'-formation occurs in two successive stages ; possible transformation models are considered. No unique formula relating Ms to composition is applicable to the whole composition range studied

RÔLE DES IMPURETÉS ET DES ADDITIONS SUR LA CORROSION ET LA FRAGILISATION INTERGRANULAIRES D'ALLIAGES A BASE DE NICKEL

Nous avons étudié l'influence de l'addition d'un certain nombre d'éléments sur la corrosion intergranulaire et la fragilisation par l'hydrogène d'alliages très purs, à base de nickel. Nos essais montrent que le titane réduit la sensibilité à la corrosion intergranulaire de ces alliages. Cependant, l'action de cet élément s'exerce moins par un effet de stabilisation que par une modification de la diffusion intergranulaire du chrome. Les alliages de haute pureté sont extrêmement sensibles à la fragilisation par l'hydrogène et la rupture est intergranulaire. En revanche, dans les matériaux contenant du carbone en solution solide, la décohésion est intergranulaire. Par ailleurs, dans les alliages ayant subi un traitement de sensibilisation, la rupture est intergranulaire. Nos résultats semblent montrer que la fragilisation par l'hydrogène des joints de grains contenant des précipités de carbures doit être attribuée à la présence d'une très faible teneur en carbone au voisinage des particules de carbure et non pas à la formation de contraintes aux interfaces carbure-matrice.We have studied the specific influence of some additional elements on the intergranular corrosion and hydrogen embrittlement of very high purity nickel base alloys. Ours tests showed that titanium reduce intergranular corrosion susceptibility. However in these alloys titanium is not an effective stabilizer but acts on the chromium depletion mechanism. High purity alloys are very susceptible to hydrogen embrittlement and the fracture is of intergranular mode. In contrast with carbon doped alloys in solution annealed conditions, the fracture path observed is transgranular. Additionaly in carbide sensitized materials brittle fracture is intergranular. From these results it was concluded that brittle fracture of sensitized boundaries seems to be a consequence of the lower carbon content in the vicinity of the carbide particles. This conclusion is in marked contrast with the more usual assumption that brittle fracture of sensitized industrial alloys is related to the stresses developed in carbide precipitation process