Programa de reducción de estrés basado en técnicas Mindfulness para funcionarios del área administrativa Mazco Bogota S.A.S.

Realizar un programa, basado en técnicas Mindfulness, a fin de la reducción de los niveles de estrés en los funcionarios del área administrativa de Mazco Bogotá S.A.S.Reconociendo que el estrés es la enfermedad del siglo XXI y más allá de sus alcances, es un tema de interés tanto a nivel individual como laboral, la desolación y desilusión que esta enfermedad causa a niveles familiares, sociales y culturales nos lleva a plantear mecanismos de defensa y manejo de esta situación. El diseño e implementación de un programa de manejo del estrés es una forma de abarcar esta problemática en la compañía, creando momentos de integración, comunicación y emotividad para lograr mejores resultados a nivel organizacional. El objetivo es poder minimizar el estrés en la organización, mediante técnicas de Mindfulness recolectando la información indicada para así y la efectividad del programa para así pronosticar intervenciones futuras en toda la organizació

Mycobacterium tuberculosis multi-drug-resistant strain M induces IL-17+ IFNγ- CD4+ T cell expansion through an IL-23 and TGF-β-dependent mechanism in patients with MDR-TB tuberculosis

We have previously reported that T cells from patients with multidrug-resistant tuberculosis (MDR-TB) express high levels of IL-17 in response to the MDR strain M(Haarlem family) of Mycobacterium tuberculosis (M.tuberculosis). Herein, we explore the pathways involved in the induction of h17 cells in MDR-TB patients and healthy tuberculin reactors (PPD+HD) by the M strain and the laboratory strain H37Rv. Our results show that IL-1β and IL-6 are crucial for the H37Rv and M-induced expansion of IL-17+IFNγ¯ and IL-17+IFNγ+ in CD4+ T cells from MDR-TB and PPD+HD. IL-23 plays an ambiguous role in Th1 and Th17 profiles: alone, IL-23 is responsible for M.tuberculosis induced IL-17 and IFNγ expression in CD4+ T cells from PPD+HD whereas, together with TGF-β, it promotes IL-17+IFNγ¯ expansion in MDR-TB. In fact, spontaneous and M.tuberculosis-induced TGF-β secretion is increased in cells from MDR-TB being theM strain the highest inducer. Interestingly, TLR-2 signaling mediates the expansion of IL-17+IFNγ¯ cells and the enhancement of latency-associated protein (LAP) expression in CD14+ and CD4+ T cells from MDR-TB, which suggests that M strain promotes IL-17+IFNγ¯ T cells through a strong TLR-2-dependent TGF-β production by antigenpresenting cells and CD4+ T cells. Finally, CD4+ T cells from MDR-TB patients infected with MDR Haarlem strains show higher IL-17+IFNγ¯ and lower IL-17+IFNγ+ levels than LAM-infected patients. The present findings deepen our understanding on the role of IL-17 in MDR-TB and highlight the influence of the genetic background of the infecting M.tuberculosis strain on the ex vivo Th17 response.Fil: Basile, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Kviatcovsky, Denise. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Romero, María Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Balboa, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Monteserin, Johana. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; ArgentinaFil: Ritacco, Gloria Viviana. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; ArgentinaFil: López, Beatriz. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; ArgentinaFil: Sabio y García, Carmen Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: García, A.. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas “Dr. Francisco Javier Muñiz”; ArgentinaFil: Vescovo, M.. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas “Dr. Francisco Javier Muñiz”; ArgentinaFil: Gonzalez Montaner, Pablo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas “Dr. Francisco Javier Muñiz”; ArgentinaFil: Palmero, Domingo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas “Dr. Francisco Javier Muñiz”; ArgentinaFil: Sasiain, María del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: de la Barrera, Silvia Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentin

Non-conservation of folding rates in the thioredoxin family reveals degradation of ancestral unassisted-folding

Evolution involves not only adaptation, but also the degradation of superfluous features. Many examples of degradation at the morphological level are known (vestigial organs, for instance). However, the impact of degradation on molecular evolution has been rarely addressed. Thioredoxins serve as general oxidoreductases in all cells. Here, we report extensive mutational analyses on the folding of modern and resurrected ancestral bacterial thioredoxins. Contrary to claims from recent literature, in vitro folding rates in the thioredoxin family are not evolutionarily conserved, but span at least a ∼100-fold range. Furthermore, modern thioredoxin folding is often substantially slower than ancestral thioredoxin folding. Unassisted folding, as probed in vitro, thus emerges as an ancestral vestigial feature that underwent degradation, plausibly upon the evolutionary emergence of efficient cellular folding assistance. More generally, our results provide evidence that degradation of ancestral features shapes, not only morphological evolution, but also the evolution of individual proteins.This research was supported by FEDER Funds, grant BIO2015-66426-R from the Spanish Ministry of Economy and Competitiveness ( J.M.S.-R.), grant RGP0041/2017 from the Human Frontier Science Program ( J.M.S.-R. and E.A.G.) and National Institutes of Health 1R01AR069137 (E.A.G.), Department of Defence MURI W911NF-16-1-0372 (E.A.G.)

Growth of the deep water rose shrimp Parapenaeus longirostris in Mauritanian waters (NW Africa)

The deep water rose shrimp Parapenaeus longirostris is the main target species of a Spanish fleet of shrimp bottom trawlers operating in the Mauritanian EEZ. The life history of this species is well known in north eastern Atlantic and Mediterranean waters, while the information is quite limited for the eastern central Atlantic. Biological samplings of the species were conducted by scientific observers onboard this fleet, from catches obtained during 17 fishing trips performed between March 2014 and June 2019. The carapace lengths (CL) of 91662 specimens (54% females and 46% males) were grouped in 33 monthly length frequency distributions. For the study of the length–age relationship, the Von Bertalanffy Growth Function (VBGF) was fit to the monthly length distributions by using the ELEFAN I routine followed by separating the frequency histograms into normal components through the Bhattacharya’s method and the NORMSEP routine. These analyses were carried out separately for males, females, and combined sexes, using the FISAT II automatic calculation program. CL of females and males ranged from 11.6 to 39.2 mm and 10.5 to 30.5 mm, respectively. Three and five modal components (annual cohorts) were identified for females and males, respectively. The growth function estimated parameters were CL∞=41.74, k=0.51 for combined sexes, CL∞= 41.67, k= 0.51 for females and CL∞= 32.24, k=0.84 for males. Estimated growth performance indices were around 2.95 for combined sexes, females and males. The estimated parameters may be used as input to test length-based methodologies for the assessment of this data-limited stock, for which only production models have been used so far

Characterisation and classification of oligometastatic disease : a European Society for Radiotherapy and Oncology and European Organisation for Research and Treatment of Cancer consensus recommendation

Oligometastatic disease has been proposed as an intermediate state between localised and systemically metastasised disease. In the absence of randomised phase 3 trials, early clinical studies show improved survival when radical local therapy is added to standard systemic therapy for oligometastatic disease. However, since no biomarker for the identification of patients with true oligometastatic disease is clinically available, the diagnosis of oligometastatic disease is based solely on imaging findings. A small number of metastases on imaging could represent different clinical scenarios, which are associated with different prognoses and might require different treatment strategies. 20 international experts including 19 members of the European Society for Radiotherapy and Oncology and European Organisation for Research and Treatment of Cancer OligoCare project developed a comprehensive system for characterisation and classification of oligometastatic disease. We first did a systematic review of the literature to identify inclusion and exclusion criteria of prospective interventional oligometastatic disease clinical trials. Next, we used a Delphi consensus process to select a total of 17 oligometastatic disease characterisation factors that should be assessed in all patients treated with radical local therapy for oligometastatic disease, both within and outside of clinical trials. Using a second round of the Delphi method, we established a decision tree for oligometastatic disease classification together with a nomenclature. We agreed oligometastatic disease as the overall umbrella term. A history of polymetastatic disease before diagnosis of oligometastatic disease was used as the criterion to differentiate between induced oligometastatic disease (previous history of polymetastatic disease) and genuine oligometastatic disease (no history of polymetastatic disease). We further subclassified genuine oligometastatic disease into repeat oligometastatic disease (previous history of oligometastatic disease) and de-novo oligometastatic disease (first time diagnosis of oligometastatic disease). In de-novo oligometastatic disease, we differentiated between synchronous and metachronous oligometastatic disease. We did a final subclassification into oligorecurrence, oligoprogression, and oligopersistence, considering whether oligometastatic disease is diagnosed during a treatment-free interval or during active systemic therapy and whether or not an oligometastatic lesion is progressing on current imaging. This oligometastatic disease classification and nomenclature needs to be prospectively evaluated by the OligoCare study

Evolutionary scenarios associated with the Pteronotus parnellii cryptic species-complex (Chiroptera: Mormoopidae).

One of the major challenges to understanding the evolution of Neotropical bats concerns our capacity to successfully scrutinize phylogenetic patterns associated with cases of cryptic species complexes. In this study Pteronotus parnellii is examined as a selected example of a known lineage of mormoopid bat that potentially contains several cryptic species. A samples of 452 individuals from 83 different localities, essentially covering its entire mainland distribution, was evaluated using two genetic markers: COI (mitochondrial) and DBY (nuclear) genes. The findings of this study strongly support the hypothesis of high genetic variability and identify at least six lineages within P. parnellii, some of which appear to be cryptic species.Peer reviewe

Renovada sismicidad superficial en el oriente venezolano después del sismo de Cariaco de julio de 1997

This research shows a clear increase in shallow seismicity in the 21st century, after the Cariaco July 09th, 1997 earthquake, from the qualitative-quantitative analysis of a more than 30-year-long record of instrumental seismicity (1983-2017). The seismic activity increase is not randomly distributed but comes in patches, which align along with the El Pilar (FEP), Los Bajos (FLB), El Soldado (FES) and Bohordal (FB) faults, very particularly with their portions close or within the Paria gulf. Equally, this seismicity occurs South of the easternmost south-dipping FEP segment, and East of the San Juan Graben fault system. No major or destructive historical and instrumental earthquake is associated to this segment for the last 520 years. From the assumption that the contiguous-to-the-west FEP segment recurs roughly every 350-450 years with an Mw +7.0 event, we invoke that stress transfer from the recently-broken 1997 segment is responsible for the unusually high crustal seismicity happening in this 21st century, activating the easternmost FEP segment as well as the mechanically interconnected southern faults. This could lead to a major destructive (eventually  tsunamigenic) earthquake on FEP in the near future. On the other hand, the higher creep (50 over 40%) and slower slip rate (10 vs 12 mm/yr) of the easternmost segment than its western contiguous segment could account for the longer return period; longer than the 350-450 year return period determined from paleoseismic trench studies undertaken across the 1997 earthquake rupture. La presente investigación muestra que la región oriental venezolana se caracteriza por una mayor actividad sísmica en el presente siglo XXI, después de la ocurrencia del sismo de Cariaco del 09 de julio de 1997 de magnitud Mw 6,9, a partir del análisis cualitativo-cuantitativo de la sismicidad instrumental sobre una ventana temporal de más de 30 años (1983-2017). Este incremento de la actividad sísmica no es aleatorio y se presenta bajo “nubes” de sismos corticales que se alinean a lo largo de las fallas El Pilar (FEP), Los Bajos (FLB), El Soldado (FES) y Bohordal (FB), particularmente en sus porciones circunscritas al golfo de Paria. Igualmente, tal sismicidad se ubica al Sur del segmento más oriental de la FEP de buzamiento sur y al Este del sistema de fallas del Graben de San Juan. A este segmento de FEP se le desconoce sismo histórico, o instrumental, destructor, de profundidad cortical, sobre al menos 520 años. Dado que el segmento contiguo al Oeste de la FEP recurre cada 350-450 años con sismos Mw +7,0, cabe proponer que la sismicidad actual inusitada, sobre FEP y todas las fallas cuaternarias mecánicamente vinculadas a ellas, resulte de transferencia de esfuerzos de la ruptura reciente del segmento al Occidente en 1997, preparando al segmento más oriental de FEP para su eventual ruptura con un sismo de capacidad destructora, Mw +7,0, con eventual asociación de tsunami (sismo tsunamigénico). El hecho de presentar un porcentaje de movimiento asísmico (creep) más elevado que aquel roto durante el sismo de Cariaco de 1997 (50% vs 40%), así como una tasa de movimiento algo más lenta también (10 vs 12 mm/a), justificaría que su período de retorno sea algo más largo que 350-450 años; éste último estimado de evaluaciones paleosísmicas para el segmento activado en 1997.&nbsp

Time series spectroscopic and photometric observations of Massive DAV BPM37093

BPM 37093 was the first of only a handful of massive (1.05+/-0.05 Msun; Bergeron et al. 2004; sitta 2000) WD pulsators discovered (Kanaan et al. 1992). These stars are particularly interesting because the exact process of core crystallization (Abrikosov 1960; Kirzhnitz 1960; Salpeter 1961). is poorly constrained by observation, yet adds a 1?2 Gyr uncertainty in the ages of the oldest white dwarf stars observed and hence, in the ages of associations that contain them. Last year, we discovered that ESO uses BPM 37093 as standard star and extracted corresponding spectra from the public archive. The data suggested a variation in the observed hydrogen line profiles that could potentially be due to pulsations, but the measurement did not reach a detection-quality threshold. To further explore this possibility, though, we obtained 4hrs of continuous time series spectroscopy of BPM37093 with Gemini in the Northern Spring of 2014. We present our preliminary results from these data along with those from the accompanying time series photometric observations we gathered from Mt. John (New Zealand), SAAO and PROMPT　to support the Gemini observations.Fil: Atsuko, Nitta. Gemini Observatory; Estados UnidosFil: Kepler, S. O.. Universidade Federal do Rio Grande do Sul; BrasilFil: Chené, André Nicholas. Gemini Observatory; Estados UnidosFil: Koester, D.. Universitat Kiel; AlemaniaFil: Provencal, J. L.. University of Delaware; DinamarcaFil: Kleinmani, S. J.. Gemini Observatory; Estados UnidosFil: Sullivan, D. J.. Victoria University of Wellington; Nueva ZelandaFil: Chote, Paul. Victoria University of Wellington; Nueva ZelandaFil: Safeco, Ramotholo. South African Astronomical Observatory; SudáfricaFil: Kanaan, A.. Universidade Federal de Santa Catarina; BrasilFil: Romero, Alejandra Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; Argentina. Universidade Federal do Rio Grande do Sul; BrasilFil: Corti, Mariela Alejandra. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas; ArgentinaFil: Kilic, Mukremin. University of Oklahoma; Estados UnidosFil: Montgomery, M. H.. University of Texas at Austin; Estados UnidosFil: Widget, D. E.. University of Texas at Austin; Estados UnidosEUROWD 14: 19th European White Dwarf WorkshopMontrealCanadáUniversidad de Montrea