Motivators of adopting social computing in global software development: Initial results

context: Real-time collaboration is critical for developing high quality software systems at low cost in a geographically distributed Global Software Development (GSD) environment. It is anticipated that emerging Social Computing tools can play an important role in facilitating realtime effective collaboration among teams working in the GSD. Objective: The objective of this research paper is to identify motivators for adopting social computing in GSD organizations. Method: We adopted a Systematic Literature Review (SLR) approach by applying customized search strings derived from our research questions. Results: We have identified factors such as real-time communication and coordination, information sharing, knowledge acquisition and expert feedback as key motivators for adoption of social computing in GSD. Conclusion: Based on the SLR results, we suggest that GSD organizations should embrace social computing as a tool for real-time collaboration between distributed GSD teams. The results of this initial study also suggest the need for developing the social computing strategies and policies to guide the effective social computing adoption by GSD teams

Synthetic induction of immunogenic cell death by genetic stimulation of endoplasmic reticulum stress.

Cis-diamminedichloridoplatinum(II) (CDDP), commonly referred to as cisplatin, is a chemotherapeutic drug used for the treatment of a wide range of solid cancers. CDDP is a relatively poor inducer of immunogenic cell death (ICD), a cell death modality that converts dying cells into a tumor vaccine, stimulating an immune response against residual cancer cells that permits long-lasting immunity and a corresponding reduction in tumor growth. The incapacity of CDDP to trigger ICD is at least partially due to its failure to stimulate the premortem endoplasmic reticulum (ER)-stress response required for the externalization of the "eat-me" signal calreticulin (CRT) on the surface of dying cancer cells. Here, we developed a murine cancer cell line genetically modified to express the ER resident protein reticulon-1c (Rtn-1c) by virtue of tetracycline induction and showed that enforced Rtn-1c expression combined with CDDP treatment promoted CRT externalization to the surface of cancer cells. In contrast to single agent treatments, the tetracycline-mediated Rtn-1c induction combined with CDDP chemotherapy stimulated ICD as measured by the capacity of dying tumor cells, inoculated into syngenic immunocompetent mice, to mount an immune response to tumor re-challenge 1 week later. More importantly, established tumors, forced to constitutively express Rtn-1c in vivo by continuous treatment with tetracycline, became responsive to CDDP and exhibited a corresponding reduction in the rate of tumor growth. The combined therapeutic effects of Rtn-1c induction with CDDP treatment was only detected in the context of an intact immune system and not in nu/nu mice lacking thymus-dependent T lymphocytes. Altogether, these results indicate that the artificial or "synthetic" induction of immunogenic cell death by genetic manipulation of the ER-stress response can improve the efficacy of chemotherapy with CDDP by stimulating anticancer immunity

A numerical model of two-phase flow at the micro-scale using the volume-of-fluid method

This study presents a simple and robust numerical scheme to model two-phase flow in porous media where capillary forces dominate over viscous effects. The volume-of-fluid method is employed to capture the fluid-fluid interface whose dynamics is explicitly described based on a finite volume discretization of the Navier–Stokes equations. Interfacial forces are calculated directly on reconstructed interface elements such that the total curvature is preserved. The computed interfacial forces are explicitly added to the Navier–Stokes equations using a sharp formulation which effectively eliminates spurious currents. The stability and accuracy of the implemented scheme is validated on several two- and three-dimensional test cases, which indicate the capability of the method to model two-phase flow processes at the micro-scale. In particular we show how the co-current flow of two viscous fluids leads to greatly enhanced flow conductance for the wetting phase in corners of the pore space, compared to a case where the non-wetting phase is an inviscid gas

Energy Efficient Service Distribution in Internet of Things

The Internet of Things (IoT) networks are expected to involve myriad of devices, ranging from simple sensors to powerful single board computers and smart phones. The great advancement in computational power of embedded technologies have enabled the integration of these devices into the IoT network, allowing for cloud functionalities to be extended near to the source of data. In this paper we study a multi-layer distributed IoT architecture supported by fog and cloud. We optimize the placement of the IoT services in this architecture so that the total power consumption is minimized. Our results show that, introducing local computation at the IoT layer can bring up to 90% power savings compared with general purpose servers in a central cloud

Energy Efficient Service Distribution in Internet of Things

The Internet of Things (IoT) networks are expected to involve myriad of devices, ranging from simple sensors to powerful single board computers and smart phones. The great advancement in computational power of embedded technologies have enabled the integration of these devices into the IoT network, allowing for cloud functionalities to be extended near to the source of data. In this paper we study a multi-layer distributed IoT architecture supported by fog and cloud. We optimize the placement of the IoT services in this architecture so that the total power consumption is minimized. Our results show that, introducing local computation at the IoT layer can bring up to 90% power savings compared with general purpose servers in a central cloud

Noiseless nonreciprocity in a parametric active device

Nonreciprocal devices such as circulators and isolators belong to an important class of microwave components employed in applications like the measurement of mesoscopic circuits at cryogenic temperatures. The measurement protocols usually involve an amplification chain which relies on circulators to separate input and output channels and to suppress backaction from different stages on the sample under test. In these devices the usual reciprocal symmetry of circuits is broken by the phenomenon of Faraday rotation based on magnetic materials and fields. However, magnets are averse to on-chip integration, and magnetic fields are deleterious to delicate superconducting devices. Here we present a new proposal combining two stages of parametric modulation emulating the action of a circulator. It is devoid of magnetic components and suitable for on-chip integration. As the design is free of any dissipative elements and based on reversible operation, the device operates noiselessly, giving it an important advantage over other nonreciprocal active devices for quantum information processing applications.Comment: 17 pages, 4 figures + 12 pages Supplementary Informatio

Empirical Investigation of Critical Requirements Engineering Practices for Global Software Development

There is a need to identify requirements engineering (RE) practices that are important to global software development (GSD) project success. The objective of this paper is to report our recent empirical study results which aimed to identify the RE practices that are important to GSD projects. This study used an online survey questionnaire to elicit data from 56 RE experts of GSD projects. The survey included 66 RE practices identified by Sommerville et al. for non-GSD projects. The participants were asked to rank each RE practice on a four-point scale to determine the degree of importance of each practice in the context of GSD projects. This research identified a set of six key RE practices that mainly focuses on GSD project stakeholders, scope, standards and requirements traceability management. One common theme that is evident from the RE experts' feedback analysis is the standardization of requirements documents to reduce requirements inconsistencies and improve communication in diverse and distributed GSD project environments Our results show that not all 66 RE best practices are important for GSD projects. We believe that a good understanding of the identified RE practices is vital in developing and implementing the situation-specific RE processes for GSD projects

Depression and self-esteem among Afghan school-going adolescents under the Taliban government: a cross-sectional study

Background: During the period of adolescence, several major developmental changes occur that can have significant impact on an individual’s brain structure and functioning through their entire life. Aims: The present study aimed to examine the association between depression and self-esteem alongside specific sociodemographic factors among school-going adolescents living under the rule of Taliban. Methods: A cross-sectional survey study was conducted with adolescents (n = 452) from 20 randomly selected public primary, secondary and high schools of Herat province (Afghanistan) out of the 86 schools registered in Herat Education Department. The survey included the Center for Epidemiological Studies-Depression Scale (CES-D) and Rosenberg's Self-Esteem Scale (RSES). Results: Two-thirds of adolescents reported depression symptoms (65.3%) and 86.3% reported poor self-esteem. Multiple regression analysis indicated that (i) mother's education level was significantly associated with depression symptoms and (ii) low-income economic status was significantly associated with self-esteem. Conclusion: As well as being one of the few studies in Afghanistan, the present study is one of the very few to assess the association between class group, self-esteem, and depression symptoms. These findings may be used by healthcare authorities and school administrators to raise awareness and implement strategies to facilitate self-esteem among school school-going adolescents

Low-carbon transition through a duty to divest: Back to the future, ahead to the past

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