Adenosine diphosphate and thromboxane A2 platelet activation in type II diabetes mellitus

https://drive.google.com/file/d/1ajT5RbHi1SLx1ywu19M8tpH8WHs6Hzjq/view?usp=sharinghttps://drive.google.com/drive/folders/1ynCBgeV1Fuxgy7BEVV3EKvtXALdcaXlH?usp=sharinghttps://drive.google.com/drive/folders/1T4pPY-uxwRUSDcYMCSHWePcUA6u_uyqb?usp=sharin

Compensation in Verbal and Nonverbal Communication after Total Laryngectomy

Total laryngectomy is a major surgical procedure with life-changing consequences. As a result of the surgery, the upper and lower airways are disconnected, the natural voice is lost, and patients breathe through a tracheostoma in the neck. Tracheoesophageal speech is the most common speech rehabilitation technique. Due to the lack of air volume, and the amount of muscle tension in the esophagus, some patients may suffer from a hyper- or hypo-tonic voice, resulting in less intelligible speech. To communicate as intelligibly as possible, patients likely adapt their verbal and nonverbal communication to their physical disabilities. The current study aimed to explore the compensation techniques in verbal and nonverbal communication after total laryngectomy focusing on the complexity of grammar and the use of co-speech gestures. We analyzed previously obtained interviews of eight laryngectomized women on the syntactic complexity in speech and the use and type of co-speech gestures. Results were compared with analyses of productions by healthy controls. We found that laryngectomized women reduce the syntactic complexity of their speech, and use nonverbal gestures in their communication. Further research is needed with systematically obtained data and more suitable match-groups

Holding back the genes: limitations of research into canine behavioural genetics

Canine behaviours that are both desirable and undesirable to owners have a demonstrable genetic component. Some behaviours are breed-specific, such as the livestock guarding by maremmas and flank sucking seen in Dobermanns. While the identification of genes responsible for common canine diseases is rapidly advancing, those genes underlying behaviours remain elusive. The challenges of accurately defining and measuring behavioural phenotypes remain an obstacle, and the use of variable phenotyping methods has prevented meta-analysis of behavioural studies. International standardised testing protocols and terminology in canine behavioural evaluations should facilitate selection against behavioural disorders in the modern dog and optimise breeding success and performance in working dogs. This review examines the common hurdles faced by researchers of behavioural genetics and the current state of knowledge

Acrophyseal growth arrest in a long-term survivor of acute lymphoblastic leukemia

Growth arrest at the secondary growth plate, also known as the acrophysis, is a rare phenomenon with only very few known published case reports. We report on a case of formation of ghost secondary ossification centers at the acrophyses of the knee joint in a 14-year-old female, who survived early childhood acute lymphoblastic leukemia. The patient suffered from severe side effects from both disease and subsequent treatment strategies with a 10-month immobilization period as a consequence at the age of 3 years. The ghost secondary ossification centers were encountered on radiographs and MRI 10 years later, when she presented for evaluation of chronic pain in her left knee related to sports activities, due to a meniscal cyst. Awareness of this phenomenon is nevertheless important, because it seems that endochondral bone growth recovery at the acrophyses might be different from recovery in physes, because we found no concomitant sequelae of growth arrest in the metaphyses

When are anti-fat attitudes understood as prejudice versus truth? An experimental study of social influence effects

Background/Objectives If people who hold anti-fat attitudes believe these attitudes to be true, then anti-prejudice appeals are likely to be unsuccessful, if only because the targets will not see their attitudes as in need of change. The current study examined processes that may lead people to see their anti-fat attitudes as 'truth' or as 'prejudice'. Subjects/Methods Participants (N = 482) read anti-fat statements and were then presented with an interpretation of these statements as 'truth' or 'prejudice'. The source of this interpretation was either an (i) in-group or out-group member and (ii) expert or non-expert. Participants' judgements of the statements were expected to vary such that in-group others and experts would exert more influence than would out-group others and non-experts. Results Participants aligned their own interpretations of an anti-fat statement with those of an expert, but not with those of a non-expert, F(1,466) = 8.97, p <0.05, eta(2)(p) = 0.02. The group membership variable had no effect on judgements of 'truth' or 'prejudice' of the anti-fat statement. Conclusion The expressions that people believe constitute anti-fat prejudice versus truth about people described as overweight are influenced by exposure to expert opinion (in this case, by medical doctors). Implications for the success of weight-based anti-prejudice appeals and for healthcare provision are discussed

LANSCE Digital Low Level RF Upgrade

Incremental upgrades of the legacy low level RF (LLRF) equipment-50 years for the Los Alamos Neutron Science Center (LANSCE)-involves challenges and problems not seen with new and total replacement opportunities. The digital LLRF upgrade at LANSCE has deployed 30 of the 53 required systems as of September 2022. This paper describes the performance of the digital upgrade, current status, and future installations along with the technical challenges, including unexpected challenges, associated with deploying new digital systems in conjunction with legacy analog equipment. In addition, this paper discusses the operational details of simultaneous multi-energy beam operations using high energy re-bunching, beam-type specific set points and simultaneous multi-beam operations at LANSCE. The adaptability of the digital LLRF systems is essential as the design is able to accommodate new control and beam parameters associated with future systems without significant hardware modifications such as the expected LANSCE Modernization Program. This adaptability of the digital LLRF technology was recently demonstrated with the Module 1, 201.25-MHz high-power RF upgrade completed in 2021.Comment: Talk presented at LLRF Workshop 2022 (LLRF2022, arXiv:2208.13680