1,190 research outputs found
Avian cerebellar floccular fossa size is not a proxy for flying ability in birds
Extinct animal behavior has often been inferred from qualitative assessments of relative brain region size in fossil endocranial casts. For instance, flight capability in pterosaurs and early birds has been inferred from the relative size of the cerebellar flocculus, which in life protrudes from the lateral surface of the cerebellum. A primary role of the flocculus is to integrate sensory information about head rotation and translation to stabilize visual gaze via the vestibulo-occular reflex (VOR). Because gaze stabilization is a critical aspect of flight, some authors have suggested that the flocculus is enlarged in flying species. Whether this can be further extended to a floccular expansion in highly maneuverable flying species or floccular reduction in flightless species is unknown. Here, we used micro computed-tomography to reconstruct “virtual” endocranial casts of 60 extant bird species, to extract the same level of anatomical information offered by fossils. Volumes of the floccular fossa and entire brain cavity were measured and these values correlated with four indices of flying behavior. Although a weak positive relationship was found between floccular fossa size and brachial index, no significant relationship was found between floccular fossa size and any other flight mode classification. These findings could be the result of the bony endocranium inaccurately reflecting the size of the neural flocculus, but might also reflect the importance of the flocculus for all modes of locomotion in birds. We therefore conclude that the relative size of the flocculus of endocranial casts is an unreliable predictor of locomotor behavior in extinct birds, and probably also pterosaurs and non-avian dinosaurs
Tolerance without clonal expansion: Self-antigen-expressing B cells program self-reactive T cells for future deletion
B cells have been shown in various animal models to induce immunological tolerance leading to reduced immune responses and protection from autoimmunity. We show that interaction of B cells with naive T cells results in T cell triggering accompanied by the expression of negative costimulatory molecules such as PD-1, CTLA-4, B and T lymphocyte attenuator, and CD5. Following interaction with B cells, T cells were not induced to proliferate, in a process that was dependent on their expression of PD-1 and CTLA-4, but not CD5. In contrast, the T cells became sensitive to Ag-induced cell death. Our results demonstrate that B cells participate in the homeostasis of the immune system by ablation of conventional self-reactive T cells
Low-rank multi-parametric covariance identification
We propose a differential geometric construction for families of low-rank
covariance matrices, via interpolation on low-rank matrix manifolds. In
contrast with standard parametric covariance classes, these families offer
significant flexibility for problem-specific tailoring via the choice of
"anchor" matrices for the interpolation. Moreover, their low-rank facilitates
computational tractability in high dimensions and with limited data. We employ
these covariance families for both interpolation and identification, where the
latter problem comprises selecting the most representative member of the
covariance family given a data set. In this setting, standard procedures such
as maximum likelihood estimation are nontrivial because the covariance family
is rank-deficient; we resolve this issue by casting the identification problem
as distance minimization. We demonstrate the power of these differential
geometric families for interpolation and identification in a practical
application: wind field covariance approximation for unmanned aerial vehicle
navigation
Gingival and submandibular lymph node metastasis of sigmoid colon adenocarcinoma
Introduction: Metastatic tumors of oral and maxillofacial region compromise 1% of all malignant oral neoplasms.
Most commonly affect the jaw bone and less commonly intraoral soft tissues. They originate mainly from primary
tumors of lung, breast, colon-rectum, prostate and kidney. Case report: a 77 years old man with history of sigmoid
colon adenocarcinoma and liver metastasis. Two years later of being free of disease, he presented with submandi-
bular lymphadenopathy and a gingival mass in right upper jaw. Fine needle aspiration of the node and biopsy of
the gingival mass were performed. The cytological smears showed cohesive cell groups on a necrotic background.
Biopsy examination showed subepithelial infiltration by neoplasm of glandular pattern with immunoreactivity for
keratin 20 and carcinoembryonic antigen. A definitive diagnosis of node and oral metastases of colon adenocarcinoma was made. Discussion: Metastases in the oral and maxillofacial region are very uncommon and usually
represent an advanced stage and disseminated disease. They present non specific radiologic and clinical features
so it is imperative to reach a definitive diagnosis the cytological/histological examination. Because of its rarity, the
diagnosis of metastases in the oral region are a challenging, both to the clinician and to the pathologist, in recogni-
sing that a lesion is metastasic and in determining the site of origi
A revised position for the rotated Falkland Islands microplate
The early stages of transform margin formation are associated with crustal fragmentation and block rotation. The restricted size of the resultant microcontinental blocks precludes palaeogeographical reconstructions and reliable estimations of the amount of rotation they can undergo. An example considered here is the Falkland Plateau. This is located adjacent to the Agulhas–Falkland Fracture Zone and its westernmost province is the Falkland Islands microcontinent. The position of the plateau and the islands prior to Gondwana break-up remains contentious. This study integrates seismic reflection and gravity data to propose a revised position of the Falkland Islands microcontinent constrained by (1) the presence of a mega-décollement, controlling the Gondwanide Orogen, described north of the Falkland Islands and underneath South Africa and the Outeniqua Basin, and (2) the similar architecture of fault networks mapped north of the islands and in the northernmost Outeniqua Basin. This revised position requires a re-evaluation of the timing and rate of rotation of the Falkland Islands microcontinent and affects the expected crustal architecture adjacent to the islands. Our model yields rotation rates between 5.5° and 8° Ma−1 and two potential times for rotation, and predicts more unstretched crust beneath the basin east of the Falkland Islands than previous model
The speaking vocabulary of 454 third grade children.
Thesis (Ed.M.)--Boston Universit
Characterisation of the fouling of an ultrafiltration polyethersulfone membrane fouled by an emulsion modelling lipids issued from Microalgae
International audienc
Injected Power Fluctuations in 1D Dissipative Systems
Using fermionic techniques, we compute exactly the large deviation function
(ldf) of the time-integrated injected power in several one-dimensional
dissipative systems of classical spins. The dynamics are T=0 Glauber dynamics
supplemented by an injection mechanism, which is taken as a Poissonian flipping
of one particular spin. We discuss the physical content of the results,
specifically the influence of the rate of the Poisson process on the properties
of the ldf.Comment: 18 pages, 8 figure
MiR393 regulation of auxin signaling and redox-related components during acclimation to salinity in Arabidopsis
One of the most striking aspects of plant plasticity is the modulation of development in response to environmental changes. Plant growth and development largely depend on the phytohormone auxin that exerts its function through a partially redundant family of F-box receptors, the TIR1-AFBs. We have previously reported that the Arabidopsis double mutant tir1 afb2 is more tolerant to salt stress than wild-type plants and we hypothesized that down-regulation of auxin signaling might be part of Arabidopsis acclimation to salinity. In this work, we show that NaCl-mediated salt stress induces miR393 expression by enhancing the transcription of AtMIR393A and leads to a concomitant reduction in the levels of the TIR1 and AFB2 receptors. Consequently, NaCl triggers stabilization of Aux/IAA repressors leading to down-regulation of auxin signaling. Further, we report that miR393 is likely involved in repression of lateral root (LR) initiation, emergence and elongation during salinity, since the mir393ab mutant shows reduced inhibition of emergent and mature LR number and length upon NaCl-treatment. Additionally, mir393ab mutant plants have increased levels of reactive oxygen species (ROS) in LRs, and reduced ascorbate peroxidase (APX) enzymatic activity compared with wild-type plants during salinity. Thus, miR393 regulation of the TIR1 and AFB2 receptors could be a critical checkpoint between auxin signaling and specfic redoxassociated components in order to coordinate tissue and time-specific growth responses and tolerance during acclimation to salinity in Arabidopsis.Instituto de Fisiología Vegeta
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