Estimating sunspot number

An empirical method is developed to predict certain parameters of future solar activity cycles. Sunspot cycle statistics are examined, and curve fitting and linear regression analysis techniques are utilized

Three photometric methods tested on ground-based data of Q 2237+0305

The Einstein Cross, Q~2237+0305, has been photometrically observed in four bands on two successive nights at NOT (La Palma, Spain) in October 1995. Three independent algorithms have been used to analyse the data: an automatic image decomposition technique, a CLEAN algorithm and the new MCS deconvolution code. The photometric and astrometric results obtained with the three methods are presented. No photometric variations were found in the four quasar images. Comparison of the photometry from the three techniques shows that both systematic and random errors affect each method. When the seeing is worse than 1.0", the errors from the automatic image decomposition technique and the Clean algorithm tend to be large (0.04-0.1 magnitudes) while the deconvolution code still gives accurate results (1{sigma} error below 0.04) even for frames with seeing as bad as 1.7". Reddening is observed in the quasar images and is found to be compatible with either extinction from the lensing galaxy or colour dependent microlensing. The photometric accuracy depends on the light distribution used to model the lensing galaxy. In particular, using a numerical galaxy model, as done with the MCS algorithm, makes the method less seeing dependent. Another advantage of using a numerical model is that eventual non-homogeneous structures in the galaxy can be modeled. Finally, we propose an observational strategy for a future photometric monitoring of the Einstein Cross.Comment: 9 pages, accepted for publication in A&

Increased host investment in extrafloral nectar (EFN) improves the efficiency of a mutualistic defensive service

Extrafloral nectar (EFN) plays an important role as plant indirect defence through the attraction of defending ants. Like all rewards produced in the context of a mutualism, however, EFN is in danger of being exploited by non-ant consumers that do not defend the plant against herbivores. Here we asked whether plants, by investing more in EFN, can improve their indirect defence, or rather increase the risk of losing this investment to EFN thieves. We used the obligate plant-ant Acacia-Pseudomyrmex system and examined experimentally in the field during the dry and the rainy seasons how variations in EFN secretion are related to (i) ant activity, to (ii) the ant-mediated defence against herbivores and (iii) the exploitation of EFN by non-ant consumers. Extrafloral investment enhanced ant recruitment and was positively related to the ant mediated defence against herbivores. The ant-mediated protection from exploiters also increased in proportion to the nectar sugar concentration. Although the daily peak of EFN production coincided with the highest activity of EFN thieves, Pseudomyrmex ferrugineus ants protected this resource effectively from exploiters. Nevertheless, the defensive effects by ants differed among seasons. During the dry season, plants grew slower and secreted more EFN than in the rainy season, and thus, experienced a higher level of ant-mediated indirect defence. Our results show that an increased plant investment in an indirect defence trait can improve the resulting defensive service against both herbivores and exploiters. EFN secretion by obligate ant-plants represents a defensive trait for which the level of investment correlates positively with the beneficial effects obtained

Current Perspectives on Primary Immunodeficiency Diseases

Since the original description of X-linked agammaglobulinemia in 1952, the number of independent primary immunodeficiency diseases (PIDs) has expanded to more than 100 entities. By definition, a PID is a genetically determined disorder resulting in enhanced susceptibility to infectious disease. Despite the heritable nature of these diseases, some PIDs are clinically manifested only after prerequisite environmental exposures but they often have associated malignant, allergic, or autoimmune manifestations. PIDs must be distinguished from secondary or acquired immunodeficiencies, which are far more common. In this review, we will place these immunodeficiencies in the context of both clinical and laboratory presentations as well as highlight the known genetic basis

Retreatment with interferon-alpha and ribavirin in primary interferon-alpha non-responders with chronic hepatitis C

Background/Aims: Combination therapy with interferon-alpha (IFN-alpha) plus ribavirin is more efficacious than IFN-alpha monotherapy in previously untreated patients with chronic hepatitis C and patients with IFN-alpha relapse. Only limited data are available in IFN-alpha non-responders. In a multicenter trial we therefore evaluated the efficacy of combination therapy in IFN-alpha-resistant chronic hepatitis C. Methods: Eighty-two patients (mean age 46.8 years, 54 males, 28 females) with chronic hepatitis C were treated with IFN-alpha-2a (3 x 6 MIU/week) and ribavirin (14 mg/kg daily) for 12 weeks. Thereafter, treatment was continued only in virological responders (undetectable serum HCV RNA at week 12) with an IFN-alpha dose of 3 x 3 MIU/week and without ribavirin for a further 9 months. The primary study endpoint was an undetectable HCV RNA by RT-PCR at the end of the 24-week follow-up period. Results: After 12 weeks of combination therapy, an initial virological response was observed in 29 of 82 (35.4%) patients. Due to a high breakthrough rate after IFN-a dose reduction and ribavirin discontinuation, an end-of-treatment response was only achieved in 12 of 82 (14.6%) patients. After the follow-up period, a sustained virological response was observed in 8 of 82 (9.8%) patients. Infection with HCV genotype 3 was the only pretreatment parameter, which could predict a sustained response (HCV-1, 5%; HCV-3, 57.1%; p < 0.001). Conclusions: Despite a high initial response rate of 35.4%, sustained viral clearance was achieved only in 9.8% of the retreated primary IFN-alpha non-responders. Higher IFN-alpha induction and maintenance dose, as well as prolonged ribavirin treatment may possibly increase the virological response rates in non-responders, particularly in those infected by HCV-1

Mineral Deposits Behind Waterless Urinals

The objectives of this study were to compare the extent of deposition in drain pipes behind different waterless urinal systems and to determine the nature of those deposits. Urinals were removed from the walls of men's restrooms in different buildings on the University of North Carolina at Chapel Hill campus and at the Raleigh-Durham International Airport, and samples of mineral deposits in the drain pipes were collected. Upon analysis of these mineral deposits, it was determined that the deposits are composed primarily of struvite (magnesium ammonium phosphate). This determination was made using x-ray diffraction analysis, and the results were confirmed using scanning electron microscopy. Additionally, a chemical equilibrium model was used to simulate the hydrolysis of urea in the drain lines behind water-free urinals and determine the equilibrium pH of the system as urea hydrolyzes. This model showed that water-free urinal collection systems are oversaturated with respect to struvite, calcite, and calcium hydroxylapatite, indicating that these minerals are likely to deposit in these systems.Master of Science in Environmental Engineerin

VZV-associated acute retinal necrosis in a patient with MS treated with natalizumab

Natalizumab (NTZ) was the first approved humanized monoclonal antibody in highly active relapsing remitting MS (RRMS). Because of the mechanism of inhibiting the migration of immune cells through the blood-brain barrier into the CNS, NTZ is associated with an increased risk of progressive multifocal leukoencephalopathy (PML) by the John Cunningham virus (JCV). Infections with other neurotropic viruses are rarely reported. We present a case of rapid retinal necrosis induced by varicella zoster virus (VZV) in a patient with RRMS under long-term NTZ treatment

Remote Sensing of Coniferous Forest Leaf Area

Many important ecological questions concern ecosystem processes occurring over large areas. However, our understanding o f ecosystem functions is derived primarily from research executed on small, intensively studied sites, and extrapolation to large areas is difficult