Nondestructive testing of railroad wheels and rails by ultrasonics

Quality control of wheels and rails can be improved by using ultrasonic technique developed for measuring stresses in metallic materials. In addition, parts already in use can be tested and replaced if they are found to be unsafe. Test equipment includes two transducers

Net N mineralization in subalpine grasslands: effect of aboveground vertebrate and invertebrate herbivores

Aboveground herbivores have strong effects on grassland nitrogen (N) cycling. They can accelerate or slow down soil net N mineralization depending on ecosystem productivity and grazing intensity. We assessed how a diverse herbivore community affects net N mineralization in subalpine grasslands. By using size-selective fences, we progressively excluded large, medium, and small mammals, as well as invertebrates from two vegetation types, and assessed how the exclosure types (ET) affected net N mineralization. The two vegetation types differed in long-term management (centuries), forage quality, and grazing history and intensity. To gain a more mechanistic understanding of how herbivores affect net N mineralization, we linked mineralization to soil abiotic (temperature; moisture; NO3, NH4, and total inorganic N concentrations/pools; C, N, P concentrations; pH; bulk density), soil biotic (microbial biomass; abundance of collembolans, mites, and nematodes) and plant (shoot and root biomass; consumption; plant C, N, and fiber content; plant N pool) properties. Net N mineralization differed between ET, but not between vegetation types. Thus, shortterm changes in herbivore community composition and, therefore, in grazing intensity had a stronger effect on net N mineralization than long-term management and grazing history. We found highest N mineralization values when only invertebrates were present, suggesting that mammals had a negative effect on net N mineralization. Of the variables included in our analyses, only mite abundance and aboveground plant biomass explained variation in net N mineralization among ET. Abundances of both mites and leaf-sucking invertebrates were positively correlated with aboveground plant biomass, and biomass increased with progressive exclusion. The negative impact of mammals on net N mineralization may be related partially to (1) differences in the amount of plant material (litter) returned to the belowground subsystem, which induced a positive bottom-up effect on mite abundance, and (2) alterations in the amount and/or distribution of dung, urine, and food waste. Thus, our results clearly show that short-term alterations of the aboveground herbivore community, can strongly impact nutrient cycling within ecosystems independent of long-term management and grazing history

Association of smoking and nicotine dependence with pre-diabetes in young and healthy adults.

INTRODUCTION: Several studies have shown an increased risk of type 2 diabetes among smokers. Therefore, the aim of this analysis was to assess the relationship between smoking, cumulative smoking exposure and nicotine dependence with pre-diabetes. METHODS: We performed a cross-sectional analysis of healthy adults aged 25-41 in the Principality of Liechtenstein. Individuals with known diabetes, Body Mass Index (BMI) >35 kg/m² and prevalent cardiovascular disease were excluded. Smoking behaviour was assessed by self-report. Pre-diabetes was defined as glycosylated haemoglobin between 5.7% and 6.4%. Multivariable logistic regression models were done. RESULTS: Of the 2142 participants (median age 37 years), 499 (23.3%) had pre-diabetes. There were 1,168 (55%) never smokers, 503 (23%) past smokers and 471 (22%) current smokers, with a prevalence of pre-diabetes of 21.2%, 20.9% and 31.2%, respectively (p <0.0001). In multivariable regression models, current smokers had an odds ratio (OR) of pre-diabetes of 1.82 (95% confidential interval (CI) 1.39; 2.38, p <0.0001). Individuals with a smoking exposure of <5, 5-10 and >10 pack-years had an OR (95% CI) for pre-diabetes of 1.34 (0.90; 2.00), 1.80 (1.07; 3.01) and 2.51 (1.80; 3.59) (p linear trend <0.0001) compared with never smokers. A Fagerström score of 2, 3-5 and >5 among current smokers was associated with an OR (95% CI) for pre-diabetes of 1.27 (0.89; 1.82), 2.15 (1.48; 3.13) and 3.35 (1.73; 6.48) (p linear trend <0.0001). DISCUSSION: Smoking is strongly associated with pre-diabetes in young adults with a low burden of smoking exposure. Nicotine dependence could be a potential mechanism of this relationship

On the Significance of the Die Design for Electromagnetic Sheet Metal Forming

Electromagnetic Forming is a high speed forming process using a pulsed magnetic field to form metals with high electrical conductivity, such as copper or aluminium alloys. During the process, typical pressure peaks up to 200 MPa and velocities in the range of 300 m/s can be achieved. As significant process parameters the pressure maximum as well as the local and temporal varying pressure distribution have been identified. As of a certain drawing depth and distance between workpiece and tool coil, the pressure does not act any longer on the workpiece, but the deformation process is still driven by the inertia forces. It has been found out that the velocity distribution within the sheet metal during the forming stages as well as at the time of impact with a die significantly influences the forming result. Additionally, a special undesired effect is the rebound behaviour of flat workpiece areas being in contact with the die. To investigate the influence capability of the die concerning this effect, the parameters stiffness and damping properties have been varied by means of simulation using a mechanical substitute model

Perch-type Characteristics of Overwintering Red-tailed Hawks (Buteo jamaicensis) and American Kestrels (Falco sparverius)

Red-tailed Hawks (Buteo jamaicensis) and American Kestrels (Falco sparverius) are primarily sitand-wait predators that rely on perches to forage most efficiently. Overwintering Red-tailed Hawks and American Kestrels use available perches (e.g., utility poles and wires, trees, fences, gates, etc.) to hunt for prey items in agricultural fields in northeast Arkansas. Observations were made from December 2011-March 2012 and November 2012-March 2013 in three representative cover-types (short rice stubble, soybean stubble, and fallow areas including roadsides) to determine which perch-types were used by Red-tailed Hawks and American Kestrels. Utility pole crossbeams at an average height of 6.3 m were the main perchtypes used by Red-tailed Hawks, demonstrating the use of man-made structures’. These perches were generally in or near fallow areas or short rice stubble fields. Conversely, American Kestrels usually perched on wires at an average height of 4.9 m, over fallow roadsides’. Fallow areas had high prey density and vegetation cover. Niche separation via differential use of perches may be one factor that allows these raptors to avoid inter-specific competition

Exploratory topic modeling with distributional semantics

As we continue to collect and store textual data in a multitude of domains, we are regularly confronted with material whose largely unknown thematic structure we want to uncover. With unsupervised, exploratory analysis, no prior knowledge about the content is required and highly open-ended tasks can be supported. In the past few years, probabilistic topic modeling has emerged as a popular approach to this problem. Nevertheless, the representation of the latent topics as aggregations of semi-coherent terms limits their interpretability and level of detail. This paper presents an alternative approach to topic modeling that maps topics as a network for exploration, based on distributional semantics using learned word vectors. From the granular level of terms and their semantic similarity relations global topic structures emerge as clustered regions and gradients of concepts. Moreover, the paper discusses the visual interactive representation of the topic map, which plays an important role in supporting its exploration.Comment: Conference: The Fourteenth International Symposium on Intelligent Data Analysis (IDA 2015

Effects of Electromagnetic and Hydraulic Forming Processes on the Microstructure of the Material

Over the past few years, various papers have been published in the field of high speed forming processes. The focus was mainly on the technological aspects of metal forming, however. Therefore, the present contribution puts an emphasis on transmission electron microscopy analyses. The present research work describes the effects of the two forming processes upon the aluminum microstructure and their influence on the material properties. The objective is to characterise the micro processes determining the plastic deformation with both forming velocities the electromagnetic high speed forming process with strain rates of 10,000 s^(-1) and the bulge test, having deformation rates of less than 0.1 s^(-1) as a quasistatic process. In this article sheet metals out of technical pure aluminum 99.5% with a thickness of 1 mm were investigated. To this end, sample specimens were taken from manufactured workpieces along the radius at various distances from the center. Because of the similarity of the forming paths, two places on the specimens manufactured at different forming rates were evaluated and compared to each other: immediately next to the blankholder and from the area of maximum strain. Metallographic tests of the structures, the sheet thickness, and the micro hardness distribution of the initial state and the formed sheet metals were executed in advance

The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change.

In pharmacogenomic studies of quantitative change, any association between genetic variants and the pretreatment (baseline) measurement can bias the estimate of effect between those variants and drug response. A putative solution is to adjust for baseline. We conducted a series of genome-wide association studies (GWASs) for low-density lipoprotein cholesterol (LDL-C) response to statin therapy in 34,874 participants of the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort as a case study to investigate the impact of baseline adjustment on results generated from pharmacogenomic studies of quantitative change. Across phenotypes of statin-induced LDL-C change, baseline adjustment identified variants from six loci meeting genome-wide significance (SORT/CELSR2/PSRC1, LPA, SLCO1B1, APOE, APOB, and SMARCA4/LDLR). In contrast, baseline-unadjusted analyses yielded variants from three loci meeting the criteria for genome-wide significance (LPA, APOE, and SLCO1B1). A genome-wide heterogeneity test of baseline versus statin on-treatment LDL-C levels was performed as the definitive test for the true effect of genetic variants on statin-induced LDL-C change. These findings were generally consistent with the models not adjusting for baseline signifying that genome-wide significant hits generated only from baseline-adjusted analyses (SORT/CELSR2/PSRC1, APOB, SMARCA4/LDLR) were likely biased. We then comprehensively reviewed published GWASs of drug-induced quantitative change and discovered that more than half (59%) inappropriately adjusted for baseline. Altogether, we demonstrate that (1) baseline adjustment introduces bias in pharmacogenomic studies of quantitative change and (2) this erroneous methodology is highly prevalent. We conclude that it is critical to avoid this common statistical approach in future pharmacogenomic studies of quantitative change