924 research outputs found

    Participatory Experimentation with Energy Law:Digging in a ‘Regulatory Sandbox’ for Local Energy Initiatives in the Netherlands

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    To facilitate energy transition, regulators have devised ‘regulatory sandboxes’ to create a participatory experimentation environment for exploring revision of energy law in several countries. These sandboxes allow for a two-way regulatory dialogue between an experimenter and an approachable regulator to innovate regulation and enable new socio-technical arrangements. However, these experiments do not take place in a vacuum but need to be formulated and implemented in a multi-actor, polycentric decision-making system through collaboration with the regulator but also energy sector incumbents, such as the distribution system operator. Therefore, we are exploring new roles and power division changes in the energy sector as a result of such a regulatory sandbox. We researched the Dutch executive order ‘experiments decentralized, sustainable electricity production’ (EDSEP) that invites homeowners’ associations and energy cooperatives to propose projects that are prohibited by extant regulation. Local experimenters can, for instance, organise peer-to-peer supply and determine their own tariffs for energy transport in order to localize, democratize, and decentralize energy provision. Theoretically, we rely on Ostrom’s concept of polycentricity to study the dynamics between actors that are involved in and engaging with the participatory experiments. Empirically, we examine four approved EDSEP experiments through interviews and document analysis. Our conclusions focus on the potential and limitations of bottom-up, participatory innovation in a polycentric system. The most important lessons are that a more holistic approach to experimentation, inter-actor alignment, providing more incentives, and expert and financial support would benefit bottom-up participatory innovation

    Determinants of the clinical course of musculoskeletal complaints in general practice: design of a cohort study

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    BACKGROUND: Musculoskeletal complaints are frequent and have large consequences for public health. Information about the prognosis after presentation in general practice is far from complete. Knowledge about determinants of the clinical course of musculoskeletal complaints is essential for management decisions and to inform patients about their prognosis. The purpose of this study is to provide information about the prognosis of musculoskeletal complaints other than low back pain by studying the course of these complaints in general practice and to identify determinants of this course. METHODS: Patients of 18 years and older, who present in general practice with a new episode of a musculoskeletal complaint of the neck, shoulder, elbow, wrist, hand, arm, hip, knee, ankle or foot, are recruited by their general practitioner (GP). Participants will receive complaint-specific questionnaires by mail at baseline and after 3, 6, 12 and 18 months. The following putative determinants of the course of the complaints will be investigated: sociodemographic characteristics, characteristics of the complaint, psychosocial job characteristics, physical workload, physical activity during leisure time, pain coping, mood, kinesiophobia, social support, optimism. The primary outcomes are perceived recovery, pain, functional status, sick leave and overall quality of life

    The role of a labial salivary gland biopsy in the diagnostic procedure for Sjögren's syndrome: a study of 94 cases

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    Objectives: The purpose of the present study is to examine the role of the outcome of the labial salivary gland biopsy (LSGB) in the diagnostic procedure of patients suspected of suffering from Sjögren's syndrome (SS). Material and Methods: In a retrospective study the result of histopathological assessment of 94 consecutively taken labial salivary gland biopsies has been examined. For the diagnosis of SS the American-European Consensus Group classification (AECG, 2002) have been used. The outcome of the assessment has been discussed in relation to a recently reported classification provided by the American College of Rheumatology (ACR, 2012). Results: In the 94 LSGBs support for a diagnosis of SS has been encountered in 24 out of 26 patients with SS. In the 68 patients with a negative diagnosis of SS only six positive LSGBs were observed. The sensitivity of the labial biopsy amounted 0.92; the specificity was 0.91, while the positive predictive value and the negative predictive value amounted 0.80 and 0.97 respectively. LSGBs taken by or on the request of the departments of Rheumatology or Internal Medicine had a significant higher yield compared to LSGBs taken in other clinical departments. Conclusion s : The LSGB may play a role in the diagnostic procedure of Sjögren's syndrome when using either the AECG classification or the ACR classification. A LSGB should preferably taken after counseling for the possible presence of SS by a department of Rheumatology or Internal Medicine since the yield of such biopsies is much higher than in patients who have not been counseled by these departments prior to the taking of a LSGB. When using the ACR classification, a positive serologic result and a positive ocular test make the taking of a LSGB redundant. Only in case of a negative serologic outcome or a negative result of the ocular test a LSGB is indicated. Since both the serologic test and the ocular test carry hardly any morbidity, these tests should, indeed, be performed first before considering to take a LSGB

    Gender-specific effects of raising Year-1 standards on medical students' academic performance and stress levels

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    Context: Medical schools are challenged to create academic environments that stimulate students to improve their study progress without compromising their well-being. Objectives: This prospective comparative cohort study investigated the effects of raising Year-1 standards on academic performance and on students' chronic psychological and biological stress levels. Methods: In a Dutch medical school, students within the last Bachelor's degree cohort (n = 410) exposed to the 40/60 (67%) credit Year-1 standard (67%-credit cohort) were compared with students within the first cohort (n = 413) exposed to a 60/60 (100%) credit standard (100%-credit cohort). Main outcome measures were Year-1 pass rate (academic performance), mean score on the Perceived Stress Scale (PSS, psychological stress) and hair cortisol concentration (HCC, biological stress). Results: Year-1 pass rates were significantly higher in the 100%-credit cohort (odds ratio [OR] 4.65). Interestingly, there was a significant interaction effect (OR 0.46), indicating that raising the standard was more effective for male than for female students. PSS scores (n = 234 [response rate [RR]: 57%] and n = 244 [RR: 59%] in the 67%- and 100%-credit cohorts, respectively) were also significantly higher in the 100%-credit cohort (F(1,474) = 15.08, P <.001). This applied specifically to female students in the 100%-credit cohort. Levels of HCC (n = 181 [RR: 44%] and n = 162 [RR: 39%] respectively) did not differ between co

    Reconstruction of humins formation mechanism from decomposition products: A GC-MS study based on catalytic continuous flow depolymerizations

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    Humins, a by-product of biomass chemical conversion technologies, still present controversies in their structural and mechanistic identification. Traditional studies of the structure and mechanism have focused so far on their syntheses from key molecules (sugars, HMF) and spectroscopic analyses of the as-synthesized oligomers/macromolecules. Herein, we propose structural and mechanism insights based on a novel down-up approach involving the decomposition of humins viacatalytic reactions in continuous flow and interpretation of product molecules. The apparent co-existence of different mechanisms proposed in literature is observed upon product distribution analysis, and the key molecules taking part into humins formation are identified, including furanics, levulinates, sugar-derived molecules, and others. This work shows the complexity of humins formation, and their need of valorization

    Ichthyological Bulletin of the J.L.B. Smith Institute of Ichthyology; No. 50

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    The publication of a new phase of research on the fishes of the Okavango drainage starts with this account which gives the valid names and broad distribution patterns of all species known from the system. Eighty species and subspecies are recognised, of which at least two (Parakneria fortuita Penrith; Serranochromis gracilis Greenwood) are endemic. Notes on early collections, synonymy, taxonomic status and distribution are given. New synonyms are recognized under Aplocheilichthys hutereaui (A. schalleri), Aplocheilichthys johnstoni (Haplochilus carlislei) and Ctenopoma multispinis (Ctenopoma machadoi) respectively. Recently published taxonomic changes are incorporated including two genera (Mesobola and Afromastacembelus), a species Serranochromis (Sargochromis) gracilis and the re-allocated Amphilius uranoscopus. The Zambezian Hemichromis species is re-identified as H. elongatus. A number of unresolved taxonomic problems are pointed out and certain dubious records are excluded from the checklist. The Okavango has a diverse fish fauna with tropical affinities. Many fish species are poorly studied. Man-induced threats to the continued natural functioning of this complex and dynamic system, especially large-scale water abstraction, overgrazing, deforestation and biocide spraying to eliminate tsetse fly, make it imperative that studies on the nature and role of the fishes are continued.Rhodes University Libraries (Digitisation
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