11 research outputs found
Cost-effectiveness analysis of therapeutic strategies for patients with chronic hepatitis C previously non-responders to interferon.
Background: The efficacy of combination therapy in previous non responders to
interferon (IFN) monotherapy with chronic hepatitis C is lower than in naĂŻve patients,
and there has been no economic evaluation in this population.
Aim: To develop a cost-effectiveness analysis of therapeutic regimens with IFN
alpha and ribavirin in previous interferon non-responders.
Methods: A Markov simulation model was used to project the clinical and
economic outcomes of five different therapeutic strategies including a âno treatmentâ
alternative using the health care system perspective. The effectiveness data for the
different doses and durations was obtained from a previously performed meta-analysis.
A sensitivity analysis was performed to test robustness of the model, analysing changes
in different variables.
Results: Applying a 3% discount rate, the standard patient on combination
therapy for 12 months showed an increase of 0.80 years and 1.55 quality adjusted life
years (QALYs), when comparing combination therapy for 12 months vs. âno treatmentâ
strategy. This option led to an incremental cost-effectiveness ratio of 11,767 euros per
year of life gained and 6,073 euros per QALY.
Conclusions: Combination therapy with interferon plus ribavirin in previous
interferon non-responders shows an incremental cost-effectiveness ratio within the
range of some well accepted medical interventions in our health care system.Hepatitis C; Interferon; Markov model; Non-responders; ribavirin.
IdentificaciĂłn de casos de hepatitis E aguda mediante detecciĂłn de anticuerpos especĂficos de las clases IgG e IgM por inmunoblot recombinante
Controlled Release of Nerve Growth Factor and Basic Fibroblast Growth Factor Combined with Small-Gap Anastomosis Enhances Sciatic Nerve Regeneration
Neutron and X-ray characterisation of the metallurgical properties of a 7th century BC Corinthian-type bronze helmet
Ventilation and air conditioning
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