Oscilatory modules

Developing the ideas of Bressler and Soibelman and of Karabegov, we introduce a notion of an oscillatory module on a symplectic manifold which is a sheaf of modules over the sheaf of deformation quantization algebras with an additional structure. We compare the category of oscillatory modules on a torus to the Fukaya category as computed by Polishchuk and Zaslow.Comment: To appear in the proceedings of Moshe Flato Memorial Conference, November, 2008, Ben Gurion Universit

Comprendre les mots du cancer : LexOnco, dictionnaire d'oncologie pour les personnes malades et leurs proches. Aspects méthodologiques

International audienceIn response to the evolution of the information-seeking behaviour of patients and concerns from health professionals regarding cancer patient information, nthe French National Federation of Comprehensive Cancer Centres (FNCLCC) introduced, in 1998, an information and education program dedicated to patients and relatives, the SOR SAVOIR PATIENT program. Lexonco project is a dictionary on oncology adapted for patients and relatives and validated by medical experts and cancer patients. This paper describes the methodological aspects which take into account patients and experts'perspectives to produce the definitions.Face à l'augmentation de la demande d'information des personnes malades et à leur rôle croissant dans la prise de décision médicale, l'accès à une information validée, compréhensible et systématiquement actualisée, en correspondance avec leurs besoins, est un enjeu majeur de Santé publique. Améliorer la qualité de la prise en charge des patients passe par l'appropriation des principaux termes en lien avec la maladie. Dans le cadre du programme pluridisciplinaire SOR SAVOIR PATIENT, le projet Lexonco (LEXique d'ONCOlogie) vise à offrir aux patients un dictionnaire sur le cancer, validé sur le plan médical et qui tient compte des besoins d'information et des préférences des personnes concernées par le cancer. Cet article décrit le projet en insistant plus particulièrement sur les principaux aspects méthodologiques mis en œuvre pour construire et valider les définitions destinées aux patients

Manipulation of corticosteroid release from a transiently supersaturated topical metered dose aerosol using a residual miscible co-solvent

Purpose. The creation of supersaturation transiently after application overcomes the issue of drug instability. However, if the solvents used to drive supersaturation evaporate too quickly, drug recrystallisation or rapid film drying can occur which will inhibit drug release. As such the effects of a residual solvent, poly(ethylene glycol) 400 (PEG), on the release, mobility and supersaturation kinetics of a transiently supersaturated formulation were studied. Materials and Methods. Metered dose aerosol (MDA) formulations consisting of hydrofluoroalkane 134a, ethanol, poly(vinyl pyrrolidone) K90, beclomethasone dipropionate (BDP), and 0%, 5% or 10% w/w PEG were prepared in canisters sealed with metered dose valves and tested for release and adhesion over time. Results. The addition of 10% PEG to the MDA formulation resulted in a significant reduction (p < 0.05) in steady state drug release rate (230.4 +/- 17.3 mu g/cm(2)/h for 0% PEG MDA, 83.6 +/- 4.9 mu g/cm(2)/h for 10% PEG MDA). The presence of PEG caused a delay in dose depletion (2 h for 0% PEG MDA versus 4 h for 10% PEG), retarded supersaturation kinetics and increased film drying time. Conclusion. Whilst equivalent amounts of BDP were released, the residual solvent altered the drug release profile to achieve more constant delivery.Peer reviewe