149 research outputs found
Avances en la selección del Melón de Torres de Berrellén
El trabajo ha sido financiado por el Convenio CITA - Ayuntamiento de Torres
de Berrellén, el Grupo de Cooperación GCP2020004900. Producción ecológica de alimentos
ligados al territorio aragonés. 2020 -2023. Cofinanciado por el Fondo Europeo Agrícola de
Desarrollo Rural (FEADER) y por la Comunidad Autónoma de Aragón en un 80% y un 20%
respectivamente, y por el Grupo de Investigación del Gobierno de Aragón A11_20R Producción
Vegetal Sostenible PROVESOSPublishe
SSDSS IV MaNGA - Properties of AGN host galaxies
We present here the characterization of the main properties of a sample of 98
AGN host galaxies, both type-II and type-I, in comparison with those of about
2700 non-active galaxies observed by the MaNGA survey. We found that AGN hosts
are morphologically early-type or early-spirals. For a given morphology AGN
hosts are, in average, more massive, more compact, more central peaked and
rather pressurethan rotational-supported systems. We confirm previous results
indicating that AGN hosts are located in the intermediate/transition region
between star-forming and non-star-forming galaxies (i.e., the so-called green
valley), both in the ColorMagnitude and the star formation main sequence
diagrams. Taking into account their relative distribution in terms of the
stellar metallicity and oxygen gas abundance and a rough estimation of their
molecular gas content, we consider that these galaxies are in the process of
halting/quenching the star formation, in an actual transition between both
groups. The analysis of the radial distributions of the starformation rate,
specific star-formation rate, and molecular gas density shows that the
quenching happens from inside-out involving both a decrease of the efficiency
of the star formation and a deficit of molecular gas. All the intermediate
data-products used to derive the results of our analysis are distributed in a
database including the spatial distribution and average properties of the
stellar populations and ionized gas, published as a Sloan Digital Sky Survey
Value Added Catalog being part of the 14th Data Release:
http://www.sdss.org/dr14/manga/manga-data/manga-pipe3d-value-added-catalog/Comment: 48 pages, 14 figures, in press in RMxA
Study of breast cancer incidence in patients of lymphangioleiomyomatosis
The online version of this article (doi:10.1007/s10549-016-3737-8) contains supplementary material, which is available to authorized user
Lymphangioleiomyomatosis biomarkers linked to lung metastatic potential and cell stemness
Lymphangioleiomyomatosis (LAM) is a rare lung-metastasizing neoplasm caused by the proliferation of smooth muscle-like cells that commonly carry loss-of-function mutations in either the tuberous sclerosis complex 1 or 2 (TSC1 or TSC2) genes. While allosteric inhibition of the mechanistic target of rapamycin (mTOR) has shown substantial clinical benefit, complementary therapies are required to improve response and/or to treat specific patients. However, there is a lack of LAM biomarkers that could potentially be used to monitor the disease and to develop other targeted therapies. We hypothesized that the mediators of cancer metastasis to lung, particularly in breast cancer, also play a relevant role in LAM. Analyses across independent breast cancer datasets revealed associations between low TSC1/2 expression, altered mTOR complex 1 (mTORC1) pathway signaling, and metastasis to lung. Subsequently, immunohistochemical analyses of 23 LAM lesions revealed positivity in all cases for the lung metastasis mediators fascin 1 (FSCN1) and inhibitor of DNA binding 1 (ID1). Moreover, assessment of breast cancer stem or luminal progenitor cell biomarkers showed positivity in most LAM tissue for the aldehyde dehydrogenase 1 (ALDH1), integrin-ß3 (ITGB3/CD61), and/or the sex-determining region Y-box 9 (SOX9) proteins. The immunohistochemical analyses also provided evidence of heterogeneity between and within LAM cases. The analysis of Tsc2-deficient cells revealed relative over-expression of FSCN1 and ID1; however, Tsc2-deficient cells did not show higher sensitivity to ID1-based cancer inhibitors. Collectively, the results of this study reveal novel LAM biomarkers linked to breast cancer metastasis to lung and to cell stemness, which in turn might guide the assessment of additional or complementary therapeutic opportunities for LAM
EstuPlan: Methodology for the development of creativity in the resolution of scientific and social problems
Creative thinking is necessary to generate novel ideas and solve problems."EstuPlan" is a methodology in which knowledge and creativity converge for the resolution of scientific problems with social projection. It is a training programme that integrates teachers, laboratory technicians and PhD students, master and undergraduate students which form working groups for the development of projects. Projects have a broad and essential scope and projection in terms of environmental problems, sustainable use of natural resources, food, health, biotechnology or biomedicine. The results show the success of this significant learning methodology using tools to develop creativity in responding to scientific and social demand for problem-solving to transfer academic knowledge to different professional environments. Bioplastics, Second Life of Coffee, LimBio, Algae oils, Ecomers, Caring for the life of your crop and Hate to Deforestate are currently being developed
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