Turbulent Fluid Flow Over Aerodynamically Rough Surfaces Using Direct Numerical Simulations

Incompressible turbulent fluid flow in aerodynamically rough channels is investigated using direct numerical simulations. A comprehensive database of simulation data for rough surfaces with different topographical properties has been developed for 17 industrially relevant rough surface samples. It includes numerous commonlyseen industrial rough surfaces such as concrete, graphite, carbon-carbon composite and ground, shotblasted and spark-eroded steel. Other surfaces such as cast, filed and gritblasted steel are also studied, along with replicas of ship propeller surfaces eroded by periods of service. The Reynolds number considered is Reτ = 180, for which the flow is in the transitionally rough regime. A study with variable δ/Sq ratio while keeping S + q constant, where Sq is the root mean squared roughness height, is conducted for one of the samples with the mean profiles showing convergence for δ/Sq >≈ 25. A Reynolds number dependence study is conducted for two of the samples with Reτ up to 720 showing a more complete range up to the fully rough flow regime, allowing the equivalent sandgrain roughness height, ks to be computed. A correlation based on the frontal and wetted roughness area is found to be superior to the surface skewness in predicting ∆U + based on the topographic surface parameters

Study of salivary α-amylase immunoglobulin, a and flow rate in diabetic subjects: a cross sectional study

Background: Diabetes is possibly the mainly common metabolic syndrome with salivary inference. However, lack of literature on the possible relationship between diabetes and salivary α-amylase, Immunoglobulin-A (IgA) and flow rate. Therefore, present study aims to estimate of salivary α-amylase, immunoglobulin-A and flow rate in diabetic subjects of Indian population.Methods: The present cross sectional study was done on 60 subjects of diabetes mellitus (T2DM) and 60 subjects’ non-diabetic healthy controls at Banas medical college and our hospital. The subject’s demographic and anthropometric parameters were recorded; detailed history and clinical examination were performed in the entire cases. The un-stimulated saliva was collected in the fasting state. Salivary flow rate, biochemical variables and IgA were analyzed. Data which was collected was statistically analyzed.Results: The results showed that salivary glucose (p0.05) between diabetic and non-diabetic subjects.Conclusions: In our study, we conclude that significant differences were reported in salivary flow rate, α-amylase and IgA between diabetics and non diabetics. Therefore, we suggested that estimation of salivary parameters might be a cost effective and a non invasive choice for screening, diagnosis and monitoring of diabetes instead of blood

A comparative clinical study of two source plant Motha (Cyprus Rotundus Linn.) and Nagarmotha (Cyprus Scariousus) in Sthaulya (Obeisty)

Herbal product market is increasing day by day throughout the world and various pharmaceutical companies conducting extensive research on plant material for their potential medicinal value. Motha (Cyperus rotundus), a is found in all tropical, subtropical and temperate region of the world, in India its commonly known as Motha and its in cypereacea and Nagarmotha (Cyperus Scariosus) is pestiferous perennial, delicate slender sedge found wildly in various parts of the country, especially in damp or marshy areas and collected wildly for extraction of its essential oil using steam distillation. The present review article provide an overview on comparative clinical study done on Sthaulya (Obesity)

The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 1: modifications to the androgen receptor

Prostate cancer is the second most common male malignancy in the western world an increasing incidence in an ageing population. Treatment of advanced prostate cancer relies on androgen deprivation. Although the majority of patients initially respond favourably to androgen deprivation therapy, the mean time to relapse is 12-18 months. Currently there are few treatments available for men who have developed resistance to hormone therapy, due to the lack of understanding of the molecular mechanisms underlying development of this disease. Recently, however, major advances have been made in understanding both androgen receptor (AR) dependent and independent pathways which promote development of hormone resistant prostate cancer. This review will focus on modifications to the AR and associated pathways. Molecular modifications to the androgen receptor itself, e.g. mutations and/or amplification, although involved in the development of hormone resistance cannot explain all cases. Phosphorylation of AR, via either Ras/MAP kinase or PI3K/Akt signal transduction pathways, have been shown to activate AR in both a ligand (androgen) dependent and independent fashion. During this review we will discuss the clinical evidence to support AR dependent pathways as mediators of hormone resistance

Study of salivary electrolyte in type 2 diabetes mellitus patients of North Gujarat region of India

Background: A lack of literature on the probable relationship between diabetes and salivary electrolyte. Therefore, present study aims to study of salivary electrolyte in type 2 diabetes mellitus patients of North Gujarat region of India.Methods: The present cross sectional study was done on 60 subjects of diabetes mellitus (T2DM) and 60 subjects’ non-diabetic healthy controls at Banas medical college and our hospital. The subject’s demographic and anthropometric parameters were recorded; detailed history and clinical examination were performed in the entire cases. The saliva was collected in the fasting state during resting state. Salivary pH, flow rate, biochemical variables and electrolytes were analyzed. Data which was collected was statistically analyzed.Results: Predominance of the T2DM subjects was in the age group of 41-45 years. Mean value for age (p<0.05), body mass index (p<0.01), waist- hip ratio (p<0.05), salivary Potassium (p<0.001), glucose (p<0.001), Chloride (p<0.01), bicarbonates (p<0.01) and sodium levels (p<0.001) were significantly higher in the T2DM subjects where as salivary pH (p<0.01), flow rate (p<0.01) and calcium level (p<0.001) were significantly lower in the T2DM subjects.Conclusions: In our study, we conclude that significant variations were reported in salivary pH, flow rate and electrolyte variables between diabetics and non diabetics. Therefore, we suggested that estimation of salivary variables might be a cost effective and a non invasive choice for screening, diagnosis and monitoring of diabetes instead of blood

2001 Bhuj-Kachchh earthquake: surface faulting and its relation with neotectonics and regional structures, Gujarat, Western India

Primary and secondary surface deformation related to the 2001 Bhuj-Kachchh earthquake suggests that thrusting movement took place along an E-W fault near the western extension of the South Wagad Fault, a synthetic fault of the Kachchh Mainland Fault (KMF). Despite early reconnaissance reports that concluded there was no primary surface faulting, we describe an 830 m long, 15-35 cm high, east-west-trending thrust fault scarp near where the seismogenic fault plane would project to the surface, near Bharodiya village (between 23°34.912'N, 70°23.942'E and 23°34.304'N, 70°24.884'E). Along most of the scarp Jurassic bedrock is thrust over Quaternary deposits, but the fault scarp also displaces Holocene alluvium and an earth dam, with dips of 13° to 36° south. Secondary co-seismic features, mainly liquefaction and lateral spreading, dominate the area south of the thrust. Transverse right-lateral movement along the «Manfara Fault» and a parallel fault near Bharodiya suggests segmentation of the E-W master faults. Primary (thrust) surface rupture had a length of 0.8 km, maximum displacement of about 35 cm, and average displacement of about 15 cm. Secondary (strike-slip) faulting was more extensive, with a total end-to-end length of 15 km, maximum displacement of 35 cm, and average displacement of about 20 cm

Comparison of etomidate and propofol as an induction agent to study hemodynamic effects and serum cortisol level following endotracheal intubation in hypertensive patients

Background: The present study aimed to compare hemodynamic parameters (heart rate, blood pressure) and adverse effects (injection pain, myoclonus, postoperative nausea/vomiting) between Etomidate and propofol groups. Methods: Patients were divided into two groups: Etomidate Group E and a Propofol Group P. All hemodynamic data were measured during induction, intubation, and post-intubation up to 15 min. Intravenous cortisol levels were measured at baseline, just after induction and at 24 hours after induction. Results: At 3 min and 5 min SBP was decreased by 22.04% and 18.39% in Group P. At 3 min there was fall in DBP by 20.13% in group P whereas there was an increase in group E by 0.13% which is statistically significant (p&lt;0.001). At 1 min, 3 min and 5 min after intubation, fall in the MAP by 26.07%, 21.08% and 18.60% in group P and 0.77%, 0.42% and 1.30% in group E (p value &lt;0.001). Serum cortisol level immediate after surgery was decrease (54%) in Group E (p value &lt;0.001). In Group P, 40% of the patients and in group E 16.66 % of the patients complained of pain on injection (p value 0.046). Conclusions: The cortisol suppression by Etomidate may be beneficial for intubation stress response. Etomidate is better for its hemodynamic stability over propofol

Antibodies to Enteroviruses in Cerebrospinal Fluid of Patients with Acute Flaccid Myelitis.

Acute flaccid myelitis (AFM) has caused motor paralysis in &gt;560 children in the United States since 2014. The temporal association of enterovirus (EV) outbreaks with increases in AFM cases and reports of fever, respiratory, or gastrointestinal illness prior to AFM in &gt;90% of cases suggest a role for infectious agents. Cerebrospinal fluid (CSF) from 14 AFM and 5 non-AFM patients with central nervous system (CNS) diseases in 2018 were investigated by viral-capture high-throughput sequencing (VirCapSeq-VERT system). These CSF and serum samples, as well as multiple controls, were tested for antibodies to human EVs using peptide microarrays. EV RNA was confirmed in CSF from only 1 adult AFM case and 1 non-AFM case. In contrast, antibodies to EV peptides were present in CSF of 11 of 14 AFM patients (79%), significantly higher than controls, including non-AFM patients (1/5 [20%]), children with Kawasaki disease (0/10), and adults with non-AFM CNS diseases (2/11 [18%]) (P = 0.023, 0.0001, and 0.0028, respectively). Six of 14 CSF samples (43%) and 8 of 11 sera (73%) from AFM patients were immunoreactive to an EV-D68-specific peptide, whereas the three control groups were not immunoreactive in either CSF (0/5, 0/10, and 0/11; P = 0.008, 0.0003, and 0.035, respectively) or sera (0/2, 0/8, and 0/5; P = 0.139, 0.002, and 0.009, respectively).IMPORTANCE The presence in cerebrospinal fluid of antibodies to EV peptides at higher levels than non-AFM controls supports the plausibility of a link between EV infection and AFM that warrants further investigation and has the potential to lead to strategies for diagnosis and prevention of disease

Mathematical Model for Impact of Media on Cleanliness Drive in India

A mathematical model on cleanliness drive in India is analysed for active cleaners and passive cleaners. Cleanliness and endemic equilibrium points are found. Local and global stability of these equilibrium points are discussed using Routh-Hurwitz criteria and Lyapunov function respectively. Impact of media (as a control) is studied on passive cleaners to become active. Numerical simulation of the model is carried out which indicates that with the help of media transfer rate to active cleaners from passive cleaners is higher

Foreign body ingestion during the COVID-19 pandemic: a retrospective single centre review

Introduction: During the COVID-19 pandemic in 2020, there were many changes in the provision of healthcare as well as home and educational environments for children. We noted an apparent increase in the number of children presenting with ingested foreign bodies and due to the potential impact of injury from this, further investigated this phenomenon. Method: Using a prospective electronic record, data were retrospectively collected for patients referred to our institution with foreign body ingestion from March 2020 to September 2020 and compared with the same period the year prior as a control. Results: During the 6-month pandemic period of review, it was observed that 2.5 times more children were referred with foreign body ingestion (n=25) in comparison to the control period (n=10). There was also a significant increase in the proportion of button battery and magnet ingestions during the COVID-19 pandemic (p 0.04). Conclusion: These findings raise concerns of both increased frequency of foreign body ingestion during the COVID-19 pandemic and the nature of ingested foreign bodies linked with significant morbidity. This may relate to the disruption of home and work environments and carries implications for ongoing restrictions. Further awareness of the danger of foreign body ingestion, especially batteries and magnets, is necessary (project ID: 2956)