2,155 research outputs found
When two worlds collide: A story about collaboration, witnessing and life story research with soldiers returning from war
The story we share here stems from our research with British military personnel who are adapting to life with a physical and/or psychological disability after serving in the Iraq or Afghanistan wars. Throughout our research, we have struggled to answer the kinds of questions that plague qualitative researchers: How might we gain insights into intense, traumatic, even life-changing experiences? Should we be inviting individuals to recount or revisit such potent moments from their lives? What interpretive framework might we draw on to make sense of what are sometimes senseless experiences? How can we share any ensuing understanding with others without diluting, diminishing or disrespecting the lives of soldiers or their families? The story we share here – which responds to Denzin’s (2003) challenge to reanimate life and Erickson’s (2010) provocation to do so with greater modesty, visibility, and reflexivity – offers one answer to these questions
A theory on reports of constructive (real) and illusory posttraumatic growth
It has been suggested that self-reported posttraumatic growth could sometimes be considered as a way for people to protect themselves from the distress of trauma. In this case, reports of posttraumatic growth could be illusory. We suggest a theory on self-reported constructive (real) posttraumatic growth and illusory posttraumatic growth by using Rogers’s (1959) theory and the work by Vaillant (1995). Through this theoretical framework we attempt to explain when reports of posttraumatic growth are likely to be constructive and real and when such reports are likely to represent aspects of illusions. We will also consider the implications for research practice
CD34-related coexpression of MDR1 and BCRP indicates a clinically resistant phenotype in patients with acute myeloid leukemia (AML) of older age
Clinical resistance to chemotherapy in acute myeloid leukemia (AML) is associated with the expression of the multidrug resistance (MDR) proteins P-glycoprotein, encoded by the MDR1/ABCB1 gene, multidrug resistant-related protein (MRP/ABCC1), the lung resistance-related protein (LRP), or major vault protein (MVP), and the breast cancer resistance protein (BCRP/ABCG2). The clinical value of MDR1, MRP1, LRP/MVP, and BCRP messenger RNA (mRNA) expression was prospectively studied in 154 newly diagnosed AML patients ≥60 years who were treated in a multicenter, randomized phase 3 trial. Expression of MDR1 and BCRP showed a negative whereas MRP1 and LRP showed a positive correlation with high white blood cell count (respectively, p < 0.05, p < 0.001, p < 0.001 and p < 0.001). Higher BCRP mRNA was associated with secondary AML (p < 0.05). MDR1 and BCRP mRNA were highly significantly associated (p < 0.001), as were MRP1 and LRP mRNA (p < 0.001) expression. Univariate regression analyses revealed that CD34 expression, increasing MDR1 mRNA as well as MDR1/BCRP coexpression, were associated with a lower complete response (CR) rate and with worse event-free survival and overall survival. When adjusted for other prognostic actors, only CD34-related MDR1/BCRP coexpression remained significantly associated with a lower CR rate (p = 0.03), thereby identifying a clinically resistant subgroup of elderly AML patients
Location of the Energy Levels of the Rare-Earth Ion in BaF2 and CdF2
The location of the energy levels of rare-earth (RE) elements in the energy
band diagram of BaF2 and CdF2 crystals is determined. The role of RE3+ and RE2+
ions in the capture of charge carriers, luminescence, and the formation of
radiation defects is evaluated. It is shown that the substantial difference in
the luminescence properties of BaF2:RE and CdF2:RE is associated with the
location of the excited energy levels in the band diagram of the crystals
Measurement of the production of charm jets tagged with D mesons in pp collisions at = 7 TeV
The production of charm jets in proton-proton collisions at a center-of-mass
energy of TeV was measured with the ALICE detector at the CERN
Large Hadron Collider. The measurement is based on a data sample corresponding
to a total integrated luminosity of , collected using a
minimum-bias trigger. Charm jets are identified by the presence of a D
meson among their constituents. The D mesons are reconstructed from their
hadronic decay DK. The D-meson tagged jets are
reconstructed using tracks of charged particles (track-based jets) with the
anti- algorithm in the jet transverse momentum range
and pseudorapidity
. The fraction of charged jets containing a D-meson
increases with from to . The distribution of D-meson tagged jets as a
function of the jet momentum fraction carried by the D meson in the
direction of the jet axis () is reported for two ranges
of jet transverse momenta, and
in the intervals
and , respectively. The
data are compared with results from Monte Carlo event generators (PYTHIA 6,
PYTHIA 8 and Herwig 7) and with a Next-to-Leading-Order perturbative Quantum
Chromodynamics calculation, obtained with the POWHEG method and interfaced with
PYTHIA 6 for the generation of the parton shower, fragmentation, hadronisation
and underlying event.Comment: 29 pages, 8 captioned figures, 3 tables, authors from page 24,
published version, figures at http://alice-publications.web.cern.ch/node/525
Care after pancreatic resection according to an algorithm for early detection and minimally invasive management of pancreatic fistula versus current practice (PORSCH-trial):design and rationale of a nationwide stepped-wedge cluster-randomized trial
Background: Pancreatic resection is a major abdominal operation with 50% risk of postoperative complications. A common complication is pancreatic fistula, which may have severe clinical consequences such as postoperative bleeding, organ failure and death. The objective of this study is to investigate whether implementation of an algorithm for early detection and minimally invasive management of pancreatic fistula may improve outcomes after pancreatic resection. Methods: This is a nationwide stepped-wedge, cluster-randomized, superiority trial, designed in adherence to the Consolidated Standards of Reporting Trials (CONSORT) guidelines. During a period of 22 months, all Dutch centers performing pancreatic surgery will cross over in a randomized order from current practice to best practice according to the algorithm. This evidence-based and consensus-based algorithm will provide daily multilevel advice on the management of patients after pancreatic resection (i.e. indication for abdominal imaging, antibiotic treatment, percutaneous drainage and removal of abdominal drains). The algorithm is designed to aid early detection and minimally invasive step-up management of postoperative pancreatic fistula. Outcomes of current practice will be compared with outcomes after implementation of the algorithm. The primary outcome is a composite of major complications (i.e. post-pancreatectomy bleeding, new-onset organ failure and death) and will be measured in a sample size of at least 1600 patients undergoing pancreatic resection. Secondary endpoints include the individual components of the primary endpoint and other clinical outcomes, healthcare resource utilization and costs analysis. Follow up will be up to 90 days after pancreatic resection. Discussion: It is hypothesized that a structured nationwide implementation of a dedicated algorithm for early detection and minimally invasive step-up management of postoperative pancreatic fistula will reduce the risk of major complications and death after pancreatic resection, as compared to current practice. Trial registration: Netherlands Trial Register: NL 6671. Registered on 16 December 2017
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