29 research outputs found
Polarization of macrophages toward M2 phenotype is favored by reduction in iPLA2ÎČ (group VIA phospholipase A2)*
- Author
- Publication venue
- Digital Commons@Becker
- Publication date
- 01/01/2016
- Field of study
Macrophages are important in innate and adaptive immunity. Macrophage participation in inflammation or tissue repair is directed by various extracellular signals and mediated by multiple intracellular pathways. Activation of group VIA phospholipase A2 (iPLA2ÎČ) causes accumulation of arachidonic acid, lysophospholipids, and eicosanoids that can promote inflammation and pathologic states. We examined the role of iPLA2ÎČ in peritoneal macrophage immune function by comparing wild type (WT) and iPLA2ÎČâ/â mouse macrophages. Compared with WT, iPLA2ÎČâ/â macrophages exhibited reduced proinflammatory M1 markers when classically activated. In contrast, anti-inflammatory M2 markers were elevated under naĂŻve conditions and induced to higher levels by alternative activation in iPLA2ÎČâ/â macrophages compared with WT. Induction of eicosanoid (12-lipoxygenase (12-LO) and cyclooxygenase 2 (COX2))- and reactive oxygen species (NADPH oxidase 4 (NOX4))-generating enzymes by classical activation pathways was also blunted in iPLA2ÎČâ/â macrophages compared with WT. The effects of inhibitors of iPLA2ÎČ, COX2, or 12-LO to reduce M1 polarization were greater than those to enhance M2 polarization. Certain lipids (lysophosphatidylcholine, lysophosphatidic acid, and prostaglandin E2) recapitulated M1 phenotype in iPLA2ÎČâ/â macrophages, but none tested promoted M2 phenotype. These findings suggest that (a) lipids generated by iPLA2ÎČ and subsequently oxidized by cyclooxygenase and 12-LO favor macrophage inflammatory M1 polarization, and (b) the absence of iPLA2ÎČ promotes macrophage M2 polarization. Reducing macrophage iPLA2ÎČ activity and thereby attenuating macrophage M1 polarization might cause a shift from an inflammatory to a recovery/repair milieu
Bordetella PlrSR regulatory system controls BvgAS activity and virulence in the lower respiratory tract
- Author
- Publication venue
- Publication date
- 01/01/2017
- Field of study
Bordetella spp. includes Bordetella pertussis, the causal agent of whooping cough. The Bordetella virulence gene (BvgAS) two-component regulatory system (TCS) is considered the âmaster virulence regulatorâ in Bordetella, as it controls expression of all known virulence factor-encoding genes. We show here that another TCS, PlrSR, is required for BvgAS activity in the lower respiratory tract (LRT) and for virulence even when BvgAS is rendered constitutively active, suggesting that it controls critical functions for bacterial survival in the LRT independently of BvgAS. Our data introduce a new layer of complexity to a paradigm of Bordetella virulence control that has held for more than 30 y, and they indicate the existence of previously unknown bacterial factors that may serve as vaccine components and therapeutic targets
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; pâ=â0.40). There was no significant effect of DMF on any secondary outcome
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
- Abraham T.
- Abrams J.
- Abu H.
- Abu-Arafeh A.
- Acton C.
- Adam F.
- Adam M.
- Adams C.
- Adams D.
- Adams L.
- Addo A.
- Adedeji O.
- Adegoke K.
- Adewunmi E.
- Adeyemo T.
- Agbeko R.
- Aggarwal S.
- Ahmad S.
- Ahmed A.
- Ahmed I.
- Ahmed M.
- Ahmed R.
- Ainsworth M.
- Ajmi A.
- Akili S.
- Al Aaraj A.
- Al Balushi A.
- Al-Asadi A.
- Al-Khalil M.
- Al-Ramadhani B.
- Al-Saadi Z.
- Al-Shahi Salman R.
- Al-Sheklly B.
- Albert P.
- Alegria A.
- Alexander A.
- Alexander P.
- Alhabsha O.
- Ali M.
- Aliberti E.
- Alin J.
- Aliyuda F.
- Alkhudhayri A.
- Allan N.
- Allanson A.
- Allen E.
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- Alshaer I.
- Altaf S.
- Amezaga M.
- Amin A.
- Amit B.
- Anand A.
- Anantapatnaikuni S.
- Anderson L.
- Anderson M.
- Anderson N.
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- Andrews A.
- Ang A.
- Anguvaa L.
- Aniruddhan K.
- Antonina Z.
- Araujo M.
- Archer A.
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- Arimoto R.
- Arkley C.
- Armah C.
- Armistead J.
- Armstrong C.
- Arnison-Newgass C.
- Arora D.
- Arya A.
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- Buttress D.
- Byrne J.
- Byrne W.
- Byrne-Watts V.
- Cale E.
- Calisti G.
- Callens C.
- Cameron E.
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- Carroll A.
- Carson R.
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- Caws C.
- Central Coordinating Office (for the RECOVERY Collaborative Group)
- Century H.
- Chadwick J.
- Chakkarapani E.
- Chakraborty A.
- Chamberlain S.
- Chambers E.
- Chambers L.
- Chan E.
- Chan R.
- Chaplin J.
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- Chappell L.
- Charles B.
- Charlton D.
- Chatar K.
- Chatterton D.
- Chaudhuri N.
- Chauhan R.
- Chawla V.
- Chen F.
- Cheng F.
- Cherrie M.
- Cheung E.
- Cheyne C.
- Chilcott S.
- Chilvers A.
- Chin K.
- Chineka R.
- Chinonso E.
- Chisnall B.
- Chiswick C.
- Chivima B.
- Chmiel C.
- Chrisopoulou A.
- Christian P.
- Christides A.
- Christmas D.
- Church E.
- Cianci N.
- Cicconi P.
- Clare E.
- Clark E.
- Clark G.
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- Clark R.
- Clarke A.
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- Clayton-Smith J.
- Cleaver C.
- Clemente de la Torre C.
- Clifford S.
- Coakley M.
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- Cochrane P.
- Cocks S.
- Coe A.
- Coey D.
- Cohen D.
- Coker O.
- Cole J.
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- Collier D.
- Collini Paul
- Collins J.
- Collins V.
- Colton H.
- Condliffe R.
- Connell E.
- Connell L.
- Connelly K.
- Connolly G.
- Connor E.
- Conroy K.
- Conteh V.
- Conway R.
- Cook E.
- Cooke G.
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- Cooper D.
- Cooper L.
- Cooper N.
- Cooray S.
- Corbett C.
- Corbishley A.
- Cornwell J.
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- Corrigan R.
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- Cotterill D.
- Coull A.
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- Cremona J.
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- Crichton C.
- Crisp L.
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- Dalgleish H.
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- Darbyshire Janet
- Darnell S.
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- Das S.
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- Data Monitoring Committee of the RECOVERY Collaborative Group
- Daunt A.
- Dave V.
- Davey M.
- Davidson N.
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- Dawson A.
- Day Jeremy
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- de Silva T.
- De Soyza A.
- de Vos J.
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- Dear J.
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- Deery J.
- DeMets David
- Denis E.
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- Desai A.
- Deshpande S.
- Dey P.
- Dhaliwal K.
- Dhani S.
- Dhasmana Devesh J.
- Dhillon R.
- Dicks P.
- Digby J.
- Dimitri P.
- Dismore L.
- Ditchfield L.
- Dixon C.
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- Dobbie L.
- Dobson C.
- Dobson L.
- Docherty M.
- Dockrell D.
- Dodds R.
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- Dolan D.
- Dolman M.
- Donald L.
- Donaldson D.
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- Donlon S.
- Donohoe A.
- Donohoe G.
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- Dosanjh D.
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- Downey R.
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- Drewett O.
- Drogan H.
- Drummond G.
- Druryk K.
- Du Thinh A.
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- Duffield E.
- Duffy H.
- Duggan A.
- Dummer S.
- Duncan C.
- Duncan F.
- Duncan G.
- Duncan R.
- Dunleavy J.
- Dunn A.
- Duran B.
- Durrans L.
- Durrington H.
- Duru I.
- Dymond H.
- DâCosta J.
- DâMello A.
- Eades C.
- Early J.
- Eatough R.
- Eddleston M.
- Edgerley K.
- Edmond N.
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- Ekoi M.
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- Elgohary A.
- Ellis C.
- Ellwood A.
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- Elyoussfi S.
- Emberson Jonathan R.
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- Emonts M.
- Essa F.
- Evans B.
- Evans G.
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- Everden C.
- Everden S.
- Evison L.
- Ezenduka C.
- Fairbairn I.
- Fairclough A.
- Falconer E.
- Faluyi D.
- Fancois V.
- Farmery T.
- Farooq H.
- Farrell B.
- Farzana S.
- Fatemi A.
- Fatemi M.
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- Faust Saul N.
- Fearby S.
- Felton T.
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- Fenn A.
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- Fenton C.
- Ferenando G.
- Ferguson C.
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- Ferguson V.
- Fernandez Lopez S.
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- Fiouni S.
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- Fordham I.
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- Fowler Robert
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- G N.
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- George B.
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- George V.
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- Giannopoulou S.
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- Headon E.
- Health records (for the RECOVERY Collaborative Group)
- Hector G.
- Heddon S.
- Henry J.
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- Ijaz M.
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- Ionita A.
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- Irons R.
- Irving R.
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- Islim A.
- Ismail O.
- Iwanikiw S.
- Jack C.
- Jackman S.
- Jackson B.
- Jackson S.
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- Jaki Thomas
- Jaly Y.
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- Jameson J.
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- Jeebun V.
- Jeffery Katie
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- Johnstone D.
- Johnstone E.
- Jones A.
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- Josiah B.
- Ju Wen Kwek A.
- Judge P.
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- Kailey A.
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- Lloyd A.
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- Lo S.
- Loader D.
- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
- Lock S.
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- Lockett T.
- Lodhia K.
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- Logan M.
- Logue C. A.
- Lokanathan S.
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- Majumdar Jaydip
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- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; pâ=â0.40). There was no significant effect of DMF on any secondary outcome
Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial
- Author
- Abani Obbina
- Abbas Ali
- Abbas Fatima
- Abbas Mustafa
- Abbasi Sadia
- Abbass Hakam
- Abbott Alfie
- Abdallah Nabeel
- Abdelaziz Ashraf
- Abdelfattah Mohamed
- Abdelqader Bushra
- Abdo David
- Abdul Rasheed Althaf
- Abdul Basir
- Abdul-Kadir Rezan
- Abdul-Raheem Rasheed
- Abdulakeem Ajibode
- Abdulle Amina
- Abdulmumeen Abdulfatahi
- Abdulshukkoor Niyaz
- Abdusamad Kula
- Abed El Khaleq Yazeed
- Abedalla Mai
- Abeer Ul Amna Abeer Ul Amna
- Abernethy Katrina
- Abo-Leyah Hani
- Aboaba Adebanke
- Abou-Haggar Ahmed
- Abouibrahim Mahmoud
- Abraham Miriam
- Abraham Tizzy
- Abraheem Abraheem
- Abrams Judith
- Abu Hyacinth-John
- Abu-Arafeh Ahmed
- Abubacker Syed M
- Abung Akata
- Aceampong Yaa
- Achara Amaka
- Acharya Devikumar
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- Adewunmi Emmanuel O
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- Adnan Adnan
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- Ashour Abd-El-Aziz
- Ashraf Muhammad Z
- Ashraf Saima
- Ashraq Mohammad B
- Ashton Deborah
- Ashton Susan
- Ashworth Andrew
- Ashworth Rebecca
- Aslam Arshia
- Asogan Harshini
- Asquith Abigail
- Asrar Atif
- Assaf Omar
- Astin-Chamberlain Raine
- Athay-Hunt Richard
- Athorne Deborah
- Atkins Billie
- Atkins Christopher
- Atkins Stacey
- Atkinson John
- Atkinson Vicki
- Atraskiewicz Brygitta
- Atterbury Claire
- Attia Abdul Ahmad
- Atugonza Rita
- Aubrey Paula
- Aujayeb Avinash
- Aung Aye Chan Thar
- Aung Hnin
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- Aung Ni
- Aung Yin
- Aung Zaw Myo
- Austin Emily
- Austin Karen
- Auwal Abdusshakur
- Avery Miriam
- Avis Joanne
- Aviss Georgina
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- Avram Paula
- Awadzi Gabriel
- Awan Atia
- Aya Aszad
- Ayaz Eman
- Ayers Amanda
- Azam Jawwad
- Azharuddin Mohammed
- Aziz Ghazala
- Aziz N
- Azkoul Ali
- Azman Shah Ashaari
- Azzopardi Giada
- Azzoug Hocine
- Babatunde Fiyinfoluwa
- Babi Melvin
- Babiker Babiker
- Babington Gayna
- Babirecki Matthew
- Babores Marta
- Babs-Osibodu Adetona O
- Bacciarelli Sammy
- Bachar Roudi
- Bacon Gina
- Bacon Jenny
- Badal Bibi
- Badhan Gurpreet R
- Badhrinarayanan Shreya
- Bae Joseph P
- Bafekr Mishamandani Sibel
- Baggaley Alice
- Baggott Amy
- Bagley Graham
- Bagmane Dinesh
- Bagshaw Lynsey
- Bahadori Kasra
- Bailey James
- Bailey Katie
- Bailey Lindsey
- Bailey Liz
- Bailey Morgan
- Bailey Pippa
- Bailey Sarah
- Bailey Stephen
- Baillie Hamish
- Baillie J Kenneth
- Bain Jennifer
- Baines Sanchia
- Bains Vikram
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- Balachandran Niranjan
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- Balaskas Theodosios
- Balasubramaniam Madhu
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- Baldwin Ashley
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- Bamford Peter
- Bamgboye Adefunke
- Bancroft Elizabeth
- Bancroft Hollie
- Bancroft Tanya
- Banda Joyce
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- Bandla Nageswar
- Bandyopadhyam Somaditya
- Banerjee Amit
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- Barnett Amy
- Barnett Matthew
- Barnett-Vanes Ashton
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- Barr Andrew
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- Barratt Shaney
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- Barrett Jessica
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- Barton Rachael
- Baruah Rosaleen
- Baryschpolec Sonia
- Bashyal Archana
- Basker Betsy
- Basoglu Ayten
- Bass Gilda
- Bassett G
- Bassett John
- Bassford Chris
- Bassi Pavinder
- Bassis Betsy
- Bassoy Bengisu
- Bastion Victoria
- Basumatary Anupam
- Bate Tristan
- Bateman Harry J
- Bateman Ian
- Bateman Kathryn
- Bateman Vhairi
- Bates Eleanor
- Bates Hayley
- Bates Michelle
- Bates Simon
- Batham Sally
- Batista Ana
- Batla Amit
- Batra Dushyant
- Batty Donna
- Batty Harry
- Batty Thomas
- Baughan Peter
- Baum Miranda
- Bautista Carina
- Bawa Fareha
- Bawani Fatima S
- Bax Simon
- Baxter Lydia
- Baxter Matt
- Baxter Nicola
- Baxter Zachary
- Bayes Hannah
- Baylem Charlotte
- Bayliss Lee
- Bays Eileen
- Bazari Farid
- Bazaz Rohit
- Bazli Ahmad
- Beacham Laura
- Beadles Wendy
- Beak Philip
- Beale Andy
- Beard Kirk
- Bearpark Jack
- Beaumont Karen
- Beaumont-Jewell Dawn
- Beaver Theresa
- Beavis Sarah
- Beazley Christy
- Beck Sarah
- Beckett Virginia
- Beckitt Rosie
- Beddall Heidi
- Beddows Seonaid
- Beeby Deborah
- Beech Gail
- Beecroft Michelle
- Beer Sally
- Beety Jane
- Bega Gabriela
- Begg Alison
- Begg Susan
- Beghini Sara
- Begum Ayesha
- Begum Salman
- Begum Selina
- Behan Teresa
- Beharry Jasmine
- Behrouzi Roya
- Beishon Jon
- Beith Claire
- Belcher James
- Belfield Holly
- Belfield Katherine
- Belgaumkar Ajay
- Bell Dina
- Bell Gareth
- Bell Gill
- Bell Gillian
- Bell Jennifer L
- Bell Joshua
- Bell Lauren
- Bell Louise
- Bell Nicholas
- Bell Pippa
- Bell Stephanie
- Bellamu Jennifer
- Bellamy Mary
- Bellini Arianna
- Bellis Amanda
- Bellis Fionn
- Bendall Lesley
- Benesh Naveena
- Benetti Nicola
- Benham Leonie
- Benison-Horner Guy
- Bennett Alexander
- Bennett Ann
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- Bentley Andrew
- Bentley Dionne
- Bentley James
- Benton Ian
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- Beresford Matthew
- Bergin Colin
- Bergstrom Malin
- Bernatoniene Jolanta
- Berriman Thomas
- Berry Zoe
- Berwick Marnie
- Best Kimberley
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- Bevins Sarah
- Bewick Tom
- Bexley Andrew
- Beyatli Sonay
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- Bhadi Arjun
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- Bhandal Khushpreet
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- Bhandari Ashwin
- Bhandari Sangam
- Bhanot Aashutosh
- Bhanot Ravina
- Bhaskara Sruti
- Bhat Prashanth
- Bhatia Nikhil
- Bhatnagar Rahul
- Bhatt Karan
- Bhayani Janki
- Bhojwani Deepika
- Bhuiyan Salimuzzaman
- Bibby Anna
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- Bicanic Tihana
- Bidgood Sarah
- Bigg Julie
- Biggs Sarah
- Biju Alphonsa
- Bikov Andras
- Billingham Sophie
- Billings Jessica
- Bilton Carron
- Binas Teodirico
- Binney Martin
- Binns Alice
- BinRofaie Muhammad
- Bintcliffe Oliver
- Birch Catherine
- Birch Jenny
- Birch Louann
- Birchall Janet
- Birchall Katherine
- Bird Sam
- Bird Sumedha
- Biring Charndip
- Birt Mark
- Bisa Raquel
- Bishop Kilanalei
- Bishop Linda
- Bishop Lisa
- Bisnauthsing Karen
- Biswas Nibedan
- Biuk Sahar
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- Black Ethel
- Black Helen
- Black Karen
- Black Mairead
- Black Polly
- Blackgrove Hayley
- Blackledge Bethan
- Blackler Joanne
- Blackley Samantha
- Blackman Helen
- Blackmore Stuart
- Blackstock Caroline
- Blackwood Loraine
- Blakemore Francesca
- Blamey Helen
- Bland Alison
- Blane Sujata
- Blankley Simon
- Blanton Mary
- Blaxill Parry
- Blaxland Jenny
- Blaylock Katie
- Blazeby Jane
- Blears Carol
- Blencowe Natalie
- Blofield Donna
- Bloom Ben
- Bloomfield Jack
- Bloss Angela
- Bloxham Hannah
- Blundell Louise
- Blunsum Andrew
- Blunt Mark
- Blyth Ian
- Blyth Kevin
- Blythe Andrew
- Blythe Karen
- Boampoaa Marilyn
- Bobie Boniface
- Bobruk Karen
- Bodalia Pritesh
- Bodasing Neena
- Bodenham Tanya
- Bodh Sherin
- Boehmer Gabriele
- Boffito Marta
- Bohmova Kristyna
- Bokhandi Sumit
- Bokhar Maria
- Bokhari Saba
- Bokhari Sakina
- Bokhari Syed Owais
- Boles Ambrose
- Bollington Sarah
- Bolton Sam
- Bomken Charlotte
- Bond Charlotte
- Bond Hayley
- Bond Helena
- Bond Stuart
- Bond Thomas
- Bone Alice
- Boniface Georgia
- Bonnert Wendy
- Bonney Lizzy
- Boorman Leigh
- Booth Catherine
- Borbone Joanne
- Borhani Cameron
- Borman Naomi
- Borrell Rachel
- Boshir Mamu
- Bottrill Fiona
- Bough Laura
- Boughton Hayley
- Boult Zoe
- Bourke Miriam
- Bourke Stephen
- Bourne Michelle
- Bousfield Rachel
- Boustred Lucy
- Bowen Darren
- Bowen Kaye
- Bowes Alexandra
- Bowes Amy
- Bowker Philip
- Bowman Louise
- Bowman Simon
- Bowmer Rachel
- Bowring Angie
- Bowyer Geoff
- Bowyer Helen
- Boyd Carmel
- Boyd Jenny
- Boyd Laura
- Boyd Maxine
- Boyle Namoi
- Boyle Pauline
- Boyle Rosalind
- Boyles Louise
- Bozdag Osman
- Brace Leanna
- Brack David
- Brackstone Charlotte
- Bradburn Rob
- Bradder Jodie
- Bradley Barry
- Bradley Clare Jane
- Bradley Pamela
- Bradley Patrick
- Bradley Paul
- Bradley-Potts Joanne
- Bradshaw Lynne
- Bradshaw Sarah
- Bradshaw Zena
- Brady Rebecca
- Brady Shirin
- Braganza Denise
- Brailsford Suhail
- Braithwaite Jill
- Branch Marie
- Brankin-Frisby Thomas
- Brannigan Jamie
- Brassington Louise
- Brattan Sophie
- Bray Fiona
- Bray Nancy
- Brazier Angela
- Brazil Manny
- Brear Lucy
- Brear Tracy
- Brearey Stephen
- Bremner Laura
- Brend Morwenna
- Bretland Giovanna
- Brewer Chris
- Bridge Hannah
- Bridgwood Gavin
- Briggs Hayley
- Briggs Mark
- Brigham Sara
- Bright John
- Brightling Chris
- Brimfield Lutece
- Brinkworth Elaine
- Brittain-Long Robin
- Britten Vianne
- Brittin Terri
- Broad Lauren
- Broad Sarah
- Broadhurst Rosie
- Broadley Andrew
- Broadway Marie
- Brockelsby Christopher
- Brocken Megan
- Brockley Tomos
- Broderick Andrew
- Brodsky Mary
- Brogan Fiona
- Broggio David
- Brohan Liz
- Brokke Felicity
- Brolly Jacob
- Bromley David
- Brooke-Ball Hannah
- Brooker Verity
- Brookes Ceri
- Brookes Matthew
- Brooks Alison
- Brooks Karen
- Brooks Nicole
- Brooks Philip
- Brooks Rachel
- Brooks Sophie
- Broomhead Natalie
- Broughton Chloe
- Broughton Nathaniel
- Brouns Matt
- Browett Marie
- Brown Alison
- Brown Ammani
- Brown Carly
- Brown Catrin
- Brown Chloe
- Brown Elizabeth
- Brown Ellen
- Brown Heather
- Brown Janet
- Brown Louise
- Brown Niall
- Brown Pauline
- Brown Rachel
- Brown Richard
- Brown Robert
- Brown Steven
- Brown Tom
- Brown Wayne
- Browne Bria
- Browne Charlotte
- Browne Duncan
- Browne Mitchell
- Brownlee Stephen
- Brraka Alba
- Bruce David
- Bruce Johanna
- Bruce Michelle
- Brudlo Wojciech
- Brunskill Nigel
- Brunton Alan
- Brunton Margaret
- Bryan Mandy
- Bryant Meera
- Buazon April
- Buch Maya
- Buchan Julie
- Buchan Ruaridh
- Buchanan Alexis
- Buchanan Ruaridh
- Buche Danielle
- Buck Amanda
- Buckland Matthew
- Buckley Laura
- Buckley Philip
- Buckley Sarah
- Buckman Carol
- Buckmire Kathleen
- Bugg George
- Bujazia Ramadan
- Bukhari Marwan
- Bukhari Shanze
- Bulbulia Richard
- Bull Alex
- Bull Damian
- Bull Rhian
- Bull Thomas
- Bulteel Naomi
- Bumunarachchi Kasun
- Bungue-Tuble Roneleeh
- Burchett Caroline
- Burda Dorota
- Burden Christy
- Burden Thomas G
- Burgess Mika
- Burgess Paula
- Burgess Richard
- Burgess Sophia
- Burgett Paula
- Burman Adrian
- Burnard Sara
- Burnett Caroline
- Burnett John
- Burns Amanda
- Burns Amy
- Burns Collette
- Burns James
- Burns Karen
- Burns Samuel
- Burns Sarah
- Burrage Daniel
- Burrage Sadie
- Burrows Kate
- Burston Claire
- Burton Ben
- Burton Fiona
- Burton Matthew
- Busby Angela
- Butcher Deborah
- Butler Aaron
- Butler Jessica
- Butler Joanne
- Butler Joshua
- Butler Lesley
- Butler Peter
- Butler Susan
- Butt Al-Tahoor
- Butt Mohammad M
- Butt Sophia
- Butterworth Caryl
- Butterworth-Cowin Nicola
- Buttery Robert
- Buttle Tom
- Button Heather
- Buttress Daniel
- Publication venue
- 'Elsevier BV'
- Publication date
- 13/02/2021
- Field of study
SummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87â1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98â1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87â1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro CarĂ Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Bailey Lucy
- Baillie Kenneth
- Bain William
- Baker Alice
- Baker Evelyn
- Baker Stuart
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Balls-Burgess Sam
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barber Russell
- Barbier François
- Barge Deborah
- Bariola Ryan
- Barker Gareth
- Barker Stephanie
- Barnes Nicky
- Baron Rebecca M.
- Barreau Amelie
- Barreau Amélie
- Bart Robert
- Bartholomew Jazz
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bayne Madeleine
- Bean Sarah
- Beane Abi
- Beane Abigail
- Beard Gregory
- Beasley Richard
- Beaudoin Rosalie
- Beavis Sarah
- Beddows Seonaid
- Bedford Caroline
- Beer Deborah
- Beer Sally
- Begin Phillipe
- Begum Salma
- Bell Gillian
- Bellemare David
- Belletti Allesandro
- Bendjemar Lynda
- Benettaib Fatna
- Bensen Nicole
- Bentley Andrew
- Benyon Sarah
- Benzekri Dalila
- Beqai Besa
- Berdaguer Fernando
- Beresford Stephanie
- Bergin Colin
- Berry Lindsay R.
- Berry Scott
- Berryman Emily
- Bertel Melanie
- Best-Lane Janis
- Besten Henny
- Bevan Emily
- Bewley Jeremy
- Beyerl Ashley
- Bhagani Sanjay
- Bhandal Khushpreet
- Bharaj Kiranjit
- Bhattarai Bina
- Bhattarai Binita
- Bhonagiri Deepak
- Biddie Simon
- Bigas Judit
- Bihari Shailesh
- Bin Hasan Mohd Shahnaz
- Bindels Manon
- Binnie Alexandra
- Biradar Vishwanath
- Birch Catherine
- Birch Janine
- Birch Sophie
- Birchall Kathrine
- Birkinshaw Isobel
- Black Ethel
- Blackledge Bethany
- Blakemore Hayley
- Blanck Wendy
- Bland Yvonne
- Blank Elisabeth
- Bleasdale John
- Bloomfield Jack
- Bloos Frank
- Board Jasmin
- Boardman Melanie
- Boari Gianluca
- Bocher Simon
- Bociek Aneta
- Boivin Anne-Helene
- Boivin Anne-HĂ©lĂšne
- Bojunga Jörg
- Bomken Charlotte
- Bonaccorso Allesandra
- Bongaerts Katherine
- Bonner Stephen
- Bonten Marc J. M.
- Borgatta Barbara
- Borislavova Borislava
- Borrill Zoe
- Boschert Catherine
- Bossard Isabelle
- Bothma Pieter
- Boudineau Michel
- Boulanger Marie-Claude
- Boumahni Dounia
- Bouman Angela
- Bounab Rania
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Boutin Mireille
- Bouvier Elodie
- Bouw-Ruiter Marianne
- Boué Yvonnick
- Bowen James
- Bowler Helen
- Boyd Craig
- Boyles Rebecca
- Bracke Stephanie
- Bradbury Charlotte A.
- Bradley Paul
- Brady Kara
- Brailsford Jane
- Brain Matthew
- Brakké Karen
- Brant Emily
- Brasselet Aurélie
- Breen Patrick
- Bremmer Pamela
- Brend Morwenna
- Brennan Aoife
- Bretagnol Anne
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Bridges Sarah
- Brieger Klaus-Gerd
- Brightling Chris
- Brimfield Lutece
- Brittain Michael
- Britton Kate
- Brochard Laurent
- Brodbeck Andreas
- Brohi Farooq
- Brooks Nicole
- Brown Cynthia
- Brown Julia
- Brown Louise
- Brown Nerissa
- Brown Zarah
- Brugman Curt
- Brunetta Enrico
- Brunkhorst Frank M.
- Brunskill Nigel
- Bryan-Morris Kayla
- Bryden Emma
- Budd Joanna
- Buehner Ulrike
- Buhay Megan
- Buhr Heidi
- Burbee Dylan
- Burda Dorota
- Burgess Richard
- Burke David
- Burke Tara
- Burkey Jason
- Burnish Rachel
- Burns Dean
- Burns Karen
- Burrell Aidan
- Burt Karen
- Buscher Hergen
- Butler Amelia
- Butler Magdalena
- Butler Susan
- Buxton Meredith
- Buzgau Adrian
- Byrne Kathleen
- Byrne Rahim
- Cabrelli Louise
- Cabreros Leilani
- Cairns Tom
- Calfee Carolyn
- Callahan Jean-Christophe
- Cambalova Lenka
- Campbell Andrew
- Campbell Bridget
- Campbell Debbie
- Campbell Hilary
- Campbell Lewis
- Campbell Marion
- Campbell Ryan
- Campion Alexandra
- Campisi Josie
- Camsooksai Julie
- Caplin Cecile
- Carbonneau Elaine
- Carmichael Samantha
- Carmona Rosario
- Carn Vanessa
- Carpio Lillian
- Carr Zoe
- Carr-Wilkinson Joanne
- Carrier François
- Carrier Marc
- Carter Angus
- Carter Brittney
- Carter David
- Carter Jay
- Carter Michael
- Casali Sherry
- Casey Ruth
- Casey Siobhan
- Castelain Vincent
- Castle James
- Cathcart Susanne
- Catorze Nuno José Teodoro Amaro dos Santos
- Cattelan Jessy
- Cavayas Alexandros
- Cawley Kathryn
- Cecconi Maurizio
- Centofanti John
- Chambers Emma
- Champanerkar Shreekant
- Chan Carmen
- Chan Charles
- Chan Peter
- Chapman Rachel
- Chapman Susan
- Charles Bethan
- Charles Walton
- Charlewood Richard
- Charlton Sam
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Jonathan
- Chen Lixian
- Chen Yan
- Cheng Allen C.
- Cherian Shiney
- Chhablani Manish
- Chin Teri
- Chudeau Nicolas
- Chukkambotla Sri
- Ciccarelli Michele
- Cirstea Emanuel
- Clair Bernard
- Clark Amy
- Clark Michele
- Clark Richard
- Clark Sarah
- Clarke Frances
- Clarke Jennifer
- Claxton Andrew
- Cleary Joanne
- Clement Ian
- Clere-Jehl Raphael
- Clermont Giles
- Clermont Gilles
- Clinton Alison
- Cloutier Ăve
- Cockrell Maeve
- Codreanu Daniel
- Coetzee Samantha
- Coghlan Phoebe
- Cole Jade
- Coles Jennifer
- Colin Gwenhael
- Collier Dawn
- Collins Amy
- Collins Daniel
- Collins Emma
- Collins Joanne
- Collins Ărin
- Collis Matthew
- Combaux Daniele
- Commons Robert
- Comp Susan
- Concha Pablo
- Connolly Karen
- Constantini Elena
- Constantino-Occhipinti Claudia
- Contou Damien
- Convery Karen
- Conway Robert
- Conzelmann Nadine
- Cook Deborah
- Cook Tim
- Cooke Jill
- Cooke Justin
- Cooper Jamie
- Cooper Josh
- Cooper Lauren
- Cooper Melanie
- Cooper Nichola
- Corbett Sarah
- Corcoran Ele
- Corcoran Kathleen
- Cornell Sarah
- Cornell Thomas
- Cort Jon
- Costerousse Olivier
- Couillard-ChĂ©nard Ămilie
- Courtin Laura
- Coutts Amanda
- Couture Lourie
- Cove Matthew
- Cowdrey Keri-Anne
- Cowley Nicholas
- Cowton Amanda
- Coyne Mark
- Craddock Richard
- Craner Michelle
- Craven Thomas
- Crawshaw Sarah
- Creagh-Brown Ben
- Creange Vanessa
- Cremer Olaf
- Crisp Nikki
- Croft Maria
- Csabi Peter
- Cudlipp Joanna
- Cuesta Jeronimo
- Cuffaro Raffaele
- Curley Gerard
- Currie Andrew
- Cusack Rebecca
- Cuthbertson Brian
- Cutler Sean
- CĂĄrcel Sheila
- CĂŽtĂ© Ămilie
- D?Amato Fabiola
- D?Aragon Frédérick
- Daebis Admad
- Daher Rana
- Dale Katie
- Daley Jessica
- Dalton James
- Daly James
- Daly Zoe
- Daneman Nick
- Dark Paul
- Darnell Robert
- Darreau Cedric
- Daugherty Jason
- Davey Miriam
- Davidson Neil
- Davies Ellie
- Davies Gwyneth
- Davies Jennifer
- Davies Louisa
- Davies Michelle
- Davies Rhys
- Dawson Laura Ann
- Dawvda Ashlish
- Day Christopher
- Da Rocha Joana
- De Bus Liesbet
- de Courcy-Golder Kim
- de Groot Klaas
- de Jong Menno
- de Jonge Evert
- De Keulenaer Bart
- de la Torre Cisneros Julian
- de Man Angelique
- De Neef Mark
- De Smeytere Anouska
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- Dean Tessa
- Dearden Joy
- Dechert William
- Declercq Pierre-Louis
- Degracia Anna
- del Sorbo Lorenzo
- Dela Rosa Arnold
- Delaney Kirsha
- Dell Abbie
- del Prado Michael
- Demetriou Carrie
- Dempster Debra
- Denham Lynn
- Denmade Craig
- Dent Martin
- Depante Maria
- Depuydt Pieter
- Dequin Pierre-François
- Derde Lennie P. G.
- Deshpande Kush
- Detry Michelle A.
- Deye Nicolas
- de la Fuente Carmen
- De Waele Jan
- Dheke Krishan
- Di Lucca Giuseppe
- Dias Priya
- Dice Julie
- Digby Stephen
- Diridis Kristina
- Distler Michael
- Dobell-Brown Kelsey
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- Doherty Ronan
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- Duric Natalie
- Duroux Maree
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- Dyas Sarah
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- Eastgate Christine
- Ebenezer R
- Edmunds Natasha
- Edwards Alexandra
- Efford Georgia
- Egreteau Pierre
- Ehrmann Stephan
- Eichenauer Dennis
- Eisenbeis Simone
- Ekhérian Jean-Michel
- El-Khawas Khaled
- Elender Corinna
- Elgendy Ahmad
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- English Shane
- Epelmanž Slava
- Eroglu Ege
- Estcourt Lise J.
- Estensen Kristen
- Evans Amy
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- Evers Mirjam
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- Ewalds Esther
- Ezekowitz Justin
- Fagan Laura
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- Fartoukh Muriel
- Faulkner Beverley
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- Felton Tim
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- Ferguson Susan
- Fergusson Dean
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- Fernåndez de Pinedo Artaraz Ziortza
- Ferreira Ricardo Manuel Castro
- Ferrier Janet
- Ferringer Cindy
- Fesz Jessica
- Fierens Jan
- Finch Cheryl
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- Fitzgerald Mark
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- Ford Megan
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- Foulds Angela
- Fowler Rob
- Fowler Robert
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- Fox Eleonore
- Fragner Gertrud
- Frakking Thuy
- Franch-LLasat Diego
- Francis Olesya
- Francoeur François
- Francois Bruno
- Frankfurter Claudia
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- Frost Victoria
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- Fujitani Shigeki
- Fysh Ed
- Gachet Alexandre
- Galbiati Carola
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- Ganguly Saibal
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- Gardiner-Hill Caroline
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- Garrard Hywel
- Garrard William
- Garrett Peter
- Garrier Ludivine
- Garrod Esther
- Garton Mark
- Garvey James
- Gascoyne Rachel
- Gattas David
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- Gemmell Lisa
- Gendall Emma
- Geng Wenli
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- Geri Guillaume
- Geurts Heidi
- Ghaffari Mehrdad
- Ghamraoui Ali
- Ghattaoraya Amardeep
- Ghosh Alison
- Giardina Giuseppe
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- Gill Mandy
- Gilliam Matthew
- Gilmour Kate
- Girard Timothy
- Girijadevi Dinuraj
- Gladas Kirsty
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- Gledhill Lisa
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- Glynou Loukia
- Goddard Wendy
- Godement Mathieu
- Godoy Lucas C.
- Goebeler M.E.
- Golden David
- Goldman John
- Goligher Ewan
- Gomez Keith
- Gommans Frank
- Goodwin Jayne
- Goossens Herman
- Gopal Shameer
- Gopinath Amitha
- Goralski Patricia
- Gordon Anthony C.
- Gosbell Iain
- Gould Richard
- Grady Bart
- Graham Cheryl
- Graham Libby
- Graniewski Jaroslaw
- Grant Caroline
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- Greco Massimiliano
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- Grieve Richard
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- Grimmer Lisa
- Groeneveld Erika
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- GrĂŒnewaldt Achim
- Guanco Mark
- Guerineau Elodie
- Guitton Christophe
- Gummadi Mahitha
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- Guérin Emmanuelle
- GĂłmez Francisco
- Göpel Siri
- Habeichi Wadih
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- Haghi Theerata
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- Haidar Ghady
- Haider Nafeesah
- Haider Syeda
- Hajdu Bence
- Hakak Sheeba
- Halden Sandra
- Haldeos Anne
- Hall Alistair S
- Hall Amelia
- Hall Andrew
- Hall Kathryn
- Hall Rebecca
- Hamilton David
- Hamilton-Davies Colin
- Hamlyn Vincent
- Hammond Naomi
- Hammonds Fiona
- Hand James
- Haniffa Rashan
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- Hansen Dan
- Hanson Helen
- Hanson Jane
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- Harding Daniel
- Hardy Chloe
- Harford Rachel
- Harland Cain
- Harper Heather
- Harrington Claire
- Harrington Kate
- Harris Celia
- Harris Jade
- Harris John
- Harrison David A.
- Harrison Susan
- Harrow Kath
- Hartley Melissa
- Harvala-Simmonds Heli
- Harvey Alice
- Harvey Daniel
- Harvey James
- Harward Meg
- Hashmi Madhia
- Hashmi Madiha
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- Hawcutt Daniel
- Hawes Joanne
- Hawkins Nancy
- Hay Sophie
- Haydon Tim
- Hayes Amber
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- HC Ooi
- Headdon William
- Headlam Evie
- Healey Gail
- Hegazy Ahmed
- Hegazy Mohamed
- Heinonen Jonna
- Helms Julie
- Heming Nicholas
- Henderson Kelly
- Henderson Steven
- Henning Jeremy
- Henri-Lagarrigue Matthieu
- Henry Joanne
- Henry Lavinia
- Hensley Joseph
- Heritier Stephane
- Hernandez Erik
- Hewitt Claire
- Hey Samuel
- Hickey John
- Hierons Sarah
- Higgins Alisa M.
- Hill Claire
- Hill Dianne
- Hill Helen
- Hilldrith Anette
- Hills Thomas
- Hin Lui Lok
- Hindle Grace
- Hinrichs Carl
- Hird Clare
- Hodge Christopher
- Hodgson Carol
- Hodgson Helen
- Hoff Uwe
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- Holland Nicky
- Holland Susan
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- Homes Jennifer
- Honda Hitoshi
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- Hopkins Phil
- Hormis Anil
- Horner Dan
- Hornsby James
- Horton Michelle
- Horvat Christopher M.
- Howcroft Clare
- Howell Alice
- Hower Martin
- Howie Lucy
- Howle Ryan
- Hoxha Elvira
- Huang David T.
- Hughes Debbie
- Hugill Keith
- Huijbens Danique
- Hullegie Sebastiaan
- Hulley Amanda
- Hulme Jonathan
- Hulse Sarah
- Humphrey Charlotte
- Hunt Beverley
- Hunter Stephanie
- Hurford Sally-Anne
- Hussain Mahwish
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- Hutchinson Christina
- Hutton Paula
- HĂŒning Vanessa
- Ichihara Nao
- Ijaz Nazia
- Ikhena Ikhuemose
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- Irving Ben
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- Jackson Shane
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- Jacob Reni
- Jacquier Sophie
- Jafarzadeh Mina
- Jagannathan Vijay
- Jain Susan
- James Augustian
- James Christie
- Jan Hassing Robert
- Janin Pierre
- Jarczak Dominik
- Jarman Claire
- Jayakumar Deva
- Jayakumar Devachandran
- Jean-Pierre Eraldi
- Jeblaoui Asma
- Jenkins Samuel
- Jenkins Sarah
- Jenkins Steve
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- Jepson Eleanor
- Jerenec Katja
- Jesty Robert
- Jha Avinash
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- Jongebloed Katherine
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- Kadam Umesh
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- Kalchko-Veyssal Selver
- Kalchthaler Kyle
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- Kalogirou Michael
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- Kamel Toufik
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- Kamra Maneesha
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- Karlikowski Michal
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- Katary Amro
- Kato Hideaki
- Kavanagh Lisa
- Kayani Abdul
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- KC Shirsh
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- Keeler Sheryl
- Keen Alexandra
- Keen Sherbrina
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- Kendrick Sara
- Kernan Maeve
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- Khoud Ahmed
- Khwaja Kosar
- Kidwai Aneela
- Kiiski Heikki
- Kilner Mari
- Kim Edy Y.
- Kimpton Sarah
- King Andrew
- Kinney Fiona
- Kirk Jill
- Kirk Rosemary
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- Kirkham Simon
- Kit Barbara
- Kitsios Georgios
- Kittridge Lauren
- Klein Daniela
- Klop-Riehl Margreet
- Kluge Stefan
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- Kochanek Matthias
- Kochert Erik
- Koelink Maaike
- Koirala Kanchan
- Koirala Sabin
- Kolanos Steffi
- Kolovou Angeliki
- Konecny Pam
- Kong Jing
- Koopmans Matty
- Kosa Alma
- Kremling Julius
- KreĂ Gabriele
- Krishnamoorthy S
- Krishnamurthy Vinodh
- Kruger Peter
- Kruisdijk-Gerritsen Arriette
- Kruisselbrink Rebecca
- Kuitunen Anne
- Kumar Anand
- Kumar Nikhil
- Kumar Rohit
- Kummerlen Christine
- Kunishima Hiroyuki
- Kunwar Puja
- Kunz Kevin
- Kurenda Catherine
- Kutsogiannis Demetrios
- Kuybida Yuriy
- Kwan Yvonne
- Kyeremeh Lynsey
- Kyle Laura
- L?Hotellier Sylvie
- Labbe Vincent
- Laffan Mike
- Laffey John
- Laha Shondipon
- Lai Vivian
- Lambert Bridget
- Lamontagne Francois
- Lampro Lamprini
- Landais Michaël
- Landoni Giovanni
- Landsiedel-Mechenbier Elke
- Lang Eva
- Langridge Emma
- Latham Victoria
- Latino Reece
- Laudi Svenja
- Laugs Fabian
- Lavana Jayshree
- Laver Russell D.
- Law Daniel
- Lawler Patrick R.
- Le Basnier Elliot
- Le Guen LenaĂŻg
- Le Loup Guillaume
- Leaf David E.
- Lean Richard
- Leaver Susannah
- Leavis Helen
- Leblond Julie
- Leditschke Anne
- Lee Kelvin
- Lee Stephanie
- Lee Stephen
- Lefevre Montaine
- Leffelaar Evelien
- Lehalleur Adrien
- Lellouche Francois
- Lemaire-Brunel Delphine
- Lembo Rosalba
- Leparco CĂ©cile
- Leroyer Marie-Helene
- Lesona Eden
- Levett Chris
- Lewis Joanne
- Lewis Roger J.
- Lewis Sarah
- LewisProsser Lorraine
- Liao Angela
- Lim Rosario
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- Lindergard Gabriella
- Linnett Vanessa
- Linstrum Kelsey M.
- Litton Ed
- Litton Edward
- Liu Theresa
- Lizotte Patricia
- Lock Stephen
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- Lorenzi Elizabeth
- Lother Sylvain
- Lowe Benjamin
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- Lucas Rachael
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- Luo Ji
- Lye Alison
- Lynch Ceri
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- LĂłpez Maria
- LĂłpez Rafael
- Löbel Madlen
- MacKay Callum
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- Marroquin Oscar
- Marsden Tracy
- Marsh Emma
- Marshall John C.
- Marshall Lucy
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- Mayr Florian
- Mc-Kenzie Josette
- McAdams David
- McArthur Colin J.
- McAuley Daniel F.
- McAuley Julie
- McCallion Edmund
- McCarthy Aine
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- McGoldrick Clare
- McGuigan Peter
- McGuinness Shay P.
- McIntyre Joanne
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- McKee Madeleine
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- McVerry Bryan J.
- McWilliam Stephen
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- Mouncey Paul R.
- Mowery Brent
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- Nguyen-Valat Thi-My-Hue
- Nichol Alistair D.
- Nicholier Tiphaine
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- Nicholson Anne
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- Oza Deepali
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- Paramasivam Elankumaran
- Parekh Dhruv
- Parikh Harshel G.
- Parke Rachael L.
- Parker Jane C.
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- Williamson James D
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- Woodward Robert
- Woolett Melissa
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- Wright Chris
- Wright Kim
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- Wyatt Rachel
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- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 nonâcritically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (nâ=â257), ARB (nâ=â248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; nâ=â10), or no RAS inhibitor (control; nâ=â264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ supportâfree days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ supportâfree days among critically ill patients was 10 (â1 to 16) in the ACE inhibitor group (nâ=â231), 8 (â1 to 17) in the ARB group (nâ=â217), and 12 (0 to 17) in the control group (nâ=â231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ supportâfree days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
THE RELATIONSHIP BETWEEN COMBINED NITROGEN UPTAKES AND NITROGEN FIXATION IN AZOLLA-ANABAENA SYMBIOSIS
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Bordetella
- Author
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- Field of study
Fluorophosphonate-functionalised titanium via a pre-adsorbed alkane phosphonic acid: a novel dual action surface finish for bone regenerative applications
- Author
- Ashley W. Blom
- BD Brause
- C Queffélec
- DC Laux
- EL Hanson
- GD Prestwich
- Heather K. Bone
- J Blackburn
- J Clover
- J Gidley
- Jason P. Mansell
- JB Parsons
- JF Moulder
- JJ Kabara
- JP Mansell
- JP Mansell
- JP Mansell
- KA Krogfelt
- Keith Hallam
- LF Bonewald
- M Bachle
- M Katsikogianni
- M Salis-Soglio von
- MP Whyte
- SJ Yarram
- ST Lancaster
- Stephen Denyer
- TJ Foster
- Tom Scott
- Wayne Nishio Ayre
- Y Paz
- Y Xu
- Y Xu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 24/12/2015
- Field of study
© 2015, Springer Science+Business Media New York. Abstract: Enhancing vitamin D-induced human osteoblast (hOB) maturation at bone biomaterial surfaces is likely to improve prosthesis integration with resultant reductions in the need for revision arthroplasty consequent to aseptic loosening. Biomaterials that are less appealing to microorganisms implicated in implant failures through infection are also highly desirable. However, finding surfaces that enhance hOB maturation to active vitamin D yet deter bacteria remain elusive. In addressing this, we have sought to bio-functionalise titanium (Ti) with lysophosphatidic acid (LPA) and related, phosphatase-resistant, LPA analogues. The impetus for this follows our discovery that LPA co-operates with active vitamin D3 metabolites to secure hOB maturation in vitro including cells grown upon Ti. LPA has also been found, by others, to inhibit virulence factor production and biofilm formation of the human opportunistic pathogen Pseudomonas aeruginosa. Collectively, selected LPA species might offer potential dual-action surface finishes for contemporary bone biomaterials. In attaching a phosphatase-resistant LPA analogue to Ti we took advantage of the affinity of alkane phosphonic acids for TiO 2 . Herein, we provide evidence for the facile development of a dual-action Ti surface for potential orthopaedic and dental applications. Successful conjugation of an LPA analogue (3S)1-fluoro-3-hydroxy-4-(oleoyloxy)butyl-1-phosphonate (FHBP) to the Ti surface was supported through physiochemical characterisation using x-ray photoelectron spectroscopy and secondary ion mass spectrometry. hOB maturation to active vitamin D3 was enhanced for cells grown on FHBP-Ti whilst these same surfaces exhibited clear antiadherent properties towards a clinical isolate of Staphylococcus aureus. Graphical Abstract: [Figure not available: see fulltext.
Parvalbumins and muscle relaxation: a computer simulation study
- Author
- A. K. Campbell
- A. M. Weber
- A. Ralston
- A. V. Somlyo
- C. C. Ashley
- C. C. Ashley
- C. C. Ashley
- C. C. Ashley
- C. Gosselin-Rey
- C. W. Gear
- D. D. McCraken
- E. Homsher
- G. Baron
- G. Hamoir
- G. Hamoir
- G. Hamoir
- G. Inesi
- G. Inesi
- G. W. Heizmann
- H. Diebler
- H. E. Blum
- H. E. Blum
- J. A. Cox
- J. D. Johnson
- J. D. Potter
- J. D. Potter
- J. D. Potter
- J. D. Potter
- J. Demaille
- J. Demaille
- J. Demaille
- J. F. PechĂšre
- J. F. PechĂšre
- J. F. PechĂšre
- J. F. PechĂšre
- J. M. Gillis
- J. M. Gillis
- J. M. Gillis
- J. R. Blinks
- J. R. Blinks
- K. S. P. Bhushana Rao
- L. D. Peachey
- L. F. Shampine
- M. Endo
- N. A. Curtin
- N. Briggs
- Q. Bone
- S. E. Hitchcock
- S. Ebashi
- S. M. Cohen
- S. P. Robertson
- S. Winegrad
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study