299 research outputs found
Phase correlation of laser waves with arbitrary frequency spacing
The theoretically predicted correlation of laser phase fluctuations in
Lambda-type interaction schemes is experimentally demonstrated. We show, that
the mechanism of correlation in a Lambda scheme is restricted to high frequency
noise components, whereas in a double- scheme, due to the laser phase
locking in closed-loop interaction, it extends to all noise frequencies. In
this case the correlation is weakly sensitive to coherence losses. Thus the
double-Lambda scheme can be used to correlate e.m. fields with carrier
frequency differences beyond the GHz regime.Comment: 4 pages, 4 figure
Ultrastable CO2 Laser Trapping of Lithium Fermions
We demonstrate an ultrastable CO2 laser trap that provides tight confinement
of neutral atoms with negligible optical scattering and minimal laser-noise-
induced heating. Using this method, fermionic 6Li atoms are stored in a 0.4 mK
deep well with a 1/e trap lifetime of 300 sec, consistent with a background
pressure of 10^(-11) Torr. To our knowledge, this is the longest storage time
ever achieved with an all-optical trap, comparable to the best reported
magnetic traps.Comment: 4 pages using REVTeX, 1 eps figur
Efficient Raman Sideband Generation in a Coherent Atomic Medium
We demonstrate the efficient generation of Raman sidebands in a medium
coherently prepared in a dark state by continuous-wave low-intensity laser
radiation. Our experiment is performed in sodium vapor excited in
configuration on the D line by two laser fields of resonant frequencies
and , and probed by a third field .
First-order sidebands for frequencies , and up to the
third-order sidebands for frequency are observed. The generation
starts at a power as low as 10 microwatt for each input field. Dependencies of
the intensities of both input and generated waves on the frequency difference
(), on the frequency and on the optical
density are investigated.Comment: 7 pages, 6 figure
Effects of Genetic Variants in ADCY5, GIPR, GCKR and VPS13C on Early Impairment of Glucose and Insulin Metabolism in Children
OBJECTIVE: Recent genome-wide association studies identified novel candidate genes for fasting and 2 h blood glucose and insulin levels in adults. We investigated the role of four of these loci (ADCY5, GIPR, GCKR and VPS13C) in early impairment of glucose and insulin metabolism in children. RESEARCH DESIGN AND METHODS: We genotyped four variants (rs2877716; rs1260326; rs10423928; rs17271305) in 638 Caucasian children with detailed metabolic testing including an oGTT and assessed associations with measures of glucose and insulin metabolism (including fasting blood glucose, insulin levels and insulin sensitivity/secretion indices) by linear regression analyses adjusted for age, sex, BMI-SDS and pubertal stage. RESULTS: The major allele (C) of rs2877716 (ADCY5) was nominally associated with decreased fasting plasma insulin (P = 0.008), peak insulin (P = 0.009) and increased QUICKI (P = 0.016) and Matsuda insulin sensitivity index (P = 0.013). rs17271305 (VPS13C) was nominally associated with 2 h blood glucose (P = 0.009), but not with any of the insulin or insulin sensitivity parameters. We found no association of the GIPR and GCKR variants with parameters of glucose and insulin metabolism. None of the variants correlated with anthropometric traits such as height, WHR or BMI-SDS, which excluded potential underlying associations with obesity. CONCLUSIONS: Our data on obese children indicate effects of genetic variation within ADCY5 in early impairment of insulin metabolism and VPS13C in early impairment of blood glucose homeostasis
GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits
© 2019, The Author(s). Urinary sodium and potassium excretion are associated with blood pressure (BP) and cardiovascular disease (CVD). The exact biological link between these traits is yet to be elucidated. Here, we identify 50 loci for sodium and 13 for potassium excretion in a large-scale genome-wide association study (GWAS) on urinary sodium and potassium excretion using data from 446,237 individuals of European descent from the UK Biobank study. We extensively interrogate the results using multiple analyses such as Mendelian randomization, functional assessment, co localization, genetic risk score, and pathway analyses. We identify a shared genetic component between urinary sodium and potassium expression and cardiovascular traits. Ingenuity pathway analysis shows that urinary sodium and potassium excretion loci are over-represented in behavioural response to stimuli. Our study highlights pathways that are shared between urinary sodium and potassium excretion and cardiovascular traits
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