252 research outputs found
Consistency of Empirical Bayes And Kernel Flow For Hierarchical Parameter Estimation
Hierarchical modeling and learning has proven very powerful in the field of Gaussian process regression and kernel methods, especially for machine learning applications and, increasingly, within the field of inverse problems more generally. The classical approach to learning hierarchical information is through Bayesian formulations of the problem, implying a posterior distribution on the hierarchical parameters or, in the case of empirical Bayes, providing an optimization criterion for them. Recent developments in the machine learning literature have suggested new criteria for hierarchical learning, based on approximation theoretic considerations that can be interpreted as variants of cross-validation, and exploiting approximation consistency in data splitting. The purpose of this paper is to compare the empirical Bayesian and approximation theoretic approaches to hierarchical learning, in terms of large data consistency, variance of estimators, robustness of the estimators to model misspecification, and computational cost. Our analysis is rooted in the setting of Matérn-like Gaussian random field priors, with smoothness, amplitude and inverse lengthscale as hierarchical parameters, in the regression setting. Numerical experiments validate the theory and extend the scope of the paper beyond the Matérn setting
Production of Gadolinium-loaded Liquid Scintillator for the Daya Bay Reactor Neutrino Experiment
We report on the production and characterization of liquid scintillators for
the detection of electron antineutrinos by the Daya Bay Reactor Neutrino
Experiment. One hundred eighty-five tons of gadolinium-loaded (0.1% by mass)
liquid scintillator (Gd-LS) and two hundred tons of unloaded liquid
scintillator (LS) were successfully produced from a linear-alkylbenzene (LAB)
solvent in six months. The scintillator properties, the production and
purification systems, and the quality assurance and control (QA/QC) procedures
are described.Comment: 15 pages, 11 figures. Submitted to Nuclear Instruments and Methods in
Physics Research Section
On the Optimum Long Baseline for the Next Generation Neutrino Oscillation Experiments
For high energy long baseline neutrino oscillation experiments, we propose a
Figure of Merit criterion to compare the statistical quality of experiments at
various oscillation distances under the condition of identical detectors and a
given neutrino beam. We take into account all possible experimental errors
under general consideration. In this way the Figure of Merit is closely related
to the usual statistical criterion of number of sigmas. We use a realistic
neutrino beam for an entry level neutrino factory and a possible superbeam from
a meson source and a 100 kt detector for the calculation. We considered in
detail four oscillation distances, 300 km, 700 km, 2100 km and 3000 km, in the
neutrino energy range of 0.5-20 GeV for a 20 GeV entry level neutrino factory
and a 50 GeV superbeam. We found that the very long baselines of 2100 km and
3000 km are preferred for the neutrino factory according to the figure of merit
criterion. Our results also show that, for a neutrino factory, lower primary
muon energies such as 20 GeV are preferred rather than higher ones such as 30
or 50 GeV. For the superbeam, the combination of a long baseline such as 300 km
and a very long baseline like 2100 km will form a complete measurement of the
oscillation parameters besides the CP phase. To measure the CP phase in a
superbeam, a larger detector (a factor 3 beyond what is considered in this
article) and/or a higher intensity beam will be needed to put some significant
constraints on the size of the CP angle.Comment: 21 LaTeX pages, 13 PS figures, typos corrected, references adde
Foot Bone in Vivo: Its Center of Mass and Centroid of Shape
This paper studies foot bone geometrical shape and its mass distribution and
establishes an assessment method of bone strength. Using spiral CT scanning,
with an accuracy of sub-millimeter, we analyze the data of 384 pieces of foot
bones in vivo and investigate the relationship between the bone's external
shape and internal structure. This analysis is explored on the bases of the
bone's center of mass and its centroid of shape. We observe the phenomenon of
superposition of center of mass and centroid of shape fairly precisely,
indicating a possible appearance of biomechanical organism. We investigate two
aspects of the geometrical shape, (i) distance between compact bone's centroid
of shape and that of the bone and (ii) the mean radius of the same density bone
issue relative to the bone's centroid of shape. These quantities are used to
interpret the influence of different physical exercises imposed on bone
strength, thereby contributing to an alternate assessment technique to bone
strength.Comment: 9 pages, 4 figure
The prebiotic effects of oats on blood lipids, gut microbiota, and short-chain fatty acids in mildly hypercholesterolemic subjects compared with rice: a randomized, controlled trial
20openInternationalInternational coauthor/editorPhytochemicals derived from oats are reported to possess a beneficial effect on modulating dyslipidemia, specifically on lowering total and LDL cholesterol. However, deeper insights into its mechanism remain unclear. In this randomized controlled study, we assigned 210 mildly hypercholesterolemic subjects from three study centers across China (Beijing, Nanjing, and Shanghai) to consume 80 g of oats or rice daily for 45 days. Plasma lipid profiles, short chain fatty acids (SCFAs), and fecal microbiota were measured. The results showed that total cholesterol (TC) and non-high-density lipoprotein cholesterol (non-HDL-C) decreased significantly with both oats and rice intake after 30 and 45 days. The reduction in TC and non-HDL-C was greater in the participants consuming oats compared with rice at day 45 (p = 0.011 and 0.049, respectively). Oat consumption significantly increased the abundance of Akkermansia muciniphila and Roseburia, and the relative abundance of Dialister, Butyrivibrio, and Paraprevotella, and decreased unclassified f-Sutterellaceae. In the oat group, Bifidobacterium abundance was negatively correlated with LDL-C (p = 0.01, r = −0.31) and, TC and LDL-C were negatively correlated to Faecalibacterium prausnitzii (p = 0.02, r = −0.29; p = 0.03, r = −0.27, respectively). Enterobacteriaceae, Roseburia, and Faecalibacterium prausnitzii were positively correlated with plasma butyric acid and valeric acid concentrations and negatively correlated to isobutyric acid. HDL-C was negatively correlated with valeric acid (p = 0.02, r = −0.25) and total triglyceride (TG) was positively correlated to isovaleric acid (p = 0.03, r = 0.23). Taken together, oats consumption significantly reduced TC and LDL-C, and also mediated a prebiotic effect on gut microbiome. Akkermansia muciniphila, Roseburia, Bifidobacterium, and Faecalibacterium prausnitzii, and plasma SCFA correlated with oat-induced changes in plasma lipids, suggesting prebiotic activity of oats to modulate gut microbiome could contribute towards its cholesterol-lowering effect.openXu, Dengfeng; Feng, Meiyuan; Chu, YiFang; Wang, Shaokang; Shete, Varsha; Tuohy, Kieran M; Liu, Feng; Zhou, Xirui; Kamil, Alison; Pan, Da; Liu, Hechun; Yang, Xian; Yang, Chao; Zhu, Baoli; Lv, Na; Xiong, Qian; Wang, Xin; Sun, Jianqin; Sun, Guiju; Yang, YuexinXu, D.; Feng, M.; Chu, Y.; Wang, S.; Shete, V.; Tuohy, K.M.; Liu, F.; Zhou, X.; Kamil, A.; Pan, D.; Liu, H.; Yang, X.; Yang, C.; Zhu, B.; Lv, N.; Xiong, Q.; Wang, X.; Sun, J.; Sun, G.; Yang, Y
Identification of a nucleoside analog active against adenosine kinase-expressing plasma cell malignancies
Primary effusion lymphoma (PEL) is a largely incurable malignancy of B cell origin with plasmacytic differentiation. Here, we report the identification of a highly effective inhibitor of PEL. This compound, 6-ethylthioinosine (6-ETI), is a nucleoside analog with toxicity to PEL in vitro and in vivo, but not to other lymphoma cell lines tested. We developed and performed resistome analysis, an unbiased approach based on RNA sequencing of resistant subclones, to discover the molecular mechanisms of sensitivity. We found different adenosine kinase–inactivating (ADK-inactivating) alterations in all resistant clones and determined that ADK is required to phosphorylate and activate 6-ETI. Further, we observed that 6-ETI induces ATP depletion and cell death accompanied by S phase arrest and DNA damage only in ADK-expressing cells. Immunohistochemistry for ADK served as a biomarker approach to identify 6-ETI–sensitive tumors, which we documented for other lymphoid malignancies with plasmacytic features. Notably, multiple myeloma (MM) expresses high levels of ADK, and 6-ETI was toxic to MM cell lines and primary specimens and had a robust antitumor effect in a disseminated MM mouse model. Several nucleoside analogs are effective in treating leukemias and T cell lymphomas, and 6-ETI may fill this niche for the treatment of PEL, plasmablastic lymphoma, MM, and other ADK-expressing cancers
Natural gaits of the non-pathological flat foot and high-arched foot
There has been a controversy as to whether or not the non-pathological flat
foot and high-arched foot have an effect on human walking activities. The 3D
foot scanning system was employed to obtain static footprints from subjects
adopting a half-weight-bearing stance. Based upon their footprints, the
subjects were divided into two groups: the flat-footed and the high-arched. The
plantar pressure measurement system was used to measure and record the
subjects' successive natural gaits. Two indices were proposed: distribution of
vertical ground reaction force (VGRF) of plantar and the rate of the footprint
areas. Using these two indices to compare the natural gaits of the two subject
groups, we found that (1) in stance phase, there is a significant difference
(p<0.01) in the distributions of VGRF of plantar; (2) in a stride cycle, there
is also a significant difference (p<0.01) in the rates of the footprint areas.
Our analysis suggests that when walking, the VGRF of the plantar brings greater
muscle tension to the flat-footed while a smaller rate of the footprint areas
brings greater stability to the high-arched.Comment: 8 pages, 4 figure
In vitro test of external Qigong
BACKGROUND: Practitioners of the alternative medical practice 'external Qigong' generally claim the ability to emit or direct "healing energy" to treat patients. We investigated the ability of experienced Qigong practitioners to enhance the healthy growth of cultured human cells in a series of studies, each following a rigorously designed protocol with randomization, blinding and controls for variability. METHODS: Qigong practitioners directed healing intentionality toward normal brain cell cultures in a basic science laboratory. Qigong treatments were delivered for 20 minutes from a minimum distance of 10 centimeters. Cell proliferation was measured by a standard colony-forming efficiency (CFE) assay and a CFE ratio (CFE for treated samples/CFE for sham samples) was the dependent measure for each experiment. RESULTS: During a pilot study (8 experiments), a trend of increased cell proliferation in Qigong-treated samples (CFE Qigong/sham ratios > 1.0) was observed (P = 0.162). In a formal study (28 experiments), a similar trend was observed, with Qigong-treated samples showing on average more colony formation than sham samples (P = 0.036). In a replication study (60 experiments), no significant difference between Qigong-treated samples and sham samples was observed (P = 0.465). CONCLUSION: We observed an apparent increase in the proliferation of cultured cells following external Qigong treatment by practitioners under strictly controlled conditions, but we did not observe this effect in a replication study. These results suggest the need for more controlled and thorough investigation of external Qigong before scientific validation is claimed
Status Report of the DPHEP Study Group: Towards a Global Effort for Sustainable Data Preservation in High Energy Physics
Data from high-energy physics (HEP) experiments are collected with
significant financial and human effort and are mostly unique. An
inter-experimental study group on HEP data preservation and long-term analysis
was convened as a panel of the International Committee for Future Accelerators
(ICFA). The group was formed by large collider-based experiments and
investigated the technical and organisational aspects of HEP data preservation.
An intermediate report was released in November 2009 addressing the general
issues of data preservation in HEP. This paper includes and extends the
intermediate report. It provides an analysis of the research case for data
preservation and a detailed description of the various projects at experiment,
laboratory and international levels. In addition, the paper provides a concrete
proposal for an international organisation in charge of the data management and
policies in high-energy physics
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