2,736 research outputs found
AC voltage regulation of a bidirectional high-frequency link converter using a deadbeat controller
This paper presents a digital controller for AC voltage regulation of a bidirectional high-frequency link (BHFL) inverter using Deadbeat control. The proposed controller consists of inner current loop, outer voltage loop and a feed-forward controller, which imposes a gain scheduling effect according to the reference signal to compensate the steady-state error of the system. The main property of the proposed controller is that the current- and the voltage-loop controllers have the same structure, and use the same sampling period. This simplifies the design and implementation processes. To improve the overall performance of the system, additional disturbance decoupling networks are employed. This takes into account
the model discretization effect. Therefore, accurate
disturbance decoupling can be achieved, and the system
robustness towards load variations is increased. To avoid
transformer saturation due to low frequency voltage envelopes, an equalized pulse width modulation (PWM)
technique has been introduced. The proposed controller
has been realized using the DS1104 digital signal processor
(DSP) from dSPACE. Its performances have been tested on
a one kVA prototype inverter. Experimental results showed
that the proposed controller has very fast dynamic and good
steady-state responses even under highly nonlinear loads
Role of Interleukin 17 in arthritis chronicity through survival of synoviocytes via regulation of synoviolin expression
Background:
The use of TNF inhibitors has been a major progress in the treatment of chronic inflammation. However, not all patients respond. In addition, response will be often lost when treatment is stopped. These clinical aspects indicate that other cytokines might be involved and we focus here on the role of IL-17. In addition, the chronic nature of joint inflammation may contribute to reduced response and enhanced chronicity. Therefore we studied the capacity of IL-17 to regulate synoviolin, an E3 ubiquitin ligase implicated in synovial hyperplasia in human rheumatoid arthritis (RA) FLS and in chronic reactivated streptococcal cell wall (SCW)-induced arthritis.<p></p>
Methodology/Principal Findings:
Chronic reactivated SCW-induced arthritis was examined in IL-17R deficient and wild-type mice. Synoviolin expression was analysed by real-time RT-PCR, Western Blot or immunostaining in RA FLS and tissue, and p53 assessed by Western Blot. Apoptosis was detected by annexin V/propidium iodide staining, SS DNA apoptosis ELISA kit or TUNEL staining and proliferation by PCNA staining. IL-17 receptor A (IL-17RA), IL-17 receptor C (IL-17-RC) or synoviolin inhibition were achieved by small interfering RNA (siRNA) or neutralizing antibodies. IL-17 induced sustained synoviolin expression in RA FLS. Sodium nitroprusside (SNP)-induced RA FLS apoptosis was associated with reduced synoviolin expression and was rescued by IL-17 treatment with a corresponding increase in synoviolin expression. IL-17RC or IL-17RA RNA interference increased SNP-induced apoptosis, and decreased IL-17-induced synoviolin. IL-17 rescued RA FLS from apoptosis induced by synoviolin knockdown. IL-17 and TNF had additive effects on synoviolin expression and protection against apoptosis induced by synoviolin knowndown. In IL-17R deficient mice, a decrease in arthritis severity was characterized by increased synovial apoptosis, reduced proliferation and a marked reduction in synoviolin expression. A distinct absence of synoviolin expressing germinal centres in IL-17R deficient mice contrasted with synoviolin positive B cells and Th17 cells in synovial germinal centre-like structures.<p></p>
Conclusion/Significance:
IL-17 induction of synoviolin may contribute at least in part to RA chronicity by prolonging the survival of RA FLS and immune cells in germinal centre reactions. These results extend the role of IL-17 to synovial hyperplasia.<p></p>
An Exploratory Study of Lecturers' Views of Out-of-class Academic Collaboration Among Students
This article reports an exploratory study of lecturers' perceptions of out-of-class academic collaboration (OCAC) among students at a large Singapore university. Two types of OCAC were investigated: collaboration initiated by students, e.g., groups decide on their own to meet to prepare for exams, and collaboration required by teachers, e.g., teachers assign students to do projects in groups. Data were collected via one-on-one interviews with 18 faculty members from four faculties at the university. Findings suggest that OCAC, especially of a teacher-required kind, is fairly common at the university. Faculty members' views on factors affecting the success of OCAC are discussed for the light they might shed on practices to enhance the effectiveness of OCAC
Mutually Penetrating Motion of Self-Organized 2D Patterns of Soliton-Like Structures
Results of numerical simulations of a recently derived most general
dissipative-dispersive PDE describing evolution of a film flowing down an
inclined plane are presented. They indicate that a novel complex type of
spatiotemporal patterns can exist for strange attractors of nonequilibrium
systems. It is suggested that real-life experiments satisfying the validity
conditions of the theory are possible: the required sufficiently viscous
liquids are readily available.Comment: minor corrections, 4 pages, LaTeX, 6 figures, mpeg simulations
available upon or reques
Surface-reconstructed Icosahedral Structures for Lead Clusters
We describe a new family of icosahedral structures for lead clusters. In
general, structures in this family contain a Mackay icosahedral core with a
reconstructed two-shell outer-layer. This family includes the anti-Mackay
icosahedra, which have have a Mackay icosahedral core but with most of the
surface atoms in hexagonal close-packed positions. Using a many-body glue
potential for lead, we identify two icosahedral structures in this family which
have the lowest energies of any known structure in the size range from 900 to
15000 lead atoms. We show that these structures are stabilized by a feature of
the many-body glue part of the interatomic potential.Comment: 9 pages, 8 figure
A Simple Model for Anisotropic Step Growth
We consider a simple model for the growth of isolated steps on a vicinal
crystal surface. It incorporates diffusion and drift of adatoms on the terrace,
and strong step and kink edge barriers. Using a combination of analytic methods
and Monte Carlo simulations, we study the morphology of growing steps in
detail. In particular, under typical Molecular Beam Epitaxy conditions the step
morphology is linearly unstable in the model and develops fingers separated by
deep cracks. The vertical roughness of the step grows linearly in time, while
horizontally the fingers coarsen proportional to . We develop scaling
arguments to study the saturation of the ledge morphology for a finite width
and length of the terrace.Comment: 20 pages, 12 figures; [email protected]
Sharper and Simpler Nonlinear Interpolants for Program Verification
Interpolation of jointly infeasible predicates plays important roles in
various program verification techniques such as invariant synthesis and CEGAR.
Intrigued by the recent result by Dai et al.\ that combines real algebraic
geometry and SDP optimization in synthesis of polynomial interpolants, the
current paper contributes its enhancement that yields sharper and simpler
interpolants. The enhancement is made possible by: theoretical observations in
real algebraic geometry; and our continued fraction-based algorithm that rounds
off (potentially erroneous) numerical solutions of SDP solvers. Experiment
results support our tool's effectiveness; we also demonstrate the benefit of
sharp and simple interpolants in program verification examples
- …