14 research outputs found
Efficacy and Safety of Three Antiretroviral Regimens for Initial Treatment of HIV-1: A Randomized Clinical Trial in Diverse Multinational Settings
- Author
- Adams M.
- Amod F.
- Andrade A.
- Asmuth D.
- Baer J.
- Bailey V.L.
- Balfour H.H.
- Barnett R.L.
- Basler C.
- Berendes S.
- Berthaud V.
- Bischofberger N.
- Bollinger R.C.
- Brizz B.
- Bryson Y.
- Burke K.
- Campbell T.B.
- Cardoso S.W.
- Celentano D.
- Cespedes M.
- Chariyalertsak S.
- Chen Y.
- Chen Y.
- Cheng A.
- Chilongozi D.
- Chisada A.
- Cohen M.
- Collier A.C.
- Corales R.
- Cox G.M.
- Cu-Uvin S.
- Currier J.S.
- Currin D.
- Daar E.S.
- de Gruttola V.
- Delph Y.
- Descallar R.S.
- Dhayarkar S.
- Eron J.
- Eshleman S.
- Faesen S.
- Faria D.L.
- Feinberg J.
- Firnhaber C.
- Fiscus S.A.
- Flanigan T.
- Flexner C.
- Forcht J.
- Frarey L.
- Fritsche J.M.
- Gaikwad A.
- Gallant J.E.
- Gangakhedkar R.R.
- Geiseler P.J.
- Gettinger N.
- Godbole S.
- Gormley J.
- Grinsztejn B.
- Gulick R.M.
- Haas D.H.
- Haas D.W.
- Hakim J.G.
- Hammer S.M.
- Hoffman I.
- Hosseinipour M.C.
- Hurley C.
- Infante R.
- Jaffe H.
- Jain M.
- Joglekar A.A.
- Kanyama C.
- Kayoyo V.
- Kazembe P.
- Kim G.-Y.
- Klebert M.K.
- Klingman K.L.
- Kumarasamy N.
- Kumwenda J.
- Kumwenda N.
- la Rosa A.
- Lalloo U.
- Lama J.R.
- Lawrence J.
- Lira R.A.
- Loeliger E.
- Lopez R.
- Lopez-Detres L.
- Luque A.
- Maponga C.
- Marcus C.J.
- Martin J.C.
- Martinez A.I.
- Martinson F.
- Mayer K.
- McGregor D.
- Melo M.
- Mildvan D.
- Mitsuyasu R.T.
- Mngqibisa R.
- Mogridge C.
- Moran L.
- Mullan B.
- Nair A.
- Nielsen K.
- Noel-Connor J.
- Ntshele S.
- OBrien W.A.
- Palmer M.
- Pappa K.A.
- Para M.F.
- Patterson H.
- Pendame R.B.
- Petersen T.
- Pollard R.B.
- Poongulali S.
- Putnam B.
- Ramratnam B.
- Ray M.G.
- Revuelta M.
- Riviere C.
- Rooney J.F.
- Safren S.
- Said F.
- Samaneka W.P.
- Sanchez J.
- Sanne I.
- Santos B.
- Santos B.
- Schooley R.T.
- Severe P.
- Sha B.E.
- Sharma J.
- Shugarts D.L.
- Silberman M.
- Sirisanthana T.
- Smeaton L.M.
- Snowden W.
- Solomon S.
- Steele J.
- Stroberg T.
- Supparatpinyo K.
- Swann E.
- Tabet S.
- Taha T.
- Taiwo B.
- Tashima K.T.
- Tebas P.
- Torres M.
- Tripathy S.
- Uy J.
- van der Horst C.
- Walawander A.
- Wanke C.
- Watson K.J.
- Webb N.
- Winters M.A.
- Wulfsohn M.
- Zifchak L.
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
Background:Antiretroviral regimens with simplified dosing and better safety are needed to maximize the efficiency of antiretroviral delivery in resource-limited settings. We investigated the efficacy and safety of antiretroviral regimens with once-daily compared to twice-daily dosing in diverse areas of the world.Methods and Findings:1,571 HIV-1-infected persons (47% women) from nine countries in four continents were assigned with equal probability to open-label antiretroviral therapy with efavirenz plus lamivudine-zidovudine (EFV+3TC-ZDV), atazanavir plus didanosine-EC plus emtricitabine (ATV+DDI+FTC), or efavirenz plus emtricitabine-tenofovir-disoproxil fumarate (DF) (EFV+FTC-TDF). ATV+DDI+FTC and EFV+FTC-TDF were hypothesized to be non-inferior to EFV+3TC-ZDV if the upper one-sided 95% confidence bound for the hazard ratio (HR) was Ăąâ°Â€1.35 when 30% of participants had treatment failure.An independent monitoring board recommended stopping study follow-up prior to accumulation of 472 treatment failures. Comparing EFV+FTC-TDF to EFV+3TC-ZDV, during a median 184 wk of follow-up there were 95 treatment failures (18%) among 526 participants versus 98 failures among 519 participants (19%; HR 0.95, 95% CI 0.72-1.27; p = 0.74). Safety endpoints occurred in 243 (46%) participants assigned to EFV+FTC-TDF versus 313 (60%) assigned to EFV+3TC-ZDV (HR 0.64, CI 0.54-0.76; p<0.001) and there was a significant interaction between sex and regimen safety (HR 0.50, CI 0.39-0.64 for women; HR 0.79, CI 0.62-1.00 for men; p = 0.01). Comparing ATV+DDI+FTC to EFV+3TC-ZDV, during a median follow-up of 81 wk there were 108 failures (21%) among 526 participants assigned to ATV+DDI+FTC and 76 (15%) among 519 participants assigned to EFV+3TC-ZDV (HR 1.51, CI 1.12-2.04; p = 0.007).Conclusion: EFV+FTC-TDF had similar high efficacy compared to EFV+3TC-ZDV in this trial population, recruited in diverse multinational settings. Superior safety, especially in HIV-1-infected women, and once-daily dosing of EFV+FTC-TDF are advantageous for use of this regimen for initial treatment of HIV-1 infection in resource-limited countries. ATV+DDI+FTC had inferior efficacy and is not recommended as an initial antiretroviral regimen.Trial Registration:http://www.ClinicalTrials.gov NCT00084136
Stochastic Rotation Dynamics simulations of wetting multi-phase flows.
- Publication venue
- 'Elsevier BV'
- Publication date
- 15/06/2016
- Field of study
Multi-color Stochastic Rotation Dynamics (SRDmcSRDmc) has been introduced by Inoue et al. [1] ; [2] as a particle based simulation method to study the flow of emulsion droplets in non-wetting microchannels. In this work, we extend the multi-color method to also account for different wetting conditions. This is achieved by assigning the color information not only to fluid particles but also to virtual wall particles that are required to enforce proper no-slip boundary conditions. To extend the scope of the original SRDmcSRDmc algorithm to e.g. immiscible two-phase flow with viscosity contrast we implement an angular momentum conserving scheme (View the MathML sourceSRD+mc). We perform extensive benchmark simulations to show that a mono-phase SRDmcSRDmc fluid exhibits bulk properties identical to a standard SRD fluid and that SRDmcSRDmc fluids are applicable to a wide range of immiscible two-phase flows. To quantify the adhesion of a View the MathML sourceSRD+mc fluid in contact to the walls we measure the apparent contact angle from sessile droplets in mechanical equilibrium. For a further verification of our wettability implementation we compare the dewetting of a liquid film from a wetting stripe to experimental and numerical studies of interfacial morphologies on chemically structured surfaces
Interplay between social debate and propaganda in an opinion formation model
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2013
- Field of study
Wettability controls slow immiscible displacement through local interfacial instabilities.
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2016
- Field of study
Immiscible fluid displacement with average front velocities in the capillary-dominated regime is studied in a transparent Hele-Shaw cell with cylindrical posts. Employing various combinations of fluids and wall materials allows us to cover a range of advancing contact angles 46⊠Ξa 180⊠of the invading fluid in our experiments. In parallel, we study the displacement process in particle-based simulations that account for wall wettability. Considering the same arrangement of posts in experiments and simulation, we find a consistent crossover between stable interfacial displacement at Ξa 80⊠and capillary fingering at high contact angles Ξa 120âŠ. The position of the crossover is quantified through the evolution of the interface length and the final saturation of the displaced fluid. A statistical analysis of the local displacement processes demonstrates that the shape evolution of the fluid front is governed by local instabilities as proposed by Cieplak and Robbins for a quasistatic interfacial displacement [Cieplak and Robbins, Phys. Rev. Lett. 60, 2042 (1988)]. The regime of stable front advances coincides with a corresponding region of contact angles where cooperative interfacial instabilities prevail. Capillary fingering, however, is observed only for large Ξa , where noncooperative instabilities dominate the invasion process
Spatioâtemporal Variability of the SST from Drifters and Satellites
- Publication venue
- Publication date
- 01/01/2016
- Field of study
Global changes in oceanic mesoscale currents over the satellite altimetry record
- Author
- A Foppert
- A Gnanadesikan
- A Sen Gupta
- AM Hogg
- B Wu
- C Wunsch
- C Wunsch
- CG Holladay
- CG Piecuch
- DB Chelton
- DB Chelton
- DJ Seidel
- GC Johnson
- GSE Lagerloef
- H Uchida
- H Yang
- H Yang
- J Marshall
- J MartĂnez-Moreno
- JJ Early
- JJM Busecke
- JR Toggweiler
- K Wolter
- K Wyrtki
- L Patara
- L Wu
- L-C Wang
- M Castellani
- M Ding
- M Sanchez de La Lama
- MA Cane
- MJ McPhaden
- MP Meredith
- NJ Abram
- NP Gillett
- OA Saenko
- PS Polito
- R Ruela
- RJ Haarsma
- RT Sutton
- S Hu
- S Yue
- T Ezer
- T Radko
- V Banzon
- Y Yuan
- Y-O Kwon
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Measurement of tau polarization in W -> tau nu decays with the ATLAS detector in pp collisions at root s=7 TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Acerbia E
- Acharyaa BS
- Adam ER
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akdogan T
- Akesson TP
- Akimoto G
- Akimov AV
- Akiyama A
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandriaa F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Aliyev M
- Allbrooke BMM
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alviggi MG
- Amako K
- Amaral P
- Amelung C
- Ammosov VV
- Amorim A
- Amoros G
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Andrieux ML
- Anduaga XS
- Angerami A
- Anghinolfi F
- Anh TV
- Anisenkov A
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoun S
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Aranda CP
- Arce ATH
- Arfaoui S
- Arguin JF
- Arik E
- Armbruster AJ
- Arnaez O
- Arnal V
- Arnault C
- Artamonov A
- Artoni G
- Arutinov D
- Asai S
- Asfandiyarov R
- Ask S
- Asman B
- Asquith L
- Assamagan K
- Astbury A
- Aubert B
- Auge E
- Augsten K
- Aurousseaua M
- Avolio G
- Avramidou R
- Axen D
- Ay C
- Azuelos G
- Azuma Y
- Baak MA
- Baccaglioni G
- Bacci C
- Bach AM
- Bachacou H
- Bachas K
- Backes M
- Backhaus M
- Badescu E
- Bagnaia P
- Bahinipati S
- Bai Y
- Bailey DC
- Bain T
- Baines JT
- Baker MD
- Baker OK
- Baker S
- Banas E
- Banerjee P
- Banerjee S
- Banfi D
- Bangert A
- Bansal V
- Bansil HS
- Barajas CAC
- Barak L
- Baranov SP
- Barashkou A
- Barber T
- Barberio EL
- Barberis D
- Barbero M
- Bardin DY
- Barillari T
- Barisonzi M
- Barklow T
- Barlow N
- Barnett BM
- Barnett RM
- Baroncellia A
- Barone G
- Barr AJ
- Barreiro F
- Barrera CO
- Barrillon P
- Bartoldus R
- Barton AE
- Bartsch V
- Bates RL
- Batkova L
- Batley JR
- Battaglia A
- Battistin M
- Bauer F
- Bawa HS
- Beale S
- Beau T
- Beauchemin PH
- Beccherle R
- Bechtle P
- Beck HP
- Becker S
- Beckingham M
- Becks KH
- Beddall A
- Beddall AJ
- Bedikian S
- Bednyakov VA
- Bee CP
- Begel M
- Behera PK
- Beimforde M
- Belanger-Champagne C
- Belenguer MJ
- Bell PJ
- Bell WH
- Bella G
- Bella LA
- Bellagamba L
- Bellina F
- Bellomo M
- Belloni A
- Beloborodova O
- Belotskiy K
- Beltramello O
- Benary O
- Benchekroun D
- Bendel M
- Bendtz K
- Benekos N
- Benhammou Y
- Benjamin DP
- Benoit M
- Bensinger JR
- Benslama K
- Bentvelsen S
- Bentvelsen S
- Berge D
- Berge D
- Berger N
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- Berghaus F
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- Berglund E
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- Beringer J
- Beringer J
- Bernat P
- Bernat P
- Bernhard R
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- Bernius C
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- Berry T
- Berry T
- Bertella C
- Bertella C
- Bertin A
- Bertin A
- Bertinelli F
- Bertolucci F
- Bertolucci F
- Besana MI
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- Besson N
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- Bethke S
- Bethke S
- Bhimji W
- Bhimji W
- Bianchi RM
- Bianchi RM
- Bianco M
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- Biebel O
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- Bieniek SP
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- Bierwagen K
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- Biesiada J
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- Biglietti M
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- Bilokon H
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- Bindi M
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- Binet S
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- Bingul A
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- Biscarat C
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- Black KM
- Blair RE
- Blanchard JB
- Blanchot G
- Blazek T
- Blocker C
- Blocki J
- Blondel A
- Blum W
- Blumenschein U
- Bobbink GJ
- Bobrovnikov VB
- Bocchetta SS
- Bocci A
- Boddy CR
- Boehler M
- Boek J
- Boelaert N
- Boeriu OEV
- Bogaerts JA
- Bogdanchikov A
- Bogouch A
- Bohm C
- Bohm J
- Boisvert V
- Bold T
- Boldea V
- Bolnet NM
- Bomben M
- Bona M
- Bondarenko VG
- Bondioli M
- Boonekamp M
- Booth CN
- Bordoni S
- Borer C
- Borisov A
- Borissov G
- Borjanovica I
- Borri M
- Borroni S
- Bortolotto V
- Bos K
- Boscherini D
- Bosman M
- Boterenbrood H
- Botterill D
- Bouchami J
- Boudreau J
- Bouhova-Thacker EV
- Boumediene D
- Bourdarios C
- Bousson N
- Boveia A
- Boyd J
- Boyko IR
- Bozhko NI
- Bozovic-Jelisavcic I
- Bracinik J
- Braem A
- Branchini P
- Brandenburg GW
- Brandt A
- Brandt G
- Brandt O
- Bratzler U
- Brau B
- Brau JE
- Braun HM
- Brelier B
- Bremer J
- Brendlinger K
- Brenner R
- Bressler S
- Britton D
- Brochu FM
- Brock I
- Brock R
- Brodbeck TJ
- Brodet E
- Broggi F
- Bromberg C
- Bronner J
- Brooijmans G
- Brooks WK
- Brown G
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- Bruncko D
- Bruneliere R
- Brunet S
- Bruni A
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- Bruschi M
- Buanes T
- Buat Q
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- Buchanan J
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- Buckingham RM
- Buckley AG
- Budaa SI
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- Budick B
- Bueso XP
- Bugge L
- Bulekov O
- Bundock AC
- Bunse M
- Buran T
- Burckhart H
- Burdin S
- Burgess T
- Burke S
- Busato E
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- Butin F
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- Buttar CM
- Butterworth JM
- Buttinger W
- Caforio D
- Cakir IT
- Cakira O
- Calafiura P
- Calderini G
- Calfayan P
- Calkins R
- Caloba LP
- Caloi R
- Calvet D
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- Camarri P
- Cambiaghi M
- Cameron D
- Camillocci ES
- Caminada LM
- Campana S
- Campanelli M
- Canale V
- Canelli F
- Canepa A
- Cantero J
- Capasso L
- Caprini I
- Caprini M
- Capriotti D
- Capua M
- Caputo R
- Cardarelli R
- Carli T
- Carlino G
- Carminati L
- Caron B
- Caron S
- Carquin E
- Carter AA
- Carter JR
- Carvalho J
- Casadei D
- Casado MP
- Cascella M
- Caso C
- Castaneda-Miranda E
- Castanheira MTD
- Castillo LRF
- Castro NF
- Cataldi G
- Catastini P
- Catinaccio A
- Catmore JR
- Cattai A
- Cattani G
- Caughron S
- Cauz D
- Cavalcanti TP
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- Cavalli D
- Cavalli-Sforza M
- Cavasinni V
- Ceradini F
- Cerqueira AS
- Cerri A
- Cerrito L
- Cerutti F
- Cetin SA
- Cevenini F
- Chafaq A
- Chakraborty D
- Chalupkova I
- Chan K
- Chapleau B
- Chapman JD
- Chapman JW
- Chareyre E
- Charlton DG
- Chavda V
- Cheatham S
- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chelstowska MA
- Chen C
- Chen H
- Chen S
- Chen T
- Chen X
- Cheng S
- Cheplakov A
- Chepurnov VF
- Chernyatin V
- Cheu E
- Cheung SL
- Chevalier L
- Chiefari G
- Chikovani L
- Childers JT
- Chilingarov A
- Chiodini G
- Chisholm AS
- Chislett RT
- Chizhov MV
- Choudalakis G
- Chouridou S
- Christidi IA
- Christov A
- Chromek-Burckhart D
- Chu ML
- Chudoba J
- Ciapetti G
- Ciftci AK
- Ciftci R
- Cinca D
- Cindro V
- Ciocca C
- Ciocio A
- Cirilli M
- Citterio M
- Ciubancan M
- Clark A
- Clark PJ
- Cleland W
- Clemens JC
- Clement B
- Clement C
- Coadou Y
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- Coccaro A
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- Codina EP
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- Cogan JG
- Coggeshall J
- Cogneras E
- Colas J
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- Collins NJ
- Collins-Tooth C
- Collot J
- Colon G
- Coniavitis E
- Conidi MC
- Consonni M
- Consonni SM
- Consorti V
- Constantinescu S
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- Conti G
- Conventi F
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- Cooke M
- Cooper BD
- Cooper-Sarkar AM
- Copic K
- Cornelissen T
- Corradi M
- Correia AMH
- Corriveau F
- Cortes-Gonzalez A
- Cortiana G
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- Costa MJ
- Costanzo D
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- Cote D
- Courneyea L
- Cowan G
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- Cox BE
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- Crepe-Renaudin S
- Crescioli F
- Cristinziani M
- Crosetti G
- Crupi R
- Cuciuc CM
- Cummings J
- Curatolo M
- Curtis CJ
- Curull XE
- Cuthbert C
- Cwetanski P
- Czirr H
- Czodrowski P
- Czyczula Z
- D'Auria S
- D'Onofrio M
- D'Orazio A
- da Costa JBG
- Da Costa JCPF
- Da Silva PVM
- Da Via C
- Dabrowski W
- Dafinca A
- Dai T
- Dallapiccola C
- Dam M
- Damazio DO
- Dameri M
- Damiani DS
- Danielsson HO
- Dannheim D
- Dao V
- Darbo G
- Darlea GL
- Davey W
- Davidek T
- Davidson N
- Davidson R
- Davies E
- Davies M
- Davison AR
- Davygora Y
- Dawe E
- Dawson I
- Dawson JW
- Daya-Ishmukhametova RK
- de Andrade LM
- de Asmundis R
- De Castro S
- De Cecco S
- de Graat J
- De Groot N
- de Jong P
- De K
- de la Hoz SG
- De La Taille C
- De la Torre H
- de Lima DEF
- de Lima JGR
- De Lorenzi F
- De Lotto B
- de Mora L
- De Nooij L
- De Pedis D
- De Regie JBD
- de Renstrom PAB
- De Salvo A
- De Sanctis U
- De Santo A
- De Zorzi G
- Dean S
- Dearnaley WJ
- Debbe R
- Debenedetti C
- Dechenaux B
- Dedovich DV
- Degenhardt J
- Del Papa C
- Del Peso J
- Del Prete T
- Delemontex T
- Deliyergiyev M
- Dell'Acqua A
- Dell'Asta L
- Della Pietra M
- della Porta GZ
- della Volpe D
- Delmastro M
- Delruelle N
- Delsart PA
- Deluca C
- Demers S
- Demichev M
- Demirkoz B
- Deng J
- Denisov SP
- Derendarz D
- Derkaoui JE
- Derue F
- Dervan P
- Desch K
- Devetak E
- Deviveiros PO
- Dewhurst A
- DeWilde B
- Dhaliwal S
- Dhullipudi R
- Di Ciaccio A
- Di Ciaccio L
- Di Girolamo A
- Di Girolamo B
- Di Luise S
- Di Mattia A
- Di Micco B
- Di Nardo R
- Di Simone A
- Di Sipio R
- Diaz MA
- Diblen F
- Diehl EB
- Dietrich J
- Dietzsch TA
- Diglio S
- Dingfelder J
- Dionisi C
- Dita P
- Dita S
- Dittus F
- Djama F
- Djobava T
- do Vale MAB
- Do ValleWemans A
- Doan TKO
- Dobbs M
- Dobinson R
- Dobos D
- Dobson E
- Dodd J
- Doglioni C
- Doherty T
- Dohmae T
- Doi Y
- Dolejsi J
- Dolenc I
- Dolezal Z
- Dolgoshein BA
- Donadelli M
- Donega M
- Donini J
- Donszelmann TC
- Dopke J
- Doria A
- Dos Anjos A
- Dos Santos DR
- Dosil M
- Dotti A
- Dova MT
- Doxiadis AD
- Doyle AT
- Drasal Z
- Dressnandt N
- Driouichi C
- Dris M
- Dubbert J
- Dube S
- Duchovni E
- Duckeck G
- Dudarev A
- Dudziak F
- Duerdoth IP
- Duflot L
- Dufour MA
- Duhrssen M
- Dunford M
- Duren M
- Duxfield R
- Dwuznik M
- Dydak F
- Ebenstein WL
- Ebke J
- Eckweiler S
- Edmonds K
- Edwards CA
- Edwards NC
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
In this paper, a measurement of tau polarization in W -> tau nu decays is presented. It is measured from the energies of the decay products in hadronic tau decays with a single final state charged particle. The data, corresponding to an integrated luminosity of 24 pb(-1), were collected by the ATLAS experiment at the Large Hadron Collider in 2010. The measured value of the tau polarization is P-tau = -1.06 +/- 0.04 (stat)(-0.07)(+0.05) (syst), in agreement with the Standard Model prediction, and is consistent with a physically allowed 95 % CL interval [-1,-0.91]. Measurements of tau polarization have not previously been made at hadron colliders. RI Fazio, Salvatore /G-5156-2010; Fabbri, Laura/H-3442-2012; Villa, Mauro/C-9883-2009; Jones, Roger/H-5578-2011; valente, paolo/A-6640-2010; Takai, Helio/C-3301-2012; Delmastro, Marco/I-5599-2012; Livan, Michele/D-7531-201
8th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2015).
- Author
- Abdel-Mohsen M
- Abimiku A
- Abrahams F
- Abram M
- Abrams EJ
- Achii P
- Achu MN
- Adams R
- Adler M
- Agot K
- Agot K
- Agyei Y
- Ahlers J
- Ahmed S
- Ajibola G
- Akapirat S
- Akello I
- Akelo V
- Alave J
- Alcaide M
- Alcami J
- Alimenti A
- Alimenti A
- Allegre T
- Allison S
- Altice F
- Amaros I
- Ambinder RF
- Amedee A
- Amico KR
- Amico KR
- Amzal B
- Ananworanich J
- Ananworanich J
- Ananworanich J
- Ananworanich J
- Anastos K
- Anato S
- Ancuta P
- Anderson P
- Anderson PL
- Andrade J
- Andrew K
- Andrew P
- Angin M
- Ansari A
- Anstett K
- Antonini-Michelle T
- Apornpong T
- Apps R
- Arasteh K
- Archin N
- Arendt M
- Argento E
- Arheart K
- Arredondo J
- Arribas J
- Arthos J
- Arts E
- Asamoah-Odei E
- Aschman N
- Asila V
- Asire B
- Asmuth D
- Aumaitre H
- Aurpibul L
- Auvert B
- Avettand-Fenoel V
- Avihingsanon A
- Avila-Rios S
- Awa JC
- Ayadi AE
- Bacchetti P
- Bachireddy C
- Bacon O
- Badal-Faesen S
- Badal-Faesen S
- Baddeley A
- Baeten J
- Baeten JM
- Bai F
- Bailer R
- Bajos N
- Baltazar CS
- Bamford A
- Banchongkit S
- Bandason T
- Bangsberg DR
- Bao J
- Baral S
- Baral S
- Barash E
- Barbara C
- Barbee L
- Barnabas R
- Barrios R
- Barrios R
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- Padian NS
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- Piwowar-Manning E
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- Planas D
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- Welty T
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- Wertheim JO
- Westgard T
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- Wijayaratne S
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- Wimonsate W
- Wittkop L
- Woelk G
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- Wolff M
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- Wood E
- Wood E
- Wood E
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- Wu HL
- Wu V
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- Xaba T
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- Xiao H
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- Yazdanpanah Y
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- Zablotska I
- Zamor P
- Zang O
- Zash R
- Zerbe A
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- Zhang Y
- Zhou S
- Zhuang M
- Ziegler JB
- Zink A
- Zink C
- Zolla-Pazner S
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- Zolowere DB
- Zou H
- Zuma N
- ĂsbjörnsdĂłttir KH
- Ăvila-RĂos S
- Publication venue
- 'International AIDS Society'
- Publication date
- 01/01/2015
- Field of study
Enhanced infection prophylaxis reduces mortality in severely immunosuppressed HIV-infected adults and older children initiating antiretroviral therapy in Kenya, Malawi, Uganda and Zimbabwe: the REALITY trial
- Author
- Abach J
- Abdallah J
- Abdallah S
- Abdallah S
- Aberle-Grasse J
- Abimiku A
- Abishev A
- Abongomera G
- Aboud M
- Aboud M
- Abramovitz D
- Abrams E
- Abrams E
- Abrams E
- Abrams E
- Abravaya K
- Abreu L
- Achra A
- Adera F
- Adetokunboh O
- Adeyemi O
- Adeyemi O
- Adipo T
- Affolabi D
- Agegnehu D
- Agius P
- Agolory S
- Agot K
- Agot K
- Agovi A-A
- Aguiar P
- Aguilar-Martinez J
- Agutu C
- Ahmed M
- Ahmed R
- Ahmed S
- Ahmed S
- Ahmed S
- Aizire J
- Ajibola G
- Ajok S
- Albert-Hope C
- Alejos B
- Alexander G
- Alicea C
- Allen H
- Allen M
- Allen S
- Allen S
- Allen S
- Alloui C
- Altice F
- Altice F
- Amara R
- Ambani A
- Ambrose K
- Amico R
- Amin J
- Amin T
- Amole C
- Amoros I
- Anahtar M
- Ananworanich J
- Ananworanich J
- Ancuta P
- Andama A
- Anderegg N
- Anderson A
- Anderson A
- Anderson E
- Anderson J
- Anderson J
- Anderson S
- Andersson M
- Andrade A
- Andrew E
- Andrew P
- Andrew P
- Andrews L
- Angel J
- Angelidou K
- Anglaret X
- Anoma C
- Ansari A
- Apetrei C
- Apetrei C
- Apetrei C
- Apetrei C
- Apetrei C
- Apollon A
- Apondi E
- Aptekar S
- Ardiet D
- Arellano G
- Arenas-Pinto A
- Arhel N
- Armstrong D
- Arthos J
- Artz L
- Arunmanakul A
- Asari V
- Asege L
- Asiimwe S
- Asiimwe S
- Asiimwe S
- Asokan M
- Aspin C
- Athiambo M
- Atuhumuza E
- Atujuna M
- Audet C
- Auerbach J
- Auld A
- Aung P
- Aurpibul L
- Aurpibul L
- Avalos A
- Avihingsanon A
- Avihingsanon A
- Avihingsanon A
- Awori Q
- Awotwi E
- Ayala V
- Ayalew M
- Ayaya S
- Ayieko J
- Ayieko J
- Ayieko J
- Aylott A
- Azar M
- Azbel L
- Azizuyo B
- Babiker A
- Babikhina K
- Back D
- Badjé A
- Baeten J
- Baeten J
- Baeten J
- Baeten J
- Baeten J
- Baeten J
- Baggaley R
- Baghazal A
- Bagley Z
- Bah-sow O
- Baijnath P
- Bailey R
- Bailey R
- Bajos N
- Bajracharya A
- Bajunirwe F
- Bakowska E
- Bakwalufu J
- Balestre E
- Balkan S
- Balzer L
- Bamba A
- Banda G
- Banda K
- Bandason T
- Bangsberg
- Baral S
- Baral S
- Baral S
- Baral S
- Baral S
- Barasa M
- Barber M
- Barbour R
- Barde A
- Bardeguez A
- Barihuta T
- Barker C
- Barnabas R
- Barnes P
- Barnighausen T
- Baron D
- Barone M
- Barr D
- Barrenas C
- Barrington C
- Barron P
- Baruwa E
- Basar M
- Bassett I
- Bassett J
- Bassett J
- Bastos F
- Batrouney C
- Bauer G
- Baum M
- Bautista-Arredondo S
- Bautista-Arredondo S
- Bautista-Arredondo S
- Bavinton B
- Bavinton B
- Baxter C
- Baya J
- Bazin B
- Bañón S
- Beauchamp G
- Beauchamp G
- Beck G
- Beckham S
- Bedi K
- Bekker L-G
- Beletsky L
- Belkind U
- Bell J
- Belloso W
- Belonosova E
- Belzer M
- Benedetti M
- Benfield T
- Bennett K
- Bennett K
- Bennett K
- Benson S
- Bere A
- Berkhout B
- Bermudez LG
- Bernard E
- Bernardo V
- Bernaud C
- Bertrand S
- Bhagani
- Bhardwaj K
- Bhardwaj S
- Bhardwaj S
- Bhayani L
- Bi G
- Biello K
- Biello K
- Bii S
- Bilkovski R
- Binda K
- Binley J
- Bisht M
- Bisignano A
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- Blantari J
- Blick G
- Blumenthal S
- Bock N
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- Boleo C
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- Bond V
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- Bonnington O
- Bonzela J
- Boonsuk S
- Bor J
- Bor J
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- Bor J
- Bor J
- Borkird T
- Borquez A
- Bose M
- Bosomprah S
- Bouchaud O
- Boulle A
- Boum Y
- Bouzas M
- Bowman B
- Boyd A
- Boyd R
- Boyer S
- Boyer S
- Boyes M
- Bozinoff N
- Bozzi G
- Bradley J
- Brahmbhatt H
- Brainard D
- Brand R
- Bredeek U
- Brenchley J
- Brennan A
- Brennan A
- Brennan A
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- Brennan D
- Brewster-Lee D
- Brezak A
- Brigham F
- Brigstock-Barron O
- Brill I
- Brill I
- Brittain K
- Britto P
- Brocca-Cofano E
- Brocca-Cofano E
- Brocca-Cofano E
- Brocca-Cofano E
- Brooks R
- Brooks-Pollock E
- Brothers J
- Brotto L
- Brouwers P
- Brown E
- Brown G
- Brown H
- Brown L
- Browning R
- Browning R
- Brummel S
- Brummel S
- Bryant H
- Bryant K
- BrÀu N
- Bucek A
- Bucek A
- Buchanan A
- Buehler S
- Bukenya D
- Bukenya D
- Bukenya D
- Bukowski L
- Bukowski L
- Bukusi D
- Bukusi E
- Bukusi E
- Bukusi E
- Bukusi E
- Bukusi E
- Bulterys M
- Bulya N
- Bulya N
- Bunu A
- Burchett S
- Burgener A
- Burke S
- Burman W
- Burmeister S
- Burton R
- Burwitz B
- Busch M
- Busch M
- Busza J
- Bwakura-Dangarembizi M
- Bwakura-Dangarembizi M
- Bwana M
- Bygrave H
- Byrareddy S
- Byrd J
- Byrne E
- BĂ€rnighausen T
- BĂ€rnighausen T
- Cadigan J
- Cahn P
- Cahn P
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- Carolus G
- Carrasco M
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- Casavant I
- Cassell M
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- Cathcart R
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- Cazein F
- Cecchini D
- Cecilio M
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- Ceranto A
- Chabala C
- Chabata S
- Chabeda S
- Chakhtoura N
- Chakhtoura N
- Chakhtoura N
- Chamanga R
- Chamie G
- Chanaiwa V
- Chandawale A
- Chandra C
- Chandra S
- Chang E
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- Chapman S
- Chappell E
- Charlebois E
- Charlebois E
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- Charlebois E
- Charoenying S
- Charreau I
- Charreau I
- Chas J
- Chas J
- Chasanov
- Chaturvedi S
- Chaudhury S
- Chege W
- Chelbi-Alix M
- Chemhuru M
- Chen C-H
- Chen L
- Chen M
- Chen S
- Chen Y
- Chen Y
- Chen Y
- Chen Z
- Cheng H
- Cheng Z
- Cheu R
- Chidiac C
- Chigayo M
- Chihana NK
- Chikandiwa A
- Chikandiwa A
- Chikonda J
- Chileshe C
- Chilima B
- Chilima B
- Chilongani J
- Chimanpure V
- Chimbetete C
- Chimbetete C
- Chime C
- Chinkonde J
- Chinsinga B
- Chipadze
- Chipeta Z
- Chipungu J
- Chirchir B
- Chirowodza A
- Chirwa E
- Chirwa E
- Chirwa Z
- Chiyaka T
- Chomba E
- Chomba E
- Chomchey N
- Chomont N
- Chomont N
- Chopera D
- Chung A
- Church K
- Church K
- Cianci G
- Cicala C
- Clark T
- Clark T
- Clark T
- Clarke A
- Clarke K
- Clotet B
- Cluver L
- Cluver L
- Coffey-Esquivel J
- Cofield S
- Cohen
- Cohen C
- Cohen C
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- Cohort S
- Cole M
- Colebunders R
- Coletti A
- Coletti A
- Collins I
- Collins S
- Colua E
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- Comstock L
- Condo J
- Contreras D
- Contreras-Loya D
- Conway D
- Cook A
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- Coombs R
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- Cooper D
- Cooper K
- Copas A
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- Corey L
- Coris
- Corrigan B
- Cossa L
- Costagliola D
- Costiniuk C
- Cotte L
- Couderc C
- Coulibaly A
- Coulter R
- Cowan F
- Cowan F
- Cowan F
- Crampin A
- Crandall B
- Cranston R
- Crauwels H
- Crooks E
- Crosno K
- Crouch P-C
- Cua E
- Cuembelo F
- Cummins N
- Curran K
- Currier J
- Currier J
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- D'Aquila R
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- Daho S
- Dalal S
- Dam K
- Danboise B
- Danel C
- Dange A
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- Darbes L
- Darong G
- Darr E
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- Datong P
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- Davey DJ
- Davies M-A
- Davies N
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- Davis VR
- Davis W
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- Dawood H
- Dawson L
- Dayton F
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- Ddaaki W
- Ddaaki W
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- De Gruttola V
- De Jong B
- de la Grecca R
- de Lima Pereira ME
- de Lima CE
- de Oliveira T
- De Oliveira T
- de Pedro A
- de Pokomandy A
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- Zablotska I
- Zabsonre I
- Zampieri T
- Zandamela A
- Zanolini A
- Zapiola I
- Zash R
- Zaza S
- Zeh C
- Zembe L
- Zeng W
- Zerbe A
- Zevin A
- Zhang F
- Zhang H
- Zhang W
- Zhang Y
- Zhanpeisova A
- Zhao Y
- Zhu L
- Zieman B
- Zieman B
- Zulu C
- Zuma T
- Zurla C
- Publication venue
- 'International AIDS Society'
- Publication date
- 01/01/2016
- Field of study
Meeting abstract FRAB0101LB from 21st International AIDS Conference 18â22 July 2016, Durban, South Africa.
Introduction: Mortality from infections is high in the first 6 months of antiretroviral therapy (ART) among HIVâinfected adults and children with advanced disease in subâSaharan Africa. Whether an enhanced package of infection prophylaxis at ART initiation would reduce mortality is unknown.
Methods:
The REALITY 2Ă2Ă2 factorial openâlabel trial (ISRCTN43622374) randomized ARTânaĂŻve HIVâinfected adults and children >5 years with CD4 <100 cells/mm3. This randomization compared initiating ART with enhanced prophylaxis (continuous cotrimoxazole plus 12 weeks isoniazid/pyridoxine (antiâtuberculosis) and fluconazole (antiâcryptococcal/candida), 5 days azithromycin (antiâbacterial/protozoal) and singleâdose albendazole (antiâhelminth)), versus standardâofâcare cotrimoxazole. Isoniazid/pyridoxine/cotrimoxazole was formulated as a scored fixedâdose combination. Two other randomizations investigated 12âweek adjunctive raltegravir or supplementary food. The primary endpoint was 24âweek mortality.
Results:
1805 eligible adults (n = 1733; 96.0%) and children/adolescents (n = 72; 4.0%) (median 36 years; 53.2% male) were randomized to enhanced (n = 906) or standard prophylaxis (n = 899) and followed for 48 weeks (3.8% lossâtoâfollowâup). Median baseline CD4 was 36 cells/mm3 (IQR: 16â62) but 47.3% were WHO Stage 1/2. 80 (8.9%) enhanced versus 108(12.2%) standard prophylaxis died before 24 weeks (adjusted hazard ratio (aHR) = 0.73 (95% CI: 0.54â0.97) p = 0.03; Figure 1) and 98(11.0%) versus 127(14.4%) respectively died before 48 weeks (aHR = 0.75 (0.58â0.98) p = 0.04), with no evidence of interaction with the two other randomizations (p > 0.8). Enhanced prophylaxis significantly reduced incidence of tuberculosis (p = 0.02), cryptococcal disease (p = 0.01), oral/oesophageal candidiasis (p = 0.02), deaths of unknown cause (p = 0.02) and (marginally) hospitalisations (p = 0.06) but not presumed severe bacterial infections (p = 0.38). Serious and grade 4 adverse events were marginally less common with enhanced prophylaxis (p = 0.06). CD4 increases and VL suppression were similar between groups (p > 0.2).
Conclusions:
Enhanced infection prophylaxis at ART initiation reduces early mortality by 25% among HIVâinfected adults and children with advanced disease. The pill burden did not adversely affect VL suppression. Policy makers should consider adopting and implementing this lowâcost broad infection prevention package which could save 3.3 lives for every 100 individuals treated
A randomized trial of planned cesarean or vaginal delivery for twin pregnancy
- Author
- Abalos Gorostiaga Raul
- Abdelradey Tarek
- Abreo Griselda Itati
- Aguirre Jesus Daniel
- Ahlbom Monica
- Al-Jassim Amal Abdullah
- Al-Taher Hamed
- AlFaris Lama
- Alleman Sjaak
- Allen Alexander C.
- Alonso Justo
- Andina Elsa
- Antsaklis Aris
- Arevalo Martinez Silvia
- Arias Carlos
- Armson B. Anthony
- Aronoff Christine
- Asztalos Elizabeth J.
- Ayub Antonio C.K.
- Baade Robert
- Barbosa de Moraes Filho Olimpio
- Barbosa Lima Antonio Carlos
- Bargh Amanda
- Barrere Maria Beatriz
- Barrett Jon F.R.
- Bartha TĂŒnde
- Ben-Ami Moshe
- Benitez Patricia
- Bertin Marta Susana
- Bland Kimberley
- Bordin Jennifer
- Borowski Kristi
- Bracken Michael
- Breborowicz Grzegorz
- Breugelmans Ria
- Bricker Leanne
- Brown Melissa
- Brown Stanette
- Bugg George
- Bugg George
- Buraschi Fernanda
- Burgis Judith
- Calderon Iracema
- Cameron Helen
- Canete Palomo Maria Luisa
- Caracostea Gabriela
- Carreras Moratonas Elena
- Carson George
- Castagnola Maria Cecilia
- Castaldi Jose Luis
- Cecatti Jose Guilherme
- Chalem Elisa
- Chan Sunny
- Chaplin Jackie
- Chayen Benny
- Coelho Marques Caio
- Coonrod Dean V.
- Cortizo Vidal Augusto
- Crane Joan
- Crowley Patricia
- Crowther Caroline
- Cundiff Geoffrey
- Curioni Miguel
- Daitchman Rhona
- Dalmolin Bollis MĂĄrcia
- Dans Fernando
- Davis Greg
- Davis Yvette
- de la Calle Maria
- de Sagastizabal Maria Teresa
- Deaver John
- Deguer Carlos
- Delius Maria
- Dera Anna
- Deshpande Ruta
- Deussen Andrea
- Diogo Mary
- Dip Viviana
- Dodd Jodie
- Donner Allan
- Dower Michelle
- Drakakis Peter
- Duhalde Esteban Marcos
- Duley Lelia
- Dunaievsky Armando
- Duncan Christine
- Edmundson Dawn
- Ehrenkranz Richard
- El-Zibdeh Mazen
- Fanning Cora
- Farquharson Duncan
- Farrar Diane
- Farrell Scott
- Fazlagic Amira
- Fernandez Ariadna
- Fisher Joanne
- Fleener Diedre
- Frailuna Maria Alejandra
- Franzé Florencio
- Gafni Amiram
- Gagnon Alain
- Galimberti Diana
- Garanhani Surita Fernanda
- Garcia Austt Alfonso
- Garcia Valeria
- GarcĂa Horacio
- Gardener Glenn
- Germaine Tracey
- Gojnic Miroslava
- Gomez Elena Elizabeth
- Gomez Ricardo
- Gonce Anna
- Gonen Ron
- Goodsell Kerry
- Gratton Robert
- Green Anne
- Gregg Anthony
- Gregorovich Sandra
- Guerios Bornia Rita
- Hakim Marwan
- Hallak Mordechai
- Hanafy Ash
- Hanigsberg Julia E.
- Hannah Mary E.
- Haran Mano
- Harel Linda
- Harrison Kristy
- Hasbargen Uwe
- Haslauer Kelly-Ann
- Heres Marion
- Herrero Rodriguez Sara
- Hewson Sheila A.
- Hinshaw Kim
- Hoac Trinh
- Hollands Heidi
- Holloway Fiona
- Hopp Hartmut
- Houda Mohammed
- Houghton Gillian
- Hutchens Donna
- Hutton Eileen K.
- Jimenez Blanca Flor
- JimĂ©nez Fournier MarĂa Carmen
- Joseph K.S.
- Kaye Stephen
- Kennedy Laura
- Kesiak Marcin
- Khan Sultana
- Kirss Fred
- Klam Stephanie
- Kontopoulos Eftichia
- Korkes Henri
- Kowal Christine
- Krasomski Grzegorz
- Krekora Michael
- Kulkarni Ramesh
- Kusanovic Juan Pedro
- Laplante Joanne
- Laterra Cristina
- Laubach Monika
- Lawrence Annemarie
- Leduc Line
- Lee Jennifer
- Leighton Valenzuela Luis
- Leita Silva Carvalho Simone Angélica
- Llurba Elisa
- Longworth Heather
- Lopez Sara
- Lovett Stuart M.
- LĂĄzaro-Carrasco Delgado Carolina
- Madariaga Leiva Erika
- MagalhĂŁes Claudia
- Mahomed Kassam
- Maia Filho Nelson Lorenço
- Major TamĂĄs
- Makhlouf Ahmad
- Maldonado del Valle MarĂa Dolores
- Mangoff Kathryn
- Mansour-Schwake Dalia
- Marcolino Luciano
- Marques Lopes Laudelino
- Martins Anice
- MartĂn Raquel de Lourdes
- Mason Dalah
- Massanes Marta
- Masuku Maxwell
- Matijevic Ratko
- McLeod Lynne
- Meehan Helen
- Mei-Dan Elad
- Mergler Sonya
- Mesas Walter
- Messina Analia
- Michaelis Silke
- Milan Carla
- Miller Leslie
- Mohedano Maria
- Mol Ben Willem
- Molina Ravanal MĂłnica
- Montes Varela Dolores
- Moore Elaine
- Morales Elba Mirta Alicia
- Moreira de Sa Renato Augusto
- Moreira Simone
- Morita Yokota Eliana Junko
- Mueller Valerie
- Nemtean Debbie
- Nonnenmacher Andreas
- Nunes Santana Danielly Saranello
- Ohlsson Arne
- Ojutiku Dale
- Okun Nanette
- Olatunbosun Femi
- Ornstein Melanie
- Ortiz Alejandra
- Palethorpe Rebecca
- Palmermo Mario
- Pansky Samuel
- Partida Yamil
- Pascall Angela
- Perlitz Yuri
- Perovic Milan
- Petchinkin Liana
- Petruskavich Shelly
- Pierson Kathleen
- Porath Martina M.
- Preis Krzysztof
- Prieto MarĂa JosĂ©
- Radfar Forough
- Ramirez Almansa Silvina
- Reid Donna
- Ribeiro da Silva Nancy
- Ribeiro de Faria Silveira Miriam
- Ribeiro de Souza Goianice
- Rinkens Jeannine
- Rivero Mabel
- Rivero Yvette
- Roberts Lynne
- Rodo Rodriguez Carlota
- RodrĂguez MartĂn MarĂa Nieves
- Rolland de Souza Alex Sandro
- Romo Cabrera Juan Guillermo
- Roque Alicia
- Rosado Luiza
- Rosman David
- Ross Susan
- Roumen Frans J.M.E.
- Rull Kristiina
- Saber Osama
- Sadan Oscar
- Salim Raed
- Sancha Marta
- Sanchez J. Johanna
- Sass Nelson
- Sau Ashis
- Savransky Ricardo
- Scarfone Rhonda
- Scavuzzi Adriana
- Scheufler Peter
- Schiaffino Orrego Rodrigo
- Schinini Josefina
- Sexer HĂ©ctor
- Shi Michael
- Siev Sima
- Silva Neculman Karla
- Simm Andy
- Simms-Stewart Donnette
- Siurna Hiliary
- Sluis Aafje
- Southam Donna
- Spinola Renata
- Stamatian Florin
- Steibel Gustavo
- Stephanovic Toma
- Sumersille Melanie
- Susacasa Sandra
- Suy Franch Anna
- Swiatkowska-Freund Malgorzata
- Thornton James
- Thorpe Kevin
- Tucker Stephen
- Tuffnell Derek
- ur Rahman Ssjjad
- Vaas Pille
- van Zandvoort Simon Gordijn
- Vasiljevic Brankica
- Verhoeven Corine
- Videla Arturo
- Visram Soraya
- Voto Geraldine N.
- Voto Liliana S.
- Watson David
- Welch Ross
- Wilczynski Jan
- Wilkins Danielle
- Willan Andrew R.
- Willekes Christine
- Williams Suzanne
- Wilson Monifa
- Wolff Leslie
- Wood Stephen
- Wright Janet
- Young Peter
- Zaltz Arthur
- Zanella Pedro Luis
- Zatinsky Shana
- Zych Katarzyna
- Publication venue
- Massachusetts Medical Society
- Publication date
- 03/10/2013
- Field of study
Background: Twin birth is associated with a higher risk of adverse perinatal outcomes than singleton birth. It is unclear whether planned cesarean section results in a lower risk of adverse outcomes than planned vaginal delivery in twin pregnancy.\ud
\ud
Methods: We randomly assigned women between 32 weeks 0 days and 38 weeks 6 days of gestation with twin pregnancy and with the first twin in the cephalic presentation to planned cesarean section or planned vaginal delivery with cesarean only if indicated. Elective delivery was planned between 37 weeks 5 days and 38 weeks 6 days of gestation. The primary outcome was a composite of fetal or neonatal death or serious neonatal morbidity, with the fetus or infant as the unit of analysis for the statistical comparison.\ud
\ud
Results: A total of 1398 women (2795 fetuses) were randomly assigned to planned cesarean delivery and 1406 women (2812 fetuses) to planned vaginal delivery. The rate of cesarean delivery was 90.7% in the planned-cesarean-delivery group and 43.8% in the planned-vaginal-delivery group. Women in the planned-cesarean-delivery group delivered earlier than did those in the planned-vaginal-delivery group (mean number of days from randomization to delivery, 12.4 vs. 13.3; P = 0.04). There was no significant difference in the composite primary outcome between the planned-cesarean-delivery group and the planned-vaginal-delivery group (2.2% and 1.9%, respectively; odds ratio with planned cesarean delivery, 1.16; 95% confidence interval, 0.77 to 1.74; P = 0.49).\ud
\ud
Conclusion: In twin pregnancy between 32 weeks 0 days and 38 weeks 6 days of gestation, with the first twin in the cephalic presentation, planned cesarean delivery did not significantly decrease or increase the risk of fetal or neonatal death or serious neonatal morbidity, as compared with planned vaginal delivery