382 research outputs found
Médecine physique et de réadaptation et cancer : état de l’art et analyse de la littérature
The cell cycle stage and batch culture stage dependent expression of the thymidylate synthase gene (TMP1) in Saccharomyces cerevisiae
Experimental application of sum rules for electron energy loss magnetic chiral dichroism
We present a derivation of the orbital and spin sum rules for magnetic
circular dichroic spectra measured by electron energy loss spectroscopy in a
transmission electron microscope. These sum rules are obtained from the
differential cross section calculated for symmetric positions in the
diffraction pattern. Orbital and spin magnetic moments are expressed explicitly
in terms of experimental spectra and dynamical diffraction coefficients. We
estimate the ratio of spin to orbital magnetic moments and discuss first
experimental results for the Fe L_{2,3} edge.Comment: 11 pages, 2 figure
Dynamic correlations of the Coulomb Luttinger liquid
The dynamic density response function, form-factor, and spectral function of
a Luttinger liquid with Coulomb electron-electron interaction are studied with
the emphasis on the short-range electron correlations. The Coulomb interaction
changes dramatically the density response function as compared to the case of
the short-ranged interaction. The form of the density response function is
smoothing with time, and the oscillatory structure appears. However, the
spectral functions remain qualitatively the same. The dynamic form-factor
contains the -peak in the long-wave region, corresponding to one-boson
excitations. Besides, the multi-boson-excitations band exists in the
wave-number region near to . The dynamic form-factor diverges at the
edges of this band, while the dielectric function goes to zero there, which
indicates the appearance of a soft mode. We develop a method to analyze the
asymptotics of the spectral functions near to the edges of the
multi-boson-excitations band.Comment: 11 pages, 3 figures, submitted to PR
Ladder approximation to spin velocities in quantum wires
The spin sector of charge-spin separated single mode quantum wires is
studied, accounting for realistic microscopic electron-electron interactions.
We utilize the ladder approximation (LA) to the interaction vertex and exploit
thermodynamic relations to obtain spin velocities. Down to not too small
carrier densities our results compare well with existing quantum Monte-Carlo
(QMC) data. Analyzing second order diagrams we identify logarithmically
divergent contributions as crucial which the LA includes but which are missed,
for example, by the self-consistent Hartree-Fock approximation. Contrary to
other approximations the LA yields a non-trivial spin conductance. Its
considerably smaller computational effort compared to numerically exact
methods, such as the QMC method, enables us to study overall dependences on
interaction parameters. We identify the short distance part of the interaction
to govern spin sector properties.Comment: 6 pages, 6 figures, to appear in Physical Review
Lithium isotopes in large rivers reveal the cannibalistic nature of modern continental weathering and erosion
The erosion of major mountain ranges is thought to be largely cannibalistic, recycling sediments that were deposited in the ocean or on the continents prior to mountain uplift. Despite this recognition, it has not yet been possible to quantify the amount of recycled material that is presently transported by rivers to the ocean. Here, we have analyzed the Li content and isotope composition (View the MathML source) of suspended sediments sampled along river depth profiles and bed sands in three of the largest Earth's river systems (Amazon, Mackenzie and Ganga–Brahmaputra rivers). The View the MathML source values of river-sediments transported by these rivers range from +5.3 to −3.6‰ and decrease with sediment grain size. We interpret these variations as reflecting a mixture of unweathered rock fragments (preferentially transported at depth in the coarse fraction) and present-day weathering products (preferentially transported at the surface in the finest fraction). Only the finest surface sediments contain the complementary reservoir of Li solubilized by water–rock interactions within the watersheds. Li isotopes also show that river bed sands can be interpreted as a mixture between unweathered fragments of igneous and sedimentary rocks. A mass budget approach, based on Li isotopes, Li/Al and Na/Al ratios, solved by an inverse method allows us to estimate that, for the large rivers analyzed here, the part of solid weathering products formed by present-day weathering reactions and transported to the ocean do not exceed 35%. Li isotopes also show that the sediments transported by the Amazon, Mackenzie and Ganga–Brahmaputra river systems are mostly sourced from sedimentary rocks (>60%) rather than igneous rocks. This study shows that Li isotopes in the river particulate load are a good proxy for quantifying both the erosional rock sources and the fingerprint of present-day weathering processes. Overall, Li isotopes in river sediments confirm the cannibalistic nature of erosion and weathering
Breathing Metal–Organic Framework Based on Flexible Inorganic Building Units
Five novel bismuth carboxylate coordination polymers were synthesized from biphenyl-3,4\u2032,5-tricarboxylic acid (H3BPT) and [1,1\u2032:4\u2032,1\u2032\u2032]terphenyl-3,3\u2032\u2032,5,5\u2032\u2032-tetracarboxylic acid (H4TPTC). One of the phases, [Bi(BPT)]\ub72MeOH (denoted SU-100, as synthesized), is the first example, to the best of our knowledge, of a reversibly flexible bismuth-based metal\u2013organic framework. The material exhibits continuous changes to its unit cell parameters and pore shape depending on the solvent it is immersed in and the dryness of the sample. Typically, in breathing carboxylate-based MOFs, flexibility occurs through tilting of the organic linkers without significantly altering the coordination environment around the cation. In contrast to this, the continuous breathing mechanism in SU-100 involves significant changes to bond angles within the Bi2O12 inorganic building unit (IBU). The flexibility of the IBU of SU-100 reflects the nondiscrete coordination geometry of the bismuth cation. A disproportionate increase in the solvent accessible void volume was observed when compared to the expansion of the unit cell volume of SU-100. Additionally, activated SU-100 (SU-100-HT) exhibits a large increase in unit cell volume, yet has the smallest void volume of all the studied samples
Chromosomal integration of LTR-flanked DNA in yeast expressing HIV-1 integrase: down regulation by RAD51
HIV-1 integrase (IN) is the key enzyme catalyzing the proviral DNA integration step. Although the enzyme catalyzes the integration step accurately in vitro, whether IN is sufficient for in vivo integration and how it interacts with the cellular machinery remains unclear. We set up a yeast cellular integration system where integrase was expressed as the sole HIV-1 protein and targeted the chromosomes. In this simple eukaryotic model, integrase is necessary and sufficient for the insertion of a DNA containing viral LTRs into the genome, thereby allowing the study of the isolated integration step independently of other viral mechanisms. Furthermore, the yeast system was used to identify cellular mechanisms involved in the integration step and allowed us to show the role of homologous recombination systems. We demonstrated physical interactions between HIV-1 IN and RAD51 protein and showed that HIV-1 integrase activity could be inhibited both in the cell and in vitro by RAD51 protein. Our data allowed the identification of RAD51 as a novel in vitro IN cofactor able to down regulate the activity of this retroviral enzyme, thereby acting as a potential cellular restriction factor to HIV infection
Energy-loss magnetic chiral dichroism (EMCD): Magnetic chiral dichroism in the electron microscope
A new technique called energy-loss magnetic chiral dichroism (EMCD) has recently been developed [P. Schattschneider, et al. Nature 441, 486 (2006)] to measure magnetic circular dichroism in the transmission electron microscope (TEM) with a spatial resolution of 10 nm. This novel technique is the TEM counterpart of x-ray magnetic circular dichroism, which is widely used for the characterization of magnetic materials with synchrotron radiation. In this paper we describe several experimental methods that can be used to measure the EMCD signal [P. Schattschneider, et al. Nature 441, 486 (2006); C. Hébert, et al. Ultramicroscopy 108(3), 277 (2008); B. Warot-Fonrose, et al. Ultramicroscopy 108(5), 393 (2008); L. Calmels, et al. Phys. Rev. B 76, 060409 (2007); P. van Aken, et al. Microsc. Microanal. 13(3), 426 (2007)] and give a review of the recent improvements of this new investigation tool. The dependence of the EMCD on several experimental conditions (such as thickness, relative orientation of beam and sample, collection and convergence angle) is investigated in the transition metals iron, cobalt, and nickel. Different scattering geometries are illustrated; their advantages and disadvantages are detailed, together with current limitations. The next realistic perspectives of this technique consist of measuring atomic specific magnetic moments, using suitable spin and orbital sum rules, [L. Calmels, et al. Phys. Rev. B 76, 060409 (2007); J. Rusz, et al. Phys. Rev. B 76, 060408 (2007)] with a resolution down to 2 to 3 n
Singular Structure and Enhanced Friedel Oscillations in the Two-Dimensional Electron Gas
We calculate the leading order corrections (in ) to the static
polarization , with dynamically screened interactions, for the
two-dimensional electron gas. The corresponding diagrams all exhibit singular
logarithmic behavior in their derivatives at and provide significant
enhancement to the proper polarization particularly at low densities. At a
density of , the contribution from the leading order {\em fluctuational}
diagrams exceeds both the zeroth order (Lindhard) response and the self-energy
and exchange contributions. We comment on the importance of these diagrams in
two-dimensions and make comparisons to an equivalent three-dimensional electron
gas; we also consider the impact these finding have on computed
to all orders in perturbation theory
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