597 research outputs found
Ancient Yersinia pestis genomes from across Western Europe reveal early diversification during the First Pandemic (541–750)
The first historically documented pandemic caused by Yersinia pestis began as the Justinianic Plague in 541 within the Roman Empire and continued as the so-called First Pandemic until 750. Although paleogenomic studies have previously identified the causative agent as Y. pestis, little is known about the bacterium’s spread, diversity, and genetic history over the course of the pandemic. To elucidate the microevolution of the bacterium during this time period, we screened human remains from 21 sites in Austria, Britain, Germany, France, and Spain for Y. pestis DNA and reconstructed eight genomes. We present a methodological approach assessing single-nucleotide polymorphisms (SNPs) in ancient bacterial genomes, facilitating qualitative analyses of low coverage genomes from a metagenomic background. Phylogenetic analysis on the eight reconstructed genomes reveals the existence of previously undocumented Y. pestis diversity during the sixth to eighth centuries, and provides evidence for the presence of multiple distinct Y. pestis strains in Europe. We offer genetic evidence for the presence of the Justinianic Plague in the British Isles, previously only hypothesized from ambiguous documentary accounts, as well as the parallel occurrence of multiple derived strains in central and southern France, Spain, and southern Germany. Four of the reported strains form a polytomy similar to others seen across the Y. pestis phylogeny, associated with the Second and Third Pandemics. We identified a deletion of a 45-kb genomic region in the most recent First Pandemic strains affecting two virulence factors, intriguingly overlapping with a deletion found in 17th- to 18th-century genomes of the Second Pandemic. © 2019 National Academy of Sciences. All rights reserved
The Progenitors of Dwarf Spheroidal Galaxies
Dwarf spheroidal (dSph) galaxies present an evolutionary puzzle that we
explore in 40 early- and late-type dwarfs in the Local Group and nearby field.
Although dSphs formed stars over extended periods, today all but one are free
of detectable interstellar matter (ISM), even in the Fornax dSph, where stars
still formed 100 Myr ago. Combining metallicities for red giants with HI data
from the literature, we show that the well-known offset in
luminosity-metallicity (L-Z) relations for dSphs and dwarf irregular (dIrr)
galaxies exists also when comparing only their old stellar populations: dSphs
have higher mean stellar metallicities for a fixed luminosity. Evidently
younger dSphs experienced more efficient enrichment than young dIrrs. Dwarf
galaxies, whose locus in the L-Z diagram is consistent with that of dSphs even
for baryonic luminosities, are the ``transition-type dwarfs'' Phoenix, DDO210,
LGS3, Antlia, and KKR25. They have mixed dIrr/dSph morphologies, low stellar
masses, low angular momentum, and HI contents of less than a few 10^6 solar
masses. Unlike dIrrs, many transition-type dwarfs would closely resemble dSphs
if their gas were removed; they are likely dSph progenitors. As gas removal is
key, we consider the empirical evidence for various gas removal processes. We
suggest that internal gas removal mechanisms are inadequate and favor ram
pressure stripping to make dSphs. A combination of initial conditions and
environment seems to support the formation of dSphs, which appear to form from
small galaxies with active early star formation, whose evolution halts due to
externally induced gas loss. Transition-type dwarfs then are dSphs that kept
their ISM, and therefore should replace dSphs in isolated locations where
stripping is ineffective. (Abridged)Comment: 25 pages in AASTeX two-column preprint style, 1 table, 3 figures.
Accepted for publication in the Astronomical Journal (April 2003 issue
Dark Matter and Stellar Mass in the Luminous Regions of Disk Galaxies
We investigate the correlations among stellar mass (M_*), disk scale length
(R_d), and rotation velocity at 2.2 disk scale lengths (V_2.2) for a sample of
81 disk-dominated galaxies (disk/total >= 0.9) selected from the SDSS. We
measure V_2.2 from long-slit H-alpha rotation curves and infer M_* from galaxy
i-band luminosities (L_i) and g-r colors. We find logarithmic slopes of
2.60+/-0.13 and 3.05+/-0.12 for the L_i-V_2.2 and M_*-V_2.2 relations, somewhat
shallower than most previous studies, with intrinsic scatter of 0.13 dex and
0.16 dex. Our direct estimates of the total-to-stellar mass ratio within
2.2R_d, assuming a Kroupa IMF, yield a median ratio of 2.4 for M_*>10^10 Msun
and 4.4 for M_*=10^9-10^10 Msun, with large scatter at a given M_* and R_d. The
typical ratio of the rotation speed predicted for the stellar disk alone to the
observed rotation speed at 2.2R_d is ~0.65. The distribution of R_d at fixed
M_* is broad, but we find no correlation between disk size and the residual
from the M_*-V_2.2 relation, implying that this relation is an approximately
edge-on view of the disk galaxy fundamental plane. Independent of the assumed
IMF, this result implies that stellar disks do not, on average, dominate the
mass within 2.2R_d. We discuss our results in the context of infall models of
disk formation in cold dark matter halos. A model with a disk-to-halo mass
ratio m_d=0.05 provides a reasonable match to the R_d-M_* distribution for spin
parameters \lambda ranging from ~0.04-0.08, and it yields a reasonable match to
the mean M_*-V_2.2 relation. A model with m_d=0.1 predicts overly strong
correlations between disk size and M_*-V_2.2 residual. Explaining the wide
range of halo-to-disk mass ratios within 2.2R_d requires significant scatter in
m_d values, with systematically lower m_d for galaxies with lower .Comment: 18 pages, 2 tables, 7 figures, Accepted to ApJ, Table 1 updated,
otherwise minor change
Leo V: A Companion of a Companion of the Milky Way Galaxy
We report the discovery of a new Milky Way dwarf spheroidal galaxy in the
constellation of Leo identified in data from the Sloan Digital Sky Survey. Leo
V lies at a distance of about 180 kpc, and is separated by about 3 degrees from
another recent discovery, Leo IV. We present follow-up imaging from the Isaac
Newton Telescope and spectroscopy from the Hectochelle fiber spectrograph at
the Multiple Mirror Telescope. Leo V's heliocentric velocity is 173.4 km/s,
which is offset by about 40 km/s from that of Leo IV. A simple interpretation
of the kinematic data is that both objects may lie on the same stream, though
the implied orbit is only modestly eccentric (e = 0.2)Comment: Submitted to ApJ (Letters
Variable Stars in the Cetus dSph Galaxy: Population Gradients and Connections with the Star Formation History
We investigate the variable star content of the isolated, Local Group, dwarf
spheroidal galaxy (dSph) Cetus. Multi-epoch, wide-field images collected with
the VLT/VIMOS camera allowed us to detect 638 variable stars (630 RR Lyrae
stars and 8 Anomalous Cepheids), 475 of which are new detections. We present a
full catalogue of periods, amplitudes, and mean magnitudes. Motivated by the
recent discovery that the pulsational properties of the RR Lyrae stars in the
Tucana dSph revealed the presence of a metallicity gradient within the oldest
(>10 Gyr old) stellar populations, we investigated the possibility of an
analogous effect in Cetus. We found that, despite the obvious radial gradient
in the Horizontal Branch (HB) and Red Giant Branch (RGB) morphologies, both
becoming bluer on average for increasing distance from the center of Cetus, the
properties of the RR Lyrae stars are homogeneous within the investigated area
(out to r~15'), with no significant evidence of a radial gradient. We discuss
this in connection with the star formation history (SFH) previously derived for
the two galaxies. The observed differences between these two systems show that
even systems this small show a variety of early evolutionary histories. These
differences could be due to different merger or accretion histories.Comment: Accepted for publication on MNRAS. The complete set of light curves
and finding charts, together with the full table of the pulsational
properties of all variable stars will be available in the on-line edition of
the pape
The SPLASH Survey: A Spectroscopic Analysis of the Metal-Poor, Low-Luminosity M31 dSph Satellite Andromeda X
Andromeda X (And X) is a newly discovered low-luminosity M31 dwarf spheroidal
galaxy (dSph) found by Zucker et al. (2007) in the Sloan Digital Sky Survey
(SDSS - York et al. 2000). In this paper, we present the first spectroscopic
study of individual red giant branch stars in And X, as a part of the SPLASH
Survey (Spectroscopic and Photometric Landscape of Andromeda's Stellar Halo).
Using the Keck II telescope and multiobject DEIMOS spectrograph, we target two
spectroscopic masks over the face of the galaxy and measure radial velocities
for ~100 stars with a median accuracy of sigma_v ~ 3 km/s. The velocity
histogram for this field confirms three populations of stars along the sight
line: foreground Milky Way dwarfs at small negative velocities, M31 halo red
giants over a broad range of velocities, and a very cold velocity ``spike''
consisting of 22 stars belonging to And X with v_rad = -163.8 +/- 1.2 km/s. By
carefully considering both the random and systematic velocity errors of these
stars (e.g., through duplicate star measurements), we derive an intrinsic
velocity dispersion of just sigma_v = 3.9 +/- 1.2 km/s for And X, which for its
size, implies a minimum mass-to-light ratio of M/L =37^{+26}_{-19} assuming the
mass traces the light. Based on the clean sample of member stars, we measure
the median metallicity of And X to be [Fe/H] = -1.93 +/- 0.11, with a slight
radial metallicity gradient. The dispersion in metallicity is large,
sigma([Fe/H]) = 0.48, possibly hinting that the galaxy retained much of its
chemical enrichment products. We discuss the potential for better understanding
the formation and evolution mechanisms for M31's system of dSphs through
(current) kinematic and chemical abundance studies, especially in relation to
the Milky Way sample. (abridged version)Comment: Accepted for Publication in Astrophys. J. 14 pages including 7
figures and 2 tables (journal format
HAGE (DDX43) is a biomarker for poor prognosis and a predictor of chemotherapy response in breast cancer
Background: HAGE protein is a known immunogenic cancer-specific antigen. Methods: The biological, prognostic and predictive values of HAGE expression was studied using immunohistochemistry in three cohorts of patients with BC (n=2147): early primary (EP-BC; n=1676); primary oestrogen receptor-negative (PER-BC; n=275) treated with adjuvant anthracycline-combination therapies (Adjuvant-ACT); and primary locally advanced disease (PLA-BC) who received neo-adjuvant anthracycline-combination therapies (Neo-adjuvant-ACT; n=196). The relationship between HAGE expression and the tumour-infiltrating lymphocytes (TILs) in matched prechemotherapy and postchemotherapy samples were investigated. Results: Eight percent of patients with EP-BC exhibited high HAGE expression (HAGEþ) and was associated with aggressive clinico-pathological features (Ps<0.01). Furthermore, HAGEþexpression was associated with poor prognosis in both univariate and multivariate analysis (Ps<0.001). Patients with HAGE+ did not benefit from hormonal therapy in high-risk ER-positive disease. HAGE+ and TILs were found to be independent predictors for pathological complete response to neoadjuvant-ACT; P<0.001. A statistically significant loss of HAGE expression following neoadjuvant-ACT was found (P=0.000001), and progression-free survival was worse in those patients who had HAGE+ residual disease (P=0.0003). Conclusions: This is the first report to show HAGE to be a potential prognostic marker and a predictor of response to ACT in patients with BC
A Keck/DEIMOS spectroscopic survey of the faint M31 satellites And IX, And XI, And XII, and And XIII
We present the first spectroscopic analysis of the faint M31 satellite
galaxies, AndXI and AndXIII, and a reanalysis of existing spectroscopic data
for two further faint companions, And IX and AndXII. By combining data obtained
using the DEIMOS spectrograph mounted on the Keck II telescope with deep
photometry from the Suprime-Cam instrument on Subaru, we have calculated global
properties for the dwarfs, such as systemic velocities, metallicites and
half-light radii.We find each dwarf to be very metal poor ([Fe/H] -2 both
photometrically and spectroscopically, from their stacked spectrum), and as
such, they continue to follow the luminosity-metallicity relationship
established with brighter dwarfs. We are unable to resolve a dispersion for And
XI due to small sample size and low S/N, but we set a one sigma upper limit of
sigma-v <5 km/s. For And IX, And XII and And XIII we resolve velocity
dispersions of v=4.5 (+3.4,-3.2), 2.6(+5.1,-2.6) and 9.7(+8.9,-4.5) km/s, and
derive masses within the half light radii of 6.2(+5.3,-5.1)x10^6 Msun, 2.4
(+6.5,-2.4)x10^6 Msun and 1.1(+1.4,-0.7)x10^7 Msun respectively. We discuss
each satellite in the context of the Mateo relations for dwarf spheroidal
galaxies, and the Universal halo profiles established for Milky Way dwarfs
(Walker et al. 2009). For both galaxies, this sees them fall below the
Universal halo profiles of Walker et al. (2009). When combined with the
findings of McConnachie & Irwin (2006a), which reveal that the M31 satellites
are twice as extended (in terms of both half-light and tidal radii) as their
Milky Way counterparts, these results suggest that the satellite population of
the Andromeda system could inhabit halos that are significantly different from
those of the Milky Way in terms of their central densities (abridged).Comment: 26 pages, 18 figures, MNRAS submitte
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