Loss of redundant gene expression after polyploidization in plants

Based on chromosomal location data of genes encoding 28 biochemical systems in allohexaploid wheat,Triticum aestivum L. (genomes AABBDD), it is concluded that the proportions of systems controlled by triplicate, duplicate, and single loci are 57%, 25%, and 18% respectively

Calidad de ensilados de pradera en el Norte de España

El ensilado de pradera está tomando cada vez más importancia como base alimenticia en las épocas en que el crecimiento vegetativo de la pradera se encuentra por debajo de las necesidades alimenticias del rebaño. Aunque desde un punto de vista cuantitativo es evidente el aumento de su utilización, se carecía de datos cualitativos en cuanto a su composición y valor nutritivo, estando las producciones animales obtenidas con base en el ensilado, por debajo de lo que cabría esperar según la experiencia de la utilización de ensilado en otros países. Por ello se consideró de interés hacer una evaluación de las calidades de nuestros ensilados. El trabajo se realizó durante los años 1976 y 1977, pensándose continuar en el futuro. Los resultados del análisis muestran que efectivamente la calidad de los ensilados analizados está por debajo de lo que cabría esperar y son una llamada de atención a los ganaderos sobre la necesidad de mejorar las técnicas del ensilado, especialmente en lo referente al momento del corte

Influence of homoeologous chromosomes on gene-dosage effects in allohexaploid wheat (Triticum aestivum L.).

Gene-dosage responses for a group of six wheat endosperm proteins have been investigated by using compensated nulli-tetrasomic lines of cv. Chinese Spring. Practically linear dosage responses have been observed for all the proteins. However, for two of the proteins (and probably for a third one), the net output of protein, at each dosage of its structural gene, was 30-80% higher when the chromosome carrying an active homoeogene was absent. The possible significance of this effect in connection with the loss of gene redundancy undergone by polyploids is discussed

Póster: Clonas internacionales CC113 y CC92 de Acinetobacter baumannii no susceptibles a carbapenémicos en hospitales mexicanos: estudio multicéntrico.

Acinetobacter baumannii resistente a carbapenémicos es un patógeno nosocomial importante asociado a ciertos complejos clonales, mediada por la producción de oxacilinasas de los grupos 23, 24 y 58 cuyos genes pueden estar asociados a elementos de inserción como las ISAba. Los 192 aislamientos fueron no susceptibles a imipenem; todos fueron sensibles a tigeciclina, colistina y la blaOXA51-like. El estudio mostró una alta prevalencia de aislamientos de A. baumannii resistentes a carbapenémicos donde predominan los complejos clonales CC113 y CC92 y la regionalización en el norte de los alelos OXA-72 y en el sur del país OXA-239. Las opciones terapéuticas para combatir estas infecciones son limitadas

The effect of triple therapy on the mortality of catastrophic anti-phospholipid syndrome patients

Objectives. The objective of this study was to assess the effect that triple therapy (anticoagulation plus CS plus plasma exchange and/or IVIGs) has on the mortality risk of patients with catastrophic APS (CAPS) included in the CAPS Registry. Methods. Patients from the CAPS Registry were grouped based on their treatments: triple therapy; drugs included in the triple therapy but in different combinations; and none of the treatments included in the triple therapy. The primary endpoint was all-cause mortality. Multivariate logistic regression models were used to compare mortality risk between groups. Results. The CAPS Registry cohort included 525 episodes of CAPS accounting for 502 patients. After excluding 54 episodes (10.3%), a total of 471 patients with CAPS were included [mean (S.D.) age 38.5 years (17); 68.2% female primary APS patients 62%]. Overall, 174 (36.9%) patients died. Triple therapy was prescribed in 189 episodes (40.1%), other combinations in 270 (57.3%) and none of those treatments in 12 episodes (2.5%); the mortality rate in the three groups was 28.6, 41.1 and 75%, respectively. Triple therapy was positively associated with a higher chance of survival when compared with non-treatment [adjusted odds ratio (OR) = 9.7, 95% CI: 2.3, 40.6] or treatment with other combinations of drugs included in the triple therapy (adjusted OR = 1.7, 95% CI: 1.2, 2.6). No statistical differences were found between patients that received triple therapy with plasma exchange or IVIGs (P = 0.92). Conclusion. Triple therapy is independently associated with a higher survival rate among patients with CAPS. © The Author(s) 2018. Published by Oxford University Press on behalf of the British Society for Rheumatology