DEVELOPMENT AND VALIDATION OF CHROMATOGRAPHIC METHOD FOR THE SIMULTANEOUS ESTIMATION OF OLMESARTAN MEDOXOMIL, AMLODIPINE BESYLATE, CILNIDIPINE IN COMBINATION TABLET DOSAGE FORM

Objective: To develop and validate a simple, sensitive and isocratic reverse phase high performance liquid chromatography (RP-HPLC) method for the simultaneous determination of olmesartan medoxomil (OLM), amlodipine besylate (AML) and cilnidipine (CIL) in pharmaceutical tablet formulation.Methods: In this work we have taken 2 combinations, combination 1-OLM & AML and combination 2-OLM & CIL. HPLC analysis was carried out by using reverse phase isocratic elution with a C 18 column and a mobile phase of 0.05 M ammonium acetate, acetonitrile and methanol in the ratio of 30:50:20, v/v, pH was adjusted to 7.3. Detection of the analyte was achieved by using UV detector at 240 nm.Results: The retention time of olmesartan medoxomil, amlodipine besylate and cilnidipine were 2.2, 3 and 4.5 minutes respectively. Linearity of the method was found to be in the concentration range of 10-100µg/ml for olmesartan medoxomil, 5-50µg/ml for amlodipine and 10-100µg/ml for cilnidipine. The correlation coefficient value was greater than 0.999 for all the analytes.Conclusion: The method was validated as per ICH guidelines and is applied for the estimation of these components simultaneously in pharmaceutical tablet formulation.Â

A Survey on Biometrics and Cancelable Biometrics Systems

Now-a-days, biometric systems have replaced the password or token based authentication system in many fields to improve the security level. However, biometric system is also vulnerable to security threats. Unlike password based system, biometric templates cannot be replaced if lost or compromised. To deal with the issue of the compromised biometric template, template protection schemes evolved to make it possible to replace the biometric template. Cancelable biometric is such a template protection scheme that replaces a biometric template when the stored template is stolen or lost. It is a feature domain transformation where a distorted version of a biometric template is generated and matched in the transformed domain. This paper presents a review on the state-of-the-art and analysis of different existing methods of biometric based authentication system and cancelable biometric systems along with an elaborate focus on cancelable biometrics in order to show its advantages over the standard biometric systems through some generalized standards and guidelines acquired from the literature. We also proposed a highly secure method for cancelable biometrics using a non-invertible function based on Discrete Cosine Transformation (DCT) and Huffman encoding. We tested and evaluated the proposed novel method for 50 users and achieved good results

A Review on the Mechanical Modeling of Composite Manufacturing Processes

© 2016, The Author(s). The increased usage of fiber reinforced polymer composites in load bearing applications requires a detailed understanding of the process induced residual stresses and their effect on the shape distortions. This is utmost necessary in order to have more reliable composite manufacturing since the residual stresses alter the internal stress level of the composite part during the service life and the residual shape distortions may lead to not meeting the desired geometrical tolerances. The occurrence of residual stresses during the manufacturing process inherently contains diverse interactions between the involved physical phenomena mainly related to material flow, heat transfer and polymerization or crystallization. Development of numerical process models is required for virtual design and optimization of the composite manufacturing process which avoids the expensive trial-and-error based approaches. The process models as well as applications focusing on the prediction of residual stresses and shape distortions taking place in composite manufacturing are discussed in this study. The applications on both thermoset and thermoplastic based composites are reviewed in detail

Effect of sulfide ions on the corrosion behavior of marine alloys in synthetic sea water

The corrosion behavior of 90 Cu-10 Ni, 70 Cu-30 Ni and monel in the presence of sulfide ions (10 ppm to 100 ppm) in synthetic sea water has been studied by DC polarization method. In the case of 70 Cu-30 Ni and 90 Cu-10 Ni alloy, the corrosion rate is found to increase for sulfide concentrations greater than 10 ppm. But for monel, the presence of 10 ppm sulfide is found to increase the corrosion rate by 10 times. These studies have shown that there exists a critical concentration of sulfide ion for each allo

SRB-cidal properties of some Cu-Mn alloys

Three different copper-manganese alloys have been fabricated and tested for their antifouling properties in SRB cultures under static condition; Among the alloys experimented, the Cu-Mn alloy containing misch metal and gallium, besides being excellent antifoulant, acts as an efficient SRB-cide as wel

SRB on the corrosion behaviour of galvanic anodes such as Zn-Al and Mg

The extent of SRB induced corrosion of magnesium, aluminium and zinc anodes, has been studied with time, in a 10% Postage (B) medium, at 303K. Simultaneously, the magnitude and activity of SRB as well as changes in pH and dissolved oxygen content have also been monitored. The results arrange these metals in terms of susceptibility to SRB-al attack, in the following order: Zn > Mg > Al. Besides, they clearly exemplify that the cathodic depolarization is the initial step for attack by SR

Effect of metal cations on the reduction of oxygen on mild steel

The effect of addition of metal cations on reduction of oxygen on mild steel has been studied using a rotating electrode. The addition of zinc, manganese and cadmium ions suppresses oxygen reduction considerabl