MgB2 conductors for dc and ac applications

The paper presents discussion on up to date results on MgB2 conductors from the point of view of their future dc and ac applications. Basic physical parameters of MgB2 compound relevant to conductors are introduced. Different conductor preparation methods and conductor architectures are presented and attainable critical current densities discussed. Some numerical results on critical currents and ac losses of future multifilamentary MgB2 conductors with magnetic cladding of their filaments are given. Recently observed anomalous decrease of ac susceptibility at 50 K in copper clad Powder-in-tube, PIT, MgB2 wires is presented.Comment: Paper presented at EUCAS'01 conference, Copenhagen, 26-30 August 200

Development of a three-level model of early rehabilitation in Perm kray

The article deals with the concept and the content of the technology of early rehabilitation and carries out a retrospective analysis of its development in the Russian Federation and abroad. The authors present the experience of organizing the system of early rehabilitation services in Perm Kray as a three-level model. At the macro-level, the model describes the content and the specificity of realization of the mechanisms of interdepartmental cooperation and highlights the problems and perspectives of their realization. The meso-level deals with the organization of activity of the services of early rehabilitation in institutions of various departments and agencies.В статье представлен опыт организации системы ранней помощи в Пермском крае, сложившейся в виде трехуровневой модели.

The origins of specificity in the microcin-processing protease TldD/E

TldD and TldE proteins are involved in the biosynthesis of microcin B17 (MccB17), an Escherichia coli thiazole/oxazole-modified peptide toxin targeting DNA gyrase. Using a combination of biochemical and crystallographic methods we show that E. coli TldD and TldE interact to form a heterodimeric metalloprotease. TldD/E cleaves the N-terminal leader sequence from the modified MccB17 precursor peptide, to yield mature antibiotic, while it has no effect on the unmodified peptide. Both proteins are essential for the activity; however, only the TldD subunit forms a novel metal-containing active site within the hollow core of the heterodimer. Peptide substrates are bound in a sequence-independent manner through beta sheet interactions with TldD and are likely cleaved via a thermolysin-type mechanism. We suggest that TldD/E acts as a "molecularpencil sharpener'': unfoldedpoly-peptides are fed through a narrow channel into the active site and processively truncated through the cleavage of short peptides from the N-terminal end

Predictors of Long-Term Outcomes after Surgical Myocardial Revascularization

High mortality from cardiovascular diseases (CVD) requires improved approaches to the treatment of this socially significant pathology. Wide implementation of surgical myocardial revascularization makes it possible to improve significantly both life quality and expectancy in patients with coronary heart disease. The aim of this work was to analyze the literature on the impact of preoperative, operative and postoperative factors on the long-term prognosis after coronary artery bypass grafting (CABG). The review refers to both recent and earlier informative works. The target groups for this article are therapists, cardiologists, rehabilitologists, who work with patients in the short and long term after CABG. Data of Russian and foreign literature show that the long-term prognosis after CABG is largely determined by preoperative factors, in particular – age, set of cardiovascular risk factors (RF) and comorbidity, specifically – severity of coronary and systemic atherosclerosis, incident cardiovascular complications, structural and functional state of the heart. In the aggregate these factors reflect the cumulative effect and further potential of actual cardiovascular RFs, affect longterm risk of adverse events, and determine the therapeutic targets of secondary prevention. Priority of arterial conduits and completeness of revascularization are the main operative factors that determine the course of the long-term period after CABG. Among the postoperative factors, the efficiency of secondary CVD prevention is of paramount importance, in particular – achievement of target RF levels, compensation of cardiac and extracardiac pathology, adherence to the long-term medical therapy, known to improve outcomes based on specific comorbidity. Efficiency of secondary CVD prevention largely depends on patient's health attitudes, the key influence on which beyond attending physician can be provided by participation in rehabilitation programs, teaching patients the meaning and essentials of lifestyle modification and cardiovascular RFs’ control

Formation of the system of internal audit in the automotive industry

© Medwell Journals, 2016.Process of an estimation to risk is one of the major making effective control systems at the enterprise. During an estimation to risk of the enterprises of a industry the description of processes of the internal control of the enterprises, revealing of potential brave of events, qualitative an estimation revealed to risk also drawing up of a card to risk on processes of the enterprises of automotive industry will be carried out

Isolation and characterization of a novel indigenous intestinal N4-related coliphage vB_EcoP_G7C

AbstractLytic coliphage vB_EcoP_G7C and several other highly related isolates were obtained repeatedly from the samples of horse feces held in the same stable thus representing a component of the normal indigenous intestinal communities in this population of animals. The genome of G7C consists of 71,759bp with terminal repeats of about 1160bp, yielding approximately 73 kbp packed DNA size. Seventy-eight potential open reading frames, most of them unique to N4-like viruses, were identified and annotated. The overall layout of functional gene groups was close to that of the original N4 phage, with some important changes in late gene area including new tail fiber proteins containing hydrolytic domains. Structural proteome analysis confirmed all the predicted subunits of the viral particle. Unlike N4 itself, phage G7C did not exhibit a lysis-inhibited phenotype

Purinergic profiling of regulatory T-cells in patients with episodic migraine

© 2018 Nurkhametova, Kudryavtsev, Khayrutdinova, Serebryakova, Altunbaev, Malm and Giniatullin. Objectives: Immune responses in migraine are poorly characterized, yet implicated in the disease pathogenesis. This study was carried out to characterize purinergic profiles of T-cells in patients with episodic migraine without aura (MWoA) to provide mechanistic evidence for ATP and adenosine involvement in modulation of immune regulation in migraine. Methods: Peripheral blood samples were obtained from patients with migraine (n = 16) and age-matched control subjects (n = 21). Subsets of T-cells were identified by flow cytometry based on specific membrane markers. Results: Migraine patients showed reduced total T-cell counts in the peripheral blood. Whereas the total number of CD3+CD4+, CD3+CD8+, or regulatory T lymphocytes (Treg) was not changed, the proportion of Treg CD45R0+CD62L– and CD45R0–CD62L– cells was increased. Interestingly, in migraine, less Treg cells expressed CD39 and CD73 suggesting disrupted ATP breakdown to adenosine. The negative correlations were observed between the duration of migraine and the relative number of CD73+CD39– Tregs and total number of CD73-positive CD45R0+CD62L+ Tregs. Conclusion: Obtained data indicate that T-cell populations are altered in episodic migraine and suggest the involvement of Tregs in the pathophysiology of this disorder. Reduced expression of CD39 and CD73 suggests promotion of ATP-dependent pro-inflammatory and reduction of adenosine-mediated anti-inflammatory mechanisms in migraine