299 research outputs found
EpimerisierungsdomÀnen aus Peptidsynthetasen - Untersuchungen zur SubstratspezifitÀt und zur Interaktion mit anderen DomÀnen
Modeling and numerical study of primary breakup under diesel conditions
A recently introduced stochastic model for reduced numerical simulation of primary jet breakup is evaluated by comparing model predictions to DNS results for primary jet breakup under diesel conditions. The model uses one-dimensional turbulence (ODT) to simulate liquid and gas time advancement along a lateral line of sight. This one-dimensional domain is interpreted as a Lagrangian object that is advected downstream at the jet bulk velocity, thus producing a flow state expressed as a function of streamwise and lateral location. Multiple realizations are run to gather ensemble statistics that are compared to DNS results. The model incorporates several empirical extensions of the original ODT model that represent the phenomenology governing the Weber number dependence of global jet structure. The model as previously formulated, including the assigned values of tunable parameters, is used here without modification in order to test its capability to predict various statistics of droplets generated by primary breakup. This test is enabled by the availability of DNS results that are suitable for model validation. Properties that are examined are the rate of bulk liquid mass conversion into droplets, the droplet size distribution, and the dependence of droplet velocities on droplet diameter. Quantities of greatest importance for engine modeling are found to be predicted with useful accuracy, thereby demonstrating a more detailed predictive capability by a highly reduced numerical model of primary jet breakup than has previously been achieved
Orientational order parameters of a de Vriesâtype ferroelectric liquid crystal obtained by polarized Raman spectroscopy and x-ray diffraction
The orientational order parameters â©P2âȘ and â©P4âȘ of the ferroelectric, de Vriesâtype liquid crystal 9HL have been determined in the SmA* and SmC* phases by means of polarized Raman spectroscopy, and in the SmA* phase using x-ray diffraction. Quantum density functional theory predicts Raman spectra for 9HL that are in good agreement with the observations and indicates that the strong Raman band probed in the experiment corresponds to the uniaxial, coupled vibration of the three phenyl rings along the molecular long axis. The magnitudes of the orientational order parameters obtained in the Raman and x-ray experiments differ dramatically from each other, a discrepancy that is resolved by considering that the two techniques probe the orientational distributions of different molecular axes. We have developed a systematic procedure in which we calculate the angle between these axes and rescale the orientational order parameters obtained from x-ray scattering with results that are then in good agreement with the Raman data. At least in the case of 9HL, the results obtained by both techniques support a âsugar loafâ orientational distribution in the SmA* phase with no qualitative difference to conventional smectics A. The role of individual molecular fragments in promoting de Vriesâtype behavior is considered
Contribution of SERCA and IP3 sensitivity to calcium signaling in astrocytes: a computational study
Effect of physical activity intervention based on a pedometer on physical activity level and anthropometric measures after childbirth: a randomized controlled trial
<p>Abstract</p> <p>Background</p> <p>Pregnancy and childbirth are associated with weight gain in women, and retention of weight gained during pregnancy can lead to obesity in later life. Diet and physical activity are factors that can influence the loss of retained pregnancy weight after birth. Exercise guidelines exist for pregnancy, but recommendations for exercise after childbirth are virtually nonexistent. The aim of this study was to evaluate the effect of physical activity intervention based on pedometer on physical activity level and anthropometric measures of women after childbirth.</p> <p>Methods</p> <p>We conducted a randomized controlled trial in which 66 women who had given birth 6 weeks to 6 months prior were randomly assigned to receive either a 12 week tailored program encouraging increased walking using a pedometer (intervention group, n = 32) or routine postpartum care (control group, n = 34). During the 12-week study period, each woman in the intervention group wore a pedometer and recorded her daily step count. The women were advised to increase their steps by 500 per week until they achieved the first target of 5000 steps per day and then continued to increase it to minimum of 10,000 steps per day by the end of 12<sup>th </sup>week. Assessed outcomes included anthropometric measures, physical activity level, and energy expenditure per week. Data were analyzed using the paired t-test, independent t-test, Mann-Whitney, chi-square, Wilcoxon, covariance analysis, and the general linear model repeated measures procedure as appropriate.</p> <p>Results</p> <p>After 12 weeks, women in the intervention group had significantly increased their physical activity and energy expenditure per week (4394 vs. 1651 calorie, <it>p </it>< 0.001). Significant differences between-group in weight (<it>P </it>= 0.001), Body Mass Index (<it>P </it>= 0.001), waist circumference (<it>P </it>= 0.001), hip circumference (<it>P </it>= 0.032) and waist-hip ratio (<it>P </it>= 0.02) were presented after the intervention. The intervention group significantly increased their mean daily step count over the study period (from 3249 before, to 9960 after the intervention, <it>p </it>< 0.001).</p> <p>Conclusion</p> <p>A physical activity intervention based on pedometer is an effective means to increase physical activity; reducing retention of weight gained during pregnancy and can improve anthropometric measures in postpartum women.</p> <p>Trial registration</p> <p>ISRCTN: <a href="http://www.controlled-trials.com/IRCT201105026362N1">IRCT201105026362N1</a></p
A Pregnancy and Postpartum Lifestyle Intervention in Women With Gestational Diabetes Mellitus Reduces Diabetes Risk Factors : A feasibility randomized control trial
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Application of X-ray micro-computed tomography on high-speed cavitating diesel fuel flows
The flow inside a purpose built enlarged single-orifice nozzle replica is quantified using time-averaged X-ray micro-computed tomography (micro-CT) and high-speed shadowgraphy. Results have been obtained at Reynolds and cavitation numbers similar to those of real-size injectors. Good agreement for the cavitation extent inside the orifice is found between the micro-CT and the corresponding temporal mean 2D cavitation image, as captured by the high-speed camera. However, the internal 3D structure of the developing cavitation cloud reveals a hollow vapour cloud ring formed at the hole entrance and extending only at the lower part of the hole due to the asymmetric flow entry. Moreover, the cavitation volume fraction exhibits a significant gradient along the orifice volume. The cavitation number and the needle valve lift seem to be the most influential operating parameters, while the Reynolds number seems to have only small effect for the range of values tested. Overall, the study demonstrates that use of micro-CT can be a reliable tool for cavitation in nozzle orifices operating under nominal steady-state conditions
Effects of an interactive CD-program on 6 months readmission rate in patients with heart failure â a randomised, controlled trial [NCT00311194]
BACKGROUND: Disease-management programmes including patient education have promoted improvement in outcome for patients with heart failure. However, there is sparse evidence concerning which component is essential for success, and very little is known regarding the validity of methods or material used for the education. METHODS: Effects of standard information to heart failure patients given prior to discharge from hospital were compared with additional education by an interactive program on all-cause readmission or death within 6 months. As a secondary endpoint, patients' general knowledge of heart failure and its treatment was tested after 2 months. RESULTS: Two hundred and thirty patients were randomised to standard information (S) or additional CD-ROM education (E). In (S) 52 % reached the endpoint vs. 49 % in (E). This difference was not significant. Of those who completed the questionnaire (37 %), patients in (E) achieved better knowledge and a marginally better outcome. CONCLUSION: The lack of effect on the readmission rate could be due to an insufficient sample size but might also indicate that in pharmacologically well-treated patients there is little room for altering the course of the condition. As there was some indication that patients who knew more about their condition might fare better, the place for intensive education and support of heart failure patients has yet to be determined
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Multiphase phenomena in Diesel fuel injection systems
Fuel Injection Equipment (FIE) are an integral component of modern Internal Combustion Engines (ICE), since they play a crucial role in the fuel atomization process and in the formation of a fuel/air combustible mixture, consequently affecting efficiency and pollutant formation. Advancements and improvements of FIE systems are determined by the complexity of the physical mechanisms taking place; the spatial scales are in the order of millimetres, flow may become locally highly supersonic, leading to very small temporal scales of microseconds or less. The operation of these devices is highly unsteady, involving moving geometries such as needle valves. Additionally, extreme pressure changes imply that many assumptions of traditional fluid mechanics, such as incompressibility, are no longer valid. Furthermore, the description of the fuel properties becomes an issue, since fuel databases are scarce or limited to pure components, whereas actual fuels are commonly hydrocarbon mixtures. Last but not least, complicated phenomena such as phase change or transition from subcritical to transcritical/supercritical state of matter further pose complications in the understanding of the operation of these devices
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