Horizontal animation deformity as unusual complication of neurotoxin modulation of the gummy smile

Injections of botulinum toxin type A represent the most common nonsurgical cosmetic treatment worldwide. The authors report a case of dynamic horizontal wrinkling in the upper lip that appeared after botulinum toxin type A injections to treat gummy smile associated with nasal alar base reduction, in a 28-year-old woman. The anatomic features and pathogenic mechanism underlying this unusual complication are analyzed and discussed

Horizontal animation deformity as unusual complication of neurotoxin modulation of the gummy smile

Injections  of  botulinum  toxin  type  A  represent  the  most    common    nonsurgical    cosmetic    treatment    worldwide.  The  authors  report  a  case  of  dynamic  horizontal  wrinkling  in  the  upper  lip  that  appeared  after   botulinum   toxin   type   A   injections   to   treat   gummy    smile    associated    with    nasal    alar    base    reduction,  in  a  28-year-old  woman.  The  anatomic  features and pathogenic mechanism underlying this unusual complication are analyzed and discussed.</p

One-loop Correction and the Dilaton Runaway Problem

We examine the one-loop vacuum structure of an effective theory of gaugino condensation coupled to the dilaton for string models in which the gauge coupling constant does not receive string threshold corrections. The new ingredients in our treatment are that we take into account the one-loop correction to the dilaton K\"ahler potential and we use a formulation which includes a chiral field $H$ corresponding to the gaugino bilinear. We find through explicit calculation that supersymmetry in the Yang-Mills sector is broken by gaugino condensation. The dilaton and $H$ field have masses on the order of the gaugino condensation scale independently of the dilaton VEV. Although the calculation performed here is at best a model of the full gaugino condensation dynamics, the result shows that the one-loop correction to the dilaton K\"ahler potential as well as the detailed dynamics at the gaugino condensation scale may play an important role in solving the dilaton runaway problem.Comment: 19 page

Development and implementation of a prescription opioid registry across diverse health systems

Objective: Develop and implement a prescription opioid registry in 10 diverse health systems across the US and describe trends in prescribed opioids between 2012 and 2018. Materials and Methods: Using electronic health record and claims data, we identified patients who had an outpatient fill for any prescription opioid, and/or an opioid use disorder diagnosis, between January 1, 2012 and December 31, 2018. The registry contains distributed files of prescription opioids, benzodiazepines and other select medications, opioid antagonists, clinical diagnoses, procedures, health services utilization, and health plan membership. Rates of outpatient opioid fills over the study period, standardized to health system demographic distributions, are described by age, gender, and race/ethnicity among members without cancer. Results: The registry includes 6 249 710 patients and over 40 million outpatient opioid fills. For the combined registry population, opioid fills declined from a high of 0.718 per member-year in 2013 to 0.478 in 2018, and morphine milligram equivalents (MMEs) per fill declined from 985 MMEs per fill in 2012 to 758 MMEs in 2018. MMEs per member declined from 692 MMEs per member in 2012 to 362 MMEs per member in 2018. Conclusion: This study established a population-based opioid registry across 10 diverse health systems that can be used to address questions related to opioid use. Initial analyses showed large reductions in overall opioid use per member among the combined health systems. The registry will be used in future studies to answer a broad range of other critical public health issues relating to prescription opioid use

WHO systematic review of prevalence of chronic pelvic pain: a neglected reproductive health morbidity

BACKGROUND: Health care planning for chronic pelvic pain (CPP), an important cause of morbidity amongst women is hampered due to lack of clear collated summaries of its basic epidemiological data. We systematically reviewed worldwide literature on the prevalence of different types of CPP to assess the geographical distribution of data, and to explore sources of variation in its estimates. METHODS: We identified data available from Medline (1966 to 2004), Embase (1980 to 2004), PsycINFO (1887 to 2003), LILACS (1982 to 2004), Science Citation index, CINAHL (January 1980 to 2004) and hand searching of reference lists. Two reviewers extracted data independently, using a piloted form, on participants' characteristics, study quality and rates of CPP. We considered a study to be of high quality (valid) if had at least three of the following features: prospective design, validated measurement tool, adequate sampling method, sample size estimation and response rate >80%. We performed both univariate and multivariate meta-regression analysis to explore heterogeneity of results across studies. RESULTS: There were 178 studies (459975 participants) in 148 articles. Of these, 106 studies were (124259 participants) on dysmenorrhoea, 54 (35973 participants) on dyspareunia and 18 (301756 participants) on noncyclical pain. There were only 19/95 (20%) less developed and 1/45 (2.2%) least developed countries with relevant data in contrast to 22/43 (51.2%) developed countries. Meta-regression analysis showed that rates of pain varied according to study quality features. There were 40 (22.5%) high quality studies with representative samples. Amongst them, the rate of dysmenorrhoea was 16.8 to 81%, that of dyspareunia was 8 to 21.8%, and that for noncyclical pain was 2.1 to 24%. CONCLUSION: There were few valid population based estimates of disease burden due to CPP from less developed countries. The variation in rates of CPP worldwide was due to variable study quality. Where valid data were available, a high disease burden of all types of pelvic pain was found

The OpenMolcas Web: A Community-Driven Approach to Advancing Computational Chemistry

The developments of the open-source OpenMolcas chemistry software environment since spring 2020 are described, with a focus on novel functionalities accessible in the stable branch of the package or via interfaces with other packages. These developments span a wide range of topics in computational chemistry and are presented in thematic sections: electronic structure theory, electronic spectroscopy simulations, analytic gradients and molecular structure optimizations, ab initio molecular dynamics, and other new features. This report offers an overview of the chemical phenomena and processes OpenMolcas can address, while showing that OpenMolcas is an attractive platform for state-of-the-art atomistic computer simulations

Gender bukan tabu: catatan perjalanan fasilitasi kelompok perempuan di Jambi

Cross-coupling of nitrogen with hydrocarbons under fragment coupling conditions stands to significantly impact chemical synthesis. Herein, we disclose a C­(sp³)–N fragment coupling reaction between terminal olefins and <i>N</i>-triflyl protected aliphatic and aromatic amines via Pd­(II)/SOX (sulfoxide-oxazoline) catalyzed intermolecular allylic C–H amination. A range of (56) allylic amines are furnished in good yields (avg. 75%) and excellent regio- and stereoselectivity (avg. >20:1 linear:branched, >20:1 <i>E</i>:<i>Z</i>). Mechanistic studies reveal that the SOX ligand framework is effective at promoting functionalization by supporting cationic π-allyl Pd

PROTOTYPE DESIGN OF HONEY EXTRACTOR MACHINE USING ARDUINO MICROCONTROLLER WITH INTERNET OF THINGS (IOT) MODEL

The application of appropriate technology based on the Adruino Uno R3 Microcontroller using the Android Operating System has been tested in this research. Sensor technology coupled with Arduino is applied to control the electric motor mounted on the honey bee extractor. It is proven that this can increase harvest efficiency because honey bees can produce directly without building a honeybee nest, which takes 14 days. In addition to time efficiency, the extractor processing process is also more efficient and optimal because all the honey in the hive is removed maximally without damaging the honeybee nest structure. A honey extractor is a tool used to squeeze honeycomb which has been produced by bees and has a high economic valu