Applying Spatial Literacy to Transform Library Space: A Selected Literature Review

Purpose The purpose of this paper is to review a selection of articles and books that highlight aspects of spatial theory and literacy from various disciplinary perspectives, along with a review of library space studies. Design/methodology/approach This study reviews library literature that uses spatial literacy and its related tools. The authors searched in two databases: Library, Information Science & Technology Abstracts, and SCOPUS. The paper records were analyzed to find primary research studies, published between 2010 and 2017, which study patron use of library space using various single and hybrid methodologies. Findings The findings of the literature reveal that of the 26 studies reviewed, 23 have a descriptive research question and three have a relational research question. Based on the analysis of the research methodologies used, there is more that can be done in support of a librarian’s research efforts as well as the arenas in which research is conducted. Practical implications These findings highlight ways in which library and information science researchers and those who educate them can broaden knowledge within the profession regarding spatial theory, literacy and applicable research methodologies for studying library space. Originality/value Current and best practices for designing library space studies that use spatial literacy to collect and analyze data are identified along with a discussion of future directions for researchers to better assess space and communicate the value of physical space in libraries

High dynamic range beam profile measurements

In future high intensity, high energy accelerators, beam loss has to be minimized to maximize performance and reduce activation of accelerator components. It is imperative to have a clear understanding of the mechanisms that can lead to halo formation and to have the possibility to test available theoretical models with an adequate experimental setup. Measurements based on optical transition radiation (OTR) provide an interesting opportunity for high resolution measurements of the transverse beam profile. In order to be applicable for measurements within the beam halo region, it is of utmost importance that a high dynamic range is covered by the image acquisition system. The existing camera system as it is installed in the CLIC Test Facility (CTF3) is compared to a step-by-step measurement with a photo multiplier tube (PMT) and measurements with a cooled charge injection device (CID) camera. The latter acquisition technique provides an innovative and highly flexible approach to high dynamic range measurements and is presented in some detail

Graduate Conversations: Assessing the Space Needs of Graduate Students

This article discusses the preferences, habits, and needs of graduate students as they relate to spaces for research and study. The findings are based on a large-scale ethnographic study of graduate students at Florida State University conducted between 2010 and 2013. Using a variety of ethnographic methods, researchers found that graduate students have diverse needs and unequal access to appropriate spaces and resources to meet those needs. Libraries can help fill the gaps left by home and academic departments by providing a range of spaces offering different noise levels, resources, and other amenities

Sur la chimiothérapie du « cancer de l’œil » des bovidés par l'éthylène-imine-benzoquinone

Lombard Charles, Perrier Marcel, Burel J. Sur la chimiothérapie du «cancer de l’œil» des Bovidés par éthylène-imine-benzo-quinone. In: Bulletin de l'Académie Vétérinaire de France tome 119 n°6, 1966. pp. 203-207

C-terminal phosphorylation of NaV1.5 impairs FGF13-dependent regulation of channel inactivation

International audienceVoltage-gated Na(+) (NaV) channels are key regulators of myocardial excitability, and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-dependent alterations in NaV1.5 channel inactivation are emerging as a critical determinant of arrhythmias in heart failure. However, the global native phosphorylation pattern of NaV1.5 subunits associated with these arrhythmogenic disorders and the associated channel regulatory defects remain unknown. Here, we undertook phosphoproteomic analyses to identify and quantify in situ the phosphorylation sites in the NaV1.5 proteins purified from adult WT and failing CaMKIIδc-overexpressing (CaMKIIδc-Tg) mouse ventricles. Of 19 native NaV1.5 phosphorylation sites identified, two C-terminal phosphoserines at positions 1938 and 1989 showed increased phosphorylation in the CaMKIIδc-Tg compared with the WT ventricles. We then tested the hypothesis that phosphorylation at these two sites impairs fibroblast growth factor 13 (FGF13)-dependent regulation of NaV1.5 channel inactivation. Whole-cell voltage-clamp analyses in HEK293 cells demonstrated that FGF13 increases NaV1.5 channel availability and decreases late Na(+) current, two effects that were abrogated with NaV1.5 mutants mimicking phosphorylation at both sites. Additional co-immunoprecipitation experiments revealed that FGF13 potentiates the binding of calmodulin to NaV1.5 and that phosphomimetic mutations at both sites decrease the interaction of FGF13 and, consequently, of calmodulin with NaV1.5. Together, we have identified two novel native phosphorylation sites in the C terminus of NaV1.5 that impair FGF13-dependent regulation of channel inactivation and may contribute to CaMKIIδc-dependent arrhythmogenic disorders in failing hearts

Challenging the growing rabbit with a moderately pathogenic E. coli under ad libitum or limited feed intake conditions: impact on digestive physiology, bacterial communities, and on post-weaning growth

[EN] The impact of a challenge with moderately pathogenic Escherichia coli O128:C6 on the digestive physiology and gut bacterial community of growing rabbits under two feeding programmes was analysed. Upon weaning (28 d old), 180 rabbits were allocated to four groups (9 cages of 5 rabbits per group) for two weeks: group C100 was non-inoculated and fed ad libitum; C70 was non-inoculated and feed intake was limited to 70% of C100; I100 and I70 were inoculated and fed ad libitum or restricted to 70%, respectively. At the age of 31 d (D0), rabbits were orally inoculated with E. coli (2.2×108 colony forming units/rabbit). The effects of inoculation spiked on D4, with a 28% lower growth rate for I100 than for C100. Limited feed intake reinforced the inoculation’s effects on growth: I70 had a 66% lower growth rate than C70. The morbidity rate peaked at 42% between D4 and D7 for inoculated groups, without significant effect of the feed intake level. E. coli concentration peaked on D5/D6 in the caecum of the I100 and I70 groups. Inoculation reduced by 30% (P<0.05) the villus height/crypt depth and villus/crypt area ratios in the ileum, with no significant effect of the intake level. Inoculation was associated with a tenfold increase in serum haptoglobin (P<0.001) for both ad libitum and restricted rabbits. On D5, the inoculation modified the structure of the ileal bacterial community (P<0.05), but not that of the caecum. The feed intake level did not affect either the structure or diversity of the bacterial community, both in the ileum and caecum.The authors would like to thank Alain Milon and Stéphane Bertagnoli (ENV Toulouse) who provided the E. coli O128:C6 strain we used. We are also grateful to ANSES staff in the “Service d’Elevage et d’Expérimentation en Pathologie Aviaire” (M. Amelot, L. Le Moal, T. 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The pace of biological aging helps explain the association between insomnia and chronic low back pain

Chronic low back pain (cLBP) is associated with insomnia and advanced age. Emerging evidence suggests that the severity of both sleep disorders (like insomnia) and chronic pain are associated with a faster pace of biological aging. We aimed to determine whether the pace of biological age mediates the relationship between insomnia and the impact of cLBP in a sample of community-dwelling adults ages 19 to 85 years. Participants (49 with no pain, 32 with low-impact pain, and 37 with high-impact pain) completed sociodemographic, pain, insomnia, and short physical performance battery assessments. We calculated the pace of biological aging using DunedinPACE from blood leukocyte DNA. On average, individuals with high-impact cLBP had significantly faster biological aging than those with low-impact and no chronic pain