The megalithic building of S.Erasmo di Cesi: architecture, astronomy, and landscape

Abstract. One of the most enigmatic megalithic buildings of Italy is the structure which lies on the S. Erasmo hill near Cesi, in Umbria, a huge complex encompassing an area of around 8000 square meters and enclosed by refined cyclopean walls. Although its date is uncertain, suggested dates comprise the Iron Age and archaic period, down to the third century B.C. The building’s function is also uncertain. Usually identified as a fortified structure, in fact there is a megalithic platform at the southern end of the enclosure which could have served as foundation of a temple or palace and, from the top of Monte Torre Maggiore, a complex of temples dating from the fourth century B.C. overlooks the hill. Similar combinations of megalithic buildings resting half-way to temples placed on high peaks are known to exist. In order to clarify the function of this structure and its position in relation to the surrounding landscape, with particular attention to its visibility and to the directions of visibility from the complex, as well as to the possible astronomical alignments, we present a multi-disciplinary approach to the study of the S. Erasmo complex, which includes the mapping of the sky at the various possible epochs of construction, the creation of a digital model of the landscape in forms of digital maps using Geographic Information System technologies, and a 3D model using various 3D software packages

Polar body array CGH for prediction of the status of the corresponding oocyte. Part II: technical aspects

The purpose of this study was to assess the technical aspects related to polar body (PB) biopsy, which might have an influence on the results of the microarray comparative genomic hybridization analysis. Furthermore, a comparison was made between two biopsy methods (mechanical and laser). Biopsy of the first and second PB (PB1 and PB2) was performed by mechanical- or laser-assisted biopsy in two different IVF centres. PBs were separately amplified by whole genome amplification. The method of biopsy, mechanical or laser had no influence on the proportion of successfully biopsied oocytes. Especially, for the PB2, the timing of biopsy after ICSI was directly correlated to amplification efficiency. Special care has to be taken with respect to the timing of biopsy of the PB2. Mechanical- and laser-assisted biopsy give the same performance in terms of diagnostic efficienc

New mathematical framework for spherical gravitational collapse

A theorem, giving necessary and sufficient condition for naked singularity formation in spherically symmetric non static spacetimes under hypotheses of physical acceptability, is formulated and proved. The theorem relates existence of singular null geodesics to existence of regular curves which are super-solutions of the radial null geodesic equation, and allows us to treat all the known examples of naked singularities from a unified viewpoint. New examples are also found using this approach, and perspectives are discussed.Comment: 8 pages, LaTeX2

The spectrum of endstates of gravitational collapse with tangential stresses

The final state--black hole or naked singularity--of the gravitational collapse of a marginally bound matter configuration in the presence of tangential stresses is classified, in full generality, in terms of the initial data and equation of state. If the tangential pressure is sufficiently strong, configurations that would otherwise evolve to a spacelike singularity, result in a locally naked singularity, both in the homogeneous and in the general, inhomogeneous density case.Comment: 9 pages, revtex4; accepted for publication in Phys. Rev.

Spherical Universes with Anisotropic Pressure

Einstein's equations are solved for spherically symmetric universes composed of dust with tangential pressure provided by angular momentum, L(R), which differs from shell to shell. The metric is given in terms of the shell label, R, and the proper time, tau, experienced by the dust particles. The general solution contains four arbitrary functions of R - M(R), L(R), E(R) and r(0,R). The solution is described by quadratures, which are in general elliptic integrals. It provides a generalization of the Lemaitre-Tolman-Bondi solution. We present a discussion of the types of solution, and some examples. The relationship to Einstein clusters and the significance for gravitational collapse is also discussed.Comment: 24 pages, 11 figures, accepted for publication in Classical and Quantum Gravit

Bone marrow-derived cells can acquire cardiac stem cells properties in damaged heart

Experimental data suggest that cell-based therapies may be useful for cardiac regeneration following ischaemic heart disease. Bone marrow (BM) cells have been reported to contribute to tissue repair after myocardial infarction (MI) by a variety of humoural and cellular mechanisms. However, there is no direct evidence, so far, that BM cells can generate cardiac stem cells (CSCs). To investigate whether BM cells contribute to repopulate the Kit+ CSCs pool, we transplanted BM cells from transgenic mice, expressing green fluorescent protein under the control of Kit regulatory elements, into wild-type irradiated recipients. Following haematological reconstitution and MI, CSCs were cultured from cardiac explants to generate 'cardiospheres', a microtissue normally originating in vitro from CSCs. These were all green fluorescent (i.e. BM derived) and contained cells capable of initiating differentiation into cells expressing the cardiac marker Nkx2.5. These findings indicate that, at least in conditions of local acute cardiac damage, BM cells can home into the heart and give rise to cells that share properties of resident Kit+ CSCs

Black holes vs. naked singularities formation in collapsing Einstein's clusters

Non-static, spherically symmetric clusters of counter-rotating particles, of the type first introduced by Einstein, are analysed here. The initial data space can be parameterized in terms of three arbitrary functions, namely; initial density, velocity and angular momentum profiles. The final state of collapse, black hole or naked singularity, turns out to depend on the order of the first non-vanishing derivatives of such functions at the centre. The work extends recent results by Harada, Iguchi and Nakao.Comment: 13 pages, LaTeX format. To appear in Physical Review

Comparison of a fast track protocol and standard care after hip arthroplasty in the reduction of the length of stay and the early weight-bearing resumption: study protocol for a randomized controlled trial

Background: To date, hip arthroplasty is one of the most commonly performed surgical procedures, with growing worldwide demand. In recent decades, major progress made in terms of surgical technique, biomechanics, and tribology knowledge has contributed to improve the medical and functional management of the patient. This study aims to assess if the application of a fast track protocol, consisting of a preoperative educational intervention, adequate postoperative pain control, and intensive rehabilitation intervention, reduces the length of stay (LOS) and allows the early functional recovery compared to standard clinical practice for patients undergoing hip arthroplasty. Methods: The study population consists of 90 patients with primary arthrosis of the hip with an anterior indication of hip arthroplasty. The exclusion criteria are older than 70 years, a contraindication to performing spinal anesthesia, and bone mass index (BMI) greater than 32. Participants, 45 for each group, are randomly allocated to one of two arms: fast track clinical pathway or standard care protocol. During allocation, baseline parameters such as Harris Hip Score (HHS) and Western Ontario and McMaster Universities (WOMAC) index are collected. On the third postoperative day, the functional autonomy for each patient is assessed by the Iowa Level of Assistance (ILOA) scale, and it is expected the discharge for patients in the fast track group (primary outcome). On the other hand, standard care patient discharge is expected after 5–7 days after surgery. During follow-up fixed at 6 weeks and 3, 6, and 12 months, HHS and WOMAC scores are collected for each patient (secondary outcomes). Discussion: Although total hip replacement has become a widespread standardized procedure, to the authors’ knowledge, only few randomized controlled trials were performed to evaluate the effectiveness of fast track pathway vs. standard care procedure in the reduction of the LOS after hip arthroplasty. It is expected that our results collected by the application of minimally invasive surgical interventions with concomitant management of perioperative pain and bleeding and early functional rehabilitation will contribute to enriching the understanding of clinical and organizational aspects linked to fast track arthroplasty. Trial registration: ClinicalTrials.gov NCT03875976. Registered on 15 March 2019—“retrospectively registered”

Analysing the elasticity difference tensor of general relativity

The elasticity difference tensor, used in [1] to describe elasticity properties of a continuous medium filling a space-time, is here analysed from the point of view of the space-time connection. Principal directions associated with this tensor are compared with eigendirections of the material metric. Examples concerning spherically symmetric and axially symmetric space-times are then presented.Comment: 17 page