The First Science Results from SPHERE: Disproving the Predicted Brown Dwarf around V471 Tau

Variations of eclipse arrival times have recently been detected in several post common envelope binaries consisting of a white dwarf and a main sequence companion star. The generally favoured explanation for these timing variations is the gravitational pull of one or more circumbinary substellar objects periodically moving the center of mass of the host binary. Using the new extreme-AO instrument SPHERE, we image the prototype eclipsing post-common envelope binary V471 Tau in search of the brown dwarf that is believed to be responsible for variations in its eclipse arrival times. We report that an unprecedented contrast of 12.1 magnitudes in the H band at a separation of 260 mas was achieved, but resulted in a non-detection. This implies that there is no brown dwarf present in the system unless it is three magnitudes fainter than predicted by evolutionary track models, and provides damaging evidence against the circumbinary interpretation of eclipse timing variations. In the case of V471 Tau, a more consistent explanation is offered with the Applegate mechanism, in which these variations are prescribed to changes in the quadrupole moment within the main-sequence sta

Timing variations in the secondary eclipse of NN Ser

The eclipsing white dwarf plus main-sequence binary NN Serpentis provides one of the most convincing cases for the existence of circumbinary planets around evolved binaries. The exquisite timing precision provided by the deep eclipse of the white dwarf has revealed complex variations in the eclipse arrival times over the last few decades. These variations have been interpreted as the influence of two planets in orbit around the binary. Recent studies have proved that such a system is dynamically stable over the current lifetime of the binary. However, the existence of such planets is by no means proven and several alternative mechanisms have been proposed that could drive similar variations. One of these is apsidal precession, which causes the eclipse times of eccentric binaries to vary sinusoidally on many year time-scales. In this Letter, we present timing data for the secondary eclipse of NN Ser and show that they follow the same trend seen in the primary eclipse times, ruling out apsidal precession as a possible cause for the variations. This result leaves no alternatives to the planetary interpretation for the observed period variations, although we still do not consider their existence as proven. Our data limit the eccentricity of NN Ser to e < 10−3. We also detect a 3.3 ± 1.0 s delay in the arrival times of the secondary eclipses relative to the best planetary model. This delay is consistent with the expected 2.84 ± 0.04 s Rømer delay of the binary, and is the first time this effect has been detected in a white dwarf plus M dwarf system

Hunting For Eclipses: High Speed Observations of Cataclysmic Variables

We present new time-resolved photometry of 74 cataclysmic variables (CVs), 47 of which are eclipsing. 13 of these eclipsing systems are newly discovered. For all 47 eclipsing systems we show high cadence (1-20 seconds) light curves obtained with the high-speed cameras ultracam and ultraspec. We provide new or refined ephemerides, and supply mid-eclipse times for all observed eclipses. We assess the potential for light curve modelling of all 47 eclipsing systems to determine their system parameters, finding 20 systems which appear to be suitable for future study

Long-term functional outcome of distal radius fractures is associated with early post-fracture bone stiffness of the fracture region:An HR-pQCT exploratory study

\u3cp\u3eIdentifying determinants of long-term functional outcome after a distal radius fracture is challenging. Previously, we reported on the association between early HR-pQCT measurements and clinical outcome 12 weeks after a conservatively treated distal radius fracture. We extended the follow-up and assessed functional outcome after two years in relation to early HR-pQCT derived bone parameters. HR-pQCT scans of the fracture region were performed in 15 postmenopausal women with a distal radius fracture at 1-2 (baseline), 3-4 weeks and 26 months post-fracture. Additionally, the contralateral distal radius was scanned at baseline. Bone density, micro-architecture parameters and bone stiffness using micro-finite element analysis (μFEA) were evaluated. During all visits, wrist pain and function were assessed using the patient-rated wrist evaluation questionnaire (PRWE), quantifying functional outcome with a score between 0 and 100. Two-year PRWE was associated with torsional and bending stiffness 3-4 weeks post-fracture (R2: 0.49, p = 0.006 and R2: 0.54, p = 0.003, respectively). In contrast, early micro-architecture parameters of the fracture region or contralateral bone parameters did not show any association with long-term outcome. This exploratory study indicates that HR-pQCT with μFEA performed within four weeks after a distal radius fracture captures biomechanical fracture characteristics that are associated with long-term functional outcome and therefore could be a valuable early outcome measure in clinical trials and clinical practice.\u3c/p\u3

The planets around NN Serpentis : still there

We present 25 new eclipse times of the white dwarf binary NN Ser taken with the high-speed camera ULTRACAM on the William Herschel Telescope and New Technology Telescope, the RISE camera on the Liverpool Telescope and HAWK-I on the Very Large Telescope to test the two-planet model proposed to explain variations in its eclipse times measured over the last 25 yr. The planetary model survives the test with flying colours, correctly predicting a progressive lag in eclipse times of 36 s that has set in since 2010 compared to the previous 8 yr of precise times. Allowing both orbits to be eccentric, we find orbital periods of 7.9 ± 0.5 and 15.3 ± 0.3 yr, and masses of 2.3 ± 0.5 and 7.3 ± 0.3 MJ. We also find dynamically long-lived orbits consistent with the data, associated with 2:1 and 5:2 period ratios. The data scatter by 0.07 s relative to the best-fitting model, by some margin the most precise of any of the proposed eclipsing compact object planet hosts. Despite the high precision, degeneracy in the orbit fits prevents a significant measurement of a period change of the binary and of N-body effects. Finally, we point out a major flaw with a previous dynamical stability analysis of NN Ser, and by extension, with a number of analyses of similar systems

Using Gaussian processes to model light curves in the presence of flickering: the eclipsing cataclysmic variable ASASSN-14ag

The majority of cataclysmic variable (CV) stars contain a stochastic noise component in their light curves, commonly referred to as flickering. This can significantly affect the morphology of CV eclipses and increases the difficulty in obtaining accurate system parameters with reliable errors through eclipse modelling. Here we introduce a new approach to eclipse modelling, which models CV flickering with the help of Gaussian processes (GPs). A parameterised eclipse model - with an additional GP component - is simultaneously fit to 8 eclipses of the dwarf nova ASASSN-14ag and system parameters determined. We obtain a mass ratio $q$ = 0.149 $\pm$ 0.016 and inclination $i$ = 83.4 $^{+0.9}_{-0.6}$ $^{\circ}$. The white dwarf and donor masses were found to be $M_{w}$ = 0.63 $\pm$ 0.04 $M_{\odot}$ and $M_{d}$ = 0.093 $^{+0.015}_{-0.012}$ $M_{\odot}$, respectively. A white dwarf temperature $T_{w}$ = 14000 $^{+2200}_{-2000}$ K and distance $d$ = 146 $^{+24}_{-20}$ pc were determined through multicolour photometry. We find GPs to be an effective way of modelling flickering in CV light curves and plan to use this new eclipse modelling approach going forward

A large, long-lived structure near the trojan L5 point in the post common-envelope binary SDSS J1021+1744

SDSS J1021+1744 is a detached, eclipsing white dwarf / M dwarf binary discovered in the Sloan Digital Sky Survey. Outside the primary eclipse, the light curves of such systems are usually smooth and characterised by low-level variations caused by tidal distortion and heating of the M star component. Early data on SDSS J1021+1744 obtained in June 2012 was unusual in showing a dip in flux of uncertain origin shortly after the white dwarf’s eclipse. Here we present high-time resolution, multi-wavelength observations of 35 more eclipses over 1.3 years, showing that the dip has a lifetime extending over many orbits. Moreover the “dip” is in fact a series of dips that vary in depth, number and position, although they are always placed in the phase interval 1.06 to 1.26 after the white dwarf’s eclipse, near the L5 point in this system. Since SDSS J1021+1744 is a detached binary, it follows that the dips are caused by the transit of the white dwarf by material around the Lagrangian L5 point. A possible interpretation is that they are the signatures of prominences, a phenomenon already known from Hα observations of rapidly rotating single stars as well as binaries. What makes SDSS J1021+1744 peculiar is that the material is dense enough to block continuum light. The dips appear to have finally faded out around 2015 May after the first detection by Parsons et al. in 2012, suggesting a lifetime of year

Evaluating the Validity of a Food Frequency Questionnaire in Comparison with a 7-Day Dietary Record for Measuring Dietary Intake in a Population of Survivors of Colorectal Cancer

Background: Food frequency questionnaires (FFQs) are a commonly used method to assess dietary intake in epidemiological studies. It is important to evaluate the validity of FFQs in the population of interest. Objective: To evaluate the validity of an FFQ for measuring dietary intake in survivors of colorectal cancer (CRC), relative to a 7-day dietary record. Design: Dietary intake was assessed 1 year after the end of CRC treatment. Participants first completed a 7-day dietary record and 2 weeks later a 253-item FFQ that measured intake in the preceding month. Participants/setting: Data were used from a subsample of participants (n=100) enrolled in an ongoing prospective study (EnCoRe study) in the Netherlands, from 2015 to 2018. Main outcome measures: Estimated intakes of total energy, 19 nutrients, and 20 food groups as well as scoring adherence to the dietary recommendations of the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) were compared between both dietary assessment methods. Statistical analyses performed: Means and standard deviations, Spearman rank correlations corrected for within-person variation and total energy, and κ agreement between quintiles were assessed. Results: The median Spearman correlation corrected for within-person variation for nutrients and total energy was 0.60. Correlations >0.50 were found for 15 of 19 nutrients, with highest agreement for vitamin B-12 (0.74), polysaccharides (0.75), and alcohol (0.91). On average, 73% (range=60% to 84%) of participants were classified into the exact same or adjacent nutrient quintile. The median Spearman correlation corrected for within-person variation for food groups was 0.62. Correlations >0.50 were found for 17 of 20 food groups, with highest agreement for cereals and cereal products (0.96), fish (0.96), and potatoes (0.99). The Spearman correlation between total scores of the WCRF/AICR dietary recommendations was 0.53. Conclusions: Relative to a 7-day dietary record, the validity of an FFQ for measuring dietary intake among survivors of CRC appeared moderate to good for most nutrients and food groups.</p

Clinical pharmacology of exogenously administered alkaline phosphatase

Purpose: To evaluate the clinical pharmacology of exogenous alkaline phosphatase (AP). Methods: Randomized, double-blind, placebo-controlled sequential protocols of (1) ascending doses and infusion duration (volunteers) and (2) fixed dose and duration (patients) were conducted at clinical pharmacology and intensive care units. A total of 103 subjects (67 male volunteers and 36 patients with severe sepsis) were administered exogenous, 10-min IV infusions (three ascending doses) or 24-72 h continuous (132.5-200 U kg-124 h-1) IV infusion with/without preceding loading dose and experimental endotoxemia for evaluations of pharmacokinetics, pharmacodynamics, safety parameters, antigenicity, inflammatory markers, and outcomes. Results: Linearity and dose-proportionality were shown during 10-min infusions. The relatively short elimination half-life necessitated a loading dose to achieve stable enzyme levels. Pharmacokinetic parameters in volunteers and patients were similar. Innate immunity response was not significantly influenced by AP, while renal function significantly improved in sepsis patients. Conclusions: The pharmacokinetics of exogenous AP is linear, dose-proportional, exhibit a short half-life, and are not influenced by renal impairment or dialysis

A parameter study of the eclipsing CV in the Kepler field, KIS J192748.53+444724.5

We present high-speed, three-colour photometry of the eclipsing dwarf nova KIS J192748.53+444724.5 (KISJ1927) which is located in the Kepler field. Our data reveal sharp features corresponding to the eclipses of the accreting white dwarf followed by the bright spot where the gas stream joins the accretion disc. We determine the system parameters via a parametrized model of the eclipse fitted to the observed light curve. We obtain a mass ratio of q = 0.570 ± 0.011 and an orbital inclination of 84. ◦6 ± 0. ◦3. The primary mass is Mw = 0.69 ± 0.07 M. The donor star’s mass and radius are found to be Md = 0.39 ± 0.04 M and Rd = 0.43 ± 0.01 R, respectively. From the fluxes of the white dwarf eclipse, we find a white dwarf temperature of Tw = 23000 ± 3000 K, and a photometric distance to the system of 1600 ± 200 pc, neglecting the effects of interstellar reddening. The white dwarf temperature in KISJ1927 implies the white dwarf is accreting at an average rate of M˙ = 1.4 ± 0.8 × 10−9 M yr−1, in agreement with estimates of the secular mass loss rate from the donor