4,261 research outputs found
Estimation of the material budget of the LHCb detector
The material budget of the LHCb detector at the time of the DC 06 data challenge is estimated
Branch Module for an Inductive Voltage Adder for Driving Kicker Magnets with a Short Circuit Termination
For driving kicker magnets terminated in a short circuit, a branch module for an inductive voltage adder has been designed and assembled. The module has been designed for a maximum charging voltage of 1.2 kV and an output current of 200 A considering the current doubling due to the short circuit termination. It features three consecutive modes of operation: energy injection, freewheeling, and energy extraction. Therefore, the topology of the branch module consists of two independently controlled SiC MOSFET switches and one diode switch. In order not to extend the field rise time of the kicker magnet significantly beyond the magnet fill time, the pulse must have a fast rise time. Hence, the switch for energy injection is driven by a gate boosting driver featuring a half bridge of GaN HEMTs and a driving voltage of 80 V. Measurements of the drain source voltage of this switch showed a fall time of 2.7 ns at a voltage of 600 V resulting in a voltage rise time of 5.4 ns at the output terminated with a resistive load. To meet both the rise time and current requirements, a parallel configuration of four SiC MOSFETs was implemented
Bubble concentration on spheres for supercritical elliptic problems
We consider the supercritical Lane-Emden problem (P_\eps)\qquad
-\Delta v= |v|^{p_\eps-1} v \ \hbox{in}\ \mathcal{A} ,\quad u=0\ \hbox{on}\
\partial\mathcal{A}
where is an annulus in \rr^{2m}, and
p_\eps={(m+1)+2\over(m+1)-2}-\eps, \eps>0.
We prove the existence of positive and sign changing solutions of (P_\eps)
concentrating and blowing-up, as \eps\to0, on dimensional spheres.
Using a reduction method (see Ruf-Srikanth (2010) J. Eur. Math. Soc. and
Pacella-Srikanth (2012) arXiv:1210.0782)we transform problem (P_\eps) into a
nonhomogeneous problem in an annulus \mathcal D\subset \rr^{m+1} which can be
solved by a Ljapunov-Schmidt finite dimensional reduction
Proposal to Search for Heavy Neutral Leptons at the SPS
A new fixed-target experiment at the CERN SPS accelerator is proposed that
will use decays of charm mesons to search for Heavy Neutral Leptons (HNLs),
which are right-handed partners of the Standard Model neutrinos. The existence
of such particles is strongly motivated by theory, as they can simultaneously
explain the baryon asymmetry of the Universe, account for the pattern of
neutrino masses and oscillations and provide a Dark Matter candidate.
Cosmological constraints on the properties of HNLs now indicate that the
majority of the interesting parameter space for such particles was beyond the
reach of the previous searches at the PS191, BEBC, CHARM, CCFR and NuTeV
experiments. For HNLs with mass below 2 GeV, the proposed experiment will
improve on the sensitivity of previous searches by four orders of magnitude and
will cover a major fraction of the parameter space favoured by theoretical
models.
The experiment requires a 400 GeV proton beam from the SPS with a total of
2x10^20 protons on target, achievable within five years of data taking. The
proposed detector will reconstruct exclusive HNL decays and measure the HNL
mass. The apparatus is based on existing technologies and consists of a target,
a hadron absorber, a muon shield, a decay volume and two magnetic
spectrometers, each of which has a 0.5 Tm magnet, a calorimeter and a muon
detector. The detector has a total length of about 100 m with a 5 m diameter.
The complete experimental set-up could be accommodated in CERN's North Area.
The discovery of a HNL would have a great impact on our understanding of
nature and open a new area for future research
Disorder-induced phonon self-energy of semiconductors with binary isotopic composition
Self-energy effects of Raman phonons in isotopically disordered
semiconductors are deduced by perturbation theory and compared to experimental
data. In contrast to the acoustic frequency region, higher-order terms
contribute significantly to the self-energy at optical phonon frequencies. The
asymmetric dependence of the self-energy of a binary isotope system on the concentration of the heavier isotope mass x can be explained by
taking into account second- and third-order perturbation terms. For elemental
semiconductors, the maximum of the self-energy occurs at concentrations with
, depending on the strength of the third-order term. Reasonable
approximations are imposed that allow us to derive explicit expressions for the
ratio of successive perturbation terms of the real and the imaginary part of
the self-energy. This basic theoretical approach is compatible with Raman
spectroscopic results on diamond and silicon, with calculations based on the
coherent potential approximation, and with theoretical results obtained using
{\it ab initio} electronic theory. The extension of the formalism to binary
compounds, by taking into account the eigenvectors at the individual
sublattices, is straightforward. In this manner, we interpret recent
experimental results on the disorder-induced broadening of the TO (folded)
modes of SiC with a -enriched carbon sublattice.
\cite{Rohmfeld00,Rohmfeld01}Comment: 29 pages, 9 figures, 2 tables, submitted to PR
Optical phonons in isotope superlattices of GaAs, GaP, and GaSb studied by Raman scattering
We have investigated the LO-phonon Raman spectra of [100] oriented gallium isotope superlattices (69GaX)n(71GaX)n [X=P,As; both elements have a single stable isotope] at low temperature. When the number of monolayers 2n within one superlattice (SL) unit cell is varied, anticrossings between phonons confined in the 69GaX and 71GaX layers are observed. We have used a planar bond-charge model to calculate the frequencies and intensities of the modes as a function of layer thickness. For the GaP isotope SL’s, we find that a simulation of isotopically mixed interface layers is in good agreement with the experiment, while the assumption of ideal interfaces does not reproduce the data well. Spectra from the GaAs isotope SL’s are substantially broadened compared to the LO phonon width in bulk samples, thus allowing only a qualitative discussion of phonon-confinement effects. Predictions for GaSb isotope SL’s, in which both Ga and Sb isotopes can be substituted, are given. Raman spectra of bulk GaAs with varying gallium-isotope ratio are also discussed.Peer reviewe
Effect of quantum confinement on exciton-phonon interactions
We investigate the homogeneous linewidth of localized type-I excitons in
type-II GaAs/AlAs superlattices. These localizing centers represent the
intermediate case between quasi-two-dimensional (Q2D) and
quasi-zero-dimensional localizations. The temperature dependence of the
homogeneous linewidth is obtained with high precision from
micro-photoluminescence spectra. We confirm the reduced interaction of the
excitons with their environment with decreasing dimensionality except for the
coupling to LO-phonons. The low-temperature limit for the linewidth of these
localized excitons is five times smaller than that of Q2D excitons. The
coefficient of exciton-acoustic-phonon interaction is 5 ~ 6 times smaller than
that of Q2D excitons. An enhancement of the average exciton-LO-phonon
interaction by localization is found in our sample. But this interaction is
very sensitive to the detailed structure of the localizing centers.Comment: 6 pages, 4 figure
Exposure to Leptospira spp. and associated risk factors in the human, cattle and dog populations in Bhutan
Leptospirosis is a neglected worldwide zoonotic bacterial disease with a high prevalence in subtropical and tropical countries. The prevalence of Leptospira spp. in humans, cattle and dogs is unknown in Bhutan. Therefore, we sought to find out whether humans, cattle or dogs had been infected in the past with leptospires by measuring antibodies in the serum. We therefore collected blood from 864 humans >/=13 years of age, 130 bovines and 84 dogs from different rural and urban areas in Bhutan and tested the serum for antibodies specific for leptospires with a screening of enzyme-linked immunosorbent assays (ELISA) and a confirmatory microscopic agglutination test (MAT). In humans, 17.6% were seropositive by ELISA and 1.6% by MAT. The seropositivity was stronger in bovines (36.9%) and dogs (47.6%). "Having had a fever recently" (OR 5.2, p = 0.004), "working for the military" (OR 26.6, p = 0.028) and "being unemployed" (OR 12.9, p = 0.041) (reference category = housemaker) were statistically significantly associated with seropositivity when controlled for the effects of other risk factors. However, due to the small number of positive test results, the findings on risk factors should be interpreted with caution. Based on the serogroups found in the three species, dogs could be a source of infection for humans, or dogs and humans are exposed to the same environmental risk factors Clinical leptospirosis in humans and domestic animals should be investigated by testing blood and urine for the presence of leptospires by molecular methods (qPCR)
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Mycolactone-dependent depletion of endothelial cell thrombomodulin is strongly associated with fibrin deposition in Buruli ulcer lesions
A well-known histopathological feature of diseased skin in Buruli ulcer (BU) is coagulative necrosis caused by the Mycobacterium ulcerans macrolide exotoxin mycolactone. Since the underlying mechanism is not known, we have investigated the effect of mycolactone on endothelial cells, focussing on the expression of surface anticoagulant molecules involved in the protein C anticoagulant pathway. Congenital deficiencies in this natural anticoagulant pathway are known to induce thrombotic complications such as purpura fulimans and spontaneous necrosis. Mycolactone profoundly decreased thrombomodulin (TM) expression on the surface of human dermal microvascular endothelial cells (HDMVEC) at doses as low as 2ng/ml and as early as 8hrs after exposure. TM activates protein C by altering thrombin's substrate specificity, and exposure of HDMVEC to mycolactone for 24 hours resulted in an almost complete loss of the cells' ability to produce activated protein C. Loss of TM was shown to be due to a previously described mechanism involving mycolactone-dependent blockade of Sec61 translocation that results in proteasome-dependent degradation of newly synthesised ER-transiting proteins. Indeed, depletion from cells determined by live-cell imaging of cells stably expressing a recombinant TM-GFP fusion protein occurred at the known turnover rate. In order to determine the relevance of these findings to BU disease, immunohistochemistry of punch biopsies from 40 BU lesions (31 ulcers, nine plaques) was performed. TM abundance was profoundly reduced in the subcutis of 78% of biopsies. Furthermore, it was confirmed that fibrin deposition is a common feature of BU lesions, particularly in the necrotic areas. These findings indicate that there is decreased ability to control thrombin generation in BU skin. Mycolactone's effects on normal endothelial cell function, including its ability to activate the protein C anticoagulant pathway are strongly associated with this. Fibrin-driven tisischemia could contribute to the development of the tissue necrosis seen in BU lesions
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