811 research outputs found
Localness of energy cascade in hydrodynamic turbulence, II. Sharp spectral filter
We investigate the scale-locality of subgrid-scale (SGS) energy flux and
inter-band energy transfers defined by the sharp spectral filter. We show by
rigorous bounds, physical arguments and numerical simulations that the spectral
SGS flux is dominated by local triadic interactions in an extended turbulent
inertial-range. Inter-band energy transfers are also shown to be dominated by
local triads if the spectral bands have constant width on a logarithmic scale.
We disprove in particular an alternative picture of ``local transfer by
nonlocal triads,'' with the advecting wavenumber mode at the energy peak.
Although such triads have the largest transfer rates of all {\it individual}
wavenumber triads, we show rigorously that, due to their restricted number,
they make an asymptotically negligible contribution to energy flux and
log-banded energy transfers at high wavenumbers in the inertial-range. We show
that it is only the aggregate effect of a geometrically increasing number of
local wavenumber triads which can sustain an energy cascade to small scales.
Furthermore, non-local triads are argued to contribute even less to the
space-average energy flux than is implied by our rigorous bounds, because of
additional cancellations from scale-decorrelation effects. We can thus recover
the -4/3 scaling of nonlocal contributions to spectral energy flux predicted by
Kraichnan's ALHDIA and TFM closures. We support our results with numerical data
from a pseudospectral simulation of isotropic turbulence with
phase-shift dealiasing. We conclude that the sharp spectral filter has a firm
theoretical basis for use in large-eddy simulation (LES) modeling of turbulent
flows.Comment: 42 pages, 9 figure
A quantum search for zeros of polynomials
A quantum mechanical search procedure to determine the real zeros of a polynomial is introduced. It is based on the construction of a spin observable whose eigenvalues coincide with the zeros of the polynomial. Subsequent quantum mechanical measurements of the observable output directly the numerical values of the zeros. Performing the measurements is the only computational resource involved
Identification of direct residue contacts in protein-protein interaction by message passing
Understanding the molecular determinants of specificity in protein-protein
interaction is an outstanding challenge of postgenome biology. The availability
of large protein databases generated from sequences of hundreds of bacterial
genomes enables various statistical approaches to this problem. In this context
covariance-based methods have been used to identify correlation between amino
acid positions in interacting proteins. However, these methods have an
important shortcoming, in that they cannot distinguish between directly and
indirectly correlated residues. We developed a method that combines covariance
analysis with global inference analysis, adopted from use in statistical
physics. Applied to a set of >2,500 representatives of the bacterial
two-component signal transduction system, the combination of covariance with
global inference successfully and robustly identified residue pairs that are
proximal in space without resorting to ad hoc tuning parameters, both for
heterointeractions between sensor kinase (SK) and response regulator (RR)
proteins and for homointeractions between RR proteins. The spectacular success
of this approach illustrates the effectiveness of the global inference approach
in identifying direct interaction based on sequence information alone. We
expect this method to be applicable soon to interaction surfaces between
proteins present in only 1 copy per genome as the number of sequenced genomes
continues to expand. Use of this method could significantly increase the
potential targets for therapeutic intervention, shed light on the mechanism of
protein-protein interaction, and establish the foundation for the accurate
prediction of interacting protein partners.Comment: Supplementary information available on
http://www.pnas.org/content/106/1/67.abstrac
Hyperactivity and Hypermotivation Associated With Increased Striatal mGluR1 Signaling in a Shank2 Rat Model of Autism
Mutations in the SHANK family of genes have been consistently identified in genetic and genomic screens of autism spectrum disorder (ASD). The functional overlap of SHANK with several other ASD-associated genes suggests synaptic dysfunction as a convergent mechanism of pathophysiology in ASD. Although many ASD-related mutations result in alterations to synaptic function, the nature of those dysfunctions and the consequential behavioral manifestations are highly variable when expressed in genetic mouse models. To investigate the phylogenetic conservation of phenotypes resultant of Shank2 loss-of-function in a translationally relevant animal model, we generated and characterized a novel transgenic rat with a targeted mutation of the Shank2 gene, enabling an evaluation of gene-associated phenotypes, the elucidation of complex behavioral phenotypes, and the characterization of potential translational biomarkers. The Shank2 loss-of-function mutation resulted in a notable phenotype of hyperactivity encompassing hypermotivation, increased locomotion, and repetitive behaviors. Mutant rats also expressed deficits in social behavior throughout development and in the acquisition of operant tasks. The hyperactive phenotype was associated with an upregulation of mGluR1 expression, increased dendritic branching, and enhanced long-term depression (LTD) in the striatum but opposing morphological and cellular alterations in the hippocampus (HP). Administration of the mGluR1 antagonist JNJ16259685 selectively normalized the expression of striatally mediated repetitive behaviors and physiology but had no effect on social deficits. Finally, Shank2 mutant animals also exhibited alterations in electroencephalography (EEG) spectral power and event-related potentials, which may serve as translatable EEG biomarkers of synaptopathic alterations. Our results show a novel hypermotivation phenotype that is unique to the rat model of Shank2 dysfunction, in addition to the traditional hyperactive and repetitive behaviors observed in mouse models. The hypermotivated and hyperactive phenotype is associated with striatal dysfunction, which should be explored further as a targetable mechanism for impairment in ASD
Yersinia enteroco/itica prevalence in a French slaughterhouse: first results
Yersinlia enterocolitica is involved in human foodbome infections. Pigs are considered as a major reservoir in many countries. The aim of the study was to contribute to the evaluation of the prevalence of Y. enterocolitica in France in pigs at the slaughterhouse level with optimized detection methods based on ISO 10273-2003. Several samples of tonsils over nine consecutive months were analyzed in a single slaughterhouse. Enumeration and isolation were achieved by using CIN agar and Y eCM chromogenic medium (modified from the Weagant medium, 2008). Two enrichment media were used: a peptone, sorbitol and biliary salts broth (PSB) and the Irgasan, Ticarcillin and potassium chlorate broth (ITC)
Multiplication and Composition in Weighted Modulation Spaces
We study the existence of the product of two weighted modulation spaces. For
this purpose we discuss two different strategies. The more simple one allows
transparent proofs in various situations. However, our second method allows a
closer look onto associated norm inequalities under restrictions in the Fourier
image. This will give us the opportunity to treat the boundedness of
composition operators.Comment: 49 page
Seasonality of aerosol optical properties in the Arctic
Given the sensitivity of the Arctic climate to short-lived climate forcers,
long-term in situ surface measurements of aerosol parameters are useful in
gaining insight into the magnitude and variability of these climate forcings.
Seasonality of aerosol optical properties – including the aerosol
light-scattering coefficient, absorption coefficient, single-scattering
albedo, scattering Ångström exponent, and asymmetry parameter – are
presented for six monitoring sites throughout the Arctic: Alert, Canada;
Barrow, USA; Pallas, Finland; Summit, Greenland; Tiksi, Russia; and Zeppelin
Mountain, Ny-Ålesund, Svalbard, Norway. Results show annual variability
in all parameters, though the seasonality of each aerosol optical property
varies from site to site. There is a large diversity in magnitude and
variability of scattering coefficient at all sites, reflecting differences in
aerosol source, transport, and removal at different locations throughout the
Arctic. Of the Arctic sites, the highest annual mean scattering coefficient
is measured at Tiksi (12.47 Mm−1), and the lowest annual mean
scattering coefficient is measured at Summit (1.74 Mm−1). At most
sites, aerosol absorption peaks in the winter and spring, and has a minimum
throughout the Arctic in the summer, indicative of the Arctic haze
phenomenon; however, nuanced variations in seasonalities suggest that this
phenomenon is not identically observed in all regions of the Arctic. The
highest annual mean absorption coefficient is measured at Pallas
(0.48 Mm−1), and Summit has the lowest annual mean absorption
coefficient (0.12 Mm−1). At the Arctic monitoring stations analyzed
here, mean annual single-scattering albedo ranges from 0.909 (at Pallas) to
0.960 (at Barrow), the mean annual scattering Ångström exponent
ranges from 1.04 (at Barrow) to 1.80 (at Summit), and the mean asymmetry
parameter ranges from 0.57 (at Alert) to 0.75 (at Summit). Systematic
variability of aerosol optical properties in the Arctic supports the notion
that the sites presented here measure a variety of aerosol populations, which
also experience different removal mechanisms. A robust conclusion from the
seasonal cycles presented is that the Arctic cannot be treated as one common
and uniform environment but rather is a region with ample spatiotemporal
variability in aerosols. This notion is important in considering the design
or aerosol monitoring networks in the region and is important for informing
climate models to better represent short-lived aerosol climate forcers in
order to yield more accurate climate predictions for the Arctic.</p
Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold
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