Additive Antinociceptive Effects of a Combination of Vitamin C and Vitamin E after Peripheral Nerve Injury

Accumulating evidence indicates that increased generation of reactive oxygen species (ROS) contributes to the development of exaggerated pain hypersensitivity during persistent pain. In the present study, we investigated the antinociceptive efficacy of the antioxidants vitamin C and vitamin E in mouse models of inflammatory and neuropathic pain. We show that systemic administration of a combination of vitamins C and E inhibited the early behavioral responses to formalin injection and the neuropathic pain behavior after peripheral nerve injury, but not the inflammatory pain behavior induced by Complete Freund's Adjuvant. In contrast, vitamin C or vitamin E given alone failed to affect the nociceptive behavior in all tested models. The attenuated neuropathic pain behavior induced by the vitamin C and E combination was paralleled by a reduced p38 phosphorylation in the spinal cord and in dorsal root ganglia, and was also observed after intrathecal injection of the vitamins. Moreover, the vitamin C and E combination ameliorated the allodynia induced by an intrathecally delivered ROS donor. Our results suggest that administration of vitamins C and E in combination may exert synergistic antinociceptive effects, and further indicate that ROS essentially contribute to nociceptive processing in special pain states

War as Rent-Seeking: A Public Choice Perspective on the Pacific War

Historical literature on the causes of the Pacific War generally focuses on either international relationships between the great powers in the interwar period or on the role of domestic interest groups in Japan, especially the Imperial Army and Navy. An alternative to these predominantly narrative approaches is to consider Japanese imperialism as explained by the public choice concept of rent seeking. Seeing both imperial expansions through armed conquest and domestic interest group rivalry as forms of rent-seeking behavior can provide a unifying perspective for understanding the Pacific War. Copyright Springer Science+Business Media, LLC 2007Imperialism, Interest groups, Pacific war, Public choice, Rent seeking, H0, H41, K4, N0, N45, O0,

Modernism, gender and consumer spectacle in 1920s’ Tokyo

A lot has been written about how in the first decades of the twentieth century cinema validated new perceptual structures and how these affected literary narrative. But the department store was also a vital part of the mobile spectacle of modernity. Ginza and its department stores provided experiences of urban flâneuring and visual consumption that would have important effects on gender and subjectivity. This essay focuses on three short stories published between 1922 and 1931, all set in department stores or on the Ginza: Tanizaki Jun’ichirō’s ‘Aoi hana’ (The Blue Flower, 1922), Itō Sei’s ‘M hyakkaten’ (The M Department Store, 1931) and Yokomitsu Riichi’s ‘Nanakai no undō’ (Seven Floors of Exercise, 1927). The stories share a radically experimental modernist form: fragmented interior monologues, montage-like juxtapositions, abrupt shifts of narrative perspective. They are also connected in their preoccupation with looking, with the drama of seeing and being seen. My analysis traces how the domain of vision becomes a place of struggle over subjectivity, how gendered visual hierarchies are undermined and at least temporarily reversed