βCaMKII regulates bidirectional long-term plasticity in cerebellar Purkinje cells by a CaMKII/PP2B switch mechanism

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise statedPeer reviewe

Are residential and nursing homes adequately screening overseas healthcare workers?

<p>Abstract</p> <p>Background</p> <p>There has been significant growth in the number of healthcare workers born outside the UK or recruited to the UK from countries with a high prevalence of TB, Hepatitis and other blood borne infections. Government policy recognises the need for occupational health procedures to facilitate treatment for these individuals and to reduce the risk of transmission of disease to patients.</p> <p>The aim of this study was to undertake a survey of nursing and residential homes in South East England, to assess whether homes had occupational health screening policies for healthcare workers who have originated from overseas, and what level of occupational health screening had been undertaken on these employees.</p> <p>Methods</p> <p>An anonymous survey was sent to all 500 homes in West Sussex assessing occupational health practices for "overseas health care workers", defined as health care workers who had been born outside the UK.</p> <p>Results</p> <p>Only one employer (0.8%) reported they had an occupational health screening policy specific for healthcare workers who originate from overseas. Over 80% of homes who had recruited directly had no evidence of screening results for HIV, TB, Hepatitis B and C. The commonest countries of origin for staff were the UK, Philippines, Poland, South Africa, Zimbabwe, and India.</p> <p>Conclusion</p> <p>This study suggests that screening of overseas healthcare workers is not routine practice for residential or nursing care homes and requires further input from Primary Care Trust's, Health Care Commission, Commission for Social Care Inspection, and Professional bodies.</p

Kinematics of Interstellar Gas in Nearby UV-Selected Galaxies Measured with HST/STIS Spectroscopy

We measure Doppler shifts of interstellar absorption lines in HST/STIS spectra of individual star clusters in nearby UV-selected galaxies. Values for systemic velocities, which are needed to quantify outflow speeds, are taken from the literature, and verified with stellar lines. We detect outflowing gas in eight of 17 galaxies via low-ionization lines (e.g., CII, SiII, AlII), which trace cold and/or warm gas. The starbursts in our sample are intermediate in luminosity (and mass) to dwarf galaxies and luminous infrared galaxies (LIRGs), and we confirm that their outflow speeds (ranging from -100 km/s to nearly -520 km/s with an accuracy of ~80 km/s) are intermediate to those previously measured in dwarf starbursts and LIRGs. We do not detect the outflow in high-ionization lines (such as CIV or SiIV); higher quality data will be needed to empirically establish how velocities vary with the ionization state of the outflow. We do verify that the low-ionization UV lines and optical NaI doublet give roughly consistent outflow velocities solidifying an important link between studies of galactic winds at low and high redshift. To obtain higher signal-to-noise, we create a local average composite spectrum, and compare it to the high-z Lyman Break composite spectrum. Surprisingly, the low-ionization lines show similar outflow velocities in the two samples. We attribute this to a combination of weighting towards higher luminosities in the local composite, as well as both samples being on average brighter than the ``turnover'' luminosity in the v-SFR relation.Comment: 41 pages, 14 figures, accepted for publication in The Astrophysical Journa

Distances to Galactic high-velocity clouds. Complex C

We report the first determination of a distance bracket for the high-velocity cloud (HVC) complex C. Combined with previous measurements showing that this cloud has a metallicity of 0.15 times solar, these results provide ample evidence that complex C traces the continuing accretion of intergalactic gas falling onto the Milky Way. Accounting for both neutral and ionized hydrogen as well as He, the distance bracket implies a mass of 3-14x10^6 M_sun, and the complex represents a mass inflow of 0.1-0.25 M_sun/yr. We base our distance bracket on the detection of CaII absorption in the spectrum of the blue horizontal branch star SDSS J120404.78+623345.6, in combination with a significant non-detection toward the BHB star BS 16034-0114. These results set a strong distance bracket of 3.7-11.2 kpc on the distance to complex C. A more weakly supported lower limit of 6.7 kpc may be derived from the spectrum of the BHB star BS 16079-0017.Comment: Accepted for publication in ApJ Letter

A Chandra Observation of the Nearby Lenticular Galaxy NGC 5102: Where are the X-ray Binaries?

We present results from a 34 ks Chandra/ACIS-S observation of the nearby (d=3.1 Mpc) lenticular galaxy NGC 5102, previously shown to have an unusually low X-ray luminosity. We detect eleven X-ray point sources within the the $D_{25}$ optical boundary of the galaxy (93% of the light), one third to one half of which are likely to be background AGN. One source is coincident with the optical nucleus and may be a low-luminosity AGN. Only two sources with an X-ray luminosity greater than 10$^{37}$ ergs s$^{-1}$ in the 0.5-5.0 keV band were detected, one of which is statistically likely to be a background AGN. We expected to detect 6 such luminous sources if the XRB population scales linearly with optical magnitude of the host galaxy. NGC 5102 has an unusually low number of XRBs. NGC 5102 is unusually blue for its morphological type, and has undergone at least two recent bursts of star formation. We present the results of optical/UV spectral synthesis analysis and demonstrate that a significant fraction ($>$50%) of the stars in this galaxy are comparatively young ($<3\times10^9$ years old). If the lack of X-ray binaries is related to the relative youth of most of the stars, this would support models of LMXB formation and evolution that require wide binaries to shed angular momentum on a timescale of Gyrs. We find that NGC 5102 has an unusually low specific frequency of globular clusters ($S_N\sim$0.4), which could also explain the lack of LMXBs. We also detect diffuse X-ray emission in the central $\sim$1 kpc of the galaxy. This hot gas is most likely a superbubble created by multiple supernovae of massive stars born during the most recent star burst, and is driving the shock into the ISM which was inferred from optical observations.Comment: 33 pages, 7 figures, 6 tables - Accepted for publication in the Astrophysical Journa

GABAergic Neuron-Specific Loss of Ube3a Causes Angelman Syndrome-Like EEG Abnormalities and Enhances Seizure Susceptibility

Loss of maternal UBE3A causes Angelman syndrome (AS), a neurodevelopmental disorder associated with severe epilepsy. We previously implicated GABAergic deficits onto layer (L) 2/3 pyramidal neurons in the pathogenesis of neocortical hyperexcitability, and perhaps epilepsy, in AS model mice. Here we investigate consequences of selective Ube3a loss from either GABAergic or glutamatergic neurons, focusing on the development of hyperexcitability within L2/3 neocortex and in broader circuit and behavioral contexts. We find that GABAergic Ube3a loss causes AS-like increases in neocortical EEG delta power, enhances seizure susceptibility, and leads to presynaptic accumulation of clathrin-coated vesicles (CCVs) – all without decreasing GABAergic inhibition onto L2/3 pyramidal neurons. Conversely, glutamatergic Ube3a loss fails to yield EEG abnormalities, seizures, or associated CCV phenotypes, despite impairing tonic inhibition onto L2/3 pyramidal neurons. These results substantiate GABAergic Ube3a loss as the principal cause of circuit hyperexcitability in AS mice, lending insight into ictogenic mechanisms in AS

Hot and Diffuse Clouds near the Galactic Center Probed by Metastable H3+

Using an absorption line from the metastable (J, K) = (3, 3) level of H3+ together with other lines of H3+ and CO observed along several sightlines, we have discovered a vast amount of high temperature (T ~ 250 K) and low density (n ~ 100 cm-3) gas with a large velocity dispersion in the Central Molecular Zone (CMZ) of the Galaxy, i.e., within 200 pc of the center. Approximately three fourths of the H3+ along the line of sight to the brightest source we observed, the Quintuplet object GCS 3-2, is inferred to be in the CMZ, with the remaining H3+ located in intervening spiral arms. About half of H3+ in the CMZ has velocities near ~ - 100 km s-1 indicating that it is associated with the 180 pc radius Expanding Molecular Ring which approximately forms outer boundary of the CMZ. The other half, with velocities of ~ - 50 km s-1 and ~ 0 km s-1, is probably closer to the center. CO is not very abundant in those clouds. Hot and diffuse gas in which the (3, 3) level is populated was not detected toward several dense clouds and diffuse clouds in the Galactic disk where large column densities of colder H3+ have been reported previously. Thus the newly discovered environment appears to be unique to the CMZ. The large observed H3+ column densities in the CMZ suggests an ionization rate much higher than in the diffuse interstellar medium in the Galactic disk. Our finding that the H3+ in the CMZ is almost entirely in diffuse clouds indicates that the reported volume filling factor (f &#8805; 0.1) for n &#8805; 104 cm-3 clouds in the CMZ is an overestimate by at least an order of magnitude.Comment: 33 pages, 5 figures, 3 table

The Contribution of HI-Rich Galaxies to the Damped Absorber Population at z=0

We present a study of HI-rich galaxies in the local universe selected from blind emission-line surveys. These galaxies represent the emission-line counterparts of local damped Lyman-alpha systems. We find that the HI cross-section of galaxies is drawn from a large range of galaxy masses below M_star, 66% of the area comes from galaxies in the range 8.5 < Log M_star < 9.7. Both because of the low mass galaxy contribution, and because of the range of galaxy types and luminosities at any given HI mass, the galaxies contributing to the HI cross-section are not exclusively L_star spirals, as is often expected. The optical and near infrared counterparts of these galaxies cover a range of types (from spirals to irregulars), luminosities (from L_star to <0.01 L_star), and surface brightnesses. The range of optical and near infrared properties as well as the kinematics for this population are consistent with the properties for the low-z damped Lyman-alpha absorbers. We also show that the number of HI-rich galaxies in the local universe does not preclude evolution of the low-z damped absorber population, but it is consistent with no evolution.Comment: 10 pages, 7 figures. To appear in "Extragalactic Gas at Low Redshift" (ASP Conf. Series, Weymann Conf.

A long-period Cepheid variable in the starburst cluster VdBH222

Galactic starburst clusters play a twin role in astrophysics, serving as laboratories for the study of stellar physics and also delineating the structure and recent star formation history of the Milky Way. In order to exploit these opportunities we have undertaken a multi-epoch spectroscopic survey of the red supergiant dominated young massive clusters thought to be present at both near and far ends of the Galactic Bar. Significant spectroscopic variability suggestive of radial pulsations was found for the yellow supergiant VdBH 222 #505. Follow-up photometric investigations revealed modulation with a period of ~23.325d; both timescale and pulsational profile are consistent with a Cepheid classification. As a consequence #505 may be recognised as one of the longest period Galactic cluster Cepheids identified to date and hence of considerable use in constraining the bright end of the period/luminosity relation at solar metallicities. In conjunction with extant photometry we infer a distance of ~6kpc for VdBH222 and an age of ~20Myr. This results in a moderate reduction in both integrated cluster mass (~2x10^4Msun) and the initial stellar masses of the evolved cluster members (~10Msun). As such, VdBH222 becomes an excellent test-bed for studying the properties of some of the lowest mass stars observed to undergo type-II supernovae. Moreover, the distance is in tension with a location of VdBH 222 at the far end of the Galactic Bar. Instead a birthsite in the near 3kpc arm is suggested; providing compelling evidence of extensive recent star formation in a region of the inner Milky Way which has hitherto been thought to be devoid of such activity